Gene DYNC1LI2 - ENSG00000135720 | NCBI Gene ID: 1783

Details for: DYNC1LI2

Gene ID: 1783

Symbol: DYNC1LI2

Ensembl ID: ENSG00000135720

Description: dynein cytoplasmic 1 light intermediate chain 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Asparagine n-linked glycosylation
(R-HSA-446203)
Autophagy
(R-HSA-9612973)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Post-translational protein modification
(R-HSA-597592)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Centrosome
(GO:0005813)
Centrosome localization
(GO:0051642)
Cytoplasmic dynein complex
(GO:0005868)
Cytosol
(GO:0005829)
Dynein complex
(GO:0030286)
Dynein heavy chain binding
(GO:0045504)
Identical protein binding
(GO:0042802)
Kinetochore
(GO:0000776)
Late endosome
(GO:0005770)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule cytoskeleton organization
(GO:0000226)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 3.2
Marker Score: 13338
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.18
Marker Score: 19093
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.14
Marker Score: 2288
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.92
Marker Score: 4381
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.84
Marker Score: 1934
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.84
Marker Score: 2705
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.82
Marker Score: 3230.5
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.78
Marker Score: 6907.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.72
Marker Score: 6361.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.72
Marker Score: 1148
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.7
Marker Score: 1905
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.69
Marker Score: 17446
Cell Name: basal cell (CL0000646)
Fold Change: 1.67
Marker Score: 2151
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.66
Marker Score: 3375
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.65
Marker Score: 101296
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.61
Marker Score: 3850
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.61
Marker Score: 792
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.6
Marker Score: 5022
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.59
Marker Score: 6165
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.59
Marker Score: 744
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.59
Marker Score: 13646
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.59
Marker Score: 15070
Cell Name: supporting cell (CL0000630)
Fold Change: 1.59
Marker Score: 2979
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.57
Marker Score: 11683
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.57
Marker Score: 14747.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.57
Marker Score: 33414
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.56
Marker Score: 13580
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.55
Marker Score: 58736
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.54
Marker Score: 451
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.53
Marker Score: 1589
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.52
Marker Score: 440
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.51
Marker Score: 52372
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.5
Marker Score: 2068
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.48
Marker Score: 54573
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.48
Marker Score: 11335
Cell Name: neuron (CL0000540)
Fold Change: 1.47
Marker Score: 5974
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.47
Marker Score: 857.5
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.45
Marker Score: 5000
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.45
Marker Score: 488
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.44
Marker Score: 1357
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.42
Marker Score: 15993
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.42
Marker Score: 1352.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.41
Marker Score: 2182
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.41
Marker Score: 2816
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.4
Marker Score: 27852
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.39
Marker Score: 527
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.38
Marker Score: 1947
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.38
Marker Score: 1722
Cell Name: peptic cell (CL0000155)
Fold Change: 1.37
Marker Score: 575
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.37
Marker Score: 340
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.37
Marker Score: 20432.5
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.36
Marker Score: 327
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.34
Marker Score: 1205
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.34
Marker Score: 6599.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.34
Marker Score: 3597
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.34
Marker Score: 13456
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.34
Marker Score: 5541
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.33
Marker Score: 8643
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.32
Marker Score: 2515
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.32
Marker Score: 1192
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.32
Marker Score: 1457
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.32
Marker Score: 417
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.31
Marker Score: 490
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.31
Marker Score: 1410
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.3
Marker Score: 3066.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.3
Marker Score: 2744
Cell Name: astrocyte (CL0000127)
Fold Change: 1.3
Marker Score: 1124
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.3
Marker Score: 714
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.29
Marker Score: 44024.5
Cell Name: stromal cell (CL0000499)
Fold Change: 1.29
Marker Score: 1515
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.29
Marker Score: 626
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.28
Marker Score: 748
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.28
Marker Score: 1358
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.28
Marker Score: 1380
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.28
Marker Score: 5039
Cell Name: keratocyte (CL0002363)
Fold Change: 1.28
Marker Score: 295
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.28
Marker Score: 2102
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.27
Marker Score: 1461
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.27
Marker Score: 835
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.27
Marker Score: 2645
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.26
Marker Score: 861
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.26
Marker Score: 1186
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.25
Marker Score: 6581
Cell Name: motor neuron (CL0000100)
Fold Change: 1.25
Marker Score: 742
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.25
Marker Score: 3400
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.25
Marker Score: 1985
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.25
Marker Score: 1505
Cell Name: Unknown (CL0002371)
Fold Change: 1.23
Marker Score: 1308
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.22
Marker Score: 581
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.22
Marker Score: 1311
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.21
Marker Score: 1232
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.21
Marker Score: 573
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.21
Marker Score: 1208.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.21
Marker Score: 289
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.21
Marker Score: 2655
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.21
Marker Score: 7705
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.21
Marker Score: 387
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.2
Marker Score: 10383.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.2
Marker Score: 856
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.2
Marker Score: 2044

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**Key characteristics:** * DYNC1LI2 is a transmembrane protein that is localized to the cytoplasm. * It is a member of the dynein family of motor proteins. * It is involved in the regulation of protein transport between the cytoplasm and the nucleus. * It is also involved in the regulation of autophagy, cell cycle, and other cellular processes. **Pathways and functions:** * DYNC1LI2 is involved in the adaptive immune system by regulating the trafficking of immune molecules between the cytoplasm and the nucleus. * It is also involved in the regulation of autophagy, a process by which cells break down and recycle their own components. * It is involved in the regulation of cell cycle by controlling the progression of cells through different phases. * DYNC1LI2 is also involved in the regulation of other cellular processes, such as metabolism, stress response, and differentiation. **Clinical significance:** DYNC1LI2 is a potential therapeutic target for a variety of diseases. For example, it is a target for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis, where it is thought to be involved in the pathogenesis of the disease. It is also a target for the treatment of cancer, where it is thought to be involved in the survival and proliferation of cancer cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytoplasmic dynein 1 light intermediate chain 2
Q63HJ8_HUMAN

Genular Protein ID: 271492504

Symbol: DC1L2_HUMAN

Name: Cytoplasmic dynein 1 light intermediate chain 2

UniProtKB Accession Codes:

O43237 A8K6V1 B4DZP4 Q8TAT3

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 29420470

Title: Cryo-EM shows how dynactin recruits two dyneins for faster movement.

PubMed ID: 29420470

DOI: 10.1038/nature25462

PubMed ID: 36071160

Title: Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

PubMed ID: 36071160

DOI: 10.1038/s41586-022-05186-y

Sequence Information:

Length: 492
Mass: 54099
Checksum: AF7B4E49E3983DCC
Sequence:

MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF 
GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 
FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 
FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL 
EKEHDYRDEH LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA 
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH DKELAAEDEQ 
VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP ASVPSSSPGT SVKKPDPNIK 
NNAASEGVLA SFFNSLLSKK TGSPGSPGAG GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD 
SMVTNSSTEN EA

Genular Protein ID: 3511536041

Symbol: Q63HJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q63HJ8

Database IDs:

Sequence Information:

Length: 209
Mass: 23552
Checksum: FF8FAB33A0230879
Sequence:

MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF 
GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 
FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 
FQDYMEPEEG CQGSPLSNRV EQMRPRNHW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DYNC1LI2

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Cryo-EM shows how dynactin recruits two dyneins for faster movement. PubMed ID: 29420470

Structure of dynein-dynactin on microtubules shows tandem adaptor binding. PubMed ID: 36071160