Details for: BANF1
Gene ID: 8815
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BANF1
Ensembl ID: ENSG00000175334
Description: barrier to autointegration nuclear assembly factor 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 79.24rCSI 69.68%PRS 9.76
-
CSI 74.8rCSI 67.55%PRS 11.91
-
CSI 69.6rCSI 67%PRS 13.94
-
CSI 69.1rCSI 55.87%PRS 13.29
-
CSI 64.44rCSI 55.8%PRS 15.01
-
CSI 57.13rCSI 47.36%PRS 12.68
-
CSI 56.95rCSI 54.91%PRS 9.35
-
CSI 55.06rCSI 63.03%PRS 27.52
-
CSI 54.2rCSI 36.02%PRS 16.04
-
CSI 50.48rCSI 52.76%PRS 14.14
-
CSI 49.85rCSI 43.78%PRS 15.13
-
CSI 48.89rCSI 61.36%PRS 17.14
-
CSI 46.26rCSI 54.33%PRS 15.81
-
CSI 46.07rCSI 65.75%PRS 15.17
-
CSI 43.68rCSI 59.52%PRS 12.01
-
CSI 43.62rCSI 62.92%PRS 18.69
-
CSI 41.22rCSI 70.61%PRS 18.04
-
CSI 35.8rCSI 27.58%PRS 12.22
-
CSI 33.73rCSI 35.34%PRS 14.39
-
CSI 33.47rCSI 33.4%PRS 11.49
-
CSI 33.46rCSI 40.17%PRS 13.28
-
CSI 31.86rCSI 26.38%PRS 13.45
-
CSI 30.64rCSI 25.68%PRS 16.1
-
CSI 29.24rCSI 83.48%PRS 23.15
-
CSI 28.71rCSI 29.26%PRS 19.24
-
CSI 28.27rCSI 32.69%PRS 9.85
-
CSI 25.45rCSI 38.93%PRS 21.85
-
CSI 25.05rCSI 22.24%PRS 13.46
-
CSI 24.9rCSI 26.08%PRS 12.54
-
CSI 23.01rCSI 33.97%PRS 21.17
-
CSI 21.51rCSI 49.02%PRS 14.03
-
CSI 21rCSI 53.33%PRS 13.65
-
CSI 19.87rCSI 63.75%PRS 19.68
-
CSI 19.48rCSI 15.4%PRS 9.25
-
CSI 19.26rCSI 27.64%PRS 10.47
-
CSI 18.66rCSI 17.22%PRS 13.68
-
CSI 18.45rCSI 62.39%PRS 22.48
-
CSI 18.09rCSI 17.8%PRS 14.64
-
CSI 17.96rCSI 36.88%PRS 30.98
-
CSI 16.59rCSI 48.03%PRS 15.27
-
CSI 16rCSI 24.59%PRS 19.08
-
CSI 15.75rCSI 30.06%PRS 31.24
-
CSI 15.4rCSI 12.12%PRS 15.99
-
CSI 15.02rCSI 10.44%PRS 15.79
-
CSI 14.85rCSI 18.37%PRS 11.81
-
CSI 14.37rCSI 77.54%PRS 25.11
-
CSI 14.04rCSI 11.81%PRS 21.63
-
CSI 14.01rCSI 18.72%PRS 25.68
-
CSI 13.87rCSI 16.01%PRS 11.81
-
CSI 13.87rCSI 18.95%PRS 14.92
-
CSI 13.72rCSI 26.69%PRS 13.74
-
CSI 13.3rCSI 23.81%PRS 12.53
-
CSI 13.17rCSI 46.21%PRS 24.25
-
CSI 12.99rCSI 19.01%PRS 14.22
-
CSI 12.79rCSI 35.14%PRS 22.16
-
CSI 12.34rCSI 9.14%PRS 11.92
-
CSI 12.32rCSI 17.75%PRS 21.59
-
CSI 12.11rCSI 55.06%PRS 45.94
-
CSI 12.09rCSI 15.39%PRS 15.63
-
CSI 11.94rCSI 28.39%PRS 20.21
-
CSI 11.89rCSI 63.46%PRS 48
-
CSI 11.55rCSI 24.55%PRS 23.07
-
CSI 11.43rCSI 15.87%PRS 13.87
-
CSI 11.16rCSI 14.31%PRS 15.54
-
CSI 11.12rCSI 43.29%PRS 22.01
-
CSI 11.09rCSI 24.5%PRS 9.7
-
CSI 10.83rCSI 47.53%PRS 25.07
-
CSI 10.79rCSI 7.27%PRS 16.19
-
CSI 10.23rCSI 40.7%PRS 23.66
-
CSI 10.12rCSI 10.41%PRS 21.98
-
CSI 10.02rCSI 22.19%PRS 12.52
-
CSI 9.71rCSI 15.63%PRS 10.37
-
CSI 9.68rCSI 8.48%PRS 17.84
-
CSI 9.41rCSI 61.73%PRS 34.48
-
CSI 9.2rCSI 27.14%PRS 16.46
-
CSI 8.77rCSI 17.6%PRS 9.97
-
CSI 8.75rCSI 31.08%PRS 22
-
CSI 8.73rCSI 8.62%PRS 49.49
-
CSI 8.73rCSI 8.25%PRS 14.05
-
CSI 8.7rCSI 19.85%PRS 11.79
-
CSI 8.48rCSI 22.32%PRS 26.3
-
CSI 8.35rCSI 12.73%PRS 12.6
-
CSI 8.2rCSI 6.09%PRS 19.92
-
CSI 8.15rCSI 19.61%PRS 21.29
-
CSI 8.13rCSI 47.28%PRS 20.2
-
CSI 8.04rCSI 6.04%PRS 13.98
-
CSI 7.98rCSI 5.57%PRS 14.12
-
CSI 7.96rCSI 7.36%PRS 24.5
-
CSI 7.94rCSI 11%PRS 19.32
-
CSI 7.82rCSI 8.81%PRS 21.59
-
CSI 7.7rCSI 6.64%PRS 21.65
-
CSI 7.63rCSI 6.63%PRS 16.61
-
CSI 7.42rCSI 6.19%PRS 38.47
-
CSI 7.38rCSI 13.4%PRS 20.59
-
CSI 7.34rCSI 5.15%PRS 34.21
-
CSI 7.28rCSI 41.73%PRS 20.67
-
CSI 7.11rCSI 77.87%PRS 24.27
-
CSI 7.08rCSI 55.48%PRS 28.97
-
CSI 7.03rCSI 10.74%PRS 17.02
-
CSI 6.9rCSI 37.34%PRS 44.55
-
CSI -11.1rCSI -19.4%PRS 9.9%
-
CSI -3.9rCSI -4.7%PRS 23.3%
-
CSI -3.9rCSI -11.0%PRS 19.6%
-
CSI -3.5rCSI -7.8%PRS 8.3%
-
CSI -3.0rCSI -4.4%PRS 15.5%
-
CSI -2.5rCSI -1.8%PRS 18.3%
-
CSI -1.7rCSI -4.5%PRS 16.1%
-
CSI -1.1rCSI -2.5%PRS 13.0%
-
CSI -1.0rCSI -8.2%PRS 13.9%
-
CSI -0.7rCSI -4.3%PRS 8.3%
-
CSI -0.6rCSI -11.8%PRS 73.5%
-
CSI -0.5rCSI -2.0%PRS 20.1%
-
CSI -0.1rCSI -0.3%PRS 20.2%
-
CSI 0.0rCSI 0.2%PRS 18.5%
-
CSI 0.1rCSI 2.1%PRS 24.3%
-
CSI 0.1rCSI 0.3%PRS 27.2%
-
CSI 0.1rCSI 1.2%PRS 62.1%
-
CSI 0.2rCSI 3.9%PRS 73.4%
-
CSI 0.2rCSI 5.0%PRS 41.9%
-
CSI 0.2rCSI 0.7%PRS 8.5%
-
CSI 0.2rCSI 0.8%PRS 7.4%
-
CSI 0.2rCSI 1.2%PRS 33.0%
-
CSI 0.2rCSI 4.6%PRS 41.4%
-
CSI 0.3rCSI 0.6%PRS 14.9%
-
CSI 0.3rCSI 2.7%PRS 46.3%
-
CSI 0.3rCSI 1.6%PRS 19.7%
-
CSI 0.3rCSI 0.9%PRS 9.1%
-
CSI 0.3rCSI 0.4%PRS 8.3%
-
CSI 0.3rCSI 1.1%PRS 47.9%
-
CSI 0.4rCSI 0.8%PRS 16.0%
-
CSI 0.4rCSI 0.4%PRS 21.2%
-
CSI 0.4rCSI 2.5%PRS 29.9%
-
CSI 0.4rCSI 1.7%PRS 29.3%
-
CSI 0.4rCSI 1.9%PRS 52.0%
-
CSI 0.5rCSI 2.6%PRS 41.9%
-
CSI 0.5rCSI 0.9%PRS 9.8%
-
CSI 0.5rCSI 7.7%PRS 33.2%
-
CSI 0.5rCSI 0.9%PRS 35.0%
-
CSI 0.6rCSI 14.2%PRS 75.6%
-
CSI 0.6rCSI 5.1%PRS 51.8%
-
CSI 0.7rCSI 1.0%PRS 12.4%
-
CSI 0.7rCSI 0.8%PRS 15.4%
-
CSI 0.7rCSI 1.1%PRS 13.3%
-
CSI 0.7rCSI 1.1%PRS 32.2%
-
CSI 0.8rCSI 6.7%PRS 75.6%
-
CSI 0.8rCSI 1.7%PRS 27.0%
-
CSI 0.8rCSI 2.2%PRS 26.0%
-
CSI 0.8rCSI 3.7%PRS 35.6%
-
CSI 0.8rCSI 3.1%PRS 27.7%
-
CSI 0.8rCSI 1.0%PRS 7.8%
-
CSI 0.8rCSI 1.4%PRS 8.7%
-
CSI 0.9rCSI 1.5%PRS 13.4%
-
CSI 0.9rCSI 1.5%PRS 7.9%
-
CSI 0.9rCSI 1.5%PRS 7.9%
-
CSI 0.9rCSI 1.6%PRS 17.8%
-
CSI 0.9rCSI 2.1%PRS 7.7%
-
CSI 0.9rCSI 21.9%PRS 44.5%
-
CSI 1.0rCSI 3.1%PRS 37.2%
-
CSI 1.0rCSI 15.5%PRS 60.0%
-
CSI 1.0rCSI 3.3%PRS 50.6%
-
CSI 1.0rCSI 9.5%PRS 39.0%
-
CSI 1.0rCSI 1.3%PRS 19.0%
-
CSI 1.1rCSI 4.6%PRS 25.6%
-
CSI 1.1rCSI 2.4%PRS 20.6%
-
CSI 1.1rCSI 1.5%PRS 21.9%
-
CSI 1.1rCSI 1.2%PRS 23.8%
-
CSI 1.1rCSI 5.6%PRS 18.3%
-
CSI 1.2rCSI 1.8%PRS 15.4%
-
CSI 1.2rCSI 3.0%PRS 10.3%
-
CSI 1.2rCSI 2.3%PRS 30.1%
-
CSI 1.2rCSI 3.4%PRS 20.8%
-
CSI 1.2rCSI 5.3%PRS 13.3%
-
CSI 1.2rCSI 21.3%PRS 51.3%
-
CSI 1.3rCSI 3.3%PRS 13.3%
-
CSI 1.3rCSI 3.2%PRS 12.6%
-
CSI 1.3rCSI 1.8%PRS 19.8%
-
CSI 1.3rCSI 14.0%PRS 49.7%
-
CSI 1.3rCSI 1.5%PRS 23.1%
-
CSI 1.3rCSI 3.7%PRS 16.0%
-
CSI 1.3rCSI 1.8%PRS 20.5%
-
CSI 1.4rCSI 1.8%PRS 20.6%
-
CSI 1.5rCSI 3.2%PRS 17.9%
-
CSI 1.5rCSI 2.0%PRS 14.7%
-
CSI 1.5rCSI 9.8%PRS 42.1%
-
CSI 1.6rCSI 4.4%PRS 51.8%
-
CSI 1.7rCSI 17.8%PRS 84.0%
-
CSI 1.7rCSI 2.1%PRS 14.2%
-
CSI 1.7rCSI 6.6%PRS 18.8%
-
CSI 1.7rCSI 4.6%PRS 17.3%
-
CSI 1.7rCSI 8.6%PRS 65.0%
-
CSI 1.8rCSI 3.0%PRS 10.3%
-
CSI 1.8rCSI 10.9%PRS 50.4%
-
CSI 1.8rCSI 1.3%PRS 18.6%
-
CSI 1.8rCSI 8.9%PRS 17.6%
-
CSI 1.8rCSI 2.8%PRS 13.5%
-
CSI 1.8rCSI 2.4%PRS 18.9%
-
CSI 1.9rCSI 2.6%PRS 27.7%
-
CSI 1.9rCSI 3.0%PRS 12.6%
-
CSI 1.9rCSI 1.4%PRS 21.8%
-
CSI 1.9rCSI 1.4%PRS 22.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1509226283
Symbol: BAF_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9465049
Title: A previously unidentified host protein protects retroviral DNA from autointegration.
PubMed ID: 9465049
PubMed ID: 9740667
Title: Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma.
PubMed ID: 9740667
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11005805
Title: Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro.
PubMed ID: 11005805
PubMed ID: 10908652
Title: Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex.
PubMed ID: 10908652
PubMed ID: 11792822
Title: BAF is required for emerin assembly into the reforming nuclear envelope.
PubMed ID: 11792822
PubMed ID: 12163470
Title: Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.
PubMed ID: 12163470
PubMed ID: 12663813
Title: The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.
PubMed ID: 12663813
PubMed ID: 14645565
Title: Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions.
PubMed ID: 14645565
PubMed ID: 15681850
Title: Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor.
PubMed ID: 15681850
PubMed ID: 16203725
Title: Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.
PubMed ID: 16203725
PubMed ID: 16371512
Title: Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo.
PubMed ID: 16371512
PubMed ID: 16337940
Title: Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF.
PubMed ID: 16337940
PubMed ID: 16495336
Title: The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus.
PubMed ID: 16495336
PubMed ID: 16680152
Title: The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity.
PubMed ID: 16680152
DOI: 10.1038/nature04682
PubMed ID: 18005698
Title: Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.
PubMed ID: 18005698
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22770216
Title: Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.
PubMed ID: 22770216
PubMed ID: 15130582
Title: BAF: roles in chromatin, nuclear structure and retrovirus integration.
PubMed ID: 15130582
PubMed ID: 22399800
Title: The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo.
PubMed ID: 22399800
DOI: 10.1242/jcs.098392
PubMed ID: 24600006
Title: Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity.
PubMed ID: 24600006
DOI: 10.1128/jvi.00427-14
PubMed ID: 25991860
Title: BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy.
PubMed ID: 25991860
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28841419
Title: DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes.
PubMed ID: 28841419
PubMed ID: 32494070
Title: LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.
PubMed ID: 32494070
PubMed ID: 31796734
Title: Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.
PubMed ID: 31796734
PubMed ID: 32792394
Title: BAF restricts cGAS on nuclear DNA to prevent innate immune activation.
PubMed ID: 32792394
PubMed ID: 9783751
Title: Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration.
PubMed ID: 9783751
DOI: 10.1038/2345
PubMed ID: 10924106
Title: Structural basis of DNA bridging by barrier-to-autointegration factor.
PubMed ID: 10924106
DOI: 10.1021/bi000572w
PubMed ID: 21549337
Title: Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.
PubMed ID: 21549337
Sequence Information:
- Length: 89
- Mass: 10059
- Checksum: 9A2180A2D284F5D0
- Sequence:
MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR EWLKDTCGAN AKQSRDCFGC LREWCDAFL