Details for: DLST

Gene ID: 1743

Symbol: DLST

Ensembl ID: ENSG00000119689

Description: dihydrolipoamide S-succinyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 185.9266
    Cell Significance Index: -28.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.8677
    Cell Significance Index: -30.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.4009
    Cell Significance Index: -33.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.7834
    Cell Significance Index: -28.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.9015
    Cell Significance Index: -32.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.4305
    Cell Significance Index: -33.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9557
    Cell Significance Index: -28.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4730
    Cell Significance Index: -32.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0980
    Cell Significance Index: -29.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4667
    Cell Significance Index: -33.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8372
    Cell Significance Index: -21.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0176
    Cell Significance Index: -13.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2790
    Cell Significance Index: 17.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0082
    Cell Significance Index: 191.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9638
    Cell Significance Index: 156.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9584
    Cell Significance Index: 190.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8922
    Cell Significance Index: 25.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8053
    Cell Significance Index: 61.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7863
    Cell Significance Index: 157.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7406
    Cell Significance Index: 17.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7238
    Cell Significance Index: 15.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6292
    Cell Significance Index: 28.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5810
    Cell Significance Index: 15.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5515
    Cell Significance Index: 15.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5408
    Cell Significance Index: 37.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4945
    Cell Significance Index: 13.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4282
    Cell Significance Index: 153.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4079
    Cell Significance Index: 21.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3984
    Cell Significance Index: 25.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3425
    Cell Significance Index: 47.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3301
    Cell Significance Index: 2.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2997
    Cell Significance Index: 5.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2972
    Cell Significance Index: 7.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2899
    Cell Significance Index: 35.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2868
    Cell Significance Index: 17.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2662
    Cell Significance Index: 31.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2617
    Cell Significance Index: 47.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2536
    Cell Significance Index: 112.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2045
    Cell Significance Index: 141.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2028
    Cell Significance Index: 11.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1828
    Cell Significance Index: 23.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1815
    Cell Significance Index: 99.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1714
    Cell Significance Index: 22.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1379
    Cell Significance Index: 13.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1199
    Cell Significance Index: 2.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1157
    Cell Significance Index: 8.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0962
    Cell Significance Index: 4.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0826
    Cell Significance Index: 1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0781
    Cell Significance Index: 3.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0731
    Cell Significance Index: 3.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0685
    Cell Significance Index: 129.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0618
    Cell Significance Index: 4.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0509
    Cell Significance Index: 2.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0453
    Cell Significance Index: 1.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0376
    Cell Significance Index: 2.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0271
    Cell Significance Index: 12.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0201
    Cell Significance Index: 12.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0123
    Cell Significance Index: 11.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0097
    Cell Significance Index: 17.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0043
    Cell Significance Index: 6.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0237
    Cell Significance Index: -17.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0270
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0301
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0382
    Cell Significance Index: -28.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0453
    Cell Significance Index: -4.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0510
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0534
    Cell Significance Index: -1.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0537
    Cell Significance Index: -30.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0551
    Cell Significance Index: -1.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0561
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0584
    Cell Significance Index: -36.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0829
    Cell Significance Index: -3.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0922
    Cell Significance Index: -4.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0974
    Cell Significance Index: -1.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0992
    Cell Significance Index: -11.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1010
    Cell Significance Index: -2.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1014
    Cell Significance Index: -2.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1135
    Cell Significance Index: -1.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1383
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1705
    Cell Significance Index: -35.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1763
    Cell Significance Index: -20.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2667
    Cell Significance Index: -7.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2669
    Cell Significance Index: -27.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2675
    Cell Significance Index: -17.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2783
    Cell Significance Index: -3.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2978
    Cell Significance Index: -3.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3215
    Cell Significance Index: -7.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3232
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3264
    Cell Significance Index: -25.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3409
    Cell Significance Index: -9.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3732
    Cell Significance Index: -2.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3943
    Cell Significance Index: -4.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4578
    Cell Significance Index: -28.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4822
    Cell Significance Index: -24.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4862
    Cell Significance Index: -10.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity:** DLST is a succinyltransferase enzyme that catalyzes the transfer of a succinyl group from succinyl-CoA to dihydrolipoyllysine (DHL) residues in the 2-oxoglutarate dehydrogenase complex. 2. **Subcellular localization:** DLST is primarily localized in the mitochondrial matrix, where it participates in the TCA cycle and energy production. 3. **Regulatory mechanisms:** DLST is subject to post-translational regulation, including phosphorylation and ubiquitination, which modulate its activity and interaction with other enzymes. 4. **Substrate specificity:** DLST exhibits a broad substrate specificity, accepting various DHL residues and transferring succinyl groups to them. **Pathways and Functions:** 1. **Citric acid cycle (TCA cycle):** DLST is a key component of the 2-oxoglutarate dehydrogenase complex, which catalyzes the conversion of 2-oxoglutarate to alpha-ketoglutarate, a critical step in the TCA cycle. 2. **Amino acid catabolism:** DLST is involved in the catabolism of lysine and other amino acids, facilitating their conversion to intermediates that can be fed into the TCA cycle or energy-producing pathways. 3. **Energy production:** DLST contributes to energy production by regulating the flux of intermediates through the TCA cycle and other metabolic pathways. 4. **Redox balance:** DLST helps maintain redox balance by participating in the transfer of electrons and protons during energy production. **Clinical Significance:** 1. **Metabolic disorders:** Alterations in DLST expression or activity have been linked to metabolic disorders, such as diabetes, obesity, and mitochondrial diseases. 2. **Cancer:** DLST has been implicated in cancer progression, with its overexpression contributing to tumor growth and metastasis. 3. **Neurological disorders:** DLST is involved in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation contributes to neuronal dysfunction and death. 4. **Cardiovascular disease:** DLST plays a role in cardiovascular disease, with its dysregulation contributing to cardiac dysfunction and arrhythmias. In conclusion, DLST is a crucial enzyme involved in maintaining cellular metabolism and energy homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and therapeutic applications.

Genular Protein ID: 1547271717

Symbol: ODO2_HUMAN

Name: 2-oxoglutarate dehydrogenase complex component E2

UniProtKB Accession Codes:

P36957 B7Z5W8 E7ESY5 Q7LDY7 Q9BQ32

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 4 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268217

Title: Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.

PubMed ID: 8268217

DOI: 10.1016/0167-4781(93)90002-u

PubMed ID: 8076640

Title: Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.

PubMed ID: 8076640

DOI: 10.1111/j.1432-1033.1994.tb20010.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 32792488

Title: ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.

PubMed ID: 32792488

DOI: 10.1038/s41467-020-17862-6

PubMed ID: 30929736

Title: Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas.

PubMed ID: 30929736

DOI: 10.1016/j.ajhg.2019.02.017

Sequence Information:

  • Length: 453
  • Mass: 48755
  • Checksum: A30E8CC959106B8F
  • Sequence:
    • MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGAAP AKAKPAEAPA AAAPKAEPTA AAVPPPAAPI 
PTQMPPVPSP SQPPSGKPVS AVKPTVAPPL AEPGAGKGLR SEHREKMNRM RQRIAQRLKE 
AQNTCAMLTT FNEIDMSNIQ EMRARHKEAF LKKHNLKLGF MSAFVKASAF ALQEQPVVNA 
VIDDTTKEVV YRDYIDISVA VATPRGLVVP VIRNVEAMNF ADIERTITEL GEKARKNELA 
IEDMDGGTFT ISNGGVFGSL FGTPIINPPQ SAILGMHGIF DRPVAIGGKV EVRPMMYVAL 
TYDHRLIDGR EAVTFLRKIK AAVEDPRVLL LDL

Genular Protein ID: 775377117

Symbol: B7Z6J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6J1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 166
  • Mass: 17876
  • Checksum: FFC861D028AD813D
  • Sequence:
    • MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGGKE VLLVVKVSSV PSWDWD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.