Details for: SNX3

Gene ID: 8724

Symbol: SNX3

Ensembl ID: ENSG00000112335

Description: sorting nexin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 443.2151
    Cell Significance Index: -68.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 318.7546
    Cell Significance Index: -80.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 279.4045
    Cell Significance Index: -115.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 237.9678
    Cell Significance Index: -112.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 237.6081
    Cell Significance Index: -96.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 209.7358
    Cell Significance Index: -107.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 168.3849
    Cell Significance Index: -112.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 102.0170
    Cell Significance Index: -97.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.8727
    Cell Significance Index: -86.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.1225
    Cell Significance Index: -78.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.1968
    Cell Significance Index: -107.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.7109
    Cell Significance Index: -78.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.3034
    Cell Significance Index: -37.8700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.3506
    Cell Significance Index: 25.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5098
    Cell Significance Index: 92.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0458
    Cell Significance Index: 418.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9858
    Cell Significance Index: 140.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6410
    Cell Significance Index: 55.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1503
    Cell Significance Index: 61.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1072
    Cell Significance Index: 259.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0217
    Cell Significance Index: 130.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9921
    Cell Significance Index: 1087.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9525
    Cell Significance Index: 250.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8637
    Cell Significance Index: 219.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7689
    Cell Significance Index: 318.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6970
    Cell Significance Index: 219.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6491
    Cell Significance Index: 330.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5800
    Cell Significance Index: 698.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5378
    Cell Significance Index: 17.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4708
    Cell Significance Index: 104.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4559
    Cell Significance Index: 25.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4014
    Cell Significance Index: 37.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3970
    Cell Significance Index: 73.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3881
    Cell Significance Index: 64.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3781
    Cell Significance Index: 102.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2005
    Cell Significance Index: 15.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9980
    Cell Significance Index: 198.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9322
    Cell Significance Index: 17.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9092
    Cell Significance Index: 47.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8217
    Cell Significance Index: 294.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6817
    Cell Significance Index: 23.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6664
    Cell Significance Index: 18.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3775
    Cell Significance Index: 19.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3202
    Cell Significance Index: 60.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3038
    Cell Significance Index: 30.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2344
    Cell Significance Index: 16.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1305
    Cell Significance Index: 117.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1129
    Cell Significance Index: 85.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1043
    Cell Significance Index: 1.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1017
    Cell Significance Index: 70.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0119
    Cell Significance Index: 8.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0236
    Cell Significance Index: -44.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0513
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0555
    Cell Significance Index: -102.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0670
    Cell Significance Index: -103.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0730
    Cell Significance Index: -99.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0850
    Cell Significance Index: -14.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1003
    Cell Significance Index: -63.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1090
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1102
    Cell Significance Index: -81.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1190
    Cell Significance Index: -19.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1665
    Cell Significance Index: -75.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1746
    Cell Significance Index: -98.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1922
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2060
    Cell Significance Index: -128.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2910
    Cell Significance Index: -33.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2922
    Cell Significance Index: -22.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3167
    Cell Significance Index: -91.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3698
    Cell Significance Index: -4.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3804
    Cell Significance Index: -23.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4249
    Cell Significance Index: -12.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4469
    Cell Significance Index: -11.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5439
    Cell Significance Index: -79.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5787
    Cell Significance Index: -121.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5800
    Cell Significance Index: -12.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6172
    Cell Significance Index: -41.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6251
    Cell Significance Index: -17.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6878
    Cell Significance Index: -17.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6929
    Cell Significance Index: -79.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7199
    Cell Significance Index: -45.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7891
    Cell Significance Index: -18.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8604
    Cell Significance Index: -68.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0196
    Cell Significance Index: -106.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0787
    Cell Significance Index: -34.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2279
    Cell Significance Index: -68.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4169
    Cell Significance Index: -37.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.6282
    Cell Significance Index: -13.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6350
    Cell Significance Index: -72.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6940
    Cell Significance Index: -103.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.8095
    Cell Significance Index: -82.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.8409
    Cell Significance Index: -47.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.8555
    Cell Significance Index: -52.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.8653
    Cell Significance Index: -25.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.9893
    Cell Significance Index: -75.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.0524
    Cell Significance Index: -43.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.0949
    Cell Significance Index: -31.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1347
    Cell Significance Index: -62.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1964
    Cell Significance Index: -37.6400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.2383
    Cell Significance Index: -13.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX3 is a small, cytosolic protein that belongs to the sorting nexin family. It is characterized by its ability to bind to phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol-4-phosphate (PI4P), which are key components of the endocytic machinery. SNX3's interaction with these lipids allows it to regulate the formation and movement of clathrin-coated vesicles, which are essential for endocytosis and exocytosis. Additionally, SNX3 has been shown to interact with various proteins, including Wnt ligands and the retromer complex, which further underscores its role in regulating cellular signaling. **Pathways and Functions:** SNX3 is involved in several key cellular pathways, including: 1. **Endocytic Recycling:** SNX3 regulates the formation and movement of clathrin-coated vesicles, which are essential for the recycling of endocytosed proteins and lipids. 2. **Wnt Signaling:** SNX3 interacts with Wnt ligands and modulates their trafficking, which is crucial for regulating cell fate decisions, including proliferation and differentiation. 3. **Retromer Complex:** SNX3 binds to the retromer complex, which is responsible for the retrograde transport of proteins and lipids from endosomes to the Golgi apparatus. 4. **Protein Transport:** SNX3 regulates the transport of proteins between the endoplasmic reticulum and the Golgi apparatus, as well as between the Golgi apparatus and the plasma membrane. **Clinical Significance:** SNX3's involvement in various cellular processes makes it a potential target for therapeutic interventions in diseases characterized by dysregulated endocytic recycling and signaling. For example: 1. **Cancer:** SNX3's role in regulating Wnt signaling and endocytic recycling makes it a potential target for cancer therapy. 2. **Neurological Disorders:** SNX3's involvement in regulating protein transport and endocytic recycling makes it a potential target for therapies aimed at treating neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immunological Disorders:** SNX3's role in regulating phagocytosis and endocytic recycling makes it a potential target for therapies aimed at treating immunological disorders, such as autoimmune diseases and cancer. In conclusion, SNX3 is a multifunctional protein that plays a crucial role in regulating endocytic recycling, Wnt signaling, and protein transport. Its involvement in various cellular processes makes it a potential target for therapeutic interventions in diseases characterized by dysregulated endocytic recycling and signaling.

Genular Protein ID: 4011276836

Symbol: SNX3_HUMAN

Name: Sorting nexin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9819414

Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.

PubMed ID: 9819414

DOI: 10.1128/mcb.18.12.7278

PubMed ID: 11433298

Title: SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.

PubMed ID: 11433298

DOI: 10.1038/35083051

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12471201

Title: Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype.

PubMed ID: 12471201

DOI: 10.1136/jmg.39.12.893

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17622474

Title: Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2.

PubMed ID: 17622474

DOI: 10.1111/j.1745-7270.2007.00303.x

PubMed ID: 18767904

Title: Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.

PubMed ID: 18767904

DOI: 10.1371/journal.pbio.0060214

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20482551

Title: Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole.

PubMed ID: 20482551

DOI: 10.1111/j.1462-5822.2010.01476.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21725319

Title: A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.

PubMed ID: 21725319

DOI: 10.1038/ncb2281

PubMed ID: 23237080

Title: SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells.

PubMed ID: 23237080

DOI: 10.1111/imm.12051

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24866125

Title: Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.

PubMed ID: 24866125

DOI: 10.1074/mcp.m113.037275

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24344282

Title: A mechanism for retromer endosomal coat complex assembly with cargo.

PubMed ID: 24344282

DOI: 10.1073/pnas.1316482111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30213940

Title: SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.

PubMed ID: 30213940

DOI: 10.1038/s41467-018-06114-3

Sequence Information:

  • Length: 162
  • Mass: 18762
  • Checksum: 983D422FCA6E07BC
  • Sequence:
  • MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE IRVKTNLPIF 
    KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRQ LPFRGDDGIF DDNFIEERKQ 
    GLEQFINKVA GHPLAQNERC LHMFLQDEII DKSYTPSKIR HA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.