Details for: CELSR3

Gene ID: 1951

Symbol: CELSR3

Ensembl ID: ENSG00000008300

Description: cadherin EGF LAG seven-pass G-type receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.88
    Marker Score: 3894
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2357
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.22
    Marker Score: 887.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.08
    Marker Score: 568
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 685.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15530
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1930
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5303
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.9
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1267
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.79
    Marker Score: 302
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.78
    Marker Score: 247
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.78
    Marker Score: 435
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.77
    Marker Score: 371
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.76
    Marker Score: 7265
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3191.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 45833
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.73
    Marker Score: 6284
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.73
    Marker Score: 6830
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7
    Marker Score: 2724
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.67
    Marker Score: 25372
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 212
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.64
    Marker Score: 9618
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2616
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.64
    Marker Score: 23678
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.63
    Marker Score: 4821
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 372
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 284
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.57
    Marker Score: 2359
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.56
    Marker Score: 11216
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.56
    Marker Score: 5804
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1290
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 157
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.49
    Marker Score: 554
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 201
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.44
    Marker Score: 287
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.43
    Marker Score: 603
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.38
    Marker Score: 1757
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.37
    Marker Score: 1956
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 145.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.29
    Marker Score: 9659
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.26
    Marker Score: 151.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.25
    Marker Score: 1038
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.24
    Marker Score: 797
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.22
    Marker Score: 112
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.21
    Marker Score: 352
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.2
    Marker Score: 1082
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.18
    Marker Score: 1375
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.17
    Marker Score: 393
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.16
    Marker Score: 45
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 287
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 412
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.13
    Marker Score: 101
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.13
    Marker Score: 324
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.13
    Marker Score: 81
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 98
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.12
    Marker Score: 2502

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Other Information

# Summary CELSR3 is a cell surface receptor that is expressed in a variety of cell types. It is a G protein-coupled receptor that is involved in a variety of cellular processes, including cell-cell adhesion, axon guidance, and signaling pathways. # Key characteristics * CELSR3 is a type of cadherin, a family of cell adhesion molecules that are involved in cell-cell adhesion. * It is a seven-pass G-type receptor, which are a class of cell surface receptors that are activated by the binding of a specific ligand. * It is expressed in a variety of cell types, including kidney epithelial cells, cardiac endothelial cells, colon goblet cells, renal alpha-intercalated cells, early T lineage precursor cells, intestinal crypt stem cells of the small intestine, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and cardiac muscle myoblasts. * It is a highly expressed protein in the developing cardiovascular and nervous systems. # Pathways and functions CELSR3 is involved in a variety of cellular processes, including: * **Cell-cell adhesion:** CELSR3 is expressed on the surface of endothelial cells and epithelial cells, where it helps to mediate cell-cell adhesion. * **Axon guidance:** CELSR3 is expressed on the surface of neurons, where it is involved in axon guidance. It is thought to be important for the formation of the neural tube and the development of the central nervous system. * **G protein-coupled receptor activity:** CELSR3 is a G protein-coupled receptor, which means that it is activated by a variety of G proteins. This allows it to communicate with a variety of intracellular signaling pathways. * **Wnt signaling pathway:** CELSR3 is a key component of the Wnt signaling pathway, which is a major signaling pathway involved in cell growth, differentiation, and apoptosis. # Clinical significance CELSR3 is a promising target for cancer therapy. It is expressed on the surface of tumor cells, where it helps to promote tumor growth and invasion. Inhibition of CELSR3 has been shown to inhibit tumor growth in animal models of cancer.

Genular Protein ID: 1372790795

Symbol: CELR3_HUMAN

Name: Cadherin EGF LAG seven-pass G-type receptor 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10716726

Title: Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PubMed ID: 10716726

DOI: 10.1073/pnas.97.7.3124

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23339110

Title: Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy.

PubMed ID: 23339110

DOI: 10.1136/jmedgenet-2012-101223

PubMed ID: 24358150

Title: A novel null homozygous mutation confirms CACNA2D2 as a gene mutated in epileptic encephalopathy.

PubMed ID: 24358150

DOI: 10.1371/journal.pone.0082154

PubMed ID: 30410802

Title: Epileptic encephalopathy and cerebellar atrophy resulting from compound heterozygous CACNA2D2 variants.

PubMed ID: 30410802

DOI: 10.1155/2018/6308283

Sequence Information:

  • Length: 3312
  • Mass: 358185
  • Checksum: 9E6B37787A9F0348
  • Sequence:
  • MMARRPPWRG LGGRSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT GPRAHIGGGA 
    LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG PPEQPNEELG IEHGVQPLGS 
    RERETGQGPG SVLYWRPEVS SCGRTGPLQR GSLSPGALSS GVPGSGNSSP LPSDFLIRHH 
    GPKPVSSQRN AGTGSRKRVG TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG 
    SGPELDSAPR TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 
    RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ DPDAGEAGRL 
    VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY LRVTAQDHGS PRLSATTMVA 
    VTVADRNDHS PVFEQAQYRE TLRENVEEGY PILQLRATDG DAPPNANLRY RFVGPPAARA 
    AAAAAFEIDP RSGLISTSGR VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND 
    NAPQFSEKRY VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 
    EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI FVSTPFQVSV 
    LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV INSATGWVSV SGPLDRESVE 
    HYFFGVEARD HGSPPLSASA SVTVTVLDVN DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA 
    VDRDANSAIS YQITGGNTRN RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD 
    HCYVHINITD ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 
    LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM VNDVNDNAPQ 
    FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF QNGEDGDGDF TIEPTSGIVR 
    TVRRLDREAV SVYELTAYAV DRGVPPLRTP VSIQVMVQDV NDNAPVFPAE EFEVRVKENS 
    IVGSVVAQIT AVDPDEGPNA HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI 
    VVQATSAPLV SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 
    DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD GLHSVTAQCV 
    LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA AVLATPAEDV FIFNIQNDTD 
    VGGTVLNVSF SALAPRGAGA GAAGPWFSSE ELQEQLYVRR AALAARSLLD VLPFDDNVCL 
    REPCENYMKC VSVLRFDSSA PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY 
    SNPCRNGGAC ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 
    QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG LLFYNGRLNE 
    KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW HTVHLRYYNK PRTDALGGAQ 
    GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP 
    ENFPVSHKDF IGCMRDLHID GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER 
    WGSFSCDCPV GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 
    VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD LRLELQEEPG 
    GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL PPGSAEEAPQ GLVGCIQGVW 
    LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG 
    CVDACLLNPC QNQGSCRHLP GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC 
    NCDVHKGFDP NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 
    GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV PCPRGALGAA 
    VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL DTMEAKKLAQ RLREVTGHTD 
    HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT ATQDAHFNEN LLWAGSALLA PETGDLWAAL 
    GQRAPGGSPG SAGLVRHLEE YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA 
    RRYPRYHSNL FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 
    PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH GRNFLRGILE 
    SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC ELVHRNGSHA RCRCSRTGTF 
    GVLMDASPRE RLEGDLELLA VFTHVVVAVS VAALVLTAAI LLSLRSLKSN VRGIHANVAA 
    ALGVAELLFL LGIHRTHNQL VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG 
    AMRFYHALGW GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 
    FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL AFHYLHAGLC 
    GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP GLGPGAYNNT ALFEESGLIR 
    ITLGASTVSS VSSARSGRTQ DQDSQRGRSY LRDNVLVRHG SAADHTDHSL QAHAGPTDLD 
    VAMFHRDAGA DSDSDSDLSL EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP 
    KDVDGNDLLS YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 
    GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI YAGGGTGSLS 
    QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG SQECMDAAPG RLEPKDRGST 
    LPRRQPPRDY PGAMAGRFGS RDALDLGAPR EWLSTLPPPR RTRDLDPQPP PLPLSPQRQL 
    SRDPLLPSRP LDSLSRSSNS REQLDQVPSR HPSREALGPL PQLLRAREDS VSGPSHGPST 
    EQLDILSSIL ASFNSSALSS VQSSSTPLGP HTTATPSATA SVLGPSTPRS ATSHSISELS 
    PDSEVPRSEG HS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.