Details for: DLST

Gene ID: 1743

Symbol: DLST

Ensembl ID: ENSG00000119689

Description: dihydrolipoamide S-succinyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.29
    Marker Score: 28731
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1920
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.22
    Marker Score: 41660
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.15
    Marker Score: 9911
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.14
    Marker Score: 4051
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.1
    Marker Score: 10451
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.09
    Marker Score: 40235
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.07
    Marker Score: 1327
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.06
    Marker Score: 593
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.06
    Marker Score: 514
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.05
    Marker Score: 438
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2457
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 63997
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.03
    Marker Score: 1186
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.03
    Marker Score: 326
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.02
    Marker Score: 10505
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.02
    Marker Score: 3998
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1055
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1
    Marker Score: 9423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71664
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1
    Marker Score: 1002
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47889
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.99
    Marker Score: 494
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.99
    Marker Score: 2175
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.98
    Marker Score: 2676
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.97
    Marker Score: 1069
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.96
    Marker Score: 278
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1205
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.96
    Marker Score: 4586
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.95
    Marker Score: 2008
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.94
    Marker Score: 3948
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.94
    Marker Score: 705
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.93
    Marker Score: 3841
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 996
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 974
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 321
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.92
    Marker Score: 623
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 668
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5166
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9
    Marker Score: 3493
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2689
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.89
    Marker Score: 2428
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.89
    Marker Score: 3833
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.88
    Marker Score: 203
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.88
    Marker Score: 937
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.88
    Marker Score: 1292
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.87
    Marker Score: 2333
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.87
    Marker Score: 1816
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.86
    Marker Score: 2709
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.86
    Marker Score: 202
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.86
    Marker Score: 472
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.85
    Marker Score: 347
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.85
    Marker Score: 567
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.85
    Marker Score: 231
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.84
    Marker Score: 893
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.84
    Marker Score: 1086
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.84
    Marker Score: 31780
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.84
    Marker Score: 980
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.83
    Marker Score: 16458
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1098
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.83
    Marker Score: 5275
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.82
    Marker Score: 8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.82
    Marker Score: 8299
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.82
    Marker Score: 750.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.81
    Marker Score: 1918
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.81
    Marker Score: 259
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8
    Marker Score: 529
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.8
    Marker Score: 1143
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12406
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16634
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3160
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.77
    Marker Score: 6610
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5829
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.76
    Marker Score: 433
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.76
    Marker Score: 4936
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.76
    Marker Score: 676
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.76
    Marker Score: 754
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.76
    Marker Score: 8787
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.75
    Marker Score: 448
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.75
    Marker Score: 549
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 804
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.75
    Marker Score: 702
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.74
    Marker Score: 257
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.74
    Marker Score: 792
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.74
    Marker Score: 3632
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.74
    Marker Score: 739
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.73
    Marker Score: 257
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 465

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Other Information

**Key characteristics:** - DLST is a glycoprotein with a molecular weight of approximately 130 kDa. - It is localized to the mitochondrial matrix. - It is a key enzyme in the citric acid cycle and the generation of precursor metabolites and energy. **Pathways and functions:** - DLST is involved in the 2-oxoglutarate metabolic process, the citric acid cycle (tca cycle), and the generation of acetyl-CoA. - It is also involved in the L-lysine catabolism pathway and the metabolism of amino acids and derivatives. - It plays a role in histone succinylation, which is essential for proper protein folding and function. **Clinical significance:** - Mutations in the DLST gene have been linked to several human diseases, including hypertrophic cardiomyopathy, mitochondrial dysfunction, and obesity. - DLST inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional information:** - The DLST gene is also involved in the regulation of apoptosis. - It is a key regulator of mitochondrial function. - It is a target for therapeutic interventions in various diseases.

Genular Protein ID: 1547271717

Symbol: ODO2_HUMAN

Name: 2-oxoglutarate dehydrogenase complex component E2

UniProtKB Accession Codes:

P36957 B7Z5W8 E7ESY5 Q7LDY7 Q9BQ32

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 4 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 2 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268217

Title: Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.

PubMed ID: 8268217

DOI: 10.1016/0167-4781(93)90002-u

PubMed ID: 8076640

Title: Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.

PubMed ID: 8076640

DOI: 10.1111/j.1432-1033.1994.tb20010.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 32792488

Title: ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.

PubMed ID: 32792488

DOI: 10.1038/s41467-020-17862-6

PubMed ID: 30929736

Title: Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas.

PubMed ID: 30929736

DOI: 10.1016/j.ajhg.2019.02.017

Sequence Information:

  • Length: 453
  • Mass: 48755
  • Checksum: A30E8CC959106B8F
  • Sequence:
    • MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGAAP AKAKPAEAPA AAAPKAEPTA AAVPPPAAPI 
PTQMPPVPSP SQPPSGKPVS AVKPTVAPPL AEPGAGKGLR SEHREKMNRM RQRIAQRLKE 
AQNTCAMLTT FNEIDMSNIQ EMRARHKEAF LKKHNLKLGF MSAFVKASAF ALQEQPVVNA 
VIDDTTKEVV YRDYIDISVA VATPRGLVVP VIRNVEAMNF ADIERTITEL GEKARKNELA 
IEDMDGGTFT ISNGGVFGSL FGTPIINPPQ SAILGMHGIF DRPVAIGGKV EVRPMMYVAL 
TYDHRLIDGR EAVTFLRKIK AAVEDPRVLL LDL

Genular Protein ID: 775377117

Symbol: B7Z6J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6J1

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 166
  • Mass: 17876
  • Checksum: FFC861D028AD813D
  • Sequence:
    • MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGGKE VLLVVKVSSV PSWDWD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.