Details for: SUCLA2

Gene ID: 8803

Symbol: SUCLA2

Ensembl ID: ENSG00000136143

Description: succinate-CoA ligase ADP-forming subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.4785
    Cell Significance Index: -41.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.6085
    Cell Significance Index: -40.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.3775
    Cell Significance Index: -41.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.2477
    Cell Significance Index: -35.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.2682
    Cell Significance Index: -40.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.4048
    Cell Significance Index: -41.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.3713
    Cell Significance Index: -35.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.7738
    Cell Significance Index: -44.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8213
    Cell Significance Index: -39.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7592
    Cell Significance Index: -34.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2898
    Cell Significance Index: -44.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5613
    Cell Significance Index: -14.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2685
    Cell Significance Index: 30.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7603
    Cell Significance Index: 205.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5097
    Cell Significance Index: 299.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.4476
    Cell Significance Index: 53.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.3750
    Cell Significance Index: 11.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3134
    Cell Significance Index: 263.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1639
    Cell Significance Index: 61.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0185
    Cell Significance Index: 78.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9257
    Cell Significance Index: 64.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9195
    Cell Significance Index: 51.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9041
    Cell Significance Index: 324.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8041
    Cell Significance Index: 7.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7579
    Cell Significance Index: 93.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7555
    Cell Significance Index: 412.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7430
    Cell Significance Index: 46.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6967
    Cell Significance Index: 125.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5705
    Cell Significance Index: 78.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4944
    Cell Significance Index: 10.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4553
    Cell Significance Index: 17.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4541
    Cell Significance Index: 20.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3726
    Cell Significance Index: 16.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3509
    Cell Significance Index: 10.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3445
    Cell Significance Index: 152.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3359
    Cell Significance Index: 8.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3260
    Cell Significance Index: 32.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3233
    Cell Significance Index: 41.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3197
    Cell Significance Index: 4.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3190
    Cell Significance Index: 19.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3048
    Cell Significance Index: 14.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2983
    Cell Significance Index: 20.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2835
    Cell Significance Index: 13.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2625
    Cell Significance Index: 30.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2555
    Cell Significance Index: 6.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2085
    Cell Significance Index: 33.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2012
    Cell Significance Index: 6.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1629
    Cell Significance Index: 2.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1550
    Cell Significance Index: 4.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1514
    Cell Significance Index: 28.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1288
    Cell Significance Index: 16.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1155
    Cell Significance Index: 2.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1041
    Cell Significance Index: 192.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0984
    Cell Significance Index: 2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0789
    Cell Significance Index: 148.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0697
    Cell Significance Index: 44.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0658
    Cell Significance Index: 29.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0630
    Cell Significance Index: 1.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0549
    Cell Significance Index: 84.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0531
    Cell Significance Index: 0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0491
    Cell Significance Index: 35.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0429
    Cell Significance Index: 38.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0389
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0236
    Cell Significance Index: 0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0134
    Cell Significance Index: 0.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0030
    Cell Significance Index: 4.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0246
    Cell Significance Index: -1.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0333
    Cell Significance Index: -0.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0387
    Cell Significance Index: -29.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0436
    Cell Significance Index: -32.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0600
    Cell Significance Index: -33.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0682
    Cell Significance Index: -4.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0717
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0756
    Cell Significance Index: -47.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0770
    Cell Significance Index: -4.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0848
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0934
    Cell Significance Index: -15.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0977
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1099
    Cell Significance Index: -2.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1152
    Cell Significance Index: -0.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1199
    Cell Significance Index: -34.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1252
    Cell Significance Index: -3.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1530
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2115
    Cell Significance Index: -44.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2173
    Cell Significance Index: -17.2100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2486
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2531
    Cell Significance Index: -29.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3259
    Cell Significance Index: -7.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3578
    Cell Significance Index: -37.2600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3764
    Cell Significance Index: -5.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4433
    Cell Significance Index: -13.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4660
    Cell Significance Index: -11.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5466
    Cell Significance Index: -13.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5470
    Cell Significance Index: -11.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5915
    Cell Significance Index: -8.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5973
    Cell Significance Index: -7.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6590
    Cell Significance Index: -14.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6759
    Cell Significance Index: -41.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6777
    Cell Significance Index: -16.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** SUCLA2 is a subunit of the succinate-CoA ligase complex, which consists of two alpha and two beta subunits. The beta subunit is essential for the formation of the active enzyme. 2. **Metabolic function:** SUCLA2 catalyzes the conversion of succinyl-CoA to succinate, releasing ATP and GTP in the process. 3. **Mitochondrial localization:** The beta subunit is localized to the mitochondrial matrix, where it plays a critical role in regulating mitochondrial function and energy production. 4. **Regulatory mechanisms:** SUCLA2 is subject to various regulatory mechanisms, including allosteric control, phosphorylation, and ubiquitination. **Pathways and Functions:** SUCLA2 is involved in several key metabolic pathways, including: 1. **Citric acid cycle (TCA cycle):** SUCLA2 plays a critical role in regulating the TCA cycle, which is a central metabolic pathway that generates energy for the cell. 2. **Electron transport chain:** The succinate-CoA ligase complex, of which SUCLA2 is a subunit, is also involved in the electron transport chain, generating ATP and GTP through oxidative phosphorylation. 3. **Pyruvate metabolism:** SUCLA2 is also involved in regulating pyruvate metabolism, which is the conversion of pyruvate to acetyl-CoA, a key step in the TCA cycle. 4. **Succinate metabolic process:** SUCLA2 is involved in regulating the metabolic process of succinate, which is a critical intermediate in the TCA cycle. **Clinical Significance:** Dysregulation of SUCLA2 has been implicated in various diseases, including: 1. **Mitochondrial disorders:** SUCLA2 mutations have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Metabolic disorders:** SUCLA2 mutations have also been linked to metabolic disorders, such as diabetes and obesity. 3. **Cancer:** SUCLA2 has been implicated in the development and progression of cancer, particularly in the context of mitochondrial dysfunction. 4. **Neurological disorders:** SUCLA2 has been linked to various neurological disorders, including epilepsy and Alzheimer's disease. In conclusion, SUCLA2 is a critical enzyme that plays a vital role in regulating cellular metabolism, energy production, and mitochondrial function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function and regulation of this enzyme.

Genular Protein ID: 4259264958

Symbol: SUCB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10727444

Title: Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia.

PubMed ID: 10727444

DOI: 10.1172/jci6816

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9765291

Title: Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.

PubMed ID: 9765291

DOI: 10.1074/jbc.273.42.27580

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14643893

Title: The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis.

PubMed ID: 14643893

DOI: 10.1016/s1357-2725(03)00246-2

PubMed ID: 15877282

Title: Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion.

PubMed ID: 15877282

DOI: 10.1086/430843

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17287286

Title: Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations.

PubMed ID: 17287286

DOI: 10.1093/brain/awl383

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17301081

Title: SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness.

PubMed ID: 17301081

DOI: 10.1093/brain/awl389

PubMed ID: 23759946

Title: The novel mutation p.Asp251Asn in the beta-subunit of succinate-CoA ligase causes encephalomyopathy and elevated succinylcarnitine.

PubMed ID: 23759946

DOI: 10.1038/jhg.2013.45

Sequence Information:

  • Length: 463
  • Mass: 50317
  • Checksum: 1E1651728AF3B5CD
  • Sequence:
  • MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS 
    MELLQEAGVS VPKGYVAKSP DEAYAIAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK 
    IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP 
    VLIGSSHGGV NIEDVAAESP EAIIKEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM 
    VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER 
    DKDAAKANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA 
    FKLITSDKKV LAILVNIFGG IMRCDVIAQG IVMAVKDLEI KIPVVVRLQG TRVDDAKALI 
    ADSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI

Genular Protein ID: 362273711

Symbol: Q9Y4T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 211
  • Mass: 22769
  • Checksum: 4407582532EB5BF7
  • Sequence:
  • TMIEINPMVE DSDGAVLCMD AKINFDSNSA YRQKKIFDLQ DWTQEDERDK DAAKANLNYI 
    GLDGNIGCLV NGAGLAMATM DIIKLHGGTP ANFLDVGGGA TVHQVTEAFK LITSDKKVLA 
    ILVNIFGGIM RCDVIAQGIV MAVKDLEIKI PVVVRLQGTR VDDAKALIAD SGLKILACDD 
    LDEAARMVVK LSEIVTLAKQ AHVDVKFQLP I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.