Details for: ECI1

Gene ID: 1632

Symbol: ECI1

Ensembl ID: ENSG00000167969

Description: enoyl-CoA delta isomerase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4477
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.58
    Marker Score: 2525.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.28
    Marker Score: 5204
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.15
    Marker Score: 5434
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.13
    Marker Score: 5708
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.12
    Marker Score: 1948
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.01
    Marker Score: 7436
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.92
    Marker Score: 4046
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9
    Marker Score: 65900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.83
    Marker Score: 7193
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.81
    Marker Score: 6425.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.79
    Marker Score: 1899
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.78
    Marker Score: 2622
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.71
    Marker Score: 2423
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.69
    Marker Score: 556
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.68
    Marker Score: 1137
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.62
    Marker Score: 7780
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.6
    Marker Score: 1666
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.49
    Marker Score: 1590
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.47
    Marker Score: 423
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.43
    Marker Score: 734
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1381
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.38
    Marker Score: 412
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.32
    Marker Score: 3139
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14757
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.31
    Marker Score: 1032
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.31
    Marker Score: 644
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.25
    Marker Score: 1930
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.25
    Marker Score: 2214
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.24
    Marker Score: 1552
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.23
    Marker Score: 820
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.22
    Marker Score: 569
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.21
    Marker Score: 2966.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.19
    Marker Score: 294
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.18
    Marker Score: 1196
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.17
    Marker Score: 3192
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.17
    Marker Score: 437
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.16
    Marker Score: 7411
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.15
    Marker Score: 3606
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.12
    Marker Score: 423
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.1
    Marker Score: 630
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.09
    Marker Score: 457
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.08
    Marker Score: 1035
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.08
    Marker Score: 2443
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.07
    Marker Score: 1700
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1133
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.04
    Marker Score: 9044
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3989
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.03
    Marker Score: 6742
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.03
    Marker Score: 386
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71683
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47905
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Marker Score: 1039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.98
    Marker Score: 9917
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.98
    Marker Score: 225
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.97
    Marker Score: 277.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.96
    Marker Score: 308
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.95
    Marker Score: 3658
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.94
    Marker Score: 8143
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.94
    Marker Score: 883
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.93
    Marker Score: 3188
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.93
    Marker Score: 20702
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5222
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.91
    Marker Score: 221.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.9
    Marker Score: 6724
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.9
    Marker Score: 628
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1452
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.89
    Marker Score: 8925
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.88
    Marker Score: 738
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.88
    Marker Score: 4643
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13757
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.88
    Marker Score: 1666
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.88
    Marker Score: 381
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.87
    Marker Score: 302
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.87
    Marker Score: 508
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.87
    Marker Score: 594
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 932
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.85
    Marker Score: 211
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.85
    Marker Score: 811
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.85
    Marker Score: 908
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.85
    Marker Score: 950
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.84
    Marker Score: 4998
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 529
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.84
    Marker Score: 517
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.84
    Marker Score: 5461
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.83
    Marker Score: 227
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.82
    Marker Score: 580
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.81
    Marker Score: 541
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.81
    Marker Score: 256
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.8
    Marker Score: 283
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1030
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.8
    Marker Score: 457

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Other Information

**Key characteristics:** * ECI1 is a protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including the kidney, pancreas, salivary gland, kidney collecting duct, choroid plexus, and cortical thymic epithelial cells. * It is a key enzyme in the fatty acid beta-oxidation pathway, which is responsible for the conversion of palmitoyl-CoA to CoA-SH. * It is involved in the metabolism of both saturated and unsaturated fatty acids. **Pathways and functions:** * The ECI1 enzyme is involved in the following pathways: * Fatty acid beta-oxidation * Fatty acid metabolism * Metabolism of lipids * Metabolism of proteins * It plays a critical role in the regulation of fatty acid metabolism. **Clinical significance:** * Mutations in the ECI1 gene have been linked to several human diseases, including hyperlipidemia, atherosclerosis, and obesity. * These diseases are characterized by high levels of triglycerides and low levels of high-density lipoprotein (HDL) cholesterol. * ECI1 is a potential target for the treatment of these diseases. **Additional notes:** * ECI1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is regulated by a variety of factors, including hormones, nutrients, and metabolic conditions. * It is a key regulatory protein in the liver, where it is responsible for the production of CoA-SH, which is used in the citric acid cycle.

Genular Protein ID: 2046756025

Symbol: ECI1_HUMAN

Name: Enoyl-CoA delta isomerase 1, mitochondrial

UniProtKB Accession Codes:

P42126 A8K512 Q13290 Q7Z2L6 Q7Z2L7 Q9BUB8 Q9BW05 Q9UDG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 14 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829074

Title: Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3.

PubMed ID: 7829074

DOI: 10.1006/geno.1994.1480

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8198519

Title: cDNA cloning and amino acid sequence of human mitochondrial delta 3 delta 2-enoyl-CoA isomerase: comparison of the human enzyme with its rat counterpart, mitochondrial short-chain isomerase.

PubMed ID: 8198519

DOI: 10.1042/bj3000001

PubMed ID: 7818490

Title: Delta 3, delta 2-enoyl-CoA isomerase is the protein that copurifies with human glutathione S-transferases from S-hexylglutathione affinity matrices.

PubMed ID: 7818490

DOI: 10.1042/bj3040849

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15351645

Title: The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.

PubMed ID: 15351645

DOI: 10.1016/j.jmb.2004.07.039

Sequence Information:

  • Length: 302
  • Mass: 32816
  • Checksum: 6E63827DE9BE886B
  • Sequence:
    • MALVASVRVP ARVLLRAGAR LPGAALGRTE RAAGGGDGAR RFGSQRVLVE PDAGAGVAVM 
KFKNPPVNSL SLEFLTELVI SLEKLENDKS FRGVILTSDR PGVFSAGLDL TEMCGRSPAH 
YAGYWKAVQE LWLRLYQSNL VLVSAINGAC PAGGCLVALT CDYRILADNP RYCIGLNETQ 
LGIIAPFWLK DTLENTIGHR AAERALQLGL LFPPAEALQV GIVDQVVPEE QVQSTALSAI 
AQWMAIPDHA RQLTKAMMRK ATASRLVTQR DADVQNFVSF ISKDSIQKSL QMYLERLKEE 
KG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.