Details for: DYNC1LI2

Gene ID: 1783

Symbol: DYNC1LI2

Ensembl ID: ENSG00000135720

Description: dynein cytoplasmic 1 light intermediate chain 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 460.3806
    Cell Significance Index: -71.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 282.5621
    Cell Significance Index: -71.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 192.2332
    Cell Significance Index: -79.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 156.2941
    Cell Significance Index: -73.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 144.0713
    Cell Significance Index: -58.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.8880
    Cell Significance Index: -68.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 110.1901
    Cell Significance Index: -73.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.4302
    Cell Significance Index: -58.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.8724
    Cell Significance Index: -73.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.7199
    Cell Significance Index: -68.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8239
    Cell Significance Index: -74.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.8650
    Cell Significance Index: -51.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.6239
    Cell Significance Index: -25.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.3390
    Cell Significance Index: 230.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4017
    Cell Significance Index: 125.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2934
    Cell Significance Index: 31.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7515
    Cell Significance Index: 351.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6358
    Cell Significance Index: 324.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5897
    Cell Significance Index: 172.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5500
    Cell Significance Index: 279.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3187
    Cell Significance Index: 162.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2942
    Cell Significance Index: 60.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2833
    Cell Significance Index: 58.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1802
    Cell Significance Index: 34.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0488
    Cell Significance Index: 376.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0286
    Cell Significance Index: 141.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9086
    Cell Significance Index: 496.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9001
    Cell Significance Index: 24.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8752
    Cell Significance Index: 23.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8509
    Cell Significance Index: 52.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8156
    Cell Significance Index: 360.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.7820
    Cell Significance Index: 488.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7400
    Cell Significance Index: 38.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6859
    Cell Significance Index: 36.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6613
    Cell Significance Index: 597.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6444
    Cell Significance Index: 18.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6387
    Cell Significance Index: 103.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5917
    Cell Significance Index: 58.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5397
    Cell Significance Index: 69.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5371
    Cell Significance Index: 371.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4986
    Cell Significance Index: 94.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4706
    Cell Significance Index: 26.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4113
    Cell Significance Index: 19.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4044
    Cell Significance Index: 28.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3801
    Cell Significance Index: 13.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3155
    Cell Significance Index: 53.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1316
    Cell Significance Index: 4.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1310
    Cell Significance Index: 9.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1258
    Cell Significance Index: 16.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1030
    Cell Significance Index: 6.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0772
    Cell Significance Index: 49.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0653
    Cell Significance Index: 122.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0500
    Cell Significance Index: 3.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0326
    Cell Significance Index: 60.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0225
    Cell Significance Index: 34.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0154
    Cell Significance Index: 20.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0008
    Cell Significance Index: -0.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0072
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0398
    Cell Significance Index: -29.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0440
    Cell Significance Index: -33.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0897
    Cell Significance Index: -50.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1130
    Cell Significance Index: -11.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1256
    Cell Significance Index: -8.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1268
    Cell Significance Index: -4.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1287
    Cell Significance Index: -1.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1502
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1628
    Cell Significance Index: -34.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1768
    Cell Significance Index: -11.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1999
    Cell Significance Index: -23.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2147
    Cell Significance Index: -61.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2159
    Cell Significance Index: -3.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2347
    Cell Significance Index: -34.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2496
    Cell Significance Index: -29.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3203
    Cell Significance Index: -6.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3274
    Cell Significance Index: -5.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3623
    Cell Significance Index: -8.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3789
    Cell Significance Index: -43.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3929
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4098
    Cell Significance Index: -46.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5231
    Cell Significance Index: -10.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6287
    Cell Significance Index: -65.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6614
    Cell Significance Index: -18.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6671
    Cell Significance Index: -13.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6851
    Cell Significance Index: -19.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7270
    Cell Significance Index: -57.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7654
    Cell Significance Index: -16.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9498
    Cell Significance Index: -58.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0461
    Cell Significance Index: -52.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0968
    Cell Significance Index: -29.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1468
    Cell Significance Index: -36.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3313
    Cell Significance Index: -34.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.4512
    Cell Significance Index: -20.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4649
    Cell Significance Index: -47.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4801
    Cell Significance Index: -47.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5083
    Cell Significance Index: -22.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.5459
    Cell Significance Index: -33.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5629
    Cell Significance Index: -54.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5641
    Cell Significance Index: -9.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5680
    Cell Significance Index: -57.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DYNC1LI2 is a member of the dynein complex family, which is characterized by its ability to utilize microtubules as a track for motor protein movement. The cytoplasmic dynein complex, to which DYNC1LI2 belongs, is composed of multiple subunits, including heavy chains, light chains, and intermediate chains. DYNC1LI2 is a light intermediate chain, which is responsible for binding to the heavy chains and facilitating the movement of the complex along microtubules. The protein has a molecular weight of approximately 57 kDa and is highly conserved across species, suggesting its essential role in cellular processes. **Pathways and Functions** DYNC1LI2 is involved in various cellular pathways, including: 1. **Microtubule-based movement**: DYNC1LI2 is essential for the movement of vesicles, organelles, and proteins along microtubules, which is critical for cellular processes such as protein transport, cell division, and migration. 2. **Protein transport**: The cytoplasmic dynein complex, to which DYNC1LI2 belongs, is responsible for transporting proteins and organelles between different compartments within the cell, including the nucleus, cytoplasm, and Golgi apparatus. 3. **Cell division**: DYNC1LI2 is involved in the regulation of cell division, including the separation of sister chromatids and the formation of the mitotic spindle. 4. **Autophagy**: The cytoplasmic dynein complex has been implicated in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins. 5. **Signaling pathways**: DYNC1LI2 has been shown to interact with various signaling molecules, including Rho GTPases, which are involved in cell migration, adhesion, and proliferation. **Clinical Significance** DYNC1LI2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the DYNC1LI2 gene have been associated with neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer**: The cytoplasmic dynein complex, to which DYNC1LI2 belongs, has been shown to play a role in cancer development and progression, including the regulation of cell migration and invasion. 3. **Autophagy-related disorders**: DYNC1LI2 has been implicated in autophagy-related disorders, such as autophagic cell death and lysosomal storage diseases. In conclusion, DYNC1LI2 is a critical component of the cytoplasmic dynein complex, which plays a vital role in various cellular processes, including microtubule-based movement, protein transport, and cell division. Its dysfunction has been implicated in various diseases, highlighting the importance of understanding the molecular mechanisms underlying its function.

Genular Protein ID: 271492504

Symbol: DC1L2_HUMAN

Name: Cytoplasmic dynein 1 light intermediate chain 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 29420470

Title: Cryo-EM shows how dynactin recruits two dyneins for faster movement.

PubMed ID: 29420470

DOI: 10.1038/nature25462

PubMed ID: 36071160

Title: Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

PubMed ID: 36071160

DOI: 10.1038/s41586-022-05186-y

Sequence Information:

  • Length: 492
  • Mass: 54099
  • Checksum: AF7B4E49E3983DCC
  • Sequence:
  • MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF 
    GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 
    FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 
    FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL 
    EKEHDYRDEH LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA 
    LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH DKELAAEDEQ 
    VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP ASVPSSSPGT SVKKPDPNIK 
    NNAASEGVLA SFFNSLLSKK TGSPGSPGAG GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD 
    SMVTNSSTEN EA

Genular Protein ID: 3511536041

Symbol: Q63HJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 209
  • Mass: 23552
  • Checksum: FF8FAB33A0230879
  • Sequence:
  • MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF 
    GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 
    FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 
    FQDYMEPEEG CQGSPLSNRV EQMRPRNHW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.