Details for: DDB1

Gene ID: 1642

Symbol: DDB1

Ensembl ID: ENSG00000167986

Description: damage specific DNA binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 266.9963
    Cell Significance Index: -41.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.9915
    Cell Significance Index: -45.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.7205
    Cell Significance Index: -53.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.6720
    Cell Significance Index: -53.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.3827
    Cell Significance Index: -43.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.9616
    Cell Significance Index: -50.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.2299
    Cell Significance Index: -53.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.7401
    Cell Significance Index: -43.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.6007
    Cell Significance Index: -46.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4403
    Cell Significance Index: -46.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1372
    Cell Significance Index: -51.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3822
    Cell Significance Index: -34.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4666
    Cell Significance Index: -18.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 6.7253
    Cell Significance Index: 80.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.6580
    Cell Significance Index: 124.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.7091
    Cell Significance Index: 432.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.0676
    Cell Significance Index: 193.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9771
    Cell Significance Index: 26.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9752
    Cell Significance Index: 52.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7807
    Cell Significance Index: 48.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7670
    Cell Significance Index: 106.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6158
    Cell Significance Index: 262.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3723
    Cell Significance Index: 272.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2256
    Cell Significance Index: 245.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0564
    Cell Significance Index: 129.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9949
    Cell Significance Index: 26.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9832
    Cell Significance Index: 177.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8486
    Cell Significance Index: 116.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7574
    Cell Significance Index: 413.6600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6953
    Cell Significance Index: 4.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6322
    Cell Significance Index: 226.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5357
    Cell Significance Index: 63.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5329
    Cell Significance Index: 27.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5278
    Cell Significance Index: 24.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5218
    Cell Significance Index: 230.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4927
    Cell Significance Index: 17.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4857
    Cell Significance Index: 438.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4817
    Cell Significance Index: 13.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4514
    Cell Significance Index: 10.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4510
    Cell Significance Index: 29.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4426
    Cell Significance Index: 12.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4320
    Cell Significance Index: 19.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4052
    Cell Significance Index: 28.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3900
    Cell Significance Index: 8.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3808
    Cell Significance Index: 72.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3575
    Cell Significance Index: 18.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3572
    Cell Significance Index: 26.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3552
    Cell Significance Index: 45.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3305
    Cell Significance Index: 228.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3286
    Cell Significance Index: 8.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3274
    Cell Significance Index: 3.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2570
    Cell Significance Index: 19.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2413
    Cell Significance Index: 11.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2379
    Cell Significance Index: 4.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1781
    Cell Significance Index: 23.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1353
    Cell Significance Index: 23.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0723
    Cell Significance Index: 7.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0472
    Cell Significance Index: 2.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0465
    Cell Significance Index: 87.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0247
    Cell Significance Index: 15.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0246
    Cell Significance Index: 18.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0236
    Cell Significance Index: 0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0109
    Cell Significance Index: 20.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0049
    Cell Significance Index: 7.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0033
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0141
    Cell Significance Index: -6.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0283
    Cell Significance Index: -17.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0436
    Cell Significance Index: -0.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0509
    Cell Significance Index: -3.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0525
    Cell Significance Index: -3.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0684
    Cell Significance Index: -38.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0702
    Cell Significance Index: -7.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0937
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1108
    Cell Significance Index: -23.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1522
    Cell Significance Index: -43.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1749
    Cell Significance Index: -20.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1919
    Cell Significance Index: -27.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2177
    Cell Significance Index: -3.7300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3267
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3290
    Cell Significance Index: -37.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3458
    Cell Significance Index: -18.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3485
    Cell Significance Index: -9.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4369
    Cell Significance Index: -45.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4643
    Cell Significance Index: -36.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4818
    Cell Significance Index: -14.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5410
    Cell Significance Index: -13.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5411
    Cell Significance Index: -6.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5448
    Cell Significance Index: -24.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6513
    Cell Significance Index: -7.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6549
    Cell Significance Index: -12.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6760
    Cell Significance Index: -25.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6912
    Cell Significance Index: -13.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7136
    Cell Significance Index: -43.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7189
    Cell Significance Index: -18.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7763
    Cell Significance Index: -4.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7790
    Cell Significance Index: -24.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8491
    Cell Significance Index: -24.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDB1 is a ubiquitin ligase complex that recognizes and binds to damaged DNA, specifically UV-induced cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). The DCR complex is composed of three subunits: DDB1, CDUN1, and RADAR1. DDB1 is the most abundant subunit and is responsible for the recognition of damaged DNA. The complex forms a protein-DNA complex that recruits other repair proteins, including XPF and ERCC1, to initiate the repair process. DDB1 is also involved in the regulation of cell cycle progression and apoptosis. It is expressed in a variety of cell types, including retinal rod cells, corneal endothelial cells, and placental villous trophoblasts. **Pathways and Functions** DDB1 is involved in several cellular pathways, including: 1. **Nucleotide Excision Repair (NER)**: DDB1 forms a complex with XPF and ERCC1 to initiate the repair of UV-induced DNA damage. 2. **Apoptotic Process**: DDB1 is involved in the regulation of apoptosis, specifically in the recognition and repair of DNA damage. 3. **Cell Cycle Regulation**: DDB1 regulates cell cycle progression by controlling the repair of DNA damage. 4. **Viral Genome Replication**: DDB1 is involved in the replication of viral genomes, specifically in the recognition and repair of viral DNA damage. 5. **Ubiquitin-Dependent Protein Catabolic Process**: DDB1 is involved in the ubiquitination of proteins, specifically in the regulation of protein degradation. **Clinical Significance** DDB1 mutations have been associated with an increased risk of skin cancer, specifically melanoma. Individuals with mutations in the DDB1 gene have impaired DNA repair mechanisms, leading to the accumulation of mutations and the development of cancer. Additionally, DDB1 has been implicated in other diseases, including neurodegenerative disorders and autoimmune diseases. In conclusion, the DDB1 gene plays a critical role in the recognition and repair of DNA damage, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which DDB1 regulates cellular processes and to develop new therapeutic strategies for the treatment of diseases associated with DDB1 dysfunction.

Genular Protein ID: 3839399743

Symbol: DDB1_HUMAN

Name: DNA damage-binding protein 1

UniProtKB Accession Codes:

Q16531 A6NG77 B2R648 B4DG00 O15176 Q13289 Q58F96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 41 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EMDB 49 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530102

Title: Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.

PubMed ID: 8530102

DOI: 10.1006/geno.1995.1215

PubMed ID: 7815490

Title: Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.

PubMed ID: 7815490

DOI: 10.1128/jvi.69.2.1107-1114.1995

PubMed ID: 8538642

Title: Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells.

PubMed ID: 8538642

DOI: 10.1016/0921-8777(95)00040-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632823

Title: p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.

PubMed ID: 9632823

DOI: 10.1128/mcb.18.7.4391

PubMed ID: 10777491

Title: Nuclear transport of human DDB protein induced by ultraviolet light.

PubMed ID: 10777491

DOI: 10.1074/jbc.m000961200

PubMed ID: 11673459

Title: UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.

PubMed ID: 11673459

DOI: 10.1074/jbc.m106808200

PubMed ID: 11531405

Title: Hepatitis B virus X protein interferes with cell viability through interaction with the p127-kDa UV-damaged DNA-binding protein.

PubMed ID: 11531405

DOI: 10.1006/viro.2001.1036

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12743284

Title: Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities.

PubMed ID: 12743284

DOI: 10.1128/jvi.77.11.6274-6283.2003

PubMed ID: 15448697

Title: Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.

PubMed ID: 15448697

DOI: 10.1038/ncb1172

PubMed ID: 14739464

Title: Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

PubMed ID: 14739464

DOI: 10.1126/science.1093549

PubMed ID: 15882621

Title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

PubMed ID: 15882621

DOI: 10.1016/j.cell.2005.02.035

PubMed ID: 16223728

Title: DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.

PubMed ID: 16223728

DOI: 10.1074/jbc.m507854200

PubMed ID: 16227264

Title: Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.

PubMed ID: 16227264

DOI: 10.1128/jvi.79.21.13434-13441.2005

PubMed ID: 16260596

Title: Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.

PubMed ID: 16260596

DOI: 10.1128/mcb.25.22.9784-9792.2005

PubMed ID: 16482215

Title: Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

PubMed ID: 16482215

DOI: 10.1038/sj.emboj.7601002

PubMed ID: 17079684

Title: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

PubMed ID: 17079684

DOI: 10.1101/gad.1483206

PubMed ID: 16407242

Title: An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage.

PubMed ID: 16407242

DOI: 10.1074/jbc.c500464200

PubMed ID: 16407252

Title: PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.

PubMed ID: 16407252

DOI: 10.1074/jbc.m512705200

PubMed ID: 16527807

Title: Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

PubMed ID: 16527807

DOI: 10.1074/jbc.m511834200

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 16940174

Title: DDB1 maintains genome integrity through regulation of Cdt1.

PubMed ID: 16940174

DOI: 10.1128/mcb.00819-06

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 16473935

Title: The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

PubMed ID: 16473935

DOI: 10.1073/pnas.0511160103

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 18593899

Title: The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

PubMed ID: 18593899

DOI: 10.1158/0008-5472.can-07-6162

PubMed ID: 18381890

Title: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

PubMed ID: 18381890

DOI: 10.1101/gad.1624008

PubMed ID: 18606781

Title: Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

PubMed ID: 18606781

DOI: 10.1128/mcb.00232-08

PubMed ID: 18332868

Title: VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

PubMed ID: 18332868

DOI: 10.1038/onc.2008.44

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19287380

Title: Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

PubMed ID: 19287380

DOI: 10.1038/ncb1848

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22935713

Title: Orc2 protects ORCA from ubiquitin-mediated degradation.

PubMed ID: 22935713

DOI: 10.4161/cc.21870

PubMed ID: 23478445

Title: CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

PubMed ID: 23478445

DOI: 10.1016/j.molcel.2013.02.003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 28790135

Title: DDB1-mediated CRY1 degradation promotes FOXO1-driven gluconeogenesis in liver.

PubMed ID: 28790135

DOI: 10.2337/db16-1600

PubMed ID: 28886238

Title: SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes.

PubMed ID: 28886238

DOI: 10.1111/febs.14259

PubMed ID: 28437394

Title: Selective degradation of splicing factor CAPERalpha by anticancer sulfonamides.

PubMed ID: 28437394

DOI: 10.1038/nchembio.2363

PubMed ID: 28302793

Title: Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

PubMed ID: 28302793

DOI: 10.1126/science.aal3755

PubMed ID: 28546157

Title:

PubMed ID: 28546157

DOI: 10.1126/science.aan7977

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30111536

Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

PubMed ID: 30111536

DOI: 10.15252/embj.201898981

PubMed ID: 31693891

Title: Aryl sulfonamides degrade RBM39 and RBM23 by recruitment to CRL4-DCAF15.

PubMed ID: 31693891

DOI: 10.1016/j.celrep.2019.09.079

PubMed ID: 31492966

Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.

PubMed ID: 31492966

DOI: 10.1007/s00018-019-03280-5

PubMed ID: 32075763

Title: The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity.

PubMed ID: 32075763

DOI: 10.1016/j.celrep.2020.01.070

PubMed ID: 35938868

Title: Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex.

PubMed ID: 35938868

DOI: 10.1128/jvi.00826-22

PubMed ID: 35105802

Title: Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.

PubMed ID: 35105802

DOI: 10.1073/pnas.2108173119

PubMed ID: 16413485

Title: Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.

PubMed ID: 16413485

DOI: 10.1016/j.cell.2005.10.033

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 19109893

Title: Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

PubMed ID: 19109893

DOI: 10.1016/j.cell.2008.10.045

PubMed ID: 19966799

Title: A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

PubMed ID: 19966799

DOI: 10.1038/nsmb.1719

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

PubMed ID: 21468892

Title: Structure and function of WD40 domain proteins.

PubMed ID: 21468892

DOI: 10.1007/s13238-011-1018-1

PubMed ID: 22822215

Title: Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.

PubMed ID: 22822215

DOI: 10.1073/pnas.1110067109

PubMed ID: 25043012

Title: Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.

PubMed ID: 25043012

DOI: 10.1038/nature13527

PubMed ID: 25108355

Title: Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

PubMed ID: 25108355

DOI: 10.1038/nsmb.2874

PubMed ID: 30564455

Title: Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase.

PubMed ID: 30564455

DOI: 10.1038/s41421-018-0064-8

PubMed ID: 31686031

Title: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.

PubMed ID: 31686031

DOI: 10.1038/s41589-019-0378-3

PubMed ID: 31819272

Title: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

PubMed ID: 31819272

DOI: 10.1038/s41589-019-0411-6

PubMed ID: 31693911

Title: Structural basis and kinetic pathway of RBM39 recruitment to DCAF15 by a sulfonamide molecular glue E7820.

PubMed ID: 31693911

DOI: 10.1016/j.str.2019.10.005

PubMed ID: 33743206

Title: A DNA repair disorder caused by de novo monoallelic DDB1 variants is associated with a neurodevelopmental syndrome.

PubMed ID: 33743206

DOI: 10.1016/j.ajhg.2021.03.007

Sequence Information:

  • Length: 1140
  • Mass: 126968
  • Checksum: 74D082023E3D846D
  • Sequence:
    • MSYNYVVTAQ KPTAVNGCVT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGK 
IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGESIDI ITRAHGNVQD RIGRPSETGI 
IGIIDPECRM IGLRLYDGLF KVIPLDRDNK ELKAFNIRLE ELHVIDVKFL YGCQAPTICF 
VYQDPQGRHV KTYEVSLREK EFNKGPWKQE NVEAEASMVI AVPEPFGGAI IIGQESITYH 
NGDKYLAIAP PIIKQSTIVC HNRVDPNGSR YLLGDMEGRL FMLLLEKEEQ MDGTVTLKDL 
RVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLNVDS NEQGSYVVAM ETFTNLGPIV 
DMCVVDLERQ GQGQLVTCSG AFKEGSLRII RNGIGIHEHA SIDLPGIKGL WPLRSDPNRE 
TDDTLVLSFV GQTRVLMLNG EEVEETELMG FVDDQQTFFC GNVAHQQLIQ ITSASVRLVS 
QEPKALVSEW KEPQAKNISV ASCNSSQVVV AVGRALYYLQ IHPQELRQIS HTEMEHEVAC 
LDITPLGDSN GLSPLCAIGL WTDISARILK LPSFELLHKE MLGGEIIPRS ILMTTFESSH 
YLLCALGDGA LFYFGLNIET GLLSDRKKVT LGTQPTVLRT FRSLSTTNVF ACSDRPTVIY 
SSNHKLVFSN VNLKEVNYMC PLNSDGYPDS LALANNSTLT IGTIDEIQKL HIRTVPLYES 
PRKICYQEVS QCFGVLSSRI EVQDTSGGTT ALRPSASTQA LSSSVSSSKL FSSSTAPHET 
SFGEEVEVHN LLIIDQHTFE VLHAHQFLQN EYALSLVSCK LGKDPNTYFI VGTAMVYPEE 
AEPKQGRIVV FQYSDGKLQT VAEKEVKGAV YSMVEFNGKL LASINSTVRL YEWTTEKELR 
TECNHYNNIM ALYLKTKGDF ILVGDLMRSV LLLAYKPMEG NFEEIARDFN PNWMSAVEIL 
DDDNFLGAEN AFNLFVCQKD SAATTDEERQ HLQEVGLFHL GEFVNVFCHG SLVMQNLGET 
STPTQGSVLF GTVNGMIGLV TSLSESWYNL LLDMQNRLNK VIKSVGKIEH SFWRSFHTER 
KTEPATGFID GDLIESFLDI SRPKMQEVVA NLQYDDGSGM KREATADDLI KVVEELTRIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.