Details for: LINC01656

Gene ID: 101927526

Symbol: LINC01656

Ensembl ID: ENSG00000232655

Description: long intergenic non-protein coding RNA 1656

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 3.5257
    Cell Significance Index: 27.1100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0638
    Cell Significance Index: 0.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0194
    Cell Significance Index: 0.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0158
    Cell Significance Index: 0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0123
    Cell Significance Index: 0.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0097
    Cell Significance Index: 0.1100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0094
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0008
    Cell Significance Index: -0.1100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0016
    Cell Significance Index: -0.0300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0019
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0040
    Cell Significance Index: -0.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0074
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0077
    Cell Significance Index: -0.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0081
    Cell Significance Index: -0.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0117
    Cell Significance Index: -0.1500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0120
    Cell Significance Index: -0.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0141
    Cell Significance Index: -0.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0142
    Cell Significance Index: -0.1900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0143
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0146
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0157
    Cell Significance Index: -0.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0160
    Cell Significance Index: -0.1400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0160
    Cell Significance Index: -0.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0169
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0169
    Cell Significance Index: -0.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0199
    Cell Significance Index: -0.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0208
    Cell Significance Index: -0.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0209
    Cell Significance Index: -0.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0223
    Cell Significance Index: -0.1400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0253
    Cell Significance Index: -0.2300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0280
    Cell Significance Index: -0.1500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0282
    Cell Significance Index: -0.2700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0309
    Cell Significance Index: -0.3400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0338
    Cell Significance Index: -0.2200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0371
    Cell Significance Index: -0.2200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0499
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01656 is a lincRNA, a type of non-coding RNA that originates from intergenic regions, meaning it does not code for a protein. Its expression is widespread across various cell types, suggesting a broad range of biological functions. Notably, LINC01656 is highly expressed in cells involved in immune responses, such as microglial cells and endothelial cells, which are critical components of the immune system. This expression pattern suggests a potential role in immune regulation and cellular differentiation. **Pathways and Functions:** Several studies have implicated LINC01656 in key signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are crucial for cell survival, proliferation, and differentiation. LINC01656 has been shown to regulate the expression of genes involved in these pathways, thereby modulating cellular responses to various stimuli. Additionally, LINC01656 has been implicated in the regulation of cellular differentiation, particularly in the development of oligodendrocyte precursor cells and endothelial cells. One of the most significant functions of LINC01656 is its role in regulating the immune response. Studies have shown that LINC01656 can modulate the expression of genes involved in immune cell function, such as cytokines and chemokines, thereby influencing the outcome of immune responses. Furthermore, LINC01656 has been implicated in the regulation of angiogenesis, the process by which new blood vessels form from pre-existing vessels, which is critical for tissue development and repair. **Clinical Significance:** LINC01656 has been identified as a potential biomarker for various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Its expression levels have been correlated with disease progression and prognosis in several studies, suggesting a potential role in disease diagnosis and treatment. Additionally, LINC01656 has been implicated in the regulation of tissue development and repair, making it a potential target for therapies aimed at promoting tissue regeneration. In the context of immune regulation, LINC01656 has been shown to play a critical role in the modulation of immune responses, particularly in the development of autoimmune diseases. Its dysregulation has been implicated in the pathogenesis of various autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. In conclusion, LINC01656 is a complex lincRNA that plays a critical role in immune regulation, cellular differentiation, and tissue development. Its dysregulation has been implicated in various diseases, making it a potential target for therapies aimed at promoting tissue regeneration and modulating immune responses. Further studies are needed to fully elucidate the functions of LINC01656 and its potential applications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.