Details for: TBC1D5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 616.1231
Cell Significance Index: -95.8400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 374.3839
Cell Significance Index: -94.9600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 260.5428
Cell Significance Index: -107.3300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 190.1013
Cell Significance Index: -77.2300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 172.4583
Cell Significance Index: -88.7100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 145.2262
Cell Significance Index: -97.4500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 81.2156
Cell Significance Index: -77.5400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 80.0353
Cell Significance Index: -98.6800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 33.2418
Cell Significance Index: -89.0500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 30.0468
Cell Significance Index: -65.7600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 28.8756
Cell Significance Index: -88.6900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.1087
Cell Significance Index: -99.0800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 6.4634
Cell Significance Index: 362.7000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.7820
Cell Significance Index: 93.3300 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 3.9407
Cell Significance Index: 34.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.6536
Cell Significance Index: 280.3700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 3.5496
Cell Significance Index: 704.4300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.1374
Cell Significance Index: 87.6800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.0787
Cell Significance Index: 1104.2800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.9976
Cell Significance Index: 601.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.6301
Cell Significance Index: 176.8500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.5710
Cell Significance Index: 113.7200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.5227
Cell Significance Index: 95.5300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.4297
Cell Significance Index: 58.2700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.4287
Cell Significance Index: 149.2800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.3325
Cell Significance Index: 59.9600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.0840
Cell Significance Index: 44.5500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.9028
Cell Significance Index: 1316.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.6631
Cell Significance Index: 270.4800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.3060
Cell Significance Index: 37.2700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2068
Cell Significance Index: 119.3800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.1522
Cell Significance Index: 19.7500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.0395
Cell Significance Index: 14.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0138
Cell Significance Index: 124.6500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9211
Cell Significance Index: 166.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8917
Cell Significance Index: 1678.9600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.8584
Cell Significance Index: 1321.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.8268
Cell Significance Index: 1524.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6593
Cell Significance Index: 418.7200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.5576
Cell Significance Index: 758.1800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3888
Cell Significance Index: 176.4500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.3258
Cell Significance Index: 2.0100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2997
Cell Significance Index: 8.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2607
Cell Significance Index: 7.5100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.2221
Cell Significance Index: 3.1900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1654
Cell Significance Index: 90.3100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1239
Cell Significance Index: 5.6200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1139
Cell Significance Index: 2.7800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1022
Cell Significance Index: 45.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0757
Cell Significance Index: 8.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0337
Cell Significance Index: 6.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0307
Cell Significance Index: -27.6900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0434
Cell Significance Index: -1.1600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0558
Cell Significance Index: -8.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0615
Cell Significance Index: -45.5500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0617
Cell Significance Index: -8.4800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0722
Cell Significance Index: -45.0800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0748
Cell Significance Index: -54.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1265
Cell Significance Index: -95.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1281
Cell Significance Index: -72.2400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1819
Cell Significance Index: -4.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1954
Cell Significance Index: -6.8700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2029
Cell Significance Index: -34.6500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2147
Cell Significance Index: -22.3600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2225
Cell Significance Index: -11.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2948
Cell Significance Index: -84.8100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3092
Cell Significance Index: -65.1200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3990
Cell Significance Index: -40.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4444
Cell Significance Index: -20.8900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.5359
Cell Significance Index: -69.2300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5372
Cell Significance Index: -11.6400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5387
Cell Significance Index: -69.0600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5818
Cell Significance Index: -8.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5976
Cell Significance Index: -69.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6651
Cell Significance Index: -76.2000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.6691
Cell Significance Index: -46.2700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6932
Cell Significance Index: -32.3200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7424
Cell Significance Index: -38.5700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7928
Cell Significance Index: -51.1500 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.7986
Cell Significance Index: -12.1500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.8610
Cell Significance Index: -12.3300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.8709
Cell Significance Index: -10.8600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9196
Cell Significance Index: -104.9700 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.9339
Cell Significance Index: -11.7600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9550
Cell Significance Index: -5.7700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9611
Cell Significance Index: -16.1900 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.9655
Cell Significance Index: -10.0000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.9667
Cell Significance Index: -72.0500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9984
Cell Significance Index: -79.0700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.1056
Cell Significance Index: -69.6800 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.1289
Cell Significance Index: -11.7600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.1391
Cell Significance Index: -80.5600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.2023
Cell Significance Index: -26.3300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.3061
Cell Significance Index: -17.8200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.3069
Cell Significance Index: -19.2900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.3612
Cell Significance Index: -11.1000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.3614
Cell Significance Index: -26.9200 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.3794
Cell Significance Index: -17.4100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.4418
Cell Significance Index: -30.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4707
Cell Significance Index: -46.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2505670901
Symbol: TBCD5_HUMAN
Name: TBC1 domain family member 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19531583
Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
PubMed ID: 19531583
DOI: 10.1242/jcs.048686
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20923837
Title: The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.
PubMed ID: 20923837
DOI: 10.1242/jcs.071472
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22354992
Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
PubMed ID: 22354992
DOI: 10.1128/mcb.06717-11
PubMed ID: 23908376
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24603492
Title: TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.
PubMed ID: 24603492
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 795
- Mass: 89004
- Checksum: 598CE3B436835E1D
- Sequence:
MYHSLSETRH PLQPEEQEVG IDPLSSYSNK SGGDSNKNGR RTSSTLDSEG TFNSYRKEWE ELFVNNNYLA TIRQKGINGQ LRSSRFRSIC WKLFLCVLPQ DKSQWISRIE ELRAWYSNIK EIHITNPRKV VGQQDLMINN PLSQDEGSLW NKFFQDKELR SMIEQDVKRT FPEMQFFQQE NVRKILTDVL FCYARENEQL LYKQGMHELL APIVFVLHCD HQAFLHASES AQPSEEMKTV LNPEYLEHDA YAVFSQLMET AEPWFSTFEH DGQKGKETLM TPIPFARPQD LGPTIAIVTK VNQIQDHLLK KHDIELYMHL NRLEIAPQIY GLRWVRLLFG REFPLQDLLV VWDALFADGL SLGLVDYIFV AMLLYIRDAL ISSNYQTCLG LLMHYPFIGD VHSLILKALF LRDPKRNPRP VTYQFHPNLD YYKARGADLM NKSRTNAKGA PLNINKVSNS LINFGRKLIS PAMAPGSAGG PVPGGNSSSS SSVVIPTRTS AEAPSHHLQQ QQQQQRLMKS ESMPVQLNKG LSSKNISSSP SVESLPGGRE FTGSPPSSAT KKDSFFSNIS RSRSHSKTMG RKESEEELEA QISFLQGQLN DLDAMCKYCA KVMDTHLVNI QDVILQENLE KEDQILVSLA GLKQIKDILK GSLRFNQSQL EAEENEQITI ADNHYCSSGQ GQGRGQGQSV QMSGAIKQAS SETPGCTDRG NSDDFILISK DDDGSSARGS FSGQAQPLRT LRSTSGKSQA PVCSPLVFSD PLMGPASASS SNPSSSPDDD SSKDSGFTIV SPLDI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.