Details for: BANF1

Gene ID: 8815

Symbol: BANF1

Ensembl ID: ENSG00000175334

Description: barrier to autointegration nuclear assembly factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 373.9748
    Cell Significance Index: -58.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 226.2626
    Cell Significance Index: -57.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 184.7322
    Cell Significance Index: -76.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.9386
    Cell Significance Index: -73.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.9596
    Cell Significance Index: -70.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.5344
    Cell Significance Index: -73.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.8099
    Cell Significance Index: -72.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.4144
    Cell Significance Index: -76.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7301
    Cell Significance Index: -39.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4041
    Cell Significance Index: -41.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.0507
    Cell Significance Index: 48.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.0454
    Cell Significance Index: 54.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.9744
    Cell Significance Index: 63.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9245
    Cell Significance Index: 129.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.7564
    Cell Significance Index: 99.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.2251
    Cell Significance Index: 35.4900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.7918
    Cell Significance Index: 21.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4922
    Cell Significance Index: 293.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3757
    Cell Significance Index: 326.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9894
    Cell Significance Index: 54.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9227
    Cell Significance Index: 44.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8909
    Cell Significance Index: 88.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8362
    Cell Significance Index: 20.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7687
    Cell Significance Index: 125.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5803
    Cell Significance Index: 117.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5603
    Cell Significance Index: 689.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5173
    Cell Significance Index: 828.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4556
    Cell Significance Index: 178.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4505
    Cell Significance Index: 93.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4302
    Cell Significance Index: 184.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3805
    Cell Significance Index: 248.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3554
    Cell Significance Index: 47.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2181
    Cell Significance Index: 56.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1889
    Cell Significance Index: 62.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1203
    Cell Significance Index: 143.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9767
    Cell Significance Index: 50.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9523
    Cell Significance Index: 859.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9164
    Cell Significance Index: 26.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7976
    Cell Significance Index: 7.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6005
    Cell Significance Index: 59.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5462
    Cell Significance Index: 32.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5006
    Cell Significance Index: 10.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4533
    Cell Significance Index: 8.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4445
    Cell Significance Index: 75.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4112
    Cell Significance Index: 25.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2860
    Cell Significance Index: 56.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2230
    Cell Significance Index: 10.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1874
    Cell Significance Index: 37.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1796
    Cell Significance Index: 3.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1704
    Cell Significance Index: 128.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1542
    Cell Significance Index: 25.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1477
    Cell Significance Index: 2.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1472
    Cell Significance Index: 3.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1102
    Cell Significance Index: 20.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0481
    Cell Significance Index: 0.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0368
    Cell Significance Index: 10.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0097
    Cell Significance Index: 7.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0207
    Cell Significance Index: -2.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0247
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0260
    Cell Significance Index: -19.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0289
    Cell Significance Index: -54.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0480
    Cell Significance Index: -88.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0571
    Cell Significance Index: -87.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0667
    Cell Significance Index: -90.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0897
    Cell Significance Index: -56.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0902
    Cell Significance Index: -50.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1464
    Cell Significance Index: -66.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1610
    Cell Significance Index: -18.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1722
    Cell Significance Index: -36.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1738
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1799
    Cell Significance Index: -20.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1929
    Cell Significance Index: -5.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2369
    Cell Significance Index: -8.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2723
    Cell Significance Index: -7.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3211
    Cell Significance Index: -10.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4427
    Cell Significance Index: -50.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4469
    Cell Significance Index: -64.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5107
    Cell Significance Index: -13.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5218
    Cell Significance Index: -6.2200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5631
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5889
    Cell Significance Index: -46.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5981
    Cell Significance Index: -36.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7068
    Cell Significance Index: -4.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7221
    Cell Significance Index: -40.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7369
    Cell Significance Index: -76.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7645
    Cell Significance Index: -10.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8698
    Cell Significance Index: -66.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9249
    Cell Significance Index: -62.1900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.9328
    Cell Significance Index: -5.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0393
    Cell Significance Index: -63.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1245
    Cell Significance Index: -33.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1414
    Cell Significance Index: -30.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.2464
    Cell Significance Index: -17.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3682
    Cell Significance Index: -35.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4139
    Cell Significance Index: -24.2300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -1.4608
    Cell Significance Index: -9.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5555
    Cell Significance Index: -57.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6551
    Cell Significance Index: -73.2100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -1.6819
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nuclear Envelope Assembly**: BANF1 is essential for the assembly and reformation of the nuclear envelope during cell division, particularly during the M phase of the cell cycle. 2. **DNA Binding**: The BAF_HUMAN protein has a DNA-binding capacity, which suggests that BANF1 may play a role in regulating gene expression and DNA replication. 3. **Homodimerization**: BAF_HUMAN is a homodimer, meaning that it consists of two identical subunits that interact with each other. 4. **Protein Binding**: The protein has a binding capacity for other proteins, which may indicate its role in protein-protein interactions and signaling pathways. 5. **Regulation of Cell Cycle**: BANF1 is involved in the regulation of the cell cycle, particularly during the M phase, where it plays a crucial role in nuclear envelope reassembly. **Pathways and Functions** 1. **2-LTR Circle Formation**: BANF1 is involved in the formation of 2-LTR circles, which are circular DNA structures formed during the integration of retroviruses into the host genome. 2. **Apobec3g Mediated Resistance to HIV-1 Infection**: BANF1 is also involved in the regulation of Apobec3g, an enzyme that confers resistance to HIV-1 infection. 3. **Autointegration Results in Viral DNA Circles**: BANF1 plays a role in autointegration, a process where the viral genome integrates into the host genome, leading to the formation of viral DNA circles. 4. **Cell Cycle Regulation**: BANF1 regulates the cell cycle, particularly during the M phase, where it ensures proper nuclear envelope reassembly and DNA replication. 5. **Negative Regulation of Innate Immune Response**: BANF1 negatively regulates the innate immune response, which may indicate its role in modulating the host's immune response to viral infections. **Clinical Significance** 1. **HIV-1 Infection**: BANF1 may play a role in the regulation of HIV-1 infection, particularly in the formation of 2-LTR circles and autointegration. 2. **Cancer**: Alterations in BANF1 expression may contribute to cancer development, particularly in cells with high proliferative rates, such as erythroid progenitor cells. 3. **Neurological Disorders**: BANF1 may be involved in the regulation of neuroinflammation and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Viral Infections**: BANF1 may play a role in the regulation of viral infections, particularly in the formation of viral DNA circles and autointegration. In conclusion, BANF1 is a critical gene involved in the regulation of various cellular processes, including nuclear envelope assembly, DNA replication, and response to viral infections. Further studies are needed to fully understand the role of BANF1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1509226283

Symbol: BAF_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75531 O60558 Q6FGG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9465049

Title: A previously unidentified host protein protects retroviral DNA from autointegration.

PubMed ID: 9465049

DOI: 10.1073/pnas.95.4.1528

PubMed ID: 9740667

Title: Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma.

PubMed ID: 9740667

DOI: 10.1006/geno.1998.5406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11005805

Title: Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro.

PubMed ID: 11005805

DOI: 10.1074/jbc.m002626200

PubMed ID: 10908652

Title: Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex.

PubMed ID: 10908652

DOI: 10.1073/pnas.150240197

PubMed ID: 11792822

Title: BAF is required for emerin assembly into the reforming nuclear envelope.

PubMed ID: 11792822

DOI: 10.1242/jcs.114.24.4575

PubMed ID: 12163470

Title: Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.

PubMed ID: 12163470

DOI: 10.1083/jcb.200202019

PubMed ID: 12663813

Title: The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.

PubMed ID: 12663813

DOI: 10.1128/jvi.77.8.5030-5036.2003

PubMed ID: 14645565

Title: Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions.

PubMed ID: 14645565

DOI: 10.1128/jvi.77.24.13084-13092.2003

PubMed ID: 15681850

Title: Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor.

PubMed ID: 15681850

DOI: 10.1074/jbc.m413020200

PubMed ID: 16203725

Title: Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.

PubMed ID: 16203725

DOI: 10.1074/jbc.m509917200

PubMed ID: 16371512

Title: Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo.

PubMed ID: 16371512

DOI: 10.1091/mbc.e05-04-0356

PubMed ID: 16337940

Title: Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF.

PubMed ID: 16337940

DOI: 10.1016/j.yexcr.2005.11.013

PubMed ID: 16495336

Title: The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus.

PubMed ID: 16495336

DOI: 10.1091/mbc.e05-12-1179

PubMed ID: 16680152

Title: The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity.

PubMed ID: 16680152

DOI: 10.1038/nature04682

PubMed ID: 18005698

Title: Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.

PubMed ID: 18005698

DOI: 10.1016/j.chom.2007.03.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22770216

Title: Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.

PubMed ID: 22770216

DOI: 10.1016/j.cell.2012.04.043

PubMed ID: 15130582

Title: BAF: roles in chromatin, nuclear structure and retrovirus integration.

PubMed ID: 15130582

DOI: 10.1016/j.tcb.2004.03.004

PubMed ID: 22399800

Title: The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo.

PubMed ID: 22399800

DOI: 10.1242/jcs.098392

PubMed ID: 24600006

Title: Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity.

PubMed ID: 24600006

DOI: 10.1128/jvi.00427-14

PubMed ID: 25991860

Title: BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy.

PubMed ID: 25991860

DOI: 10.1073/pnas.1501235112

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28841419

Title: DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes.

PubMed ID: 28841419

DOI: 10.1016/j.cell.2017.07.038

PubMed ID: 32494070

Title: LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.

PubMed ID: 32494070

DOI: 10.1038/s41586-020-2232-x

PubMed ID: 31796734

Title: Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.

PubMed ID: 31796734

DOI: 10.1038/s41467-019-13167-5

PubMed ID: 32792394

Title: BAF restricts cGAS on nuclear DNA to prevent innate immune activation.

PubMed ID: 32792394

DOI: 10.1126/science.aaw6421

PubMed ID: 9783751

Title: Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration.

PubMed ID: 9783751

DOI: 10.1038/2345

PubMed ID: 10924106

Title: Structural basis of DNA bridging by barrier-to-autointegration factor.

PubMed ID: 10924106

DOI: 10.1021/bi000572w

PubMed ID: 21549337

Title: Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.

PubMed ID: 21549337

DOI: 10.1016/j.ajhg.2011.04.010

Sequence Information:

  • Length: 89
  • Mass: 10059
  • Checksum: 9A2180A2D284F5D0
  • Sequence:
    • MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR 
EWLKDTCGAN AKQSRDCFGC LREWCDAFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.