Details for: TNFSF12

Gene ID: 8742

Symbol: TNFSF12

Ensembl ID: ENSG00000239697

Description: TNF superfamily member 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 124.0797
    Cell Significance Index: -19.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.1592
    Cell Significance Index: -18.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.1456
    Cell Significance Index: -20.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.1716
    Cell Significance Index: -16.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.5011
    Cell Significance Index: -19.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.4183
    Cell Significance Index: -16.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.7467
    Cell Significance Index: -19.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9634
    Cell Significance Index: -15.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9493
    Cell Significance Index: -19.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2228
    Cell Significance Index: -12.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2197
    Cell Significance Index: 63.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6403
    Cell Significance Index: 63.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6351
    Cell Significance Index: 13.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5797
    Cell Significance Index: 523.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4651
    Cell Significance Index: 27.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4430
    Cell Significance Index: 48.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4361
    Cell Significance Index: 59.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4014
    Cell Significance Index: 11.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3847
    Cell Significance Index: 62.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3763
    Cell Significance Index: 6.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3432
    Cell Significance Index: 44.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3004
    Cell Significance Index: 14.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2731
    Cell Significance Index: 7.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2060
    Cell Significance Index: 14.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2043
    Cell Significance Index: 40.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1095
    Cell Significance Index: 2.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1077
    Cell Significance Index: 18.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1003
    Cell Significance Index: 19.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0901
    Cell Significance Index: 1.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0724
    Cell Significance Index: 25.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0692
    Cell Significance Index: 8.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0577
    Cell Significance Index: 2.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0572
    Cell Significance Index: 10.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0346
    Cell Significance Index: 2.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0318
    Cell Significance Index: 1.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0208
    Cell Significance Index: 2.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0122
    Cell Significance Index: 5.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0035
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0031
    Cell Significance Index: 1.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0030
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0091
    Cell Significance Index: -0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0145
    Cell Significance Index: -22.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0170
    Cell Significance Index: -1.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0285
    Cell Significance Index: -18.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0310
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0343
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0391
    Cell Significance Index: -8.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0419
    Cell Significance Index: -19.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0422
    Cell Significance Index: -12.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0451
    Cell Significance Index: -4.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0560
    Cell Significance Index: -1.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0563
    Cell Significance Index: -1.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0573
    Cell Significance Index: -3.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0619
    Cell Significance Index: -0.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1059
    Cell Significance Index: -4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1073
    Cell Significance Index: -21.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1208
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1211
    Cell Significance Index: -13.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1406
    Cell Significance Index: -5.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1526
    Cell Significance Index: -22.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1584
    Cell Significance Index: -18.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1808
    Cell Significance Index: -5.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1883
    Cell Significance Index: -19.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1930
    Cell Significance Index: -11.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1940
    Cell Significance Index: -4.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2005
    Cell Significance Index: -12.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2058
    Cell Significance Index: -16.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2084
    Cell Significance Index: -15.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2562
    Cell Significance Index: -5.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3019
    Cell Significance Index: -19.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3210
    Cell Significance Index: -6.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3267
    Cell Significance Index: -21.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3518
    Cell Significance Index: -19.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3809
    Cell Significance Index: -10.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4042
    Cell Significance Index: -17.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4281
    Cell Significance Index: -7.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4294
    Cell Significance Index: -14.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4499
    Cell Significance Index: -6.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4537
    Cell Significance Index: -11.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4664
    Cell Significance Index: -17.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4970
    Cell Significance Index: -17.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5088
    Cell Significance Index: -9.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5159
    Cell Significance Index: -18.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5284
    Cell Significance Index: -17.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5369
    Cell Significance Index: -17.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5575
    Cell Significance Index: -16.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5976
    Cell Significance Index: -13.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6075
    Cell Significance Index: -14.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6412
    Cell Significance Index: -17.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFSF12 exhibits several key characteristics that distinguish it from other members of the TNF superfamily. Firstly, it is a ligand for TNFR2, a receptor that is involved in the non-canonical NF-κB signaling pathway. This pathway is distinct from the classical NF-κB pathway, which is activated by TNF-α. Secondly, TNFSF12 is known to induce apoptosis in certain cell types, particularly in endothelial cells. Finally, its expression is regulated by various transcription factors, including NF-κB, which suggests a complex interplay between TNFSF12 and other signaling pathways. **Pathways and Functions** TNFSF12 is involved in several key signaling pathways, including: 1. **Angiogenesis**: TNFSF12 promotes angiogenesis by inducing the proliferation and migration of endothelial cells. This process is essential for the formation of new blood vessels, which is critical for tissue growth and development. 2. **Apoptotic process**: TNFSF12 induces apoptosis in certain cell types, including endothelial cells. This process is involved in the regulation of cell death and tissue homeostasis. 3. **Cell differentiation**: TNFSF12 regulates cell differentiation in various cell types, including immune cells and epithelial cells. 4. **Cytokine activity**: TNFSF12 interacts with other cytokines and receptors to modulate immune responses. 5. **Extracellular region**: TNFSF12 is secreted as a soluble protein and binds to its receptor, TNFR2, on the surface of target cells. **Clinical Significance** TNFSF12 has been implicated in several diseases and disorders, including: 1. **Cancer**: TNFSF12 is overexpressed in certain types of cancer, including lung cancer and colon cancer. Its expression is associated with poor prognosis and reduced survival rates. 2. **Autoimmune diseases**: TNFSF12 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Its expression is associated with inflammation and tissue damage. 3. **Neurological disorders**: TNFSF12 is expressed in the central nervous system and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: TNFSF12 has been shown to inhibit the replication of certain viruses, such as HIV-1. In conclusion, TNFSF12 is a multifunctional protein that plays a critical role in various biological processes, including angiogenesis, apoptosis, and immune response. Its dysregulation has been implicated in several diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying TNFSF12 function.

Genular Protein ID: 3306539901

Symbol: Q4ACW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4ACW9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 ExpressionAtlas 1 GO 7 Gene3D 1 HOGENOM 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 249
  • Mass: 27216
  • Checksum: E660843361C28EBA
  • Sequence:
    • MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 
VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 
GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD 
LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL 
TYFGLFQVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.