Details for: RPL35

Gene ID: 11224

Symbol: RPL35

Ensembl ID: ENSG00000136942

Description: ribosomal protein L35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 659.6227
    Cell Significance Index: -271.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 587.3620
    Cell Significance Index: -238.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 545.0914
    Cell Significance Index: -257.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 518.0456
    Cell Significance Index: -266.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 385.1289
    Cell Significance Index: -258.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 254.2779
    Cell Significance Index: -242.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.4956
    Cell Significance Index: -89.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 16.0326
    Cell Significance Index: 409.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 15.4649
    Cell Significance Index: 132.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.5305
    Cell Significance Index: 1484.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.3981
    Cell Significance Index: 358.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.3711
    Cell Significance Index: 581.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.1329
    Cell Significance Index: 292.7400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.2672
    Cell Significance Index: 60.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.0876
    Cell Significance Index: 178.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.2232
    Cell Significance Index: 1191.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.0840
    Cell Significance Index: 260.4000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.8446
    Cell Significance Index: 93.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.7343
    Cell Significance Index: 53.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.2152
    Cell Significance Index: 1128.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.1699
    Cell Significance Index: 577.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.7415
    Cell Significance Index: 576.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.7194
    Cell Significance Index: 161.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.5526
    Cell Significance Index: 928.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.4830
    Cell Significance Index: 1348.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.3759
    Cell Significance Index: 3261.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.1460
    Cell Significance Index: 333.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.8663
    Cell Significance Index: 880.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.6151
    Cell Significance Index: 75.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6100
    Cell Significance Index: 179.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.6003
    Cell Significance Index: 152.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.3645
    Cell Significance Index: 3475.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.2862
    Cell Significance Index: 741.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.2108
    Cell Significance Index: 67.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.0537
    Cell Significance Index: 210.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.3877
    Cell Significance Index: 347.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.8510
    Cell Significance Index: 828.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.7404
    Cell Significance Index: 139.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.5691
    Cell Significance Index: 238.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.4887
    Cell Significance Index: 57.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.3062
    Cell Significance Index: 226.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5745
    Cell Significance Index: 28.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.4807
    Cell Significance Index: 3142.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.3856
    Cell Significance Index: 2562.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7937
    Cell Significance Index: 276.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1635
    Cell Significance Index: 57.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7838
    Cell Significance Index: 32.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6463
    Cell Significance Index: 15.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3569
    Cell Significance Index: 269.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3377
    Cell Significance Index: 92.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9447
    Cell Significance Index: 179.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7535
    Cell Significance Index: 39.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7256
    Cell Significance Index: 32.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6113
    Cell Significance Index: 448.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0812
    Cell Significance Index: -152.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1019
    Cell Significance Index: -75.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1416
    Cell Significance Index: -261.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1769
    Cell Significance Index: -272.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2254
    Cell Significance Index: -306.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2262
    Cell Significance Index: -127.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2892
    Cell Significance Index: -103.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3027
    Cell Significance Index: -189.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3036
    Cell Significance Index: -87.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3198
    Cell Significance Index: -25.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3264
    Cell Significance Index: -207.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3725
    Cell Significance Index: -74.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4752
    Cell Significance Index: -215.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5893
    Cell Significance Index: -124.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.0061
    Cell Significance Index: -163.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0364
    Cell Significance Index: -65.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0745
    Cell Significance Index: -123.1000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2924
    Cell Significance Index: -22.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3447
    Cell Significance Index: -43.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4865
    Cell Significance Index: -91.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6246
    Cell Significance Index: -236.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8998
    Cell Significance Index: -47.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.9413
    Cell Significance Index: -32.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.9543
    Cell Significance Index: -223.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.5017
    Cell Significance Index: -260.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.6565
    Cell Significance Index: -16.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.6890
    Cell Significance Index: -150.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8884
    Cell Significance Index: -43.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.3660
    Cell Significance Index: -258.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.3972
    Cell Significance Index: -46.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.4690
    Cell Significance Index: -208.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.4720
    Cell Significance Index: -75.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.5518
    Cell Significance Index: -217.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.7579
    Cell Significance Index: -252.6800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.8656
    Cell Significance Index: -80.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.0502
    Cell Significance Index: -36.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.1025
    Cell Significance Index: -150.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.6876
    Cell Significance Index: -67.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7011
    Cell Significance Index: -252.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.3085
    Cell Significance Index: -181.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.3470
    Cell Significance Index: -108.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.4142
    Cell Significance Index: -235.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.5802
    Cell Significance Index: -84.7400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.6076
    Cell Significance Index: -36.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.6325
    Cell Significance Index: -177.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.8919
    Cell Significance Index: -260.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL35 exhibits several key characteristics that highlight its importance in cellular function: 1. **High conservation**: RPL35 is highly conserved across species, suggesting its essential role in fundamental cellular processes. 2. **Ribosomal subunit composition**: RPL35 is a component of the 60S ribosomal subunit, which is responsible for protein synthesis and translation. 3. **Significant expression**: RPL35 is significantly expressed in various cell types, including stem cells, immune cells, and cancer cells. 4. **Diverse cellular functions**: RPL35 is involved in multiple cellular processes, including translation, stress response, and viral infection pathways. **Pathways and Functions** RPL35 is involved in various cellular pathways, including: 1. **Translation**: RPL35 is a component of the 60S ribosomal subunit, which is essential for protein synthesis and translation. 2. **Stress response**: RPL35 is involved in the cellular response to stress, including amino acid deficiency and viral infections. 3. **Viral infection pathways**: RPL35 is essential for the translation of viral RNAs, such as influenza viral RNA transcription and replication. 4. **Cellular responses to stimuli**: RPL35 is involved in the cellular response to stimuli, including axon guidance and cellular responses to stimuli. 5. **Metabolic processes**: RPL35 is involved in the metabolism of amino acids and derivatives, as well as the regulation of expression of Slits and Robos. **Clinical Significance** RPL35 has significant clinical implications, particularly in the context of: 1. **Cancer**: RPL35 is overexpressed in various types of cancer, including breast cancer and pancreatic cancer, suggesting its potential as a diagnostic or therapeutic target. 2. **Immune disorders**: RPL35 is involved in the function of immune cells, including T cells and natural T-regulatory cells, making it a potential target for the treatment of immune disorders. 3. **Neurological disorders**: RPL35 is involved in the development of the nervous system, and alterations in its expression may contribute to neurological disorders, such as Alzheimer's disease. 4. **Infectious diseases**: RPL35 plays a crucial role in the translation of viral RNAs, making it a potential target for the treatment of viral infections, such as influenza. In conclusion, RPL35 is a multifunctional protein that plays a crucial role in various cellular processes, including translation, stress response, and viral infection pathways. Its significant expression in various cell types and its involvement in multiple cellular pathways make it a promising target for the diagnosis and treatment of various diseases.

Genular Protein ID: 4205829782

Symbol: RL35_HUMAN

Name: 60S ribosomal protein L35

UniProtKB Accession Codes:

P42766 A8K4V7 Q4VBY5 Q5JTN5 Q6IBC7 Q96QJ7 Q9BYF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 80 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 95 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 11401437

Title: A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.

PubMed ID: 11401437

DOI: 10.1006/geno.2000.6470

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 28280134

Title: Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation.

PubMed ID: 28280134

DOI: 10.1136/jmedgenet-2016-104346

Sequence Information:

  • Length: 123
  • Mass: 14551
  • Checksum: 92B7694A97AC725D
  • Sequence:
    • MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV 
INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLNKHEE NLKTKKQQRK ERLYPLRKYA 
VKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.