Details for: E2F4

Gene ID: 1874

Symbol: E2F4

Ensembl ID: ENSG00000205250

Description: E2F transcription factor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.75
    Marker Score: 6872
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.47
    Marker Score: 997
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.12
    Marker Score: 1348
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.1
    Marker Score: 1170
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.02
    Marker Score: 1101.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1
    Marker Score: 1047.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71664
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47887
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.95
    Marker Score: 715
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.95
    Marker Score: 1029
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2386
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5137
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.9
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2682
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2390
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.86
    Marker Score: 1720
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.85
    Marker Score: 28882
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.84
    Marker Score: 254
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.82
    Marker Score: 8285
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.82
    Marker Score: 7217
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.82
    Marker Score: 596
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.82
    Marker Score: 3519
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.81
    Marker Score: 508
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1196
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.81
    Marker Score: 1976
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 445
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.81
    Marker Score: 853
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.79
    Marker Score: 500
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.79
    Marker Score: 1131
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.79
    Marker Score: 3220
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.78
    Marker Score: 316
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.77
    Marker Score: 3771
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2119.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.76
    Marker Score: 42762
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.76
    Marker Score: 507
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.76
    Marker Score: 710
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.76
    Marker Score: 674.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.76
    Marker Score: 2119
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.75
    Marker Score: 764
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.74
    Marker Score: 671
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.74
    Marker Score: 2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.74
    Marker Score: 1259
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.74
    Marker Score: 926
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.73
    Marker Score: 175
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.73
    Marker Score: 7211
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.73
    Marker Score: 418
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.73
    Marker Score: 173.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.72
    Marker Score: 570
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 349
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.72
    Marker Score: 1707
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.72
    Marker Score: 350
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.71
    Marker Score: 1677
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.71
    Marker Score: 671
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.71
    Marker Score: 8016
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 918
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.71
    Marker Score: 556
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.71
    Marker Score: 219
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.7
    Marker Score: 1087
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7
    Marker Score: 1467
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.7
    Marker Score: 702
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.7
    Marker Score: 155.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 458
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.69
    Marker Score: 345
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.69
    Marker Score: 1754
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.69
    Marker Score: 749
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.69
    Marker Score: 1872
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.69
    Marker Score: 414
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.68
    Marker Score: 572
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.68
    Marker Score: 431
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.68
    Marker Score: 284
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.68
    Marker Score: 608
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.67
    Marker Score: 721
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.67
    Marker Score: 788
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.67
    Marker Score: 6808
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.66
    Marker Score: 695
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 603
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.66
    Marker Score: 2444
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.66
    Marker Score: 228
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2768
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.66
    Marker Score: 4218
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.66
    Marker Score: 422
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.66
    Marker Score: 656
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.66
    Marker Score: 1046
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.66
    Marker Score: 481
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.65
    Marker Score: 701
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.65
    Marker Score: 245
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.65
    Marker Score: 491
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.65
    Marker Score: 159.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.65
    Marker Score: 2498
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.65
    Marker Score: 417

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Other Information

**Key characteristics:** * E2F4 is a transcription factor that is highly expressed in proliferating cells. * It is a key regulator of the cell cycle and is frequently dysregulated in various human cancers. * It is a member of the E2F family of transcription factors. * It is a key regulator of cell cycle progression and cell differentiation. * It is involved in the regulation of various cellular processes, including proliferation, differentiation, and apoptosis. **Pathways and functions:** * E2F4 is involved in the regulation of cell cycle progression and cell differentiation. * It is a key regulator of the G1/S transition and is expressed in proliferating cells. * It is involved in the regulation of cell cycle checkpoints and is expressed in cells that are in G1 or G2 phase. * It is involved in the regulation of apoptosis and is expressed in cells that are about to undergo apoptosis. * It is also involved in the regulation of differentiation in some cell types. **Clinical significance:** * Dysregulation of E2F4 has been linked to various human cancers. * Inhibition of E2F4 expression has been shown to inhibit cell proliferation and induce apoptosis. * Overexpression of E2F4 has been shown to promote cell proliferation and survival. * Targeting E2F4 has been investigated as a potential therapeutic strategy for cancer. **Additional information:** * E2F4 is a highly conserved transcription factor that is found in all eukaryotes. * It is a member of the E2F family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. * E2F4 is a key regulator of cell growth and differentiation, and its dysregulation has been linked to various human diseases, including cancer.

Genular Protein ID: 4278198136

Symbol: E2F4_HUMAN

Name: Transcription factor E2F4

UniProtKB Accession Codes:

Q16254 A6NGR8 B5BU56 Q12991 Q15328

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7958924

Title: E2F-4, a new member of the E2F transcription factor family, interacts with p107.

PubMed ID: 7958924

DOI: 10.1101/gad.8.22.2665

PubMed ID: 7958925

Title: E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

PubMed ID: 7958925

DOI: 10.1101/gad.8.22.2680

PubMed ID: 7892279

Title: E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

PubMed ID: 7892279

DOI: 10.1073/pnas.92.6.2403

PubMed ID: 10797289

Title: Genomic structure and mutation screening of the E2F4 gene in human tumors.

PubMed ID: 10797289

DOI: 10.1002/(sici)1097-0215(20000601)86:5<672::aid-ijc11>3.0.co;2-x

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9074408

Title: The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130.

PubMed ID: 9074408

DOI: 10.1046/j.1365-2141.1997.d01-2086.x

PubMed ID: 11418595

Title: E2F transcriptional activation requires TRRAP and GCN5 cofactors.

PubMed ID: 11418595

DOI: 10.1074/jbc.m102067200

PubMed ID: 14532282

Title: HCF-1 functions as a coactivator for the zinc finger protein Krox20.

PubMed ID: 14532282

DOI: 10.1074/jbc.m303470200

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 17671431

Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.

PubMed ID: 17671431

DOI: 10.4161/cc.6.15.4512

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22002537

Title: Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

PubMed ID: 22002537

DOI: 10.1038/emboj.2011.370

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10090723

Title: Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.

PubMed ID: 10090723

DOI: 10.1101/gad.13.6.666

PubMed ID: 10679953

Title: Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4.

PubMed ID: 10679953

DOI: 10.1002/(sici)1098-1004(200003)15:3<296::aid-humu18>3.0.co;2-x

Sequence Information:

  • Length: 413
  • Mass: 43960
  • Checksum: BAAC95DE1B7E0832
  • Sequence:
    • MAEAGPQAPP PPGTPSRHEK SLGLLTTKFV SLLQEAKDGV LDLKLAADTL AVRQKRRIYD 
ITNVLEGIGL IEKKSKNSIQ WKGVGPGCNT REIADKLIEL KAEIEELQQR EQELDQHKVW 
VQQSIRNVTE DVQNSCLAYV THEDICRCFA GDTLLAIRAP SGTSLEVPIP EGLNGQKKYQ 
IHLKSVSGPI EVLLVNKEAW SSPPVAVPVP PPEDLLQSPS AVSTPPPLPK PALAQSQEAS 
RPNSPQLTPT AVPGSAEVQG MAGPAAEITV SGGPGTDSKD SGELSSLPLG PTTLDTRPLQ 
SSALLDSSSS SSSSSSSSSN SNSSSSSGPN PSTSFEPIKA DPTGVLELPK ELSEIFDPTR 
ECMSSELLEE LMSSEVFAPL LRLSPPPGDH DYIYNLDESE GVCDLFDVPV LNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.