Details for: TBC1D5

Gene ID: 9779

Symbol: TBC1D5

Ensembl ID: ENSG00000131374

Description: TBC1 domain family member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 616.1231
    Cell Significance Index: -95.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 374.3839
    Cell Significance Index: -94.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 260.5428
    Cell Significance Index: -107.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 190.1013
    Cell Significance Index: -77.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 172.4583
    Cell Significance Index: -88.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 145.2262
    Cell Significance Index: -97.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.2156
    Cell Significance Index: -77.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 80.0353
    Cell Significance Index: -98.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.2418
    Cell Significance Index: -89.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 30.0468
    Cell Significance Index: -65.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.8756
    Cell Significance Index: -88.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.1087
    Cell Significance Index: -99.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.4634
    Cell Significance Index: 362.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.7820
    Cell Significance Index: 93.3300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.9407
    Cell Significance Index: 34.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.6536
    Cell Significance Index: 280.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.5496
    Cell Significance Index: 704.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.1374
    Cell Significance Index: 87.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0787
    Cell Significance Index: 1104.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9976
    Cell Significance Index: 601.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6301
    Cell Significance Index: 176.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5710
    Cell Significance Index: 113.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5227
    Cell Significance Index: 95.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4297
    Cell Significance Index: 58.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4287
    Cell Significance Index: 149.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3325
    Cell Significance Index: 59.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.0840
    Cell Significance Index: 44.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9028
    Cell Significance Index: 1316.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6631
    Cell Significance Index: 270.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3060
    Cell Significance Index: 37.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2068
    Cell Significance Index: 119.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1522
    Cell Significance Index: 19.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0395
    Cell Significance Index: 14.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0138
    Cell Significance Index: 124.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9211
    Cell Significance Index: 166.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8917
    Cell Significance Index: 1678.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8584
    Cell Significance Index: 1321.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.8268
    Cell Significance Index: 1524.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6593
    Cell Significance Index: 418.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5576
    Cell Significance Index: 758.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3888
    Cell Significance Index: 176.4500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.3258
    Cell Significance Index: 2.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2997
    Cell Significance Index: 8.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2607
    Cell Significance Index: 7.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2221
    Cell Significance Index: 3.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1654
    Cell Significance Index: 90.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1239
    Cell Significance Index: 5.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1139
    Cell Significance Index: 2.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1022
    Cell Significance Index: 45.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0757
    Cell Significance Index: 8.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0337
    Cell Significance Index: 6.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0307
    Cell Significance Index: -27.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0434
    Cell Significance Index: -1.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0558
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0615
    Cell Significance Index: -45.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0617
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0722
    Cell Significance Index: -45.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0748
    Cell Significance Index: -54.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1265
    Cell Significance Index: -95.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1281
    Cell Significance Index: -72.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1819
    Cell Significance Index: -4.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1954
    Cell Significance Index: -6.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2029
    Cell Significance Index: -34.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2147
    Cell Significance Index: -22.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2225
    Cell Significance Index: -11.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2948
    Cell Significance Index: -84.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3092
    Cell Significance Index: -65.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3990
    Cell Significance Index: -40.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4444
    Cell Significance Index: -20.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5359
    Cell Significance Index: -69.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5372
    Cell Significance Index: -11.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5387
    Cell Significance Index: -69.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5818
    Cell Significance Index: -8.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5976
    Cell Significance Index: -69.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6651
    Cell Significance Index: -76.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6691
    Cell Significance Index: -46.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6932
    Cell Significance Index: -32.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7424
    Cell Significance Index: -38.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7928
    Cell Significance Index: -51.1500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7986
    Cell Significance Index: -12.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8610
    Cell Significance Index: -12.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8709
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9196
    Cell Significance Index: -104.9700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.9339
    Cell Significance Index: -11.7600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9550
    Cell Significance Index: -5.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9611
    Cell Significance Index: -16.1900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.9655
    Cell Significance Index: -10.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9667
    Cell Significance Index: -72.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9984
    Cell Significance Index: -79.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1056
    Cell Significance Index: -69.6800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.1289
    Cell Significance Index: -11.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1391
    Cell Significance Index: -80.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2023
    Cell Significance Index: -26.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3061
    Cell Significance Index: -17.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3069
    Cell Significance Index: -19.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.3612
    Cell Significance Index: -11.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3614
    Cell Significance Index: -26.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.3794
    Cell Significance Index: -17.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4418
    Cell Significance Index: -30.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4707
    Cell Significance Index: -46.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBC1D5 is a small GTPase-activating protein (GAP) that belongs to the TBC1 domain family. It is characterized by its ability to stimulate the GTPase activity of its target GTPases, thereby regulating their activity and localization within the cell. TBC1D5 is also known to interact with various proteins and complexes, including the autophagosome, endosome, and Golgi apparatus. The gene's expression is highly specific, with significant levels found in photoreceptor cells, cortical cells of the adrenal gland, and oligodendrocytes. **Pathways and Functions:** TBC1D5 is involved in multiple signaling pathways, including: 1. **Autophagy:** TBC1D5 regulates the formation and maturation of autophagosomes, which are double-membraned structures responsible for engulfing and degrading cellular components. 2. **Cytoskeletal dynamics:** TBC1D5 interacts with actin-related proteins to regulate cytoskeletal dynamics, influencing cell shape, motility, and division. 3. **Receptor internalization:** TBC1D5 regulates the internalization of receptors through its interaction with the retromer complex, a protein complex involved in endocytic transport. 4. **Golgi apparatus function:** TBC1D5 regulates the function of the Golgi apparatus, a complex organelle involved in protein modification and secretion. **Clinical Significance:** Dysregulation of TBC1D5 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** TBC1D5 has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** TBC1D5 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Metabolic disorders:** TBC1D5 has been implicated in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders. In conclusion, TBC1D5 is a complex gene that plays a critical role in regulating autophagy, cytoskeletal dynamics, and receptor internalization. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying its functions.

Genular Protein ID: 2505670901

Symbol: TBCD5_HUMAN

Name: TBC1 domain family member 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19531583

Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

PubMed ID: 19531583

DOI: 10.1242/jcs.048686

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20923837

Title: The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

PubMed ID: 20923837

DOI: 10.1242/jcs.071472

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354992

Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

PubMed ID: 22354992

DOI: 10.1128/mcb.06717-11

PubMed ID: 23908376

Title: The LIR motif - crucial for selective autophagy.

PubMed ID: 23908376

DOI: 10.1242/jcs.126128

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24603492

Title: TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.

PubMed ID: 24603492

DOI: 10.1002/embr.201337995

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 795
  • Mass: 89004
  • Checksum: 598CE3B436835E1D
  • Sequence:
  • MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG TFNSYRKEWE 
    ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ DKSQWISRIE ELRAWYSNIK 
    EIHITNPRKV VGQQDLMINN PLSQDEGSLW NKFFQDKELR SMIEQDVKRT FPEMQFFQQE 
    NVRKILTDVL FCYARENEQL LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV 
    LNPEYLEHDA YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK 
    VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV VWDALFADGL 
    SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD VHSLILKALF LRDPKRNPRP 
    VTYQFHPNLD YYKARGADLM NKSRTNAKGA PLNINKVSNS LINFGRKLIS PAMAPGSAGG 
    PVPGGNSSSS SSVVIPTRTS AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP 
    SVESLPGGRE FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN 
    DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK GSLRFNQSQL 
    EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS SETPGCTDRG NSDDFILISK 
    DDDGSSARGS FSGQAQPLRT LRSTSGKSQA PVCSPLVFSD PLMGPASASS SNPSSSPDDD 
    SSKDSGFTIV SPLDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.