Details for: RNMT

Gene ID: 8731

Symbol: RNMT

Ensembl ID: ENSG00000101654

Description: RNA guanine-7 methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 408.2414
    Cell Significance Index: -63.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 236.3949
    Cell Significance Index: -59.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.7648
    Cell Significance Index: -63.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.5708
    Cell Significance Index: -71.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 142.4713
    Cell Significance Index: -57.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.8225
    Cell Significance Index: -65.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 106.7476
    Cell Significance Index: -71.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.2364
    Cell Significance Index: -58.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.7846
    Cell Significance Index: -68.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.0106
    Cell Significance Index: -67.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.8584
    Cell Significance Index: -70.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.0543
    Cell Significance Index: -49.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3282
    Cell Significance Index: -29.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.2904
    Cell Significance Index: 535.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1719
    Cell Significance Index: 219.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.8425
    Cell Significance Index: 21.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8538
    Cell Significance Index: 49.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7312
    Cell Significance Index: 23.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7156
    Cell Significance Index: 49.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5208
    Cell Significance Index: 79.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4399
    Cell Significance Index: 75.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3412
    Cell Significance Index: 241.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2348
    Cell Significance Index: 245.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2262
    Cell Significance Index: 1107.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2071
    Cell Significance Index: 148.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1966
    Cell Significance Index: 164.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1856
    Cell Significance Index: 72.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1262
    Cell Significance Index: 72.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0797
    Cell Significance Index: 589.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9387
    Cell Significance Index: 336.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9235
    Cell Significance Index: 408.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9209
    Cell Significance Index: 70.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8719
    Cell Significance Index: 40.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6356
    Cell Significance Index: 29.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6158
    Cell Significance Index: 60.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6112
    Cell Significance Index: 34.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5697
    Cell Significance Index: 40.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5092
    Cell Significance Index: 352.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4698
    Cell Significance Index: 60.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4676
    Cell Significance Index: 24.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4611
    Cell Significance Index: 12.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4569
    Cell Significance Index: 13.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4475
    Cell Significance Index: 5.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4218
    Cell Significance Index: 19.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3987
    Cell Significance Index: 750.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3941
    Cell Significance Index: 606.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3763
    Cell Significance Index: 23.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2986
    Cell Significance Index: 35.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2573
    Cell Significance Index: 6.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2184
    Cell Significance Index: 402.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2156
    Cell Significance Index: 43.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2056
    Cell Significance Index: 279.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1720
    Cell Significance Index: 109.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1605
    Cell Significance Index: 20.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1505
    Cell Significance Index: 68.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0945
    Cell Significance Index: 17.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0865
    Cell Significance Index: 6.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0501
    Cell Significance Index: 8.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0154
    Cell Significance Index: 0.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0068
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0332
    Cell Significance Index: -24.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0426
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0444
    Cell Significance Index: -33.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0482
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0495
    Cell Significance Index: -27.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0796
    Cell Significance Index: -49.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0852
    Cell Significance Index: -3.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1154
    Cell Significance Index: -11.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1249
    Cell Significance Index: -4.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1266
    Cell Significance Index: -8.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1531
    Cell Significance Index: -2.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1830
    Cell Significance Index: -1.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1849
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2046
    Cell Significance Index: -43.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2089
    Cell Significance Index: -30.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2104
    Cell Significance Index: -60.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2124
    Cell Significance Index: -3.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2925
    Cell Significance Index: -6.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3273
    Cell Significance Index: -37.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3454
    Cell Significance Index: -5.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3853
    Cell Significance Index: -40.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3959
    Cell Significance Index: -46.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5088
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5257
    Cell Significance Index: -60.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5961
    Cell Significance Index: -14.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6349
    Cell Significance Index: -69.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6573
    Cell Significance Index: -7.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7165
    Cell Significance Index: -56.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8420
    Cell Significance Index: -51.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8507
    Cell Significance Index: -22.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8981
    Cell Significance Index: -25.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9137
    Cell Significance Index: -21.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9364
    Cell Significance Index: -29.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9459
    Cell Significance Index: -23.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0069
    Cell Significance Index: -18.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0191
    Cell Significance Index: -8.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1356
    Cell Significance Index: -29.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1979
    Cell Significance Index: -35.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2735
    Cell Significance Index: -27.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNMT is a multifunctional enzyme with several key characteristics: 1. **Specificity:** RNMT specifically methylates the 7th position of the guanine nucleotide in the 5' cap of mRNA, resulting in the formation of 7-methylguanosine capping. 2. **Enzyme activity:** RNMT exhibits guanine-N7 methyltransferase activity, which is essential for mRNA capping. 3. **Cellular localization:** RNMT is primarily localized to the nucleus, where it interacts with RNA polymerase II and other transcriptional machinery. 4. **Subcellular localization:** RNMT is also found in the nucleoplasm and can interact with RNA-binding proteins and other molecules. **Pathways and Functions** RNMT is involved in several key pathways, including: 1. **7-methylguanosine mRNA capping:** RNMT is responsible for the formation of 7-methylguanosine capping on mRNA, which regulates mRNA stability, translation, and stability. 2. **Cellular response to leukemia inhibitory factor (LIF):** RNMT has been implicated in the regulation of gene expression in response to LIF. 3. **Gene expression (transcription):** RNMT is involved in the regulation of gene expression by interacting with RNA polymerase II and other transcriptional machinery. 4. **HIV life cycle:** RNMT plays a crucial role in the regulation of HIV replication by interacting with the viral RNA polymerase. 5. **Metabolism of RNA:** RNMT is involved in the regulation of RNA metabolism, including mRNA stability and translation. **Clinical Significance** Dysregulation of RNMT has been implicated in various diseases, including: 1. **Cancer:** RNMT has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Infectious diseases:** RNMT has been implicated in the regulation of HIV replication and has been found to be overexpressed in HIV-infected individuals. 3. **Neurological disorders:** RNMT has been found to be dysregulated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RNMT is a multifunctional enzyme that plays a crucial role in various cellular processes, including gene expression, transcription, and viral replication. Its dysregulation has been implicated in various diseases, highlighting the importance of RNMT in maintaining cellular homeostasis.

Genular Protein ID: 1021970630

Symbol: MCES_HUMAN

Name: mRNA cap guanine-N7 methyltransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9790902

Title: Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)methyltransferase, an mRNA cap methylase.

PubMed ID: 9790902

DOI: 10.1006/bbrc.1998.9402

PubMed ID: 9705270

Title: Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes.

PubMed ID: 9705270

DOI: 10.1074/jbc.273.34.21443

PubMed ID: 10589710

Title: The Candida albicans gene for mRNA 5'-cap methyltransferase: identification of the additional residues essential for catalysis.

PubMed ID: 10589710

DOI: 10.1099/00221287-145-11-3023

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10347220

Title: Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes.

PubMed ID: 10347220

DOI: 10.1074/jbc.274.23.16553

PubMed ID: 11114884

Title: Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha.

PubMed ID: 11114884

DOI: 10.1101/gad.848200

PubMed ID: 15767670

Title: Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability.

PubMed ID: 15767670

DOI: 10.1128/mcb.25.7.2644-2649.2005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22099306

Title: RAM/Fam103a1 is required for mRNA cap methylation.

PubMed ID: 22099306

DOI: 10.1016/j.molcel.2011.08.041

PubMed ID: 27422871

Title: Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

PubMed ID: 27422871

DOI: 10.1093/nar/gkw637

Sequence Information:

  • Length: 476
  • Mass: 54844
  • Checksum: EC919BC41BD5E2B3
  • Sequence:
  • MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK 
    EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG 
    DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK 
    SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY 
    EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM 
    LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF 
    NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP 
    YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATSIYLVF AFEKQQ

Genular Protein ID: 2188507789

Symbol: A8K946_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 504
  • Mass: 57751
  • Checksum: 9AD0806CAA3F124D
  • Sequence:
  • MANSAKAEEY EKMSLEQAKP SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK 
    EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG 
    DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK 
    SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY 
    EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM 
    LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF 
    NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP 
    YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATRLTVTI MREAWLSTVG 
    PGRAPVAASS VKWGTPRPAM QFIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.