Details for: SUCLA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 267.4785
Cell Significance Index: -41.6100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 158.6085
Cell Significance Index: -40.2300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 88.3775
Cell Significance Index: -41.7300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 87.2477
Cell Significance Index: -35.4500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 78.2682
Cell Significance Index: -40.2600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 62.4048
Cell Significance Index: -41.8800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 37.3713
Cell Significance Index: -35.6800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.7738
Cell Significance Index: -44.1100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.8213
Cell Significance Index: -39.3800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.7592
Cell Significance Index: -34.1800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.2898
Cell Significance Index: -44.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.5613
Cell Significance Index: -14.3600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2685
Cell Significance Index: 30.9500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.7603
Cell Significance Index: 205.1400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5097
Cell Significance Index: 299.6000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.4476
Cell Significance Index: 53.1400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.3750
Cell Significance Index: 11.5500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3134
Cell Significance Index: 263.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1639
Cell Significance Index: 61.1100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0185
Cell Significance Index: 78.1600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9257
Cell Significance Index: 64.0200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9195
Cell Significance Index: 51.6000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9041
Cell Significance Index: 324.2800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.8041
Cell Significance Index: 7.4100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7579
Cell Significance Index: 93.1900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7555
Cell Significance Index: 412.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7430
Cell Significance Index: 46.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6967
Cell Significance Index: 125.5900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5705
Cell Significance Index: 78.3500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4944
Cell Significance Index: 10.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4553
Cell Significance Index: 17.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4541
Cell Significance Index: 20.0900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3726
Cell Significance Index: 16.8900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3509
Cell Significance Index: 10.1100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3445
Cell Significance Index: 152.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3359
Cell Significance Index: 8.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3260
Cell Significance Index: 32.2500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3233
Cell Significance Index: 41.4500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.3197
Cell Significance Index: 4.7200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3190
Cell Significance Index: 19.6100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3048
Cell Significance Index: 14.3300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2983
Cell Significance Index: 20.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2835
Cell Significance Index: 13.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2625
Cell Significance Index: 30.9500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2555
Cell Significance Index: 6.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2085
Cell Significance Index: 33.9200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2012
Cell Significance Index: 6.9900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1629
Cell Significance Index: 2.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1550
Cell Significance Index: 4.2200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1514
Cell Significance Index: 28.8200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1288
Cell Significance Index: 16.6500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1155
Cell Significance Index: 2.9700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1041
Cell Significance Index: 192.0300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0984
Cell Significance Index: 2.4000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0789
Cell Significance Index: 148.5200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0697
Cell Significance Index: 44.2500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0658
Cell Significance Index: 29.8600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0630
Cell Significance Index: 1.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0549
Cell Significance Index: 84.5200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0531
Cell Significance Index: 0.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0491
Cell Significance Index: 35.9900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0429
Cell Significance Index: 38.7500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0389
Cell Significance Index: 2.0200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0236
Cell Significance Index: 0.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0134
Cell Significance Index: 0.9900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0030
Cell Significance Index: 4.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0224
Cell Significance Index: -3.2500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0246
Cell Significance Index: -1.5900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0333
Cell Significance Index: -0.9500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0387
Cell Significance Index: -29.2600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0436
Cell Significance Index: -32.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0600
Cell Significance Index: -33.8200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0682
Cell Significance Index: -4.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0717
Cell Significance Index: -7.3200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0756
Cell Significance Index: -47.2100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0770
Cell Significance Index: -4.0100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0848
Cell Significance Index: -2.2300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0934
Cell Significance Index: -15.9500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0977
Cell Significance Index: -1.6400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1099
Cell Significance Index: -2.3000 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.1152
Cell Significance Index: -0.9200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1199
Cell Significance Index: -34.5100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1252
Cell Significance Index: -3.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1530
Cell Significance Index: -4.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2115
Cell Significance Index: -44.5500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2173
Cell Significance Index: -17.2100 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2486
Cell Significance Index: -3.1300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2531
Cell Significance Index: -29.0000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3259
Cell Significance Index: -7.5300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3578
Cell Significance Index: -37.2600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3764
Cell Significance Index: -5.2800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4433
Cell Significance Index: -13.0200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4660
Cell Significance Index: -11.9100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5466
Cell Significance Index: -13.1100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5470
Cell Significance Index: -11.6100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5915
Cell Significance Index: -8.4200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5973
Cell Significance Index: -7.1200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6590
Cell Significance Index: -14.4300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6759
Cell Significance Index: -41.4400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6777
Cell Significance Index: -16.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4259264958
Symbol: SUCB1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10727444
Title: Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia.
PubMed ID: 10727444
DOI: 10.1172/jci6816
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9765291
Title: Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.
PubMed ID: 9765291
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 14643893
Title: The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis.
PubMed ID: 14643893
PubMed ID: 15877282
Title: Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion.
PubMed ID: 15877282
DOI: 10.1086/430843
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17287286
Title: Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations.
PubMed ID: 17287286
DOI: 10.1093/brain/awl383
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17301081
Title: SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness.
PubMed ID: 17301081
DOI: 10.1093/brain/awl389
PubMed ID: 23759946
Title: The novel mutation p.Asp251Asn in the beta-subunit of succinate-CoA ligase causes encephalomyopathy and elevated succinylcarnitine.
PubMed ID: 23759946
DOI: 10.1038/jhg.2013.45
Sequence Information:
- Length: 463
- Mass: 50317
- Checksum: 1E1651728AF3B5CD
- Sequence:
MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS MELLQEAGVS VPKGYVAKSP DEAYAIAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP VLIGSSHGGV NIEDVAAESP EAIIKEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER DKDAAKANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA FKLITSDKKV LAILVNIFGG IMRCDVIAQG IVMAVKDLEI KIPVVVRLQG TRVDDAKALI ADSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI
Genular Protein ID: 362273711
Symbol: Q9Y4T0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 211
- Mass: 22769
- Checksum: 4407582532EB5BF7
- Sequence:
TMIEINPMVE DSDGAVLCMD AKINFDSNSA YRQKKIFDLQ DWTQEDERDK DAAKANLNYI GLDGNIGCLV NGAGLAMATM DIIKLHGGTP ANFLDVGGGA TVHQVTEAFK LITSDKKVLA ILVNIFGGIM RCDVIAQGIV MAVKDLEIKI PVVVRLQGTR VDDAKALIAD SGLKILACDD LDEAARMVVK LSEIVTLAKQ AHVDVKFQLP I
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.