Details for: DRD1

Gene ID: 1812

Symbol: DRD1

Ensembl ID: ENSG00000184845

Description: dopamine receptor D1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 8.09
    Marker Score: 4483
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.32
    Marker Score: 4578
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.07
    Marker Score: 1745
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2222
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.95
    Marker Score: 1025
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.51
    Marker Score: 632
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7516
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1534.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.74
    Marker Score: 705
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.66
    Marker Score: 1344
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.64
    Marker Score: 39530
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1230
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 399
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.54
    Marker Score: 837
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.53
    Marker Score: 5025
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.53
    Marker Score: 5047
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 7946
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2845
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.46
    Marker Score: 3950
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 254
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 180
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.35
    Marker Score: 387
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.34
    Marker Score: 5063
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.29
    Marker Score: 1201
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.29
    Marker Score: 605
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.27
    Marker Score: 1109
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 443
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.22
    Marker Score: 214
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.22
    Marker Score: 634
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 220.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.17
    Marker Score: 588
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.15
    Marker Score: 145.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.14
    Marker Score: 132
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.14
    Marker Score: 97
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.13
    Marker Score: 162
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 150
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 147
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.11
    Marker Score: 246
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.11
    Marker Score: 849
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 287.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.09
    Marker Score: 422
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.08
    Marker Score: 224
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.08
    Marker Score: 114
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 45.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.08
    Marker Score: 657
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 69
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.08
    Marker Score: 224
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.07
    Marker Score: 139
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 195
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.06
    Marker Score: 510
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 1999

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Other Information

**Key characteristics:** * DRD1 is a single-pass transmembrane protein with seven transmembrane domains. * It is expressed in various cell types, including immune cells, neurons, and endocrine cells. * The protein is a ligand-gated ion channel, meaning that it opens or closes in response to the binding of a specific ligand. * It is a key receptor for dopamine, a neurotransmitter involved in various physiological and behavioral processes, including reward, motivation, and movement. **Pathways and functions:** * DRD1 signaling is thought to be involved in a variety of physiological processes, including: * Regulation of inflammation * Regulation of metabolism * Reward and motivation * Inhibition of cell death * Immune function * It plays a role in the regulation of body temperature through its interaction with the G protein-coupled receptor 5 (GPCR5), which is expressed in neurons of the hypothalamus. * DRD1 signaling is also involved in the regulation of blood pressure and blood sugar levels. **Clinical significance:** * Mutations in the DRD1 gene have been linked to several neurological and psychiatric disorders, including schizophrenia, Parkinson's disease, and obesity. * DRD1 inhibitors are being investigated as potential treatments for these disorders. **Additional points:** * DRD1 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * It is a well-characterized protein that has been extensively studied in basic and clinical research. * The discovery of DRD1 has opened up new avenues for understanding the role of GPCRs in health and disease.

Genular Protein ID: 4001877141

Symbol: DRD1_HUMAN

Name: D(1A) dopamine receptor

UniProtKB Accession Codes:

P21728 B2RA44 Q4QRJ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 59 DrugCentral 1 EMBL 11 EMDB 19 Ensembl 1 GO 69 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 20 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2144334

Title: Molecular cloning and expression of the gene for a human D1 dopamine receptor.

PubMed ID: 2144334

DOI: 10.1038/347072a0

PubMed ID: 2168520

Title: Cloning and expression of human and rat D1 dopamine receptors.

PubMed ID: 2168520

DOI: 10.1038/347076a0

PubMed ID: 1975640

Title: Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.

PubMed ID: 1975640

DOI: 10.1038/347080a0

PubMed ID: 8471124

Title: Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms.

PubMed ID: 8471124

DOI: 10.1038/npp.1993.14

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10618483

Title: Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.

PubMed ID: 10618483

DOI: 10.1016/s0014-2999(99)00727-x

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

PubMed ID: 23936473

Title: GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.

PubMed ID: 23936473

DOI: 10.1371/journal.pone.0070857

Sequence Information:

  • Length: 446
  • Mass: 49293
  • Checksum: 64E062D765D0DBA7
  • Sequence:
    • MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN 
FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD 
RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA 
ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN 
CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS 
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET 
VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL 
SVILDYDTDV SLEKIQPITQ NGQHPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.