Details for: EIF4E

Gene ID: 1977

Symbol: EIF4E

Ensembl ID: ENSG00000151247

Description: eukaryotic translation initiation factor 4E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 324.9216
    Cell Significance Index: -50.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 219.2843
    Cell Significance Index: -55.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 148.1985
    Cell Significance Index: -61.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.9213
    Cell Significance Index: -66.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 134.7423
    Cell Significance Index: -54.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.1373
    Cell Significance Index: -63.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.6108
    Cell Significance Index: -66.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.6281
    Cell Significance Index: -55.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.0423
    Cell Significance Index: -61.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4527
    Cell Significance Index: -54.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.5634
    Cell Significance Index: -65.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1020
    Cell Significance Index: -46.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2845
    Cell Significance Index: -20.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.5025
    Cell Significance Index: 524.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7032
    Cell Significance Index: 126.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6224
    Cell Significance Index: 85.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5633
    Cell Significance Index: 313.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5625
    Cell Significance Index: 44.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3487
    Cell Significance Index: 80.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2516
    Cell Significance Index: 33.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2205
    Cell Significance Index: 55.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1484
    Cell Significance Index: 227.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1158
    Cell Significance Index: 137.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0288
    Cell Significance Index: 35.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9571
    Cell Significance Index: 123.6600
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.9482
    Cell Significance Index: 2.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8968
    Cell Significance Index: 24.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8719
    Cell Significance Index: 157.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8558
    Cell Significance Index: 117.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8296
    Cell Significance Index: 297.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7658
    Cell Significance Index: 16.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7415
    Cell Significance Index: 34.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7349
    Cell Significance Index: 401.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6862
    Cell Significance Index: 303.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6621
    Cell Significance Index: 78.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6015
    Cell Significance Index: 16.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5077
    Cell Significance Index: 65.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4719
    Cell Significance Index: 46.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4506
    Cell Significance Index: 31.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3893
    Cell Significance Index: 29.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3381
    Cell Significance Index: 21.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3301
    Cell Significance Index: 8.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3252
    Cell Significance Index: 224.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3168
    Cell Significance Index: 14.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3167
    Cell Significance Index: 16.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2944
    Cell Significance Index: 16.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2309
    Cell Significance Index: 6.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2174
    Cell Significance Index: 4.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1914
    Cell Significance Index: 6.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1365
    Cell Significance Index: 8.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1334
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1148
    Cell Significance Index: 19.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1145
    Cell Significance Index: 21.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1105
    Cell Significance Index: 7.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0787
    Cell Significance Index: 148.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0767
    Cell Significance Index: 48.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0631
    Cell Significance Index: 10.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0623
    Cell Significance Index: 3.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0206
    Cell Significance Index: 31.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0150
    Cell Significance Index: 27.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0281
    Cell Significance Index: -4.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0332
    Cell Significance Index: -24.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0397
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0403
    Cell Significance Index: -25.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0427
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0662
    Cell Significance Index: -37.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0769
    Cell Significance Index: -7.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0788
    Cell Significance Index: -5.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1027
    Cell Significance Index: -0.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1030
    Cell Significance Index: -1.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1202
    Cell Significance Index: -2.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1307
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1431
    Cell Significance Index: -30.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1526
    Cell Significance Index: -3.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1790
    Cell Significance Index: -51.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2282
    Cell Significance Index: -26.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2928
    Cell Significance Index: -7.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3848
    Cell Significance Index: -5.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4490
    Cell Significance Index: -14.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4505
    Cell Significance Index: -51.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4508
    Cell Significance Index: -19.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4945
    Cell Significance Index: -7.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5091
    Cell Significance Index: -55.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5347
    Cell Significance Index: -55.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5459
    Cell Significance Index: -20.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5528
    Cell Significance Index: -3.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6347
    Cell Significance Index: -5.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6395
    Cell Significance Index: -50.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6557
    Cell Significance Index: -4.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8639
    Cell Significance Index: -45.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8725
    Cell Significance Index: -53.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8924
    Cell Significance Index: -21.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9587
    Cell Significance Index: -17.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9651
    Cell Significance Index: -27.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9715
    Cell Significance Index: -12.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0316
    Cell Significance Index: -11.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural homology**: eIF4E shares structural homology with other eIF proteins, including eIF4G and eIF3, and is part of the eIF4F complex, which plays a central role in translation initiation. 2. **mRNA cap recognition**: eIF4E recognizes the 7-methylguanosine cap structure on mRNAs, facilitating their binding to the 43S ribosomal subunit. 3. **Binding to eIF4G**: eIF4E interacts with eIF4G, a scaffold protein that bridges the cap-binding complex to the 43S ribosomal subunit. 4. **Antiviral activity**: eIF4E has been shown to inhibit viral replication by interfering with the translation of viral mRNAs. **Pathways and Functions:** 1. **Translation initiation**: eIF4E is a critical component of the cap-binding complex, which binds to mRNAs containing the 7-methylguanosine cap structure, facilitating their translation into proteins. 2. **Antiviral mechanism**: eIF4E has been shown to inhibit viral replication by interfering with the translation of viral mRNAs. 3. **Immune response**: eIF4E plays a role in the regulation of immune responses, including the production of interferons and the activation of immune cells. 4. **Stress granule formation**: eIF4E is involved in the formation of stress granules, which are cytoplasmic structures that regulate mRNA translation during stress conditions. 5. **Cytoskeletal dynamics**: eIF4E has been implicated in the regulation of cytoskeletal dynamics, including the formation of actin filaments and microtubules. **Clinical Significance:** 1. **Cancer**: eIF4E has been implicated in the regulation of cancer cell proliferation and survival, making it a potential target for cancer therapy. 2. **Neurodegenerative diseases**: eIF4E has been shown to play a role in the regulation of protein translation in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Infectious diseases**: eIF4E has been implicated in the regulation of viral replication, making it a potential target for antiviral therapy. 4. **Autoimmune diseases**: eIF4E has been shown to play a role in the regulation of immune responses, including the production of autoantibodies, making it a potential target for autoimmune disease therapy. In conclusion, eIF4E is a multifunctional protein that plays a critical role in eukaryotic translation initiation and beyond. Its involvement in various cellular processes, including antiviral mechanisms, immune responses, and stress granule formation, highlights its significance in both normal cellular physiology and disease. Further research is needed to fully elucidate the functions of eIF4E and its potential as a therapeutic target.

Genular Protein ID: 3753610345

Symbol: IF4E_HUMAN

Name: eIF-4F 25 kDa subunit

UniProtKB Accession Codes:

P06730 B7Z6V1 D6RCQ6 Q96E95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 38 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 13 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3469651

Title: Amino acid sequence of the mRNA cap-binding protein from human tissues.

PubMed ID: 3469651

DOI: 10.1073/pnas.84.4.945

PubMed ID: 1736299

Title:

PubMed ID: 1736299

DOI: 10.1073/pnas.89.3.1148a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16341674

Title: Transcriptome analysis of human gastric cancer.

PubMed ID: 16341674

DOI: 10.1007/s00335-005-0075-2

PubMed ID: 1993647

Title: Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor.

PubMed ID: 1993647

DOI: 10.1016/s0021-9258(18)49896-1

PubMed ID: 1672854

Title: Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis.

PubMed ID: 1672854

DOI: 10.1016/0014-5793(91)80294-d

PubMed ID: 3112145

Title: Phosphorylation site of eukaryotic initiation factor 4E.

PubMed ID: 3112145

DOI: 10.1016/s0021-9258(18)60978-0

PubMed ID: 1384058

Title: A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

PubMed ID: 1384058

DOI: 10.1073/pnas.89.20.9612

PubMed ID: 8505316

Title: Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells.

PubMed ID: 8505316

DOI: 10.1016/s0021-9258(19)50285-x

PubMed ID: 7590282

Title: Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells.

PubMed ID: 7590282

DOI: 10.1016/0378-1119(95)00302-m

PubMed ID: 7782323

Title: Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209.

PubMed ID: 7782323

DOI: 10.1074/jbc.270.24.14597

PubMed ID: 7665584

Title: Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells.

PubMed ID: 7665584

DOI: 10.1074/jbc.270.37.21684

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 10856257

Title: A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.

PubMed ID: 10856257

DOI: 10.1093/emboj/19.12.3142

PubMed ID: 9878069

Title: Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PubMed ID: 9878069

DOI: 10.1093/emboj/18.1.270

PubMed ID: 10648556

Title: Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles.

PubMed ID: 10648556

DOI: 10.1083/jcb.148.2.239

PubMed ID: 11500381

Title: PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.

PubMed ID: 11500381

DOI: 10.1093/emboj/20.16.4547

PubMed ID: 11606200

Title: Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.

PubMed ID: 11606200

DOI: 10.1046/j.0014-2956.2001.02478.x

PubMed ID: 11408474

Title: Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.

PubMed ID: 11408474

DOI: 10.1074/jbc.c100284200

PubMed ID: 11575918

Title: The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.

PubMed ID: 11575918

DOI: 10.1006/jmbi.2001.5003

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 11423616

Title: Coupled transcription and translation within nuclei of mammalian cells.

PubMed ID: 11423616

DOI: 10.1126/science.1061216

PubMed ID: 12138083

Title: Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells.

PubMed ID: 12138083

DOI: 10.1074/jbc.c200376200

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 12897141

Title: The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.

PubMed ID: 12897141

DOI: 10.1128/mcb.23.16.5692-5705.2003

PubMed ID: 15601771

Title: Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

PubMed ID: 15601771

DOI: 10.1073/pnas.0406927102

PubMed ID: 15657436

Title: Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

PubMed ID: 15657436

DOI: 10.1128/mcb.25.3.1100-1112.2005

PubMed ID: 16699599

Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.

PubMed ID: 16699599

DOI: 10.1371/journal.ppat.0020041

PubMed ID: 16157702

Title: A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.

PubMed ID: 16157702

DOI: 10.1083/jcb.200504039

PubMed ID: 17667941

Title: Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.

PubMed ID: 17667941

DOI: 10.1038/sj.onc.1210687

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19433856

Title: Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

PubMed ID: 19433856

DOI: 10.1182/blood-2009-02-205153

PubMed ID: 19262567

Title: Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.

PubMed ID: 19262567

DOI: 10.1038/emboj.2009.53

PubMed ID: 19556253

Title: Deregulation of EIF4E: a novel mechanism for autism.

PubMed ID: 19556253

DOI: 10.1136/jmg.2009.066852

PubMed ID: 20430826

Title: The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.

PubMed ID: 20430826

DOI: 10.1093/nar/gkq294

PubMed ID: 20212144

Title: Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.

PubMed ID: 20212144

DOI: 10.1073/pnas.0909877107

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21883093

Title: Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.

PubMed ID: 21883093

DOI: 10.1042/bj20110739

PubMed ID: 22684010

Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

PubMed ID: 22684010

DOI: 10.1016/j.febslet.2012.05.059

PubMed ID: 22578813

Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.

PubMed ID: 22578813

DOI: 10.1016/j.molcel.2012.04.004

PubMed ID: 23471078

Title: Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.

PubMed ID: 23471078

DOI: 10.1016/j.niox.2013.02.083

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23991149

Title: Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.

PubMed ID: 23991149

DOI: 10.1371/journal.pone.0072761

PubMed ID: 24207126

Title: Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.

PubMed ID: 24207126

DOI: 10.1016/j.str.2013.08.030

PubMed ID: 24335285

Title: Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.

PubMed ID: 24335285

DOI: 10.1093/nar/gkt1265

PubMed ID: 25533957

Title: Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.

PubMed ID: 25533957

DOI: 10.1038/nature13999

PubMed ID: 25923732

Title: Phosphorylation of eIF4E confers resistance to cellular stress and DNA-damaging agents through an interaction with 4E-T: a rationale for novel therapeutic approaches.

PubMed ID: 25923732

DOI: 10.1371/journal.pone.0123352

PubMed ID: 27117702

Title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.

PubMed ID: 27117702

DOI: 10.1016/j.molcel.2016.03.021

PubMed ID: 28733330

Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

PubMed ID: 28733330

DOI: 10.1042/bcj20170354

PubMed ID: 28487484

Title: Cap-binding protein 4EHP effects translation silencing by microRNAs.

PubMed ID: 28487484

DOI: 10.1073/pnas.1701488114

PubMed ID: 28325843

Title: A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

PubMed ID: 28325843

DOI: 10.1261/rna.060137.116

PubMed ID: 29358667

Title: Rbm24, a target of p53, is necessary for proper expression of p53 and heart development.

PubMed ID: 29358667

DOI: 10.1038/s41418-017-0029-8

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 31042468

Title: Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.

PubMed ID: 31042468

DOI: 10.1016/j.celrep.2019.04.008

PubMed ID: 31712417

Title: Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

PubMed ID: 31712417

DOI: 10.1073/pnas.1904752116

PubMed ID: 36843541

Title: The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.

PubMed ID: 36843541

DOI: 10.15252/embj.2021110496

PubMed ID: 11879179

Title: Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region.

PubMed ID: 11879179

DOI: 10.1042/0264-6021:3620539

PubMed ID: 12975586

Title: Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.

PubMed ID: 12975586

DOI: 10.1023/a:1025442322316

PubMed ID: 16271312

Title: Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods.

PubMed ID: 16271312

DOI: 10.1016/j.bbapap.2005.07.023

PubMed ID: 17036047

Title: Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.

PubMed ID: 17036047

DOI: 10.1038/sj.emboj.7601380

PubMed ID: 17631896

Title: Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

PubMed ID: 17631896

DOI: 10.1016/j.jmb.2007.06.033

PubMed ID: 21661078

Title: Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.

PubMed ID: 21661078

DOI: 10.1002/psc.1384

PubMed ID: 25702871

Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.

PubMed ID: 25702871

DOI: 10.1016/j.molcel.2015.01.017

Sequence Information:

  • Length: 217
  • Mass: 25097
  • Checksum: B869B8DE615E699D
  • Sequence:
    • MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 2527201253

Symbol: Q32Q75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32Q75

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 217
  • Mass: 25067
  • Checksum: 5937B62595F56769
  • Sequence:
    • MATVEPEATP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 4252939218

Symbol: X5D7E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D7E3

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 12 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 237
  • Mass: 27260
  • Checksum: D4925235C678DE08
  • Sequence:
    • MLDLTSRGQV GTSRRMAEAA CSAHFLETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ 
NRWALWFFKN DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP 
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG 
DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 304036470

Symbol: D6RBW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RBW1

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 245
  • Mass: 28512
  • Checksum: EB7C7BE4B064AC6A
  • Sequence:
    • MKKKQNKKER KKMRAEDGEN DAIKKQAESL RESQETTPTP NPPTTEEEKT ESNQEVANPE 
HYIKHPLQNR WALWFFKNDK SKTWQANLRL ISKFDTVEDF WALYNHIQLS SNLMPGCDYS 
LFKDGIEPMW EDEKNKRGGR WLITLNKQQR RSDLDRFWLE TLLCLIGESF DDYSDDVCGA 
VVNVRAKGDK IAIWTTECEN REAVTHIGRV YKERLGLPPK IVIGYQSHAD TATKSGSTTK 
NRFVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.