Details for: DRD1

Gene ID: 1812

Symbol: DRD1

Ensembl ID: ENSG00000184845

Description: dopamine receptor D1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.0126
    Cell Significance Index: 81.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4898
    Cell Significance Index: 42.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.6347
    Cell Significance Index: 12.6000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.6152
    Cell Significance Index: 22.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4528
    Cell Significance Index: 55.0200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.5754
    Cell Significance Index: 6.8000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4985
    Cell Significance Index: 6.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3371
    Cell Significance Index: 4.7900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1887
    Cell Significance Index: 2.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1408
    Cell Significance Index: 1.4600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0825
    Cell Significance Index: 1.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0682
    Cell Significance Index: 4.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0428
    Cell Significance Index: 29.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0262
    Cell Significance Index: 5.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0079
    Cell Significance Index: -14.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0122
    Cell Significance Index: -5.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0156
    Cell Significance Index: -9.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0233
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0268
    Cell Significance Index: -19.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0268
    Cell Significance Index: -4.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0313
    Cell Significance Index: -3.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0317
    Cell Significance Index: -17.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0320
    Cell Significance Index: -14.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0475
    Cell Significance Index: -13.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0697
    Cell Significance Index: -12.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0721
    Cell Significance Index: -14.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0796
    Cell Significance Index: -5.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0861
    Cell Significance Index: -12.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1010
    Cell Significance Index: -12.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1139
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1155
    Cell Significance Index: -24.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1157
    Cell Significance Index: -5.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1178
    Cell Significance Index: -13.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1205
    Cell Significance Index: -5.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1214
    Cell Significance Index: -12.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1216
    Cell Significance Index: -1.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1284
    Cell Significance Index: -17.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1575
    Cell Significance Index: -16.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1712
    Cell Significance Index: -8.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1760
    Cell Significance Index: -4.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2136
    Cell Significance Index: -14.3600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2343
    Cell Significance Index: -3.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2352
    Cell Significance Index: -12.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2410
    Cell Significance Index: -6.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2473
    Cell Significance Index: -15.2000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2482
    Cell Significance Index: -2.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2535
    Cell Significance Index: -12.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2592
    Cell Significance Index: -10.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2757
    Cell Significance Index: -14.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2931
    Cell Significance Index: -16.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3003
    Cell Significance Index: -13.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3034
    Cell Significance Index: -6.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3166
    Cell Significance Index: -6.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3169
    Cell Significance Index: -5.4300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3464
    Cell Significance Index: -3.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3476
    Cell Significance Index: -9.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3484
    Cell Significance Index: -15.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3608
    Cell Significance Index: -12.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4032
    Cell Significance Index: -12.8400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.4032
    Cell Significance Index: -4.5100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4037
    Cell Significance Index: -5.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4054
    Cell Significance Index: -11.9400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.4117
    Cell Significance Index: -5.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4145
    Cell Significance Index: -13.5700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4246
    Cell Significance Index: -4.6900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4269
    Cell Significance Index: -4.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4289
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.4406
    Cell Significance Index: -5.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.4415
    Cell Significance Index: -5.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4423
    Cell Significance Index: -9.4600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.4520
    Cell Significance Index: -6.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4812
    Cell Significance Index: -12.8500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.4942
    Cell Significance Index: -6.7200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4957
    Cell Significance Index: -5.3300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.5109
    Cell Significance Index: -6.5400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.5207
    Cell Significance Index: -4.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5214
    Cell Significance Index: -7.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5274
    Cell Significance Index: -11.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5292
    Cell Significance Index: -14.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5292
    Cell Significance Index: -13.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5361
    Cell Significance Index: -5.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5415
    Cell Significance Index: -14.2400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.5528
    Cell Significance Index: -5.1300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5612
    Cell Significance Index: -6.3400
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.5629
    Cell Significance Index: -5.5100
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.5659
    Cell Significance Index: -4.1900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5780
    Cell Significance Index: -7.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5799
    Cell Significance Index: -14.4600
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.5806
    Cell Significance Index: -5.4400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5838
    Cell Significance Index: -9.9200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.5839
    Cell Significance Index: -6.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5965
    Cell Significance Index: -20.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6019
    Cell Significance Index: -13.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6060
    Cell Significance Index: -7.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.6126
    Cell Significance Index: -7.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6177
    Cell Significance Index: -9.1200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6195
    Cell Significance Index: -9.0600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6310
    Cell Significance Index: -6.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor structure**: The DRD1 receptor is a transmembrane receptor with seven transmembrane domains, which are characteristic of G-protein-coupled receptors (GPCRs). 2. **Ligand binding**: The DRD1 receptor binds to dopamine, a neurotransmitter involved in reward processing, motivation, and motor control. 3. **Signal transduction**: Activation of the DRD1 receptor leads to the activation of adenylate cyclase, resulting in increased cAMP levels and subsequent signaling cascades. 4. **Expression**: The DRD1 gene is widely expressed in the brain, with high levels in the striatum, cortex, and hippocampus. **Pathways and Functions** 1. **Dopamine signaling pathway**: The DRD1 receptor is a key component of the dopamine signaling pathway, which regulates reward processing, motivation, and motor control. 2. **G-protein coupled receptor signaling pathway**: The DRD1 receptor is a member of the G-protein coupled receptor family, which is involved in a wide range of cellular processes, including signal transduction and gene regulation. 3. **Cyclic nucleotide signaling pathway**: Activation of the DRD1 receptor leads to the activation of adenylate cyclase, resulting in increased cAMP levels and subsequent signaling cascades. 4. **Neurotransmitter regulation**: The DRD1 receptor regulates the release of dopamine and other neurotransmitters, influencing various physiological and pathological processes. **Clinical Significance** 1. **Neurological disorders**: Dysregulation of the DRD1 receptor has been implicated in various neurological disorders, including schizophrenia, Parkinson's disease, and addiction. 2. **Cognitive functions**: The DRD1 receptor plays a crucial role in cognitive functions, including attention, memory, and decision-making. 3. **Motor control**: The DRD1 receptor is involved in motor control, with dysregulation contributing to movement disorders, such as Parkinson's disease. 4. **Therapeutic targets**: The DRD1 receptor has been identified as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. In conclusion, the DRD1 gene plays a critical role in various physiological and pathological processes, including dopamine signaling, G-protein coupled receptor signaling, and cyclic nucleotide signaling. Its dysregulation has been implicated in numerous neurological and psychiatric disorders, making it a promising therapeutic target for the treatment of these conditions.

Genular Protein ID: 4001877141

Symbol: DRD1_HUMAN

Name: D(1A) dopamine receptor

UniProtKB Accession Codes:

P21728 B2RA44 Q4QRJ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 59 DrugCentral 1 EMBL 11 EMDB 19 Ensembl 1 GO 70 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2144334

Title: Molecular cloning and expression of the gene for a human D1 dopamine receptor.

PubMed ID: 2144334

DOI: 10.1038/347072a0

PubMed ID: 2168520

Title: Cloning and expression of human and rat D1 dopamine receptors.

PubMed ID: 2168520

DOI: 10.1038/347076a0

PubMed ID: 1975640

Title: Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.

PubMed ID: 1975640

DOI: 10.1038/347080a0

PubMed ID: 8471124

Title: Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms.

PubMed ID: 8471124

DOI: 10.1038/npp.1993.14

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10618483

Title: Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.

PubMed ID: 10618483

DOI: 10.1016/s0014-2999(99)00727-x

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

PubMed ID: 23936473

Title: GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.

PubMed ID: 23936473

DOI: 10.1371/journal.pone.0070857

Sequence Information:

  • Length: 446
  • Mass: 49293
  • Checksum: 64E062D765D0DBA7
  • Sequence:
    • MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN 
FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD 
RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA 
ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN 
CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS 
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET 
VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL 
SVILDYDTDV SLEKIQPITQ NGQHPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.