DLST | ENSG00000119689 | NCBI 1743

Details for: DLST

Gene ID: 1743

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DLST

Ensembl ID: ENSG00000119689

Description: dihydrolipoamide S-succinyltransferase

Cell Significance Landscape

Display Count:

Associated with

Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Citric acid cycle (tca cycle)
(R-HSA-71403)
Glycine degradation
(R-HSA-6783984)
Glyoxylate metabolism and glycine degradation
(R-HSA-389661)
Lysine catabolism
(R-HSA-71064)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Oadh complex synthesizes glutaryl-coa from 2-oa
(R-HSA-9858328)
Ogdh complex synthesizes succinyl-coa from 2-og
(R-HSA-9853506)
Post-translational protein modification
(R-HSA-597592)
Protein lipoylation
(R-HSA-9857492)
2-oxoglutarate metabolic process
(GO:0006103)
Acyltransferase activity
(GO:0016746)
Cytosol
(GO:0005829)
Dihydrolipoyllysine-residue succinyltransferase activity
(GO:0004149)
Generation of precursor metabolites and energy
(GO:0006091)
L-lysine catabolic process to acetyl-coa via saccharopine
(GO:0033512)
Membrane
(GO:0016020)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxoadipate dehydrogenase complex
(GO:0160167)
Oxoglutarate dehydrogenase complex
(GO:0045252)
Protein binding
(GO:0005515)
Succinyl-coa metabolic process
(GO:0006104)
Tricarboxylic acid cycle
(GO:0006099)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

alveolar type 1 fibroblast cell CL4028004

CSI 8.53

rCSI 9.34%

PRS 50.78
astrocyte of the cerebral cortex CL0002605

CSI 6.9

rCSI 15.46%

PRS 31.84
regular atrial cardiac myocyte CL0002129

CSI 6.54

rCSI 21.05%

PRS 45.98
kidney connecting tubule epithelial cell CL1000768

CSI 5.1

rCSI 12.93%

PRS 37.35
intestinal crypt stem cell of small intestine CL0009017

CSI 4.42

rCSI 11.91%

PRS 55.37
intermediate monocyte CL0002393

CSI 4.03

rCSI 6.08%

PRS 48.96
chondrocyte CL0000138

CSI 3.44

rCSI 5.47%

PRS 39.88
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.37

rCSI 2.57%

PRS 58.27
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.21

rCSI 16.09%

PRS 57.97
group 3 innate lymphoid cell CL0001071

CSI 3.18

rCSI 2.39%

PRS 50.49
Kupffer cell CL0000091

CSI 3.06

rCSI 6.99%

PRS 46.29
dopaminergic neuron CL0000700

CSI 3.03

rCSI 17.1%

PRS 33.28
double negative thymocyte CL0002489

CSI 2.96

rCSI 2.06%

PRS 55.74
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.76

rCSI 8.62%

PRS 34.61
IgA plasma cell CL0000987

CSI 2.66

rCSI 2.72%

PRS 64.73
melanocyte CL0000148

CSI 2.55

rCSI 1.89%

PRS 40.42
naive T cell CL0000898

CSI 2.53

rCSI 1.76%

PRS 59.79
renal alpha-intercalated cell CL0005011

CSI 2.44

rCSI 3.26%

PRS 55.24
rod bipolar cell CL0000751

CSI 2.39

rCSI 4.29%

PRS 40.29
perivascular cell CL4033054

CSI 2.37

rCSI 3.24%

PRS 51.84
plasmacytoid dendritic cell, human CL0001058

CSI 2.35

rCSI 1.64%

PRS 48.69
common myeloid progenitor CL0000049

CSI 2.32

rCSI 1.88%

PRS 47.52
bronchus fibroblast of lung CL2000093

CSI 2.32

rCSI 1.89%

PRS 47.39
neural crest cell CL0011012

CSI 2.25

rCSI 1.77%

PRS 34.63
retinal rod cell CL0000604

CSI 2.23

rCSI 3.93%

PRS 45.1
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.23

rCSI 2.01%

PRS 43.49
lung ciliated cell CL1000271

CSI 2.19

rCSI 2.54%

PRS 37.1
hepatic stellate cell CL0000632

CSI 2.18

rCSI 8.18%

PRS 39.83
stem cell CL0000034

CSI 2.15

rCSI 2.08%

PRS 37.63
conjunctival epithelial cell CL1000432

CSI 2.12

rCSI 3.24%

PRS 47.35
blood vessel smooth muscle cell CL0019018

CSI 2.1

rCSI 17.11%

PRS 41.2
hematopoietic stem cell CL0000037

CSI 2.1

rCSI 1.4%

PRS 50.49
ON-bipolar cell CL0000749

CSI 2.1

rCSI 3.12%

PRS 49.19
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.05

rCSI 1.21%

PRS 62.27
mesodermal cell CL0000222

CSI 2.04

rCSI 2.45%

PRS 44.82
mesenchymal cell CL0008019

CSI 2.03

rCSI 5.16%

PRS 42.67
CD4-positive helper T cell CL0000492

CSI 2.01

rCSI 1.52%

PRS 59.45
myeloid leukocyte CL0000766

CSI 2.01

rCSI 1.86%

PRS 47.63
interneuron CL0000099

CSI 2

rCSI 4.02%

PRS 36.75
ciliated epithelial cell CL0000067

CSI 2

rCSI 1.76%

PRS 35.99
intestine goblet cell CL0019031

CSI 2

rCSI 1.78%

PRS 45.75
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.99

rCSI 1.34%

PRS 57.56
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.98

rCSI 1.42%

PRS 59.84
fibroblast of lung CL0002553

CSI 1.97

rCSI 1.83%

PRS 46.51
elicited macrophage CL0000861

CSI 1.96

rCSI 1.8%

PRS 54.42
epithelial cell of lower respiratory tract CL0002632

CSI 1.95

rCSI 1.51%

PRS 47.42
keratinocyte CL0000312

CSI 1.94

rCSI 1.63%

PRS 51.72
interstitial cell of Cajal CL0002088

CSI 1.93

rCSI 2.46%

PRS 52.39
pulmonary capillary endothelial cell CL4028001

CSI 1.91

rCSI 3.64%

PRS 63.8
neuroblast (sensu Vertebrata) CL0000031

CSI 1.9

rCSI 2.44%

PRS 44.77
epithelial cell of lung CL0000082

CSI 1.89

rCSI 1.57%

PRS 45.36
precursor B cell CL0000817

CSI 1.88

rCSI 1.64%

PRS 56.48
colon epithelial cell CL0011108

CSI 1.87

rCSI 1.96%

PRS 43.92
T-helper 17 cell CL0000899

CSI 1.86

rCSI 1.48%

PRS 68.91
double-positive, alpha-beta thymocyte CL0000809

CSI 1.86

rCSI 1.89%

PRS 60.03
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.85

rCSI 1.71%

PRS 66.87
retinal bipolar neuron CL0000748

CSI 1.84

rCSI 3.44%

PRS 36.69
early lymphoid progenitor CL0000936

CSI 1.82

rCSI 1.6%

PRS 51.93
activated type II NK T cell CL0000931

CSI 1.82

rCSI 2.05%

PRS 63.29
sst GABAergic cortical interneuron CL4023017

CSI 1.78

rCSI 2.3%

PRS 31.96
VIP GABAergic cortical interneuron CL4023016

CSI 1.78

rCSI 2.13%

PRS 30.95
retina horizontal cell CL0000745

CSI 1.73

rCSI 2.64%

PRS 43.58
pro-B cell CL0000826

CSI 1.69

rCSI 1.4%

PRS 47.87
megakaryocyte CL0000556

CSI 1.67

rCSI 7.26%

PRS 62.04
erythrocyte CL0000232

CSI 1.67

rCSI 3.78%

PRS 52.19
renal principal cell CL0005009

CSI 1.66

rCSI 4.31%

PRS 51.8
dendritic cell, human CL0001056

CSI 1.59

rCSI 2.44%

PRS 53.97
cerebral cortex endothelial cell CL1001602

CSI 1.56

rCSI 2.71%

PRS 37.65
enteric smooth muscle cell CL0002504

CSI 1.55

rCSI 2.21%

PRS 49.57
retinal blood vessel endothelial cell CL0002585

CSI 1.46

rCSI 2.33%

PRS 50.81
large pre-B-II cell CL0000957

CSI 1.44

rCSI 4.11%

PRS 61.06
promyelocyte CL0000836

CSI 1.43

rCSI 2.07%

PRS 56.87
cardiac neuron CL0010022

CSI 1.41

rCSI 4.51%

PRS 43.92
cardiac endothelial cell CL0010008

CSI 1.41

rCSI 5.68%

PRS 45.42
radial glial cell CL0000681

CSI 1.4

rCSI 1.95%

PRS 46.21
BEST4+ enteroycte CL4030026

CSI 1.39

rCSI 1.73%

PRS 49.4
L6b glutamatergic cortical neuron CL4023038

CSI 1.39

rCSI 4.34%

PRS 32.3
choroid plexus epithelial cell CL0000706

CSI 1.38

rCSI 2.27%

PRS 37.5
erythroid progenitor cell CL0000038

CSI 1.38

rCSI 7.92%

PRS 57.45
pvalb GABAergic cortical interneuron CL4023018

CSI 1.38

rCSI 1.72%

PRS 29.47
CD14-low, CD16-positive monocyte CL0002396

CSI 1.37

rCSI 1.06%

PRS 45.75
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.37

rCSI 2.41%

PRS 30.07
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.34

rCSI 1.55%

PRS 41.06
type B pancreatic cell CL0000169

CSI 1.33

rCSI 2.94%

PRS 44.33
mononuclear phagocyte CL0000113

CSI 1.32

rCSI 2.91%

PRS 50.71
intestinal epithelial cell CL0002563

CSI 1.32

rCSI 1.38%

PRS 46.17
cardiac muscle cell CL0000746

CSI 1.3

rCSI 1.87%

PRS 38.04
extravillous trophoblast CL0008036

CSI 1.3

rCSI 1.61%

PRS 42.71
mature B cell CL0000785

CSI 1.29

rCSI 1.12%

PRS 56.35
microcirculation associated smooth muscle cell CL0008035

CSI 1.27

rCSI 3.68%

PRS 49.16
common dendritic progenitor CL0001029

CSI 1.25

rCSI 1.56%

PRS 56.69
lung secretory cell CL1000272

CSI 1.24

rCSI 3.06%

PRS 44.78
granulocyte monocyte progenitor cell CL0000557

CSI 1.21

rCSI 1.05%

PRS 50.76
transit amplifying cell of colon CL0009011

CSI 1.15

rCSI 1.35%

PRS 50.33
colonocyte CL1000347

CSI 1.14

rCSI 1.63%

PRS 53.45
placental villous trophoblast CL2000060

CSI 1.1

rCSI 1.71%

PRS 44.58
peripheral nervous system neuron CL2000032

CSI 1.06

rCSI 1.44%

PRS 40
small intestine goblet cell CL1000495

CSI 1.05

rCSI 2.3%

PRS 56.35
amacrine cell CL0000561

CSI 1.04

rCSI 3.03%

PRS 38.24
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.04

rCSI 2.97%

PRS 64.83

OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 3.3%

PRS 40.5%
indirect pathway medium spiny neuron CL4023029

CSI 0.2

rCSI 4.5%

PRS 31.4%
direct pathway medium spiny neuron CL4023026

CSI 0.3

rCSI 6.7%

PRS 30.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.3

rCSI 1.7%

PRS 32.4%
ON parasol ganglion cell CL4033052

CSI 0.4

rCSI 5.1%

PRS 39.2%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.4%

PRS 39.4%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.8%

PRS 37.6%
podocyte CL0000653

CSI 0.5

rCSI 2.4%

PRS 45.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.6

rCSI 2.2%

PRS 32.0%
platelet CL0000233

CSI 0.6

rCSI 2.4%

PRS 55.7%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.6

rCSI 2.2%

PRS 29.9%
promonocyte CL0000559

CSI 0.6

rCSI 1.1%

PRS 56.1%
GABAergic neuron CL0000617

CSI 0.7

rCSI 2.3%

PRS 34.9%
hepatocyte CL0000182

CSI 0.7

rCSI 1.2%

PRS 45.4%
enterocyte of epithelium of large intestine CL0002071

CSI 0.7

rCSI 3.7%

PRS 60.9%
primitive red blood cell CL0002355

CSI 0.7

rCSI 4.0%

PRS 61.2%
paneth cell of epithelium of small intestine CL1000343

CSI 0.8

rCSI 2.1%

PRS 61.0%
colon goblet cell CL0009039

CSI 0.8

rCSI 1.9%

PRS 58.7%
alveolar adventitial fibroblast CL4028006

CSI 0.8

rCSI 1.3%

PRS 48.0%
retinal ganglion cell CL0000740

CSI 0.8

rCSI 1.8%

PRS 35.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.8

rCSI 1.4%

PRS 31.1%
fibroblast of cardiac tissue CL0002548

CSI 0.9

rCSI 4.2%

PRS 45.5%
glial cell CL0000125

CSI 0.9

rCSI 3.4%

PRS 39.9%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.0

rCSI 2.3%

PRS 30.1%
sncg GABAergic cortical interneuron CL4023015

CSI 1.0

rCSI 1.6%

PRS 33.1%
glycinergic amacrine cell CL4030028

CSI 1.0

rCSI 2.6%

PRS 46.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.0

rCSI 3.0%

PRS 64.8%
amacrine cell CL0000561

CSI 1.0

rCSI 3.0%

PRS 38.2%
small intestine goblet cell CL1000495

CSI 1.1

rCSI 2.3%

PRS 56.4%
peripheral nervous system neuron CL2000032

CSI 1.1

rCSI 1.4%

PRS 40.0%
placental villous trophoblast CL2000060

CSI 1.1

rCSI 1.7%

PRS 44.6%
colonocyte CL1000347

CSI 1.1

rCSI 1.6%

PRS 53.5%
transit amplifying cell of colon CL0009011

CSI 1.2

rCSI 1.4%

PRS 50.3%
granulocyte monocyte progenitor cell CL0000557

CSI 1.2

rCSI 1.1%

PRS 50.8%
lung secretory cell CL1000272

CSI 1.2

rCSI 3.1%

PRS 44.8%
common dendritic progenitor CL0001029

CSI 1.3

rCSI 1.6%

PRS 56.7%
microcirculation associated smooth muscle cell CL0008035

CSI 1.3

rCSI 3.7%

PRS 49.2%
mature B cell CL0000785

CSI 1.3

rCSI 1.1%

PRS 56.4%
extravillous trophoblast CL0008036

CSI 1.3

rCSI 1.6%

PRS 42.7%
cardiac muscle cell CL0000746

CSI 1.3

rCSI 1.9%

PRS 38.0%
intestinal epithelial cell CL0002563

CSI 1.3

rCSI 1.4%

PRS 46.2%
mononuclear phagocyte CL0000113

CSI 1.3

rCSI 2.9%

PRS 50.7%
type B pancreatic cell CL0000169

CSI 1.3

rCSI 2.9%

PRS 44.3%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.3

rCSI 1.6%

PRS 41.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.4

rCSI 2.4%

PRS 30.1%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.4

rCSI 1.1%

PRS 45.8%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.4

rCSI 1.7%

PRS 29.5%
erythroid progenitor cell CL0000038

CSI 1.4

rCSI 7.9%

PRS 57.5%
choroid plexus epithelial cell CL0000706

CSI 1.4

rCSI 2.3%

PRS 37.5%
L6b glutamatergic cortical neuron CL4023038

CSI 1.4

rCSI 4.3%

PRS 32.3%
BEST4+ enteroycte CL4030026

CSI 1.4

rCSI 1.7%

PRS 49.4%
radial glial cell CL0000681

CSI 1.4

rCSI 2.0%

PRS 46.2%
cardiac endothelial cell CL0010008

CSI 1.4

rCSI 5.7%

PRS 45.4%
cardiac neuron CL0010022

CSI 1.4

rCSI 4.5%

PRS 43.9%
promyelocyte CL0000836

CSI 1.4

rCSI 2.1%

PRS 56.9%
large pre-B-II cell CL0000957

CSI 1.4

rCSI 4.1%

PRS 61.1%
retinal blood vessel endothelial cell CL0002585

CSI 1.5

rCSI 2.3%

PRS 50.8%
enteric smooth muscle cell CL0002504

CSI 1.6

rCSI 2.2%

PRS 49.6%
cerebral cortex endothelial cell CL1001602

CSI 1.6

rCSI 2.7%

PRS 37.7%
dendritic cell, human CL0001056

CSI 1.6

rCSI 2.4%

PRS 54.0%
renal principal cell CL0005009

CSI 1.7

rCSI 4.3%

PRS 51.8%
erythrocyte CL0000232

CSI 1.7

rCSI 3.8%

PRS 52.2%
megakaryocyte CL0000556

CSI 1.7

rCSI 7.3%

PRS 62.0%
pro-B cell CL0000826

CSI 1.7

rCSI 1.4%

PRS 47.9%
retina horizontal cell CL0000745

CSI 1.7

rCSI 2.6%

PRS 43.6%
VIP GABAergic cortical interneuron CL4023016

CSI 1.8

rCSI 2.1%

PRS 31.0%
sst GABAergic cortical interneuron CL4023017

CSI 1.8

rCSI 2.3%

PRS 32.0%
activated type II NK T cell CL0000931

CSI 1.8

rCSI 2.1%

PRS 63.3%
early lymphoid progenitor CL0000936

CSI 1.8

rCSI 1.6%

PRS 51.9%
retinal bipolar neuron CL0000748

CSI 1.8

rCSI 3.4%

PRS 36.7%
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.9

rCSI 1.7%

PRS 66.9%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.9

rCSI 1.9%

PRS 60.0%
T-helper 17 cell CL0000899

CSI 1.9

rCSI 1.5%

PRS 68.9%
colon epithelial cell CL0011108

CSI 1.9

rCSI 2.0%

PRS 43.9%
precursor B cell CL0000817

CSI 1.9

rCSI 1.6%

PRS 56.5%
epithelial cell of lung CL0000082

CSI 1.9

rCSI 1.6%

PRS 45.4%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.9

rCSI 2.4%

PRS 44.8%
pulmonary capillary endothelial cell CL4028001

CSI 1.9

rCSI 3.6%

PRS 63.8%
interstitial cell of Cajal CL0002088

CSI 1.9

rCSI 2.5%

PRS 52.4%
keratinocyte CL0000312

CSI 1.9

rCSI 1.6%

PRS 51.7%
epithelial cell of lower respiratory tract CL0002632

CSI 2.0

rCSI 1.5%

PRS 47.4%
elicited macrophage CL0000861

CSI 2.0

rCSI 1.8%

PRS 54.4%
fibroblast of lung CL0002553

CSI 2.0

rCSI 1.8%

PRS 46.5%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.0

rCSI 1.4%

PRS 59.8%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.0

rCSI 1.3%

PRS 57.6%
intestine goblet cell CL0019031

CSI 2.0

rCSI 1.8%

PRS 45.8%
ciliated epithelial cell CL0000067

CSI 2.0

rCSI 1.8%

PRS 36.0%
interneuron CL0000099

CSI 2.0

rCSI 4.0%

PRS 36.8%
myeloid leukocyte CL0000766

CSI 2.0

rCSI 1.9%

PRS 47.6%
CD4-positive helper T cell CL0000492

CSI 2.0

rCSI 1.5%

PRS 59.5%
mesenchymal cell CL0008019

CSI 2.0

rCSI 5.2%

PRS 42.7%
mesodermal cell CL0000222

CSI 2.0

rCSI 2.5%

PRS 44.8%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.1

rCSI 1.2%

PRS 62.3%
ON-bipolar cell CL0000749

CSI 2.1

rCSI 3.1%

PRS 49.2%
hematopoietic stem cell CL0000037

CSI 2.1

rCSI 1.4%

PRS 50.5%
blood vessel smooth muscle cell CL0019018

CSI 2.1

rCSI 17.1%

PRS 41.2%
conjunctival epithelial cell CL1000432

CSI 2.1

rCSI 3.2%

PRS 47.4%
stem cell CL0000034

CSI 2.2

rCSI 2.1%

PRS 37.6%
hepatic stellate cell CL0000632

CSI 2.2

rCSI 8.2%

PRS 39.8%
lung ciliated cell CL1000271

CSI 2.2

rCSI 2.5%

PRS 37.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Dihydrolipoamide S-succinyltransferase ([DLST](/details-gene/1743)) is a protein-coding gene located on chromosome 14q24.3. It encodes the E2 component of the 2-oxoglutarate dehydrogenase complex (OGDHc), a critical multi-enzyme assembly within the mitochondrial matrix. Functionally, [DLST](/details-gene/1743) plays a central role in cellular energy metabolism by participating in the tricarboxylic acid (TCA) cycle, where it catalyzes the transfer of the succinyl group to coenzyme A. Its expression is significant across a wide range of metabolically active cell types, including fibroblasts, astrocytes, and cardiac myocytes. Clinically, germline mutations in [DLST](/details-gene/1743) have been associated with a predisposition to multiple pheochromocytomas and paragangliomas ([126063](https://omim.org/entry/126063)), highlighting its importance in maintaining metabolic homeostasis ([Link](https://doi.org/10.1016/j.ajhg.2019.02.017)). ## Cellular Roles and Expression Landscape The expression profile of [DLST](/details-gene/1743) underscores its fundamental role in cellular respiration and metabolism. **Overall**, the gene shows high significance in a diverse array of cell types characterized by high energy or biosynthetic demands. It is most significant in structural and support cells such as [alveolar type 1 fibroblast cell](/details-cell/CL4028004) (CSI: 8.53) and [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 6.90), as well as in cells with high metabolic turnover like [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 6.54) and [kidney connecting tubule epithelial cell](/details-cell/CL1000768) (CSI: 5.10). This pattern is consistent with its essential function in the TCA cycle, which is the primary source of ATP in these cell types. Furthermore, [DLST](/details-gene/1743) demonstrates moderate but notable significance across various components of the immune system. This includes both the innate system, with high scores in [intermediate monocyte](/details-cell/CL0002393) and [Kupffer cell](/details-cell/CL0000091), and the adaptive system, with significant expression in [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) and [IgA plasma cell](/details-cell/CL0000987). This suggests that the metabolic pathway involving [DLST](/details-gene/1743) is important for supporting the energetic requirements of immune cell activation, differentiation, and effector function. The broad, yet distinct, expression landscape of [DLST](/details-gene/1743) confirms its status as a critical housekeeping gene for central metabolism in vertebrate cells. ## Pathways and Molecular Function The molecular function of [DLST](/details-gene/1743) is well-defined as a core component of mitochondrial metabolism. It possesses dihydrolipoyllysine-residue succinyltransferase activity ([GO:0004149](https://www.ebi.ac.uk/QuickGO/term/GO:0004149)) as part of the oxoglutarate dehydrogenase complex ([GO:0045252](https://www.ebi.ac.uk/QuickGO/term/GO:0045252)). This complex is a key control point in the citric acid cycle ([R-HSA-71403](https://reactome.org/content/detail/R-HSA-71403)), where it catalyzes the conversion of 2-oxoglutarate to succinyl-CoA. This central role directly links [DLST](/details-gene/1743) to the fundamental biological process of generating precursor metabolites and energy ([GO:0006091](https://www.ebi.ac.uk/QuickGO/term/GO:0006091)). Its involvement is crucial for aerobic respiration and the respiratory electron transport chain ([R-HSA-1428517](https://reactome.org/content/detail/R-HSA-1428517)). Beyond the TCA cycle, the succinyl-CoA it helps produce is a vital substrate for other metabolic pathways, including lysine catabolism ([R-HSA-71064](https://reactome.org/content/detail/R-HSA-71064)) and post-translational protein modification ([R-HSA-597592](https://reactome.org/content/detail/R-HSA-597592)). The gene product is primarily localized to the mitochondrial matrix ([GO:0005759](https://www.ebi.ac.uk/QuickGO/term/GO:0005759)), consistent with the location of these core metabolic pathways. ## Research Directions The established role of [DLST](/details-gene/1743) in both core metabolism and cancer predisposition provides a foundation for several key research avenues. The link to pheochromocytomas and paragangliomas, which are neuroendocrine tumors, suggests a specific vulnerability in these cell lineages to metabolic disruption. Based on the available data, several testable hypotheses can be proposed: 1. Germline loss-of-function mutations in [DLST](/details-gene/1743) lead to the accumulation of the oncometabolite 2-oxoglutarate and/or succinate, which competitively inhibits dioxygenase enzymes, altering the epigenetic landscape and hypoxia-inducible factor (HIF) stability to drive tumorigenesis specifically in neuroendocrine chromaffin cells. 2. The significant expression of [DLST](/details-gene/1743) in effector T cells indicates that its activity is a rate-limiting step for the metabolic reprogramming required for T cell activation and clonal expansion. Its partial inhibition could therefore serve as a mechanism to induce a state of T cell anergy or exhaustion. To test the second hypothesis regarding its role in immunometabolism, a key experiment could be designed. A conditional knockout mouse model with a T-cell specific deletion of *Dlst* (e.g., using a CD4-Cre LoxP system) would be generated. T cells isolated from these knockout mice and wild-type littermates would be activated *in vitro* using anti-CD3/CD28 stimulation. The functional consequences of *Dlst* deletion would be assessed by measuring proliferation via CFSE dilution, cytokine secretion (IFN-γ, IL-2) by ELISA, and real-time metabolic activity using a Seahorse XF Analyzer to quantify oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), providing direct evidence of its role in T cell bioenergetics. Given its association with cancer, [DLST](/details-gene/1743) could be considered a therapeutic target. However, its ubiquitous and essential function in healthy tissues, particularly in the heart and brain, makes systemic **inhibition** a significant safety concern. A more promising therapeutic strategy would be to develop approaches that exploit the specific metabolic dependencies created by [DLST](/details-gene/1743) mutations in tumor cells, a concept known as synthetic lethality, rather than targeting the enzyme directly.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

2-oxoglutarate dehydrogenase complex component E2
B7Z6J1_HUMAN

Genular Protein ID: 1547271717

Symbol: ODO2_HUMAN

Name: 2-oxoglutarate dehydrogenase complex component E2

UniProtKB Accession Codes:

P36957 B7Z5W8 E7ESY5 Q7LDY7 Q9BQ32

Database IDs:

Citations:

PubMed ID: 8268217

Title: Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.

PubMed ID: 8268217

DOI: 10.1016/0167-4781(93)90002-u

PubMed ID: 8076640

Title: Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.

PubMed ID: 8076640

DOI: 10.1111/j.1432-1033.1994.tb20010.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 32792488

Title: ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.

PubMed ID: 32792488

DOI: 10.1038/s41467-020-17862-6

PubMed ID: 30929736

Title: Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas.

PubMed ID: 30929736

DOI: 10.1016/j.ajhg.2019.02.017

Sequence Information:

Length: 453
Mass: 48755
Checksum: A30E8CC959106B8F
Sequence:

MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGAAP AKAKPAEAPA AAAPKAEPTA AAVPPPAAPI 
PTQMPPVPSP SQPPSGKPVS AVKPTVAPPL AEPGAGKGLR SEHREKMNRM RQRIAQRLKE 
AQNTCAMLTT FNEIDMSNIQ EMRARHKEAF LKKHNLKLGF MSAFVKASAF ALQEQPVVNA 
VIDDTTKEVV YRDYIDISVA VATPRGLVVP VIRNVEAMNF ADIERTITEL GEKARKNELA 
IEDMDGGTFT ISNGGVFGSL FGTPIINPPQ SAILGMHGIF DRPVAIGGKV EVRPMMYVAL 
TYDHRLIDGR EAVTFLRKIK AAVEDPRVLL LDL

Genular Protein ID: 775377117

Symbol: B7Z6J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6J1

Database IDs:

Sequence Information:

Length: 166
Mass: 17876
Checksum: FFC861D028AD813D
Sequence:

MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF 
RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAED EVVCEIETDK TSVQVPSPAN 
GVIEALLVPD GGKVEGGTPL FTLRKTGGKE VLLVVKVSSV PSWDWD

Details for: DLST

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. PubMed ID: 8268217

Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. PubMed ID: 8076640

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase. PubMed ID: 29211711

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex. PubMed ID: 32792488

Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas. PubMed ID: 30929736