Details for: SUCLA2
Gene ID: 8803
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SUCLA2
Ensembl ID: ENSG00000136143
Description: succinate-CoA ligase ADP-forming subunit beta
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 8.77rCSI 9.61%PRS 41.81
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CSI 8rCSI 8.5%PRS 53.76
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CSI 7.96rCSI 7.19%PRS 34.93
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CSI 7.88rCSI 17.42%PRS 28.1
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CSI 7.87rCSI 7.85%PRS 32.83
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CSI 7.23rCSI 11.07%PRS 54.25
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CSI 6.81rCSI 13.24%PRS 39.58
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CSI 5.72rCSI 9.2%PRS 26.43
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CSI 5.07rCSI 12.82%PRS 45.64
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CSI 3.99rCSI 4.62%PRS 29.27
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CSI 3.21rCSI 9.22%PRS 54.21
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CSI 3.07rCSI 7.79%PRS 35.23
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CSI 3.03rCSI 4.14%PRS 42.44
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CSI 2.96rCSI 4.5%PRS 35.15
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CSI 2.89rCSI 3.47%PRS 36.34
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CSI 2.86rCSI 2.37%PRS 38.78
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CSI 2.84rCSI 3.39%PRS 24.48
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CSI 2.81rCSI 2.18%PRS 37.93
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CSI 2.79rCSI 22.69%PRS 33.84
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CSI 2.75rCSI 3.9%PRS 35.49
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CSI 2.74rCSI 3.2%PRS 52.23
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CSI 2.7rCSI 3.96%PRS 34.84
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CSI 2.69rCSI 4.33%PRS 47.98
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CSI 2.67rCSI 2.57%PRS 38.66
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CSI 2.67rCSI 1.58%PRS 51.54
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CSI 2.67rCSI 63.9%PRS 23.92
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CSI 2.61rCSI 7.43%PRS 38.43
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CSI 2.57rCSI 61.94%PRS 24.76
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CSI 2.56rCSI 1.78%PRS 45.55
-
CSI 2.54rCSI 3.26%PRS 34.75
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CSI 2.5rCSI 1.74%PRS 39.71
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CSI 2.5rCSI 2.16%PRS 41.69
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CSI 2.46rCSI 1.86%PRS 49.42
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CSI 2.46rCSI 50.13%PRS 31.78
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CSI 2.46rCSI 4.13%PRS 24.52
-
CSI 2.43rCSI 3.32%PRS 40.71
-
CSI 2.42rCSI 1.79%PRS 32.57
-
CSI 2.42rCSI 3.6%PRS 41.21
-
CSI 2.4rCSI 7.13%PRS 49.26
-
CSI 2.4rCSI 2.11%PRS 42.7
-
CSI 2.4rCSI 2.78%PRS 48.85
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CSI 2.37rCSI 1.92%PRS 38.91
-
CSI 2.32rCSI 2.14%PRS 39.05
-
CSI 2.32rCSI 3.79%PRS 29.99
-
CSI 2.3rCSI 46.83%PRS 32.99
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CSI 2.28rCSI 3.37%PRS 42.37
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CSI 2.28rCSI 3.11%PRS 48.51
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CSI 2.26rCSI 1.95%PRS 47.53
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CSI 2.21rCSI 3.37%PRS 38.36
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CSI 2.19rCSI 2.73%PRS 40.42
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CSI 2.16rCSI 2.01%PRS 37.77
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CSI 2.16rCSI 3%PRS 37.84
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CSI 2.15rCSI 8.06%PRS 32.31
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CSI 2.11rCSI 1.42%PRS 47.04
-
CSI 2.09rCSI 12.06%PRS 41.03
-
CSI 2.04rCSI 2.73%PRS 45.82
-
CSI 2rCSI 1.97%PRS 40.21
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CSI 1.94rCSI 3.85%PRS 37.85
-
CSI 1.94rCSI 4.43%PRS 37.44
-
CSI 1.92rCSI 2%PRS 38.59
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CSI 1.91rCSI 1.27%PRS 42.08
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CSI 1.9rCSI 2.73%PRS 45.83
-
CSI 1.89rCSI 1.98%PRS 40.24
-
CSI 1.87rCSI 5.16%PRS 35.35
-
CSI 1.87rCSI 1.64%PRS 47.32
-
CSI 1.84rCSI 4.21%PRS 32.6
-
CSI 1.8rCSI 1.73%PRS 29.67
-
CSI 1.78rCSI 5.01%PRS 40.06
-
CSI 1.72rCSI 3.08%PRS 36.33
-
CSI 1.71rCSI 2.2%PRS 25.37
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CSI 1.69rCSI 4.02%PRS 43.68
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CSI 1.69rCSI 2.93%PRS 29.88
-
CSI 1.65rCSI 2.67%PRS 36.94
-
CSI 1.63rCSI 3.39%PRS 36.53
-
CSI 1.62rCSI 3.87%PRS 28.77
-
CSI 1.61rCSI 3.02%PRS 29.13
-
CSI 1.6rCSI 6.25%PRS 57.43
-
CSI 1.6rCSI 1.63%PRS 50.11
-
CSI 1.59rCSI 3.19%PRS 29.16
-
CSI 1.59rCSI 4.68%PRS 42.2
-
CSI 1.57rCSI 1.64%PRS 35.59
-
CSI 1.57rCSI 1.68%PRS 35.83
-
CSI 1.56rCSI 1.8%PRS 33.16
-
CSI 1.56rCSI 1.63%PRS 37.9
-
CSI 1.55rCSI 1.23%PRS 27.25
-
CSI 1.52rCSI 6.2%PRS 36.72
-
CSI 1.52rCSI 1.18%PRS 53.41
-
CSI 1.52rCSI 1.78%PRS 41.83
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CSI 1.5rCSI 3.57%PRS 40.71
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CSI 1.43rCSI 2.52%PRS 36.77
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CSI 1.42rCSI 6.82%PRS 36.06
-
CSI 1.4rCSI 1.75%PRS 47.02
-
CSI 1.39rCSI 2.43%PRS 31.2
-
CSI 1.38rCSI 1.68%PRS 45.11
-
CSI 1.38rCSI 3.6%PRS 37.07
-
CSI 1.38rCSI 2.19%PRS 32.19
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CSI 1.38rCSI 3.68%PRS 32.18
-
CSI 1.37rCSI 3.07%PRS 25.04
-
CSI 1.37rCSI 1.87%PRS 35.47
-
CSI 1.35rCSI 3.86%PRS 53.02
-
CSI 0.1rCSI 4.1%PRS 63.4%
-
CSI 0.3rCSI 4.3%PRS 65.8%
-
CSI 0.3rCSI 1.8%PRS 25.7%
-
CSI 0.3rCSI 1.7%PRS 62.0%
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CSI 0.3rCSI 2.1%PRS 31.6%
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CSI 0.4rCSI 1.8%PRS 62.0%
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CSI 0.4rCSI 2.8%PRS 56.2%
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CSI 0.4rCSI 5.4%PRS 31.6%
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CSI 0.4rCSI 3.0%PRS 58.6%
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CSI 0.4rCSI 1.5%PRS 25.4%
-
CSI 0.4rCSI 2.1%PRS 38.3%
-
CSI 0.4rCSI 3.2%PRS 27.4%
-
CSI 0.5rCSI 1.5%PRS 25.6%
-
CSI 0.6rCSI 1.9%PRS 31.3%
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CSI 0.6rCSI 2.5%PRS 36.6%
-
CSI 0.6rCSI 1.4%PRS 36.2%
-
CSI 0.6rCSI 1.7%PRS 40.7%
-
CSI 0.6rCSI 2.0%PRS 28.3%
-
CSI 0.6rCSI 1.4%PRS 35.3%
-
CSI 0.6rCSI 1.5%PRS 23.8%
-
CSI 0.7rCSI 3.2%PRS 48.8%
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CSI 0.7rCSI 2.3%PRS 28.3%
-
CSI 0.7rCSI 3.2%PRS 35.4%
-
CSI 0.7rCSI 2.0%PRS 52.9%
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CSI 0.7rCSI 3.9%PRS 53.6%
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CSI 0.8rCSI 3.4%PRS 57.8%
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CSI 0.8rCSI 1.3%PRS 29.9%
-
CSI 0.8rCSI 3.0%PRS 33.2%
-
CSI 0.8rCSI 2.1%PRS 38.1%
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CSI 0.8rCSI 0.8%PRS 56.7%
-
CSI 0.8rCSI 1.2%PRS 54.7%
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CSI 0.8rCSI 2.2%PRS 46.8%
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CSI 0.8rCSI 2.6%PRS 27.6%
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CSI 0.9rCSI 1.3%PRS 36.2%
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CSI 0.9rCSI 1.3%PRS 55.5%
-
CSI 0.9rCSI 2.2%PRS 29.9%
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CSI 0.9rCSI 2.9%PRS 37.9%
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CSI 0.9rCSI 2.0%PRS 29.4%
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CSI 1.0rCSI 3.5%PRS 23.5%
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CSI 1.0rCSI 2.6%PRS 44.7%
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CSI 1.0rCSI 1.7%PRS 23.6%
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CSI 1.0rCSI 0.8%PRS 38.5%
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CSI 1.0rCSI 1.8%PRS 32.2%
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CSI 1.0rCSI 1.6%PRS 47.6%
-
CSI 1.0rCSI 1.5%PRS 40.6%
-
CSI 1.0rCSI 1.6%PRS 38.8%
-
CSI 1.1rCSI 3.5%PRS 46.2%
-
CSI 1.1rCSI 1.4%PRS 23.2%
-
CSI 1.1rCSI 0.9%PRS 43.1%
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CSI 1.1rCSI 3.2%PRS 30.7%
-
CSI 1.1rCSI 11.8%PRS 40.6%
-
CSI 1.1rCSI 3.0%PRS 31.5%
-
CSI 1.1rCSI 2.9%PRS 34.8%
-
CSI 1.1rCSI 1.5%PRS 39.7%
-
CSI 1.1rCSI 2.0%PRS 46.3%
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CSI 1.2rCSI 1.6%PRS 40.7%
-
CSI 1.2rCSI 1.7%PRS 48.4%
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CSI 1.2rCSI 2.2%PRS 32.9%
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CSI 1.2rCSI 3.9%PRS 40.6%
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CSI 1.2rCSI 2.9%PRS 35.0%
-
CSI 1.2rCSI 2.8%PRS 31.2%
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CSI 1.2rCSI 2.0%PRS 32.7%
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CSI 1.3rCSI 1.6%PRS 36.2%
-
CSI 1.3rCSI 4.1%PRS 35.0%
-
CSI 1.3rCSI 2.1%PRS 41.2%
-
CSI 1.3rCSI 2.0%PRS 46.6%
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CSI 1.3rCSI 1.0%PRS 36.5%
-
CSI 1.3rCSI 2.7%PRS 34.1%
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CSI 1.3rCSI 1.9%PRS 30.6%
-
CSI 1.3rCSI 2.0%PRS 42.3%
-
CSI 1.3rCSI 1.2%PRS 28.6%
-
CSI 1.3rCSI 5.4%PRS 36.7%
-
CSI 1.3rCSI 1.8%PRS 32.7%
-
CSI 1.3rCSI 2.9%PRS 47.7%
-
CSI 1.3rCSI 1.7%PRS 34.2%
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CSI 1.4rCSI 3.9%PRS 53.0%
-
CSI 1.4rCSI 1.9%PRS 35.5%
-
CSI 1.4rCSI 3.1%PRS 25.0%
-
CSI 1.4rCSI 3.7%PRS 32.2%
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CSI 1.4rCSI 2.2%PRS 32.2%
-
CSI 1.4rCSI 3.6%PRS 37.1%
-
CSI 1.4rCSI 1.7%PRS 45.1%
-
CSI 1.4rCSI 2.4%PRS 31.2%
-
CSI 1.4rCSI 1.8%PRS 47.0%
-
CSI 1.4rCSI 6.8%PRS 36.1%
-
CSI 1.4rCSI 2.5%PRS 36.8%
-
CSI 1.5rCSI 3.6%PRS 40.7%
-
CSI 1.5rCSI 1.8%PRS 41.8%
-
CSI 1.5rCSI 1.2%PRS 53.4%
-
CSI 1.5rCSI 6.2%PRS 36.7%
-
CSI 1.6rCSI 1.2%PRS 27.3%
-
CSI 1.6rCSI 1.6%PRS 37.9%
-
CSI 1.6rCSI 1.8%PRS 33.2%
-
CSI 1.6rCSI 1.7%PRS 35.8%
-
CSI 1.6rCSI 1.6%PRS 35.6%
-
CSI 1.6rCSI 4.7%PRS 42.2%
-
CSI 1.6rCSI 3.2%PRS 29.2%
-
CSI 1.6rCSI 1.6%PRS 50.1%
-
CSI 1.6rCSI 6.3%PRS 57.4%
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CSI 1.6rCSI 3.0%PRS 29.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4259264958
Symbol: SUCB1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10727444
Title: Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia.
PubMed ID: 10727444
DOI: 10.1172/jci6816
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9765291
Title: Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.
PubMed ID: 9765291
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 14643893
Title: The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis.
PubMed ID: 14643893
PubMed ID: 15877282
Title: Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion.
PubMed ID: 15877282
DOI: 10.1086/430843
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17287286
Title: Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations.
PubMed ID: 17287286
DOI: 10.1093/brain/awl383
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17301081
Title: SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness.
PubMed ID: 17301081
DOI: 10.1093/brain/awl389
PubMed ID: 23759946
Title: The novel mutation p.Asp251Asn in the beta-subunit of succinate-CoA ligase causes encephalomyopathy and elevated succinylcarnitine.
PubMed ID: 23759946
DOI: 10.1038/jhg.2013.45
Sequence Information:
- Length: 463
- Mass: 50317
- Checksum: 1E1651728AF3B5CD
- Sequence:
MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS MELLQEAGVS VPKGYVAKSP DEAYAIAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP VLIGSSHGGV NIEDVAAESP EAIIKEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER DKDAAKANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA FKLITSDKKV LAILVNIFGG IMRCDVIAQG IVMAVKDLEI KIPVVVRLQG TRVDDAKALI ADSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI
Genular Protein ID: 362273711
Symbol: Q9Y4T0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 211
- Mass: 22769
- Checksum: 4407582532EB5BF7
- Sequence:
TMIEINPMVE DSDGAVLCMD AKINFDSNSA YRQKKIFDLQ DWTQEDERDK DAAKANLNYI GLDGNIGCLV NGAGLAMATM DIIKLHGGTP ANFLDVGGGA TVHQVTEAFK LITSDKKVLA ILVNIFGGIM RCDVIAQGIV MAVKDLEIKI PVVVRLQGTR VDDAKALIAD SGLKILACDD LDEAARMVVK LSEIVTLAKQ AHVDVKFQLP I