Details for: DUT

Gene ID: 1854

Symbol: DUT

Ensembl ID: ENSG00000128951

Description: deoxyuridine triphosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.4071
    Cell Significance Index: -33.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.4502
    Cell Significance Index: -45.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 178.7363
    Cell Significance Index: -73.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.5050
    Cell Significance Index: -61.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.4572
    Cell Significance Index: -70.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.4906
    Cell Significance Index: -69.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.9444
    Cell Significance Index: -70.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.9389
    Cell Significance Index: -62.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.7472
    Cell Significance Index: -65.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.1143
    Cell Significance Index: -71.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0736
    Cell Significance Index: -40.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9441
    Cell Significance Index: -45.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2127
    Cell Significance Index: -24.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.6308
    Cell Significance Index: 177.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.4851
    Cell Significance Index: 411.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0334
    Cell Significance Index: 105.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0276
    Cell Significance Index: 82.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8718
    Cell Significance Index: 31.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.8069
    Cell Significance Index: 64.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7661
    Cell Significance Index: 72.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1788
    Cell Significance Index: 299.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1698
    Cell Significance Index: 278.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0161
    Cell Significance Index: 42.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.9088
    Cell Significance Index: 24.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7358
    Cell Significance Index: 80.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6399
    Cell Significance Index: 201.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6375
    Cell Significance Index: 471.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6322
    Cell Significance Index: 105.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6005
    Cell Significance Index: 84.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5420
    Cell Significance Index: 842.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4741
    Cell Significance Index: 265.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4043
    Cell Significance Index: 620.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3719
    Cell Significance Index: 102.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2505
    Cell Significance Index: 161.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2478
    Cell Significance Index: 88.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1563
    Cell Significance Index: 33.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1488
    Cell Significance Index: 186.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1457
    Cell Significance Index: 53.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1258
    Cell Significance Index: 77.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0387
    Cell Significance Index: 208.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9843
    Cell Significance Index: 51.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8512
    Cell Significance Index: 9.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6362
    Cell Significance Index: 121.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5674
    Cell Significance Index: 512.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4238
    Cell Significance Index: 152.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3603
    Cell Significance Index: 71.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3583
    Cell Significance Index: 21.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2304
    Cell Significance Index: 22.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1992
    Cell Significance Index: 5.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1861
    Cell Significance Index: 10.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1783
    Cell Significance Index: 30.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1087
    Cell Significance Index: 1.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0641
    Cell Significance Index: 1.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0558
    Cell Significance Index: 105.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0285
    Cell Significance Index: 19.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0192
    Cell Significance Index: 0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0170
    Cell Significance Index: 12.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0124
    Cell Significance Index: 9.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0079
    Cell Significance Index: 12.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0072
    Cell Significance Index: 13.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0307
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0359
    Cell Significance Index: -26.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0367
    Cell Significance Index: -3.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0447
    Cell Significance Index: -60.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0501
    Cell Significance Index: -0.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0893
    Cell Significance Index: -50.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1027
    Cell Significance Index: -46.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1432
    Cell Significance Index: -7.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1619
    Cell Significance Index: -34.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1747
    Cell Significance Index: -3.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2025
    Cell Significance Index: -5.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2054
    Cell Significance Index: -6.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2212
    Cell Significance Index: -5.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2310
    Cell Significance Index: -33.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2612
    Cell Significance Index: -29.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2959
    Cell Significance Index: -2.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3481
    Cell Significance Index: -12.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3545
    Cell Significance Index: -22.3400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.3932
    Cell Significance Index: -2.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3945
    Cell Significance Index: -45.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4049
    Cell Significance Index: -24.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5008
    Cell Significance Index: -38.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5449
    Cell Significance Index: -15.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5699
    Cell Significance Index: -45.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5961
    Cell Significance Index: -68.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6039
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6531
    Cell Significance Index: -28.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6547
    Cell Significance Index: -11.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6592
    Cell Significance Index: -68.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6895
    Cell Significance Index: -46.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8679
    Cell Significance Index: -32.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1298
    Cell Significance Index: -9.4900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1329
    Cell Significance Index: -15.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1432
    Cell Significance Index: -70.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1478
    Cell Significance Index: -30.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1627
    Cell Significance Index: -13.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3787
    Cell Significance Index: -40.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** DUT is a pyrophosphatase enzyme that catalyzes the hydrolysis of dUTP to dUMP, releasing pyrophosphate (PPi) as a byproduct. 2. **Substrate Specificity:** The enzyme exhibits specificity for dUTP, distinguishing it from other pyrophosphatases that may hydrolyze other nucleotide triphosphates. 3. **Regulatory Mechanism:** DUT is regulated by various factors, including the availability of dUTP and the presence of other nucleotides, such as dATP and dGTP, which can influence the enzyme's activity. 4. **Cellular Expression:** DUT is widely expressed in various cell types, including hematopoietic stem cells, neural crest cells, and epithelial cells, underscoring its importance in different biological processes. **Pathways and Functions:** 1. **DNA Replication:** DUT plays a critical role in regulating the availability of nucleotides for DNA synthesis by controlling the conversion of dUTP to dUMP. 2. **Nucleotide Metabolism:** The enzyme is involved in the regulation of nucleotide pools, influencing the levels of dUMP, dUMP, and other nucleotides that are essential for DNA synthesis and repair. 3. **Apoptosis and Cell Cycle Regulation:** DUT has been implicated in the regulation of apoptosis and cell cycle progression, suggesting that its activity may be linked to the control of cell growth and survival. 4. **Stem Cell Maintenance:** The enzyme is expressed in stem cell populations, including hematopoietic stem cells and skeletal muscle satellite stem cells, highlighting its potential role in maintaining stem cell homeostasis. **Clinical Significance:** 1. **Cancer Research:** DUT has been identified as a potential biomarker for cancer diagnosis and prognosis, as its expression and activity have been linked to various types of cancer, including leukemia and lymphoma. 2. **Neurological Disorders:** The enzyme's involvement in apoptosis and cell cycle regulation suggests that DUT dysregulation may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders:** DUT's expression in immune cells, including T cells and B cells, highlights its potential role in the regulation of immune responses and the development of immunological disorders, such as autoimmune diseases. 4. **Stem Cell Transplantation:** The enzyme's expression in hematopoietic stem cells and other stem cell populations suggests that DUT may play a role in the regulation of stem cell transplantation outcomes, including engraftment and differentiation. In conclusion, deoxyuridine triphosphatase (DUT) is a vital enzyme that plays a critical role in regulating DNA replication, nucleotide metabolism, and cell cycle progression. Its significance in various biological processes and diseases highlights the need for further research into the mechanisms and clinical applications of this enzyme.

Genular Protein ID: 808970102

Symbol: DUT_HUMAN

Name: dUTP pyrophosphatase

UniProtKB Accession Codes:

P33316 A8K650 B4DPR5 O14785 Q16708 Q16860 Q6FHN1 Q6NSA3 Q96Q81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 26 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8631816

Title: Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase.

PubMed ID: 8631816

DOI: 10.1074/jbc.271.13.7745

PubMed ID: 9070952

Title: Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization.

PubMed ID: 9070952

DOI: 10.1006/geno.1996.4540

PubMed ID: 9228092

Title: The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species.

PubMed ID: 9228092

DOI: 10.1074/jbc.272.30.19072

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1325640

Title: Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme.

PubMed ID: 1325640

DOI: 10.1073/pnas.89.17.8020

PubMed ID: 8389461

Title: Maturation stage and proliferation-dependent expression of dUTPase in human T cells.

PubMed ID: 8389461

DOI: 10.1073/pnas.90.11.4991

PubMed ID: 8631817

Title: Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.

PubMed ID: 8631817

DOI: 10.1074/jbc.271.13.7752

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8805593

Title: Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.

PubMed ID: 8805593

DOI: 10.1016/s0969-2126(96)00114-1

PubMed ID: 17880943

Title: Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.

PubMed ID: 17880943

DOI: 10.1016/j.febslet.2007.09.005

PubMed ID: 28073829

Title: dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.

PubMed ID: 28073829

DOI: 10.2337/db16-0839

PubMed ID: 35931051

Title: Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.

PubMed ID: 35931051

DOI: 10.1016/j.ajhg.2022.06.014

PubMed ID: 35611808

Title: Further evidence supporting the role of DUT gene in diabetes with bone marrow failure syndrome.

PubMed ID: 35611808

DOI: 10.1002/ajmg.a.62771

Sequence Information:

  • Length: 252
  • Mass: 26563
  • Checksum: 8E2EBC9ED5B0FAD2
  • Sequence:
    • MTPLCPRPAL CYHFLTSLLR SAMQNARGAR QRAEAAVLSG PGPPLGRAAQ HGIPRPLSSA 
GRLSQGCRGA STVGAAGWKG ELPKAGGSPA PGPETPAISP SKRARPAEVG GMQLRFARLS 
EHATAPTRGS ARAAGYDLYS AYDYTIPPME KAVVKTDIQI ALPSGCYGRV APRSGLAAKH 
FIDVGAGVID EDYRGNVGVV LFNFGKEKFE VKKGDRIAQL ICERIFYPEI EEVQALDDTE 
RGSGGFGSTG KN

Genular Protein ID: 329270867

Symbol: A0A0C4DGL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGL3

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 141
  • Mass: 15395
  • Checksum: 81CBEA632286295B
  • Sequence:
    • MQLRFARLSE HATAPTRGSA RAAGYDLYSA YDYTIPPMEK AVVKTDIQIA LPSGCYGRVA 
PRSGLAAKHF IDVGAGVIDE DYRGNVGVVL FNFGKEKFEV KKGDRIAQLI CERIFYPEIE 
EVQALDDTER GSGGFGSTGK N

Genular Protein ID: 2020471800

Symbol: H0YNW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNW5

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 167
  • Mass: 17827
  • Checksum: 53763338F78ADC29
  • Sequence:
    • MAAGGAAPET PAISPSKRAR PAEVGGMQLR FARLSEHATA PTRGSARAAG YDLYSAYDYT 
IPPMEKAVVK TDIQIALPSG CYGRVAPRSG LAAKHFIDVG AGVIDEDYRG NVGVVLFNFG 
KEKFEVKKGD RIAQLICERI FYPEIEEVQA LDDTERGSGG FGSTGKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.