Details for: SNAP23

Gene ID: 8773

Symbol: SNAP23

Ensembl ID: ENSG00000092531

Description: synaptosome associated protein 23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 284.0331
    Cell Significance Index: -44.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.7482
    Cell Significance Index: -41.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 107.3873
    Cell Significance Index: -50.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.5643
    Cell Significance Index: -42.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.9848
    Cell Significance Index: -47.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.7054
    Cell Significance Index: -50.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7974
    Cell Significance Index: -42.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.0444
    Cell Significance Index: -48.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3946
    Cell Significance Index: -41.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4175
    Cell Significance Index: -49.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3961
    Cell Significance Index: -27.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.1608
    Cell Significance Index: -34.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9253
    Cell Significance Index: 227.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.6189
    Cell Significance Index: 39.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3969
    Cell Significance Index: 83.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2719
    Cell Significance Index: 66.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2545
    Cell Significance Index: 96.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0647
    Cell Significance Index: 28.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9702
    Cell Significance Index: 192.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8881
    Cell Significance Index: 178.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7100
    Cell Significance Index: 127.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6462
    Cell Significance Index: 79.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6134
    Cell Significance Index: 424.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5703
    Cell Significance Index: 78.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5338
    Cell Significance Index: 14.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5261
    Cell Significance Index: 24.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4560
    Cell Significance Index: 30.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4465
    Cell Significance Index: 243.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4440
    Cell Significance Index: 43.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4058
    Cell Significance Index: 28.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3993
    Cell Significance Index: 24.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3979
    Cell Significance Index: 142.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3527
    Cell Significance Index: 22.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2945
    Cell Significance Index: 130.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2869
    Cell Significance Index: 8.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2821
    Cell Significance Index: 36.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2040
    Cell Significance Index: 38.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2010
    Cell Significance Index: 9.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1770
    Cell Significance Index: 13.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1753
    Cell Significance Index: 8.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1523
    Cell Significance Index: 3.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1480
    Cell Significance Index: 3.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0960
    Cell Significance Index: 0.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0930
    Cell Significance Index: 1.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0884
    Cell Significance Index: 166.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0807
    Cell Significance Index: 72.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0782
    Cell Significance Index: 10.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0661
    Cell Significance Index: 11.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0600
    Cell Significance Index: 92.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0415
    Cell Significance Index: 76.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0330
    Cell Significance Index: 0.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0315
    Cell Significance Index: 5.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0200
    Cell Significance Index: 27.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0191
    Cell Significance Index: 12.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -23.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0385
    Cell Significance Index: -28.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0551
    Cell Significance Index: -5.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0799
    Cell Significance Index: -4.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0803
    Cell Significance Index: -2.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1103
    Cell Significance Index: -3.8800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1116
    Cell Significance Index: -1.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1130
    Cell Significance Index: -3.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1216
    Cell Significance Index: -2.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1321
    Cell Significance Index: -38.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1359
    Cell Significance Index: -9.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1511
    Cell Significance Index: -2.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1714
    Cell Significance Index: -24.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1738
    Cell Significance Index: -36.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1944
    Cell Significance Index: -2.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2000
    Cell Significance Index: -4.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2273
    Cell Significance Index: -25.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2430
    Cell Significance Index: -28.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2653
    Cell Significance Index: -14.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2774
    Cell Significance Index: -31.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3050
    Cell Significance Index: -8.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3190
    Cell Significance Index: -34.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3200
    Cell Significance Index: -8.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3371
    Cell Significance Index: -9.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3572
    Cell Significance Index: -15.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3935
    Cell Significance Index: -40.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4343
    Cell Significance Index: -16.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4382
    Cell Significance Index: -14.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4462
    Cell Significance Index: -9.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4573
    Cell Significance Index: -9.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4615
    Cell Significance Index: -29.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4656
    Cell Significance Index: -12.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5231
    Cell Significance Index: -41.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5792
    Cell Significance Index: -6.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5832
    Cell Significance Index: -14.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6119
    Cell Significance Index: -14.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6192
    Cell Significance Index: -17.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7116
    Cell Significance Index: -43.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7332
    Cell Significance Index: -10.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7860
    Cell Significance Index: -13.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8373
    Cell Significance Index: -43.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8427
    Cell Significance Index: -19.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNAP23 is a member of the SNAP family of proteins, which are known for their roles in vesicle fusion and membrane trafficking. SNAP23 is characterized by its ability to bind to syntaxin-1 and synaptobrevin-2, forming a complex that is essential for synaptic vesicle fusion. Additionally, SNAP23 interacts with various signaling molecules, including GTPases and adaptor proteins, to regulate membrane trafficking and signaling pathways. **Pathways and Functions** SNAP23 is involved in several key pathways, including: 1. **Exocytosis**: SNAP23 plays a crucial role in the fusion of synaptic vesicles with the plasma membrane, allowing for the release of neurotransmitters and other molecules. 2. **Membrane Trafficking**: SNAP23 regulates the trafficking of vesicles and proteins between the endoplasmic reticulum and the Golgi apparatus, ensuring proper protein sorting and localization. 3. **Signal Transduction**: SNAP23 interacts with GTPases and adaptor proteins, modulating signaling pathways involved in immune responses, cell growth, and differentiation. 4. **Antigen Processing and Presentation**: SNAP23 is involved in the processing and presentation of antigens to T cells, a critical step in the adaptive immune response. **Clinical Significance** SNAP23 has been implicated in various diseases, including: 1. **Autoimmune Disorders**: SNAP23 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to play a role in the dysregulation of immune responses. 2. **Cancer**: SNAP23 has been found to be overexpressed in certain types of cancer, including breast and lung cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological Disorders**: SNAP23 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the dysregulation of synaptic transmission and membrane trafficking. In conclusion, SNAP23 is a multifunctional protein that plays a critical role in various cellular processes, including membrane trafficking, vesicle fusion, and signaling pathways. Its involvement in adaptive and innate immune responses highlights its significance in maintaining immune homeostasis. Further research is needed to fully elucidate the clinical significance of SNAP23 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2346383867

Symbol: SNP23_HUMAN

Name: Synaptosomal-associated protein 23

UniProtKB Accession Codes:

O00161 O00162 Q13602 Q6IAE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 12 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663154

Title: Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.

PubMed ID: 8663154

DOI: 10.1074/jbc.271.23.13300

PubMed ID: 9070898

Title: Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells.

PubMed ID: 9070898

DOI: 10.1006/bbrc.1997.6196

PubMed ID: 11354632

Title: Genomic organization, chromosomal localization, alternative splicing, and isoforms of human Synaptosome associated protein-23 gene implicated in vesicle-membrane fusion.

PubMed ID: 11354632

DOI: 10.1007/s004390100480

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12130530

Title: Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.

PubMed ID: 12130530

DOI: 10.1182/blood.v100.3.1081

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21044946

Title: Site-specific analysis of protein S-acylation by resin-assisted capture.

PubMed ID: 21044946

DOI: 10.1194/jlr.d011106

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28882895

Title: Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase.

PubMed ID: 28882895

DOI: 10.1074/jbc.m117.799650

PubMed ID: 12556468

Title: Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain.

PubMed ID: 12556468

DOI: 10.1074/jbc.m210483200

Sequence Information:

  • Length: 211
  • Mass: 23354
  • Checksum: AC378E9786C3A239
  • Sequence:
    • MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE QLNRIEEGLD 
QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK TTWGDGGENS PCNVVSKQPG 
PVTNGQLQQP TTGAASGGYI KRITNDARED EMEENLTQVG SILGNLKDMA LNIGNEIDAQ 
NPQIKRITDK ADTNRDRIDI ANARAKKLID S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.