Details for: DRG2

Gene ID: 1819

Symbol: DRG2

Ensembl ID: ENSG00000108591

Description: developmentally regulated GTP binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.1936
    Cell Significance Index: -18.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.6253
    Cell Significance Index: -17.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.0805
    Cell Significance Index: -24.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.0807
    Cell Significance Index: -22.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.9899
    Cell Significance Index: -19.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.4876
    Cell Significance Index: -21.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.0227
    Cell Significance Index: -22.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.1415
    Cell Significance Index: -19.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1863
    Cell Significance Index: -21.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6222
    Cell Significance Index: -17.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4966
    Cell Significance Index: -21.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5158
    Cell Significance Index: -13.8700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.6914
    Cell Significance Index: 43.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7105
    Cell Significance Index: 278.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2082
    Cell Significance Index: 72.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6002
    Cell Significance Index: 41.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5297
    Cell Significance Index: 72.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5149
    Cell Significance Index: 33.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4367
    Cell Significance Index: 22.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4314
    Cell Significance Index: 12.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4251
    Cell Significance Index: 5.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3975
    Cell Significance Index: 79.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3832
    Cell Significance Index: 209.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3642
    Cell Significance Index: 7.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3333
    Cell Significance Index: 9.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3318
    Cell Significance Index: 15.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3097
    Cell Significance Index: 36.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3029
    Cell Significance Index: 60.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2950
    Cell Significance Index: 29.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2945
    Cell Significance Index: 8.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2930
    Cell Significance Index: 10.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2913
    Cell Significance Index: 52.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2809
    Cell Significance Index: 124.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2755
    Cell Significance Index: 33.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2390
    Cell Significance Index: 215.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2243
    Cell Significance Index: 5.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2072
    Cell Significance Index: 9.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2071
    Cell Significance Index: 14.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2069
    Cell Significance Index: 143.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2045
    Cell Significance Index: 26.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1968
    Cell Significance Index: 4.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1884
    Cell Significance Index: 8.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1681
    Cell Significance Index: 60.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1554
    Cell Significance Index: 4.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1359
    Cell Significance Index: 17.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1335
    Cell Significance Index: 9.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0852
    Cell Significance Index: 2.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0738
    Cell Significance Index: 4.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0653
    Cell Significance Index: 1.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0509
    Cell Significance Index: 1.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0174
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0061
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0063
    Cell Significance Index: -11.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0087
    Cell Significance Index: -1.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0117
    Cell Significance Index: -8.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0140
    Cell Significance Index: -8.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0153
    Cell Significance Index: -20.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0280
    Cell Significance Index: -20.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0319
    Cell Significance Index: -14.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0385
    Cell Significance Index: -21.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0418
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0427
    Cell Significance Index: -26.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0478
    Cell Significance Index: -2.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0593
    Cell Significance Index: -8.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0614
    Cell Significance Index: -17.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0827
    Cell Significance Index: -9.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0935
    Cell Significance Index: -4.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1031
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1159
    Cell Significance Index: -13.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1274
    Cell Significance Index: -26.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1350
    Cell Significance Index: -3.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1423
    Cell Significance Index: -4.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1754
    Cell Significance Index: -10.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1886
    Cell Significance Index: -5.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1901
    Cell Significance Index: -10.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1960
    Cell Significance Index: -13.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1991
    Cell Significance Index: -20.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2196
    Cell Significance Index: -17.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2213
    Cell Significance Index: -13.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2356
    Cell Significance Index: -3.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2591
    Cell Significance Index: -11.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2667
    Cell Significance Index: -3.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2762
    Cell Significance Index: -5.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3210
    Cell Significance Index: -10.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3268
    Cell Significance Index: -7.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3299
    Cell Significance Index: -8.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3325
    Cell Significance Index: -12.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3328
    Cell Significance Index: -3.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3870
    Cell Significance Index: -11.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4037
    Cell Significance Index: -5.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4227
    Cell Significance Index: -9.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4274
    Cell Significance Index: -3.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4337
    Cell Significance Index: -21.9200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4365
    Cell Significance Index: -3.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4547
    Cell Significance Index: -15.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DRG2 is a GTP-binding protein that shares structural homology with other G-proteins, suggesting its involvement in signal transduction pathways. Its expression is developmentally regulated, indicating a role in cellular differentiation and maturation. DRG2 is primarily localized to the cytosol and membrane-bound organelles, suggesting its involvement in intracellular signaling and protein modification processes. **Pathways and Functions:** DRG2 is implicated in a diverse array of cellular processes, including: 1. **Signal Transduction:** DRG2 is involved in GTPase activity, GTP binding, and protein binding, indicating its role in transmitting signals across cell membranes. 2. **Protein Modification:** DRG2 is involved in post-translational protein modification, including hydroxylation, hydroxylation, and arylsulfatase activation, suggesting its role in regulating protein function and stability. 3. **Cellular Differentiation:** DRG2's developmental regulation and expression in various cell types suggest its involvement in cellular differentiation and maturation. 4. **Metabolic Processes:** DRG2's expression in metabolic pathways, such as metabolism of proteins and metal ion binding, indicates its role in regulating cellular metabolism. **Clinical Significance:** The clinical significance of DRG2 is multifaceted: 1. **Immunological Implications:** DRG2's involvement in signal transduction and protein modification processes makes it a potential target for immunotherapeutic interventions. 2. **Cancer Research:** DRG2's expression in various cancer cell types suggests its potential role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** DRG2's expression in GABAergic interneurons and forebrain radial glial cells suggests its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. 4. **Developmental Disorders:** DRG2's developmental regulation and expression in various cell types suggest its potential role in developmental disorders, such as birth defects and congenital abnormalities. In conclusion, DRG2 is a complex gene with diverse characteristics and functions that warrant further investigation. As an expert immunologist, I emphasize the need for further research into DRG2's role in various cellular processes and its clinical significance, particularly in the context of immunological disorders and cancer.

Genular Protein ID: 4289440170

Symbol: DRG2_HUMAN

Name: Developmentally-regulated GTP-binding protein 2

UniProtKB Accession Codes:

P55039 B2R8G5 Q53Y50 Q9BWB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 13 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929244

Title: A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts.

PubMed ID: 7929244

DOI: 10.1016/s0021-9258(18)47271-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29915238

Title: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.

PubMed ID: 29915238

DOI: 10.1038/s41589-018-0071-y

Sequence Information:

  • Length: 364
  • Mass: 40746
  • Checksum: D1754BEB02671F85
  • Sequence:
    • MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS 
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII 
EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK 
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP 
CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ 
IVKK

Genular Protein ID: 1420819642

Symbol: A8MZF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MZF9

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 343
  • Mass: 38129
  • Checksum: CBD644EE35F77B93
  • Sequence:
    • MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS 
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII 
EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK 
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP 
CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR 
PDFTDAIILR KGASVEHVCH RIHRSLASQF KAPAPSTVRS GWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.