Details for: EIF4E

Gene ID: 1977

Symbol: EIF4E

Ensembl ID: ENSG00000151247

Description: eukaryotic translation initiation factor 4E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.67
    Marker Score: 6513
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.42
    Marker Score: 820
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.3
    Marker Score: 1810
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.28
    Marker Score: 77593
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.23
    Marker Score: 19233
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.06
    Marker Score: 7939
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.03
    Marker Score: 4118
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.99
    Marker Score: 4148
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.89
    Marker Score: 2017
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.87
    Marker Score: 1976
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.84
    Marker Score: 2225
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.84
    Marker Score: 751
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.8
    Marker Score: 2594
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.79
    Marker Score: 3038
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.77
    Marker Score: 1674.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.77
    Marker Score: 4351
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.77
    Marker Score: 1180
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.73
    Marker Score: 11042
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.72
    Marker Score: 1618
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.72
    Marker Score: 1808.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.72
    Marker Score: 427
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.7
    Marker Score: 427
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.7
    Marker Score: 1817
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.66
    Marker Score: 1675
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.66
    Marker Score: 692
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.65
    Marker Score: 12864
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.64
    Marker Score: 4464
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.63
    Marker Score: 951
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.63
    Marker Score: 7025
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.62
    Marker Score: 2299
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.62
    Marker Score: 6382
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.59
    Marker Score: 1990
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.56
    Marker Score: 96011
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.56
    Marker Score: 974
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.56
    Marker Score: 20513
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.55
    Marker Score: 6350
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.54
    Marker Score: 973
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.53
    Marker Score: 2255
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.53
    Marker Score: 39198
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.53
    Marker Score: 1715.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.52
    Marker Score: 3577
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.52
    Marker Score: 362
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.51
    Marker Score: 436
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.51
    Marker Score: 4307
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.51
    Marker Score: 2499
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.5
    Marker Score: 351
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.49
    Marker Score: 7173
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.49
    Marker Score: 4676
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.48
    Marker Score: 3525
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12700
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.47
    Marker Score: 1898
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.47
    Marker Score: 54199
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.46
    Marker Score: 1947
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 584
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.45
    Marker Score: 326
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13742
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.43
    Marker Score: 901
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.43
    Marker Score: 21446
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.43
    Marker Score: 354
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.43
    Marker Score: 9136
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.42
    Marker Score: 311.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.42
    Marker Score: 552
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.42
    Marker Score: 2592
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.42
    Marker Score: 2255
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.42
    Marker Score: 13325
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.41
    Marker Score: 53617
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.41
    Marker Score: 702
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.41
    Marker Score: 3194
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.4
    Marker Score: 2151.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.39
    Marker Score: 945
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5651.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.38
    Marker Score: 5350
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.37
    Marker Score: 559
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 665
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.37
    Marker Score: 1218
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.36
    Marker Score: 497
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.35
    Marker Score: 2461
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2081
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.35
    Marker Score: 2206
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.34
    Marker Score: 918
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.34
    Marker Score: 1570
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.34
    Marker Score: 654
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.34
    Marker Score: 1117
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.34
    Marker Score: 1416
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.33
    Marker Score: 1555
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.33
    Marker Score: 2247
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.32
    Marker Score: 348
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.32
    Marker Score: 445
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.32
    Marker Score: 2342
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.32
    Marker Score: 701
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.31
    Marker Score: 1268.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.31
    Marker Score: 3631
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.31
    Marker Score: 2103
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.31
    Marker Score: 456
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.31
    Marker Score: 720
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.3
    Marker Score: 616
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3
    Marker Score: 3856
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.29
    Marker Score: 1150
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.28
    Marker Score: 25534
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.28
    Marker Score: 551

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Other Information

**Key characteristics:** * IF4E is a highly conserved protein with a conserved domain structure. * It is a key factor in the regulation of protein synthesis in eukaryotic cells. * It is involved in the initiation of translation by binding to specific DNA sequences known as E-boxes. * It is also involved in the regulation of the immune response and is expressed in various cell types. **Pathways and functions:** * **Antiviral mechanism by ifn-stimulated genes:** IF4E is a key factor in the regulation of immune responses, including the induction of antiviral genes by interferons (IFNs). * **Cytokine signaling in immune system:** IF4E is also involved in the regulation of cytokine signaling, which is essential for the inflammatory response. * **Deadenylation-dependent mrna decay:** IF4E is involved in the degradation of maternal mRNA by a process called dedenylation-dependent mRNA decay (DDRM). * **Deadenylation of mrna:** IF4E is also involved in the dedenylation of mRNA, which is a process that removes a cap structure from the 5' end of mRNA. * **Developmental biology:** IF4E is essential for the development of various organs and tissues during embryonic development. * **Eukaryotic translation initiation:** IF4E is a key factor in the initiation of translation by binding to specific DNA sequences known as E-boxes. * **Immune system:** IF4E is expressed in immune cells and is involved in the regulation of immune responses. * **Interferon signaling:** IF4E is a key factor in the regulation of IFN signaling, which is essential for the innate immune response. **Clinical significance:** * Mutations in the EIF4E gene have been linked to several human diseases, including cancer and autoimmune disorders. * Targeting IF4E has been explored as a therapeutic strategy for cancer and autoimmune disorders.

Genular Protein ID: 3753610345

Symbol: IF4E_HUMAN

Name: eIF-4F 25 kDa subunit

UniProtKB Accession Codes:

P06730 B7Z6V1 D6RCQ6 Q96E95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 38 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 13 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3469651

Title: Amino acid sequence of the mRNA cap-binding protein from human tissues.

PubMed ID: 3469651

DOI: 10.1073/pnas.84.4.945

PubMed ID: 1736299

Title:

PubMed ID: 1736299

DOI: 10.1073/pnas.89.3.1148a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16341674

Title: Transcriptome analysis of human gastric cancer.

PubMed ID: 16341674

DOI: 10.1007/s00335-005-0075-2

PubMed ID: 1993647

Title: Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor.

PubMed ID: 1993647

DOI: 10.1016/s0021-9258(18)49896-1

PubMed ID: 1672854

Title: Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis.

PubMed ID: 1672854

DOI: 10.1016/0014-5793(91)80294-d

PubMed ID: 3112145

Title: Phosphorylation site of eukaryotic initiation factor 4E.

PubMed ID: 3112145

DOI: 10.1016/s0021-9258(18)60978-0

PubMed ID: 1384058

Title: A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

PubMed ID: 1384058

DOI: 10.1073/pnas.89.20.9612

PubMed ID: 8505316

Title: Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells.

PubMed ID: 8505316

DOI: 10.1016/s0021-9258(19)50285-x

PubMed ID: 7590282

Title: Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells.

PubMed ID: 7590282

DOI: 10.1016/0378-1119(95)00302-m

PubMed ID: 7782323

Title: Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209.

PubMed ID: 7782323

DOI: 10.1074/jbc.270.24.14597

PubMed ID: 7665584

Title: Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells.

PubMed ID: 7665584

DOI: 10.1074/jbc.270.37.21684

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 10856257

Title: A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.

PubMed ID: 10856257

DOI: 10.1093/emboj/19.12.3142

PubMed ID: 9878069

Title: Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PubMed ID: 9878069

DOI: 10.1093/emboj/18.1.270

PubMed ID: 10648556

Title: Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles.

PubMed ID: 10648556

DOI: 10.1083/jcb.148.2.239

PubMed ID: 11500381

Title: PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.

PubMed ID: 11500381

DOI: 10.1093/emboj/20.16.4547

PubMed ID: 11606200

Title: Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.

PubMed ID: 11606200

DOI: 10.1046/j.0014-2956.2001.02478.x

PubMed ID: 11408474

Title: Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.

PubMed ID: 11408474

DOI: 10.1074/jbc.c100284200

PubMed ID: 11575918

Title: The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.

PubMed ID: 11575918

DOI: 10.1006/jmbi.2001.5003

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 11423616

Title: Coupled transcription and translation within nuclei of mammalian cells.

PubMed ID: 11423616

DOI: 10.1126/science.1061216

PubMed ID: 12138083

Title: Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells.

PubMed ID: 12138083

DOI: 10.1074/jbc.c200376200

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 12897141

Title: The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.

PubMed ID: 12897141

DOI: 10.1128/mcb.23.16.5692-5705.2003

PubMed ID: 15601771

Title: Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

PubMed ID: 15601771

DOI: 10.1073/pnas.0406927102

PubMed ID: 15657436

Title: Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

PubMed ID: 15657436

DOI: 10.1128/mcb.25.3.1100-1112.2005

PubMed ID: 16699599

Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.

PubMed ID: 16699599

DOI: 10.1371/journal.ppat.0020041

PubMed ID: 16157702

Title: A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.

PubMed ID: 16157702

DOI: 10.1083/jcb.200504039

PubMed ID: 17667941

Title: Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.

PubMed ID: 17667941

DOI: 10.1038/sj.onc.1210687

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19433856

Title: Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

PubMed ID: 19433856

DOI: 10.1182/blood-2009-02-205153

PubMed ID: 19262567

Title: Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.

PubMed ID: 19262567

DOI: 10.1038/emboj.2009.53

PubMed ID: 19556253

Title: Deregulation of EIF4E: a novel mechanism for autism.

PubMed ID: 19556253

DOI: 10.1136/jmg.2009.066852

PubMed ID: 20430826

Title: The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.

PubMed ID: 20430826

DOI: 10.1093/nar/gkq294

PubMed ID: 20212144

Title: Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.

PubMed ID: 20212144

DOI: 10.1073/pnas.0909877107

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21883093

Title: Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.

PubMed ID: 21883093

DOI: 10.1042/bj20110739

PubMed ID: 22684010

Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

PubMed ID: 22684010

DOI: 10.1016/j.febslet.2012.05.059

PubMed ID: 22578813

Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.

PubMed ID: 22578813

DOI: 10.1016/j.molcel.2012.04.004

PubMed ID: 23471078

Title: Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.

PubMed ID: 23471078

DOI: 10.1016/j.niox.2013.02.083

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23991149

Title: Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.

PubMed ID: 23991149

DOI: 10.1371/journal.pone.0072761

PubMed ID: 24207126

Title: Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.

PubMed ID: 24207126

DOI: 10.1016/j.str.2013.08.030

PubMed ID: 24335285

Title: Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.

PubMed ID: 24335285

DOI: 10.1093/nar/gkt1265

PubMed ID: 25533957

Title: Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

PubMed ID: 25533957

DOI: 10.1038/nature13999

PubMed ID: 25923732

Title: Phosphorylation of eIF4E confers resistance to cellular stress and DNA-damaging agents through an interaction with 4E-T: a rationale for novel therapeutic approaches.

PubMed ID: 25923732

DOI: 10.1371/journal.pone.0123352

PubMed ID: 27117702

Title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.

PubMed ID: 27117702

DOI: 10.1016/j.molcel.2016.03.021

PubMed ID: 28733330

Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

PubMed ID: 28733330

DOI: 10.1042/bcj20170354

PubMed ID: 28487484

Title: Cap-binding protein 4EHP effects translation silencing by microRNAs.

PubMed ID: 28487484

DOI: 10.1073/pnas.1701488114

PubMed ID: 28325843

Title: A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

PubMed ID: 28325843

DOI: 10.1261/rna.060137.116

PubMed ID: 29358667

Title: Rbm24, a target of p53, is necessary for proper expression of p53 and heart development.

PubMed ID: 29358667

DOI: 10.1038/s41418-017-0029-8

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 31042468

Title: Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.

PubMed ID: 31042468

DOI: 10.1016/j.celrep.2019.04.008

PubMed ID: 31712417

Title: Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

PubMed ID: 31712417

DOI: 10.1073/pnas.1904752116

PubMed ID: 36843541

Title: The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.

PubMed ID: 36843541

DOI: 10.15252/embj.2021110496

PubMed ID: 11879179

Title: Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region.

PubMed ID: 11879179

DOI: 10.1042/0264-6021:3620539

PubMed ID: 12975586

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

PubMed ID: 12975586

DOI: 10.1023/a:1025442322316

PubMed ID: 16271312

Title: Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods.

PubMed ID: 16271312

DOI: 10.1016/j.bbapap.2005.07.023

PubMed ID: 17036047

Title: Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.

PubMed ID: 17036047

DOI: 10.1038/sj.emboj.7601380

PubMed ID: 17631896

Title: Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

PubMed ID: 17631896

DOI: 10.1016/j.jmb.2007.06.033

PubMed ID: 21661078

Title: Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.

PubMed ID: 21661078

DOI: 10.1002/psc.1384

PubMed ID: 25702871

Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.

PubMed ID: 25702871

DOI: 10.1016/j.molcel.2015.01.017

Sequence Information:

  • Length: 217
  • Mass: 25097
  • Checksum: B869B8DE615E699D
  • Sequence:
    • MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 304036470

Symbol: D6RBW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RBW1

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 245
  • Mass: 28512
  • Checksum: EB7C7BE4B064AC6A
  • Sequence:
    • MKKKQNKKER KKMRAEDGEN DAIKKQAESL RESQETTPTP NPPTTEEEKT ESNQEVANPE 
HYIKHPLQNR WALWFFKNDK SKTWQANLRL ISKFDTVEDF WALYNHIQLS SNLMPGCDYS 
LFKDGIEPMW EDEKNKRGGR WLITLNKQQR RSDLDRFWLE TLLCLIGESF DDYSDDVCGA 
VVNVRAKGDK IAIWTTECEN REAVTHIGRV YKERLGLPPK IVIGYQSHAD TATKSGSTTK 
NRFVV

Genular Protein ID: 4252939218

Symbol: X5D7E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D7E3

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 237
  • Mass: 27260
  • Checksum: D4925235C678DE08
  • Sequence:
    • MLDLTSRGQV GTSRRMAEAA CSAHFLETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ 
NRWALWFFKN DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP 
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG 
DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 2527201253

Symbol: Q32Q75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32Q75

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 7 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 217
  • Mass: 25067
  • Checksum: 5937B62595F56769
  • Sequence:
    • MATVEPEATP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.