Details for: DRG2

Gene ID: 1819

Symbol: DRG2

Ensembl ID: ENSG00000108591

Description: developmentally regulated GTP binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.06
    Marker Score: 1645
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.01
    Marker Score: 3508
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 763
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.03
    Marker Score: 2177
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71695
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47919.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.97
    Marker Score: 3831
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1387
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2694
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.89
    Marker Score: 1868
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.88
    Marker Score: 10177
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.87
    Marker Score: 1153
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5225
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.84
    Marker Score: 3438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4761
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8478
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.82
    Marker Score: 597
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1260
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.81
    Marker Score: 1378
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.8
    Marker Score: 851
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.79
    Marker Score: 2146.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.79
    Marker Score: 793
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.79
    Marker Score: 836
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.78
    Marker Score: 432
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.78
    Marker Score: 7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 971
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.77
    Marker Score: 834
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.77
    Marker Score: 1758
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.77
    Marker Score: 4899
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.76
    Marker Score: 510
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.76
    Marker Score: 1080
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.76
    Marker Score: 1123
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2759
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6369
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.73
    Marker Score: 675
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.73
    Marker Score: 1422
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.72
    Marker Score: 355
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.71
    Marker Score: 1945
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.71
    Marker Score: 535.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.71
    Marker Score: 3063
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.71
    Marker Score: 342.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.71
    Marker Score: 372
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.71
    Marker Score: 1157
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7
    Marker Score: 24281
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.68
    Marker Score: 377
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2863
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.68
    Marker Score: 193
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.68
    Marker Score: 432
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.68
    Marker Score: 235
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 433
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.67
    Marker Score: 5759
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.67
    Marker Score: 7523
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.66
    Marker Score: 675
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.66
    Marker Score: 1964
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.66
    Marker Score: 4305.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.66
    Marker Score: 551
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.66
    Marker Score: 587
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.66
    Marker Score: 6248
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10273
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.65
    Marker Score: 1547
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 429
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.65
    Marker Score: 39699.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.64
    Marker Score: 159
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.64
    Marker Score: 267
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.63
    Marker Score: 315
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.63
    Marker Score: 430
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.63
    Marker Score: 289
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.63
    Marker Score: 590
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.63
    Marker Score: 1108
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.62
    Marker Score: 259
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.62
    Marker Score: 8116
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.61
    Marker Score: 947
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.61
    Marker Score: 144
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.61
    Marker Score: 250
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.61
    Marker Score: 588
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.61
    Marker Score: 1918
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6
    Marker Score: 1423
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.6
    Marker Score: 603
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.6
    Marker Score: 212
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.59
    Marker Score: 985
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.59
    Marker Score: 618
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.59
    Marker Score: 119
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.59
    Marker Score: 637
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.58
    Marker Score: 5883
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.58
    Marker Score: 30774
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.58
    Marker Score: 652
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.58
    Marker Score: 419

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Other Information

**Key characteristics:** - DRG2 is a protein of the GTP-binding protein family. - It is highly expressed in the developing brain. - It is involved in a variety of cellular processes, including cell cycle regulation, proliferation, and differentiation. **Pathways and functions:** - DRG2 is involved in the cytoplasm, cytoplasmic translation, cytosol, and gamma carboxylation pathways. - It is also involved in the regulation of Gtp binding, intracellular membrane-bounded organelle, and protein hydroxylation. - It plays a role in the control of cell proliferation and differentiation. **Clinical significance:** - Mutations in DRG2 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - DRG2 is a potential target for the treatment of these diseases. **Additional information:** - DRG2 is a highly conserved protein, with a similar protein found in other mammals. - It is a member of the Rab family of GTP-binding proteins. - It is a ubiquitin-dependent protein, meaning that it is targeted for degradation by the proteasome.

Genular Protein ID: 4289440170

Symbol: DRG2_HUMAN

Name: Developmentally-regulated GTP-binding protein 2

UniProtKB Accession Codes:

P55039 B2R8G5 Q53Y50 Q9BWB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929244

Title: A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts.

PubMed ID: 7929244

DOI: 10.1016/s0021-9258(18)47271-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29915238

Title: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

PubMed ID: 29915238

DOI: 10.1038/s41589-018-0071-y

Sequence Information:

  • Length: 364
  • Mass: 40746
  • Checksum: D1754BEB02671F85
  • Sequence:
    • MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS 
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII 
EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK 
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP 
CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ 
IVKK

Genular Protein ID: 1420819642

Symbol: A8MZF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MZF9

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 10 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 343
  • Mass: 38129
  • Checksum: CBD644EE35F77B93
  • Sequence:
    • MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS 
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII 
EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK 
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP 
CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 
PDFTDAIILR KGASVEHVCH RIHRSLASQF KAPAPSTVRS GWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.