Details for: LOC101927855

Gene ID: 101927855

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC101927855

Ensembl ID: ENSG00000267280

Description: uncharacterized LOC101927855

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • microcirculation associated smooth muscle cell CL0008035
    CSI 8.3
    rCSI 24.03%
    PRS 85.22
  • perivascular cell CL4033054
    CSI 6.06
    rCSI 8.28%
    PRS 89.79
  • rod bipolar cell CL0000751
    CSI 4.4
    rCSI 7.9%
    PRS 80.28
  • vascular associated smooth muscle cell CL0000359
    CSI 3.38
    rCSI 10.97%
    PRS 84.04
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3
    rCSI 3.28%
    PRS 87.67
  • ON-bipolar cell CL0000749
    CSI 2.85
    rCSI 4.24%
    PRS 85.53
  • epithelial cell CL0000066
    CSI 2.63
    rCSI 4.05%
    PRS 74.69
  • bronchus fibroblast of lung CL2000093
    CSI 2.41
    rCSI 1.96%
    PRS 85.44
  • peripheral nervous system neuron CL2000032
    CSI 2.41
    rCSI 3.29%
    PRS 78.65
  • OFF-bipolar cell CL0000750
    CSI 2.35
    rCSI 3.22%
    PRS 86.36
  • lung pericyte CL0009089
    CSI 2.01
    rCSI 5.31%
    PRS 90.98
  • neural crest cell CL0011012
    CSI 1.96
    rCSI 1.55%
    PRS 76.93
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.93
    rCSI 3.41%
    PRS 89.74
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.35
    rCSI 3.43%
    PRS 78.03
  • mesenchymal cell CL0008019
    CSI 0.91
    rCSI 2.3%
    PRS 79.97
  • kidney interstitial cell CL1000500
    CSI 0.53
    rCSI 8.7%
    PRS 88.72
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.5
    rCSI 7.51%
    PRS 91.86
  • blood vessel smooth muscle cell CL0019018
    CSI 0.3
    rCSI 2.45%
    PRS 81.76

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary **Overall**, [LOC101927855](/details-gene/101927855) is an uncharacterized, non-coding RNA (ncRNA) with a distinct expression profile suggestive of a specialized role in mesenchymal-derived cell types. Its significance is highest in cells associated with the vasculature, such as [microcirculation associated smooth muscle cell](/details-cell/CL0008035) and [perivascular cell](/details-cell/CL4033054), indicating a potential function in vascular biology and tissue architecture. Interestingly, it is also significantly expressed in specific neuronal populations, including retinal bipolar cells, pointing towards a pleiotropic or context-dependent function. ## Cellular Roles and Expression Landscape The expression pattern of [LOC101927855](/details-gene/101927855) strongly implicates it in the biology of structural and contractile cells, particularly those of mesenchymal origin. It is a highly significant marker in multiple smooth muscle cell populations, including [microcirculation associated smooth muscle cell](/details-cell/CL0008035), [vascular associated smooth muscle cell](/details-cell/CL0000359), and [tracheobronchial smooth muscle cell](/details-cell/CL0019019). This is further supported by its high significance in related perivascular cells like [perivascular cell](/details-cell/CL4033054) and [lung pericyte](/details-cell/CL0009089), as well as in various fibroblasts such as [alveolar type 1 fibroblast cell](/details-cell/CL4028004) and [bronchus fibroblast of lung](/details-cell/CL2000093). The presence of [mesenchymal cell](/details-cell/CL0008019) and [neural crest cell](/details-cell/CL0011012) in the expression profile suggests that [LOC101927855](/details-gene/101927855) may also play a role during cellular differentiation and development. A notable and distinct aspect of its expression landscape is its significance in specialized neurons of the retina, including [rod bipolar cell](/details-cell/CL0000751), [ON-bipolar cell](/details-cell/CL0000749), and [OFF-bipolar cell](/details-cell/CL0000750), as well as in [peripheral nervous system neuron](/details-cell/CL2000032). This dual-expression signature in both vascular/structural cells and specific neuronal subtypes suggests a potentially conserved regulatory module or a shared developmental origin governed by this ncRNA. ## Pathways and Molecular Function As an uncharacterized ncRNA, the precise molecular function of [LOC101927855](/details-gene/101927855) remains unknown, and it is not yet annotated in major pathway databases. However, based on its strong and specific expression in smooth muscle cells and pericytes, it is plausible that it functions as a regulatory RNA involved in processes critical to these cells. Such functions could include the regulation of gene expression related to cell contractility, cytoskeletal organization, cell adhesion, or the secretion of extracellular matrix components. Its role in retinal bipolar cells may relate to synaptic function, ion channel regulation, or neuronal maintenance. ## Research Directions The unique expression pattern of the uncharacterized ncRNA [LOC101927855](/details-gene/101927855) provides a strong foundation for functional investigation. **Testable Hypotheses:** 1. [LOC101927855](/details-gene/101927855) acts as a *cis*- or *trans*-acting regulatory RNA that is essential for the maturation, phenotypic maintenance, or contractile function of vascular smooth muscle cells. 2. The expression of [LOC101927855](/details-gene/101927855) in both perivascular and specific neuronal cells points to a shared transcriptional program, potentially governed by a common developmental transcription factor, that is active in both lineages. 3. [LOC101927855](/details-gene/101927855) functions as a competing endogenous RNA (ceRNA) or "sponge," sequestering microRNAs that would otherwise repress key targets involved in smooth muscle or neuronal biology. **Proposed Experiment:** To test the hypothesis that [LOC101927855](/details-gene/101927855) is critical for vascular smooth muscle cell (VSMC) function (Hypothesis 1), one could perform a loss-of-function study. Specifically, primary human aortic smooth muscle cells could be transfected with locked nucleic acid (LNA) GapmeRs or antisense oligonucleotides (ASOs) designed to degrade [LOC101927855](/details-gene/101927855) transcripts. The impact of its knockdown would be evaluated by a multi-omics approach, including RNA-sequencing to identify downstream transcriptional changes and proteomics to assess alterations in protein expression related to the cytoskeleton (e.g., ACTA2, MYH11) and cell contractility. Functional validation could be achieved through in vitro contractility assays, such as collagen gel contraction, to determine if loss of [LOC101927855](/details-gene/101927855) impairs the primary function of these cells. **Therapeutic Potential:** Given its high and specific expression in vascular smooth muscle cells, [LOC101927855](/details-gene/101927855) could represent a novel therapeutic target for pathologies characterized by vascular remodeling, such as hypertension, atherosclerosis, or restenosis. As an ncRNA, it is amenable to targeting by RNA-based therapeutics like ASOs. If [LOC101927855](/details-gene/101927855) is found to promote VSMC proliferation or migration, its **inhibition** could be a strategy to prevent neointimal formation. Conversely, if it is essential for maintaining a healthy, contractile phenotype, its **activation** or supplementation could be beneficial in diseases involving vascular dysfunction.