DUSP7 | ENSG00000164086 | NCBI 1849

Details for: DUSP7

Gene ID: 1849

Symbol: DUSP7

Ensembl ID: ENSG00000164086

Description: dual specificity phosphatase 7

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Erk/mapk targets
(R-HSA-198753)
Erks are inactivated
(R-HSA-202670)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of mapk pathway
(R-HSA-5675221)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by interleukins
(R-HSA-449147)
Signaling by mapk mutants
(R-HSA-9652817)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erk1 and erk2 cascade
(GO:0070371)
Mapk cascade
(GO:0000165)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of map kinase activity
(GO:0043407)
Nucleoplasm
(GO:0005654)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Protein binding
(GO:0005515)
Protein tyrosine/serine/threonine phosphatase activity
(GO:0008138)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Protein tyrosine phosphatase activity
(GO:0004725)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 53.7464
Cell Significance Index: -8.3600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 32.8414
Cell Significance Index: -8.3300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 16.6412
Cell Significance Index: -8.5600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.0116
Cell Significance Index: -8.6500
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 4.6335
Cell Significance Index: 13.7800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.2700
Cell Significance Index: -8.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.2199
Cell Significance Index: -8.7600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.6837
Cell Significance Index: 45.8300
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 1.3229
Cell Significance Index: 9.5200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.1742
Cell Significance Index: 10.0900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7623
Cell Significance Index: 10.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6359
Cell Significance Index: 62.9000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4728
Cell Significance Index: 209.0200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4557
Cell Significance Index: 49.5700
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.4247
Cell Significance Index: 5.9600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4126
Cell Significance Index: 372.5600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3436
Cell Significance Index: 17.8500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3241
Cell Significance Index: 52.7100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2942
Cell Significance Index: 20.8100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2934
Cell Significance Index: 13.7900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2347
Cell Significance Index: 27.3500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2081
Cell Significance Index: 14.3900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.2021
Cell Significance Index: 3.3300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1971
Cell Significance Index: 39.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1466
Cell Significance Index: 18.0300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1293
Cell Significance Index: 8.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1091
Cell Significance Index: 3.0500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1088
Cell Significance Index: 4.9300
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.1078
Cell Significance Index: 1.5400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0972
Cell Significance Index: 17.5300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0939
Cell Significance Index: 2.5200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0656
Cell Significance Index: 1.8900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0629
Cell Significance Index: 11.9700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0624
Cell Significance Index: 22.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0607
Cell Significance Index: 8.3300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0449
Cell Significance Index: 0.5100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0425
Cell Significance Index: 0.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0284
Cell Significance Index: 15.5000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0221
Cell Significance Index: 4.3800
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.0154
Cell Significance Index: 0.0900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0122
Cell Significance Index: 1.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0062
Cell Significance Index: 0.2900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0043
Cell Significance Index: 0.5500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0036
Cell Significance Index: 0.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0037
Cell Significance Index: -6.9500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0051
Cell Significance Index: -0.3400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0053
Cell Significance Index: -9.7100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0058
Cell Significance Index: -8.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0062
Cell Significance Index: -4.7000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0070
Cell Significance Index: -9.5000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0084
Cell Significance Index: -2.4100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0093
Cell Significance Index: -6.8400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0107
Cell Significance Index: -0.3800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0111
Cell Significance Index: -7.0500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0119
Cell Significance Index: -8.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0143
Cell Significance Index: -6.4800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0144
Cell Significance Index: -8.1100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0225
Cell Significance Index: -0.4800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0276
Cell Significance Index: -0.5100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0373
Cell Significance Index: -6.3700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0383
Cell Significance Index: -3.9100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0444
Cell Significance Index: -9.3600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0452
Cell Significance Index: -2.7700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0468
Cell Significance Index: -5.3600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0527
Cell Significance Index: -7.6600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0547
Cell Significance Index: -6.4500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0603
Cell Significance Index: -1.2500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0647
Cell Significance Index: -4.9700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0662
Cell Significance Index: -0.4000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0763
Cell Significance Index: -1.6700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0785
Cell Significance Index: -2.1000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0825
Cell Significance Index: -8.5900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0886
Cell Significance Index: -2.5400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0890
Cell Significance Index: -1.2800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0908
Cell Significance Index: -1.9000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0934
Cell Significance Index: -4.1300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0936
Cell Significance Index: -6.0400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0936
Cell Significance Index: -6.9800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0991
Cell Significance Index: -7.8500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1015
Cell Significance Index: -3.2500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1016
Cell Significance Index: -6.2500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1080
Cell Significance Index: -5.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1153
Cell Significance Index: -1.9300
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1228
Cell Significance Index: -1.9700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1239
Cell Significance Index: -6.4600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1286
Cell Significance Index: -4.8700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1402
Cell Significance Index: -7.8700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1545
Cell Significance Index: -4.4100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1711
Cell Significance Index: -4.5000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1713
Cell Significance Index: -5.6100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1747
Cell Significance Index: -6.0700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1771
Cell Significance Index: -6.5000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1818
Cell Significance Index: -5.7900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1828
Cell Significance Index: -5.3700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1987
Cell Significance Index: -6.9600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2010
Cell Significance Index: -8.7400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.2045
Cell Significance Index: -2.3200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2050
Cell Significance Index: -5.1200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2077
Cell Significance Index: -5.3400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2112
Cell Significance Index: -6.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** DUSP7 is a dual specificity phosphatase, meaning it can dephosphorylate both tyrosine and threonine residues. This unique property allows it to regulate a wide range of signaling pathways, including those involved in immune responses, inflammation, and cell growth. DUSP7 is highly expressed in cells of the immune system, including innate lymphoid cells, cardiac endothelial cells, and epithelial cells. It is also highly expressed in stem cells of the epidermis and in specific neuronal populations, such as GABAergic interneurons. **Pathways and Functions** DUSP7 plays a critical role in regulating various signaling pathways, including: 1. **Cytokine Signaling**: DUSP7 regulates the activity of cytokine receptors, including those involved in the signaling of IL-17, TNF-alpha, and IL-1beta. 2. **MAPK Cascades**: DUSP7 regulates the activity of MAPK kinases, including ERK1/2 and JNK, by dephosphorylating and inactivating them. 3. **Toll-like Receptor (TLR) Pathways**: DUSP7 regulates the activity of TLRs, including TLR4, TLR7, and TLR9, by dephosphorylating and inactivating downstream signaling molecules. 4. **ERK/Mapk Targets**: DUSP7 regulates the activity of ERK and MAPK targets, including transcription factors and kinases, by dephosphorylating and inactivating them. **Clinical Significance** DUSP7 has been implicated in various diseases, including: 1. **Inflammatory Disorders**: DUSP7 has been shown to play a critical role in regulating inflammation, and its dysregulation has been implicated in various inflammatory disorders, including rheumatoid arthritis and asthma. 2. **Cancer**: DUSP7 has been shown to regulate the activity of MAPK kinases, which are involved in cell growth and proliferation. Its dysregulation has been implicated in various types of cancer, including breast cancer and lung cancer. 3. **Neurological Disorders**: DUSP7 has been shown to regulate the activity of MAPK kinases, which are involved in neuronal growth and survival. Its dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, DUSP7 is a critical regulator of signaling pathways involved in immune responses, inflammation, and cell growth. Its dysregulation has been implicated in various diseases, including inflammatory disorders, cancer, and neurological disorders. Further research is needed to fully understand the role of DUSP7 in these diseases and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DUS7_HUMAN

Genular Protein ID: 505388181

Symbol: DUS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16829 Q2M3J7 Q8NFJ0

Database IDs:

Citations:

PubMed ID: 9788880

Title: Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.

PubMed ID: 9788880

DOI: 10.1242/jcs.111.22.3389

PubMed ID: 14603440

Title: Characterization of the dual-specificity phosphatase PYST2 and its transcripts.

PubMed ID: 14603440

DOI: 10.1002/gcc.10295

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8670865

Title: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

PubMed ID: 8670865

DOI: 10.1002/j.1460-2075.1996.tb00731.x

PubMed ID: 14576828

Title: Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.

PubMed ID: 14576828

DOI: 10.1038/sj.onc.1206971

PubMed ID: 26057789

Title: Structure of human dual-specificity phosphatase 7, a potential cancer drug target.

PubMed ID: 26057789

DOI: 10.1107/s2053230x1500504x

Sequence Information:

Length: 419
Mass: 44957
Checksum: 434467AC16A3F8BA
Sequence:

MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG AMPCKSAEWL 
QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM LRRLRKGNLP IRSIIPNHAD 
KERFATRCKA ATVLLYDEAT AEWQPEPGAP ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT 
EYSEHCETNV DSSSSPSSSP PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS 
QPAFPVQILP YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD 
HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM NLSLNDAYDF 
VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL YFSTPTNHNL FPLNTLEST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DUSP7

Associated with

Cells (max top 100)

Other Information

Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. PubMed ID: 9788880

Characterization of the dual-specificity phosphatase PYST2 and its transcripts. PubMed ID: 14603440

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. PubMed ID: 8670865

Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. PubMed ID: 14576828

Structure of human dual-specificity phosphatase 7, a potential cancer drug target. PubMed ID: 26057789