Details for: RPL35

Gene ID: 11224

Symbol: RPL35

Ensembl ID: ENSG00000136942

Description: ribosomal protein L35

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.12
    Marker Score: 30,057
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 5.96
    Marker Score: 3,359
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.62
    Marker Score: 75,491
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.46
    Marker Score: 3,959
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.43
    Marker Score: 8,365
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.31
    Marker Score: 2,729
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.26
    Marker Score: 3,972
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.24
    Marker Score: 4,103
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.23
    Marker Score: 10,959
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.16
    Marker Score: 51,109
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.15
    Marker Score: 1,900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.11
    Marker Score: 6,656
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5.05
    Marker Score: 8,658
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.01
    Marker Score: 14,620
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.96
    Marker Score: 168,675
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.93
    Marker Score: 4,400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.84
    Marker Score: 4,123
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.83
    Marker Score: 3,459
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.79
    Marker Score: 2,472
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.74
    Marker Score: 14,953
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.64
    Marker Score: 245,571
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.64
    Marker Score: 24,382
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.47
    Marker Score: 1,069
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.47
    Marker Score: 1,921
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.43
    Marker Score: 1,441
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.39
    Marker Score: 4,878
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.39
    Marker Score: 57,846
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.33
    Marker Score: 2,636
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.32
    Marker Score: 1,945
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.32
    Marker Score: 26,241
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.31
    Marker Score: 3,042
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.31
    Marker Score: 2,773
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.29
    Marker Score: 11,847
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.26
    Marker Score: 2,274
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.26
    Marker Score: 15,139
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.25
    Marker Score: 49,354
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.23
    Marker Score: 11,349
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.2
    Marker Score: 234,867
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.16
    Marker Score: 10,166
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.16
    Marker Score: 11,667
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.15
    Marker Score: 9,449
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.14
    Marker Score: 2,425
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.08
    Marker Score: 4,768
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.08
    Marker Score: 26,039
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.08
    Marker Score: 2,902
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 4.07
    Marker Score: 4,244
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.04
    Marker Score: 17,343
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.04
    Marker Score: 7,584
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.03
    Marker Score: 3,162
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.03
    Marker Score: 5,930
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.02
    Marker Score: 3,427
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.01
    Marker Score: 4,285
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.99
    Marker Score: 9,741
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.99
    Marker Score: 3,857
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.99
    Marker Score: 4,922
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.98
    Marker Score: 3,916
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.98
    Marker Score: 1,782
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.97
    Marker Score: 25,896
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.93
    Marker Score: 9,995
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.92
    Marker Score: 899
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.92
    Marker Score: 29,172
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.9
    Marker Score: 3,679
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.89
    Marker Score: 34,169
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.86
    Marker Score: 4,664
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.86
    Marker Score: 1,763
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.83
    Marker Score: 3,599
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.83
    Marker Score: 9,531
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.82
    Marker Score: 1,393
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.8
    Marker Score: 3,337
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.8
    Marker Score: 4,084
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.79
    Marker Score: 998
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.79
    Marker Score: 1,067
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.78
    Marker Score: 3,372
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.77
    Marker Score: 2,539
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.77
    Marker Score: 4,165
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.76
    Marker Score: 9,477
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.75
    Marker Score: 4,523
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.75
    Marker Score: 2,607
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.75
    Marker Score: 2,850
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.74
    Marker Score: 3,356
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.74
    Marker Score: 5,440
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.74
    Marker Score: 1,063
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.74
    Marker Score: 3,063
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.72
    Marker Score: 3,309
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.72
    Marker Score: 3,279
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.71
    Marker Score: 2,811
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.71
    Marker Score: 1,221
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.7
    Marker Score: 1,918
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.7
    Marker Score: 1,012
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.69
    Marker Score: 3,742
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.68
    Marker Score: 857
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.67
    Marker Score: 5,834
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.67
    Marker Score: 23,849
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.66
    Marker Score: 1,045
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.66
    Marker Score: 2,427
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.66
    Marker Score: 4,292
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.66
    Marker Score: 2,021
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.65
    Marker Score: 966
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.64
    Marker Score: 2,132
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.63
    Marker Score: 3,017

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL35 exhibits several key characteristics that highlight its importance in cellular function: 1. **High conservation**: RPL35 is highly conserved across species, suggesting its essential role in fundamental cellular processes. 2. **Ribosomal subunit composition**: RPL35 is a component of the 60S ribosomal subunit, which is responsible for protein synthesis and translation. 3. **Significant expression**: RPL35 is significantly expressed in various cell types, including stem cells, immune cells, and cancer cells. 4. **Diverse cellular functions**: RPL35 is involved in multiple cellular processes, including translation, stress response, and viral infection pathways. **Pathways and Functions** RPL35 is involved in various cellular pathways, including: 1. **Translation**: RPL35 is a component of the 60S ribosomal subunit, which is essential for protein synthesis and translation. 2. **Stress response**: RPL35 is involved in the cellular response to stress, including amino acid deficiency and viral infections. 3. **Viral infection pathways**: RPL35 is essential for the translation of viral RNAs, such as influenza viral RNA transcription and replication. 4. **Cellular responses to stimuli**: RPL35 is involved in the cellular response to stimuli, including axon guidance and cellular responses to stimuli. 5. **Metabolic processes**: RPL35 is involved in the metabolism of amino acids and derivatives, as well as the regulation of expression of Slits and Robos. **Clinical Significance** RPL35 has significant clinical implications, particularly in the context of: 1. **Cancer**: RPL35 is overexpressed in various types of cancer, including breast cancer and pancreatic cancer, suggesting its potential as a diagnostic or therapeutic target. 2. **Immune disorders**: RPL35 is involved in the function of immune cells, including T cells and natural T-regulatory cells, making it a potential target for the treatment of immune disorders. 3. **Neurological disorders**: RPL35 is involved in the development of the nervous system, and alterations in its expression may contribute to neurological disorders, such as Alzheimer's disease. 4. **Infectious diseases**: RPL35 plays a crucial role in the translation of viral RNAs, making it a potential target for the treatment of viral infections, such as influenza. In conclusion, RPL35 is a multifunctional protein that plays a crucial role in various cellular processes, including translation, stress response, and viral infection pathways. Its significant expression in various cell types and its involvement in multiple cellular pathways make it a promising target for the diagnosis and treatment of various diseases.

Genular Protein ID: 4205829782

Symbol: RL35_HUMAN

Name: 60S ribosomal protein L35

UniProtKB Accession Codes:

P42766 A8K4V7 Q4VBY5 Q5JTN5 Q6IBC7 Q96QJ7 Q9BYF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 67 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 84 PDBsum 80 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 11401437

Title: A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.

PubMed ID: 11401437

DOI: 10.1006/geno.2000.6470

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 28280134

Title: Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation.

PubMed ID: 28280134

DOI: 10.1136/jmedgenet-2016-104346

Sequence Information:

  • Length: 123
  • Mass: 14551
  • Checksum: 92B7694A97AC725D
  • Sequence:
    • MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV RKSIARVLTV 
INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLNKHEE NLKTKKQQRK ERLYPLRKYA 
VKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.