Details for: TBC1D5

Gene ID: 9779

Symbol: TBC1D5

Ensembl ID: ENSG00000131374

Description: TBC1 domain family member 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.35
    Marker Score: 3,275
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.23
    Marker Score: 75,116
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.99
    Marker Score: 16,652
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.8
    Marker Score: 5,114
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.79
    Marker Score: 3,364
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.71
    Marker Score: 1,341
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.66
    Marker Score: 8,763
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.59
    Marker Score: 4,348
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.52
    Marker Score: 78,721
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.48
    Marker Score: 4,335
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.37
    Marker Score: 2,912
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.35
    Marker Score: 6,440
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.34
    Marker Score: 2,320
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.29
    Marker Score: 10,777
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.29
    Marker Score: 2,699
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.26
    Marker Score: 2,513
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.24
    Marker Score: 14,978
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.2
    Marker Score: 1,591
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.18
    Marker Score: 1,771
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.12
    Marker Score: 3,536
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.12
    Marker Score: 4,384
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.01
    Marker Score: 3,465
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3
    Marker Score: 15,715
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.99
    Marker Score: 16,055
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.97
    Marker Score: 100,293
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.95
    Marker Score: 62,974
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.93
    Marker Score: 12,264
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.9
    Marker Score: 1,530
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.89
    Marker Score: 6,352
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.88
    Marker Score: 11,999
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.83
    Marker Score: 1,649
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.78
    Marker Score: 20,975
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.76
    Marker Score: 9,268
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.67
    Marker Score: 781
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.67
    Marker Score: 1,497
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.67
    Marker Score: 769
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.66
    Marker Score: 52,989
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.6
    Marker Score: 1,713
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.6
    Marker Score: 6,514
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.6
    Marker Score: 1,521
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.6
    Marker Score: 5,968
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.59
    Marker Score: 38,747
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.55
    Marker Score: 1,384
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.55
    Marker Score: 96,959
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.53
    Marker Score: 19,432
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.44
    Marker Score: 2,634
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.42
    Marker Score: 6,891
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88,539
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.38
    Marker Score: 9,864
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.37
    Marker Score: 38,078
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.34
    Marker Score: 773
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.33
    Marker Score: 1,536
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.31
    Marker Score: 1,382
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.3
    Marker Score: 2,192
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.29
    Marker Score: 724
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.29
    Marker Score: 593
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.28
    Marker Score: 1,327
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.28
    Marker Score: 954
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.27
    Marker Score: 1,269
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.26
    Marker Score: 820
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.24
    Marker Score: 7,961
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.23
    Marker Score: 817
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.23
    Marker Score: 824
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.22
    Marker Score: 2,451
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.22
    Marker Score: 7,878
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.19
    Marker Score: 8,479
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.18
    Marker Score: 555
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.17
    Marker Score: 739
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.17
    Marker Score: 3,647
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20,218
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.08
    Marker Score: 1,075
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.05
    Marker Score: 2,197
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 125,955
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.05
    Marker Score: 1,773
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.01
    Marker Score: 2,487
  • Cell Name: neuron (CL0000540)
    Fold Change: 2
    Marker Score: 8,148
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2
    Marker Score: 634
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.96
    Marker Score: 2,362
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.95
    Marker Score: 2,433
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.95
    Marker Score: 937
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19,923
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.91
    Marker Score: 7,388
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17,992
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.87
    Marker Score: 698
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.85
    Marker Score: 915
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15,732
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.77
    Marker Score: 554
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.77
    Marker Score: 560
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.72
    Marker Score: 2,439
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.71
    Marker Score: 468
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.66
    Marker Score: 997
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.63
    Marker Score: 613
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.62
    Marker Score: 1,142
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.61
    Marker Score: 620
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.61
    Marker Score: 2,337
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3,779
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,441
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.55
    Marker Score: 754
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.52
    Marker Score: 9,804
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.5
    Marker Score: 302

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBC1D5 is a small GTPase-activating protein (GAP) that belongs to the TBC1 domain family. It is characterized by its ability to stimulate the GTPase activity of its target GTPases, thereby regulating their activity and localization within the cell. TBC1D5 is also known to interact with various proteins and complexes, including the autophagosome, endosome, and Golgi apparatus. The gene's expression is highly specific, with significant levels found in photoreceptor cells, cortical cells of the adrenal gland, and oligodendrocytes. **Pathways and Functions:** TBC1D5 is involved in multiple signaling pathways, including: 1. **Autophagy:** TBC1D5 regulates the formation and maturation of autophagosomes, which are double-membraned structures responsible for engulfing and degrading cellular components. 2. **Cytoskeletal dynamics:** TBC1D5 interacts with actin-related proteins to regulate cytoskeletal dynamics, influencing cell shape, motility, and division. 3. **Receptor internalization:** TBC1D5 regulates the internalization of receptors through its interaction with the retromer complex, a protein complex involved in endocytic transport. 4. **Golgi apparatus function:** TBC1D5 regulates the function of the Golgi apparatus, a complex organelle involved in protein modification and secretion. **Clinical Significance:** Dysregulation of TBC1D5 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** TBC1D5 has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** TBC1D5 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Metabolic disorders:** TBC1D5 has been implicated in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders. In conclusion, TBC1D5 is a complex gene that plays a critical role in regulating autophagy, cytoskeletal dynamics, and receptor internalization. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying its functions.

Genular Protein ID: 2505670901

Symbol: TBCD5_HUMAN

Name: TBC1 domain family member 5

UniProtKB Accession Codes:

Q92609 A6NP25 C9JP52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 12 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19531583

Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

PubMed ID: 19531583

DOI: 10.1242/jcs.048686

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20923837

Title: The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

PubMed ID: 20923837

DOI: 10.1242/jcs.071472

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354992

Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

PubMed ID: 22354992

DOI: 10.1128/mcb.06717-11

PubMed ID: 23908376

Title: The LIR motif - crucial for selective autophagy.

PubMed ID: 23908376

DOI: 10.1242/jcs.126128

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24603492

Title: TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.

PubMed ID: 24603492

DOI: 10.1002/embr.201337995

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 795
  • Mass: 89004
  • Checksum: 598CE3B436835E1D
  • Sequence:
    • MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG TFNSYRKEWE 
ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ DKSQWISRIE ELRAWYSNIK 
EIHITNPRKV VGQQDLMINN PLSQDEGSLW NKFFQDKELR SMIEQDVKRT FPEMQFFQQE 
NVRKILTDVL FCYARENEQL LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV 
LNPEYLEHDA YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK 
VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV VWDALFADGL 
SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD VHSLILKALF LRDPKRNPRP 
VTYQFHPNLD YYKARGADLM NKSRTNAKGA PLNINKVSNS LINFGRKLIS PAMAPGSAGG 
PVPGGNSSSS SSVVIPTRTS AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP 
SVESLPGGRE FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN 
DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK GSLRFNQSQL 
EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS SETPGCTDRG NSDDFILISK 
DDDGSSARGS FSGQAQPLRT LRSTSGKSQA PVCSPLVFSD PLMGPASASS SNPSSSPDDD 
SSKDSGFTIV SPLDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.