Gene DUSP7 - ENSG00000164086 | NCBI Gene ID: 1849

Details for: DUSP7

Gene ID: 1849

Symbol: DUSP7

Ensembl ID: ENSG00000164086

Description: dual specificity phosphatase 7

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Erk/mapk targets
(R-HSA-198753)
Erks are inactivated
(R-HSA-202670)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of mapk pathway
(R-HSA-5675221)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by interleukins
(R-HSA-449147)
Signaling by mapk mutants
(R-HSA-9652817)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erk1 and erk2 cascade
(GO:0070371)
Mapk cascade
(GO:0000165)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of map kinase activity
(GO:0043407)
Nucleoplasm
(GO:0005654)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Protein binding
(GO:0005515)
Protein tyrosine/serine/threonine phosphatase activity
(GO:0008138)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Protein tyrosine phosphatase activity
(GO:0004725)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.56
Marker Score: 2961
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.39
Marker Score: 2824
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20367
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.24
Marker Score: 1301
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.13
Marker Score: 354.5
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.06
Marker Score: 359
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48025
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 445
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.94
Marker Score: 564
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.92
Marker Score: 296
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.92
Marker Score: 291
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5120
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.89
Marker Score: 358
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5273
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.85
Marker Score: 6599.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.77
Marker Score: 365
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1241
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.76
Marker Score: 1791
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 379
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 660
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.72
Marker Score: 1758.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.67
Marker Score: 510
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.66
Marker Score: 518
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.65
Marker Score: 288
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.55
Marker Score: 4714
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.55
Marker Score: 4709
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.54
Marker Score: 2648
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.53
Marker Score: 585
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.52
Marker Score: 332
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.51
Marker Score: 614
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.48
Marker Score: 399
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.47
Marker Score: 440
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.4
Marker Score: 621
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.4
Marker Score: 791
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.39
Marker Score: 93
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.38
Marker Score: 98
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.38
Marker Score: 119
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.37
Marker Score: 448
Cell Name: osteoblast (CL0000062)
Fold Change: 0.37
Marker Score: 199
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.37
Marker Score: 331
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.37
Marker Score: 396
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.37
Marker Score: 248.5
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.37
Marker Score: 135
Cell Name: germ cell (CL0000586)
Fold Change: 0.36
Marker Score: 634
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.36
Marker Score: 238
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.36
Marker Score: 530
Cell Name: basal cell (CL0000646)
Fold Change: 0.35
Marker Score: 458
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.34
Marker Score: 123
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.34
Marker Score: 18869
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.33
Marker Score: 294
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.33
Marker Score: 136
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.32
Marker Score: 462
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.32
Marker Score: 80
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.31
Marker Score: 742
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3
Marker Score: 18401
Cell Name: Unknown (CL0002371)
Fold Change: 0.3
Marker Score: 316
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.29
Marker Score: 163
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.28
Marker Score: 80
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.28
Marker Score: 176
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.28
Marker Score: 278
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.27
Marker Score: 2549
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.27
Marker Score: 177
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.26
Marker Score: 2955
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.26
Marker Score: 69
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.26
Marker Score: 142
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 153
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.25
Marker Score: 645
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.25
Marker Score: 626
Cell Name: microglial cell (CL0000129)
Fold Change: 0.25
Marker Score: 457
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.25
Marker Score: 89
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.25
Marker Score: 97
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.24
Marker Score: 244.5
Cell Name: malignant cell (CL0001064)
Fold Change: 0.24
Marker Score: 3249
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.24
Marker Score: 3598
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.24
Marker Score: 56
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.24
Marker Score: 237
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.24
Marker Score: 178
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.24
Marker Score: 98
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.24
Marker Score: 162
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.24
Marker Score: 1428
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.23
Marker Score: 46
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.23
Marker Score: 1527
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.23
Marker Score: 359
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.23
Marker Score: 56
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.23
Marker Score: 223
Cell Name: oocyte (CL0000023)
Fold Change: 0.23
Marker Score: 57
Cell Name: fibroblast (CL0000057)
Fold Change: 0.23
Marker Score: 220
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.23
Marker Score: 48
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.23
Marker Score: 49
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.23
Marker Score: 358
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.22
Marker Score: 152

Hover over a box to see details here...

**Key characteristics:** * DUSP7 is a serine/threonine phosphatase. * It is expressed in high levels in various immune cells, including monocytes, macrophages, dendritic cells, and lymphocytes. * It is a key regulator of innate immune responses. * It plays a role in the regulation of inflammation and apoptosis. **Pathways and functions:** * **Cytokine signaling pathway:** DUSP7 is a key regulator of the cytokine signaling pathway. It is involved in the regulation of inflammation, cell growth, and differentiation. * **MAPK/ERK pathway:** DUSP7 is a key regulator of the MAPK/ERK pathway. It is involved in the regulation of cell growth, differentiation, and survival. * **TLR pathway:** DUSP7 is a key regulator of the TLR pathway. It is involved in the regulation of inflammation, cell migration, and differentiation. **Clinical significance:** * Mutations in DUSP7 have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, lupus, and psoriasis. * DUSP7 inhibitors are being investigated as potential therapeutic agents for these diseases. * Dysregulation of DUSP7 has been linked to the development of cancer. **Additional notes:** * DUSP7 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a key regulator of innate immune responses. * It is a potential therapeutic target for the treatment of autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DUS7_HUMAN

Genular Protein ID: 505388181

Symbol: DUS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16829 Q2M3J7 Q8NFJ0

Database IDs:

Citations:

PubMed ID: 9788880

Title: Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.

PubMed ID: 9788880

DOI: 10.1242/jcs.111.22.3389

PubMed ID: 14603440

Title: Characterization of the dual-specificity phosphatase PYST2 and its transcripts.

PubMed ID: 14603440

DOI: 10.1002/gcc.10295

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8670865

Title: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

PubMed ID: 8670865

DOI: 10.1002/j.1460-2075.1996.tb00731.x

PubMed ID: 14576828

Title: Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.

PubMed ID: 14576828

DOI: 10.1038/sj.onc.1206971

PubMed ID: 26057789

Title: Structure of human dual-specificity phosphatase 7, a potential cancer drug target.

PubMed ID: 26057789

DOI: 10.1107/s2053230x1500504x

Sequence Information:

Length: 419
Mass: 44957
Checksum: 434467AC16A3F8BA
Sequence:

MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG AMPCKSAEWL 
QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM LRRLRKGNLP IRSIIPNHAD 
KERFATRCKA ATVLLYDEAT AEWQPEPGAP ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT 
EYSEHCETNV DSSSSPSSSP PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS 
QPAFPVQILP YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD 
HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM NLSLNDAYDF 
VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL YFSTPTNHNL FPLNTLEST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DUSP7

Associated with

Cells (max top 100)

Other Information

Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. PubMed ID: 9788880

Characterization of the dual-specificity phosphatase PYST2 and its transcripts. PubMed ID: 14603440

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. PubMed ID: 8670865

Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. PubMed ID: 14576828

Structure of human dual-specificity phosphatase 7, a potential cancer drug target. PubMed ID: 26057789