Details for: ECI1

Gene ID: 1632

Symbol: ECI1

Ensembl ID: ENSG00000167969

Description: enoyl-CoA delta isomerase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.7876
    Cell Significance Index: -37.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.9313
    Cell Significance Index: -38.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.3247
    Cell Significance Index: -33.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.4578
    Cell Significance Index: -38.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.8624
    Cell Significance Index: -40.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.2608
    Cell Significance Index: -33.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.6695
    Cell Significance Index: -40.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5958
    Cell Significance Index: -39.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3014
    Cell Significance Index: -40.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4264
    Cell Significance Index: -22.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6562
    Cell Significance Index: 72.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3929
    Cell Significance Index: 108.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.3191
    Cell Significance Index: 53.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8969
    Cell Significance Index: 25.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7444
    Cell Significance Index: 120.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5807
    Cell Significance Index: 73.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5320
    Cell Significance Index: 33.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4035
    Cell Significance Index: 72.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3917
    Cell Significance Index: 760.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3350
    Cell Significance Index: 94.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1860
    Cell Significance Index: 74.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1262
    Cell Significance Index: 30.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1216
    Cell Significance Index: 154.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0958
    Cell Significance Index: 197.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0695
    Cell Significance Index: 212.2500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0405
    Cell Significance Index: 8.7400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.0241
    Cell Significance Index: 5.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0183
    Cell Significance Index: 125.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8864
    Cell Significance Index: 391.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8112
    Cell Significance Index: 28.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6572
    Cell Significance Index: 84.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5803
    Cell Significance Index: 27.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5313
    Cell Significance Index: 34.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4876
    Cell Significance Index: 4.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4758
    Cell Significance Index: 7.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4351
    Cell Significance Index: 32.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3006
    Cell Significance Index: 23.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2907
    Cell Significance Index: 3.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2111
    Cell Significance Index: 190.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2030
    Cell Significance Index: 2.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1945
    Cell Significance Index: 10.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1850
    Cell Significance Index: 5.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1732
    Cell Significance Index: 126.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1681
    Cell Significance Index: 21.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1655
    Cell Significance Index: 31.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1550
    Cell Significance Index: 31.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1399
    Cell Significance Index: 13.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0815
    Cell Significance Index: 29.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0808
    Cell Significance Index: 6.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0716
    Cell Significance Index: 8.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0343
    Cell Significance Index: 5.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0294
    Cell Significance Index: 55.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0278
    Cell Significance Index: 0.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0213
    Cell Significance Index: 14.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0128
    Cell Significance Index: 23.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0072
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0169
    Cell Significance Index: -10.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0460
    Cell Significance Index: -34.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0465
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0505
    Cell Significance Index: -8.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0617
    Cell Significance Index: -8.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0665
    Cell Significance Index: -37.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0697
    Cell Significance Index: -43.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0735
    Cell Significance Index: -7.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0980
    Cell Significance Index: -11.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1099
    Cell Significance Index: -2.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1101
    Cell Significance Index: -31.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1196
    Cell Significance Index: -14.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1528
    Cell Significance Index: -7.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1710
    Cell Significance Index: -4.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1894
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2089
    Cell Significance Index: -44.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2304
    Cell Significance Index: -12.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2569
    Cell Significance Index: -4.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2689
    Cell Significance Index: -7.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3108
    Cell Significance Index: -8.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3175
    Cell Significance Index: -16.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3537
    Cell Significance Index: -36.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3591
    Cell Significance Index: -22.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4157
    Cell Significance Index: -10.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4168
    Cell Significance Index: -4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4277
    Cell Significance Index: -26.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4607
    Cell Significance Index: -11.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4766
    Cell Significance Index: -12.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5088
    Cell Significance Index: -17.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5359
    Cell Significance Index: -4.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5632
    Cell Significance Index: -37.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5678
    Cell Significance Index: -9.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5767
    Cell Significance Index: -23.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5944
    Cell Significance Index: -17.0400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.6251
    Cell Significance Index: -5.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6590
    Cell Significance Index: -16.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7420
    Cell Significance Index: -8.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7860
    Cell Significance Index: -23.1500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.8407
    Cell Significance Index: -6.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ECI1 is a mitochondrial enzyme that catalyzes the isomerization of enoyl-CoA to delta-3-enoyl-CoA, a crucial step in the beta-oxidation of fatty acids. This reaction is essential for the generation of energy in the form of ATP. ECI1 is a member of the enoyl-CoA delta isomerase family, which is conserved across species. The enzyme's activity is tightly regulated, and its dysregulation has been implicated in various metabolic disorders. **Pathways and Functions:** ECI1 is involved in several key pathways, including: 1. **Fatty acid beta-oxidation**: ECI1 catalyzes the isomerization of enoyl-CoA to delta-3-enoyl-CoA, a critical step in the beta-oxidation of fatty acids. 2. **Mitochondrial fatty acid beta-oxidation**: ECI1 plays a key role in the mitochondrial beta-oxidation of fatty acids, which is essential for energy production. 3. **Metabolism of lipids**: ECI1 is involved in the regulation of lipid metabolism, including the breakdown of triglycerides and phospholipids. 4. **Mitochondrial protein degradation**: ECI1 has been implicated in the regulation of mitochondrial protein degradation, which is essential for maintaining mitochondrial function and preventing disease. **Clinical Significance:** Dysregulation of ECI1 has been implicated in various metabolic disorders, including: 1. **Metabolic syndrome**: ECI1 dysregulation has been linked to metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. 2. **Non-alcoholic fatty liver disease (NAFLD)**: ECI1 has been implicated in the development of NAFLD, a condition characterized by excessive fat accumulation in the liver. 3. **Mitochondrial disorders**: ECI1 dysregulation has been linked to mitochondrial disorders, including Kearns-Sayre syndrome and mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). In conclusion, ECI1 is a critical enzyme involved in fatty acid metabolism and mitochondrial function. Its dysregulation has significant implications for understanding metabolic disorders and diseases. Further research is needed to fully elucidate the role of ECI1 in human health and disease.

Genular Protein ID: 2046756025

Symbol: ECI1_HUMAN

Name: Enoyl-CoA delta isomerase 1, mitochondrial

UniProtKB Accession Codes:

P42126 A8K512 Q13290 Q7Z2L6 Q7Z2L7 Q9BUB8 Q9BW05 Q9UDG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 14 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829074

Title: Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3.

PubMed ID: 7829074

DOI: 10.1006/geno.1994.1480

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8198519

Title: cDNA cloning and amino acid sequence of human mitochondrial delta 3 delta 2-enoyl-CoA isomerase: comparison of the human enzyme with its rat counterpart, mitochondrial short-chain isomerase.

PubMed ID: 8198519

DOI: 10.1042/bj3000001

PubMed ID: 7818490

Title: Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices.

PubMed ID: 7818490

DOI: 10.1042/bj3040849

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15351645

Title: The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.

PubMed ID: 15351645

DOI: 10.1016/j.jmb.2004.07.039

Sequence Information:

  • Length: 302
  • Mass: 32816
  • Checksum: 6E63827DE9BE886B
  • Sequence:
    • MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE PDAGAGVAVM 
KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH 
YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RYCIGLNETQ 
LGIIAPFWLK DTLENTIGHR AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI 
AQWMAIPDHA RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE 
KG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.