Details for: EIF4G1

Gene ID: 1981

Symbol: EIF4G1

Ensembl ID: ENSG00000114867

Description: eukaryotic translation initiation factor 4 gamma 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.73
    Marker Score: 13389
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.28
    Marker Score: 629
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.24
    Marker Score: 1498
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.23
    Marker Score: 9320
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.12
    Marker Score: 1769
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.94
    Marker Score: 34432
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.9
    Marker Score: 14148
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.89
    Marker Score: 2023
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.88
    Marker Score: 4293
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.86
    Marker Score: 489
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.85
    Marker Score: 862
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.84
    Marker Score: 1940
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.83
    Marker Score: 2693
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.8
    Marker Score: 1229
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.8
    Marker Score: 1268
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.69
    Marker Score: 1457
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.68
    Marker Score: 1812
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.67
    Marker Score: 10679
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.64
    Marker Score: 4040
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.62
    Marker Score: 12660
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.62
    Marker Score: 1951
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.62
    Marker Score: 2148
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.61
    Marker Score: 792
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6
    Marker Score: 14036
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.58
    Marker Score: 53788
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.57
    Marker Score: 5386
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.53
    Marker Score: 5912
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.52
    Marker Score: 2450
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.51
    Marker Score: 52226
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.51
    Marker Score: 4727
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.5
    Marker Score: 1022
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6237.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.48
    Marker Score: 12787
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.48
    Marker Score: 764
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.45
    Marker Score: 1544
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.45
    Marker Score: 985
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.44
    Marker Score: 2290
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.44
    Marker Score: 5326
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.44
    Marker Score: 579
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.42
    Marker Score: 8413
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.39
    Marker Score: 3156
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.39
    Marker Score: 808.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.39
    Marker Score: 1792
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.38
    Marker Score: 8969
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.37
    Marker Score: 338
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.36
    Marker Score: 393
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.36
    Marker Score: 7139
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.35
    Marker Score: 15686
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.35
    Marker Score: 75239
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.34
    Marker Score: 8134
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.34
    Marker Score: 466
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.33
    Marker Score: 1043
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.32
    Marker Score: 1376
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.32
    Marker Score: 316
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.32
    Marker Score: 14872
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.32
    Marker Score: 962
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.32
    Marker Score: 2162
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.32
    Marker Score: 3525
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.31
    Marker Score: 1034
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.31
    Marker Score: 2322
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.31
    Marker Score: 6278.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.31
    Marker Score: 5131
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.3
    Marker Score: 1310
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.3
    Marker Score: 313
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.3
    Marker Score: 3273
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.29
    Marker Score: 645
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.29
    Marker Score: 709
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.29
    Marker Score: 11164
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.28
    Marker Score: 3043
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.28
    Marker Score: 12880.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.28
    Marker Score: 325
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.27
    Marker Score: 3446
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.26
    Marker Score: 2659
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.26
    Marker Score: 2445
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.25
    Marker Score: 872
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.24
    Marker Score: 1493
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.24
    Marker Score: 3018
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.23
    Marker Score: 1114
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.23
    Marker Score: 2459
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.23
    Marker Score: 1099
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1238
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.22
    Marker Score: 768.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.22
    Marker Score: 7919
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.22
    Marker Score: 1286
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.22
    Marker Score: 759
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.21
    Marker Score: 1222
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.21
    Marker Score: 454
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.2
    Marker Score: 588
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.19
    Marker Score: 1143
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.18
    Marker Score: 441
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.17
    Marker Score: 1104
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.17
    Marker Score: 645
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.17
    Marker Score: 290
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.17
    Marker Score: 1693
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.16
    Marker Score: 771
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.16
    Marker Score: 550
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 266
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.16
    Marker Score: 1448.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.15
    Marker Score: 261
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.15
    Marker Score: 2105

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Other Information

## Summary The EIF4G1 gene encodes a protein involved in eukaryotic translation initiation. It is significantly expressed in various cell types, including myoepithelial cells of the mammary gland, IgG plasmablast, nasal mucosa goblet cell, GABAergic neuron, keratinocyte, cortical cell of adrenal gland, basal cell of epithelium of trachea, skeletal muscle satellite stem cell, acinar cell of salivary gland, IgA plasmablast. ## Key characteristics * EIF4G1 is a key regulator of eukaryotic translation initiation. * It binds to AU-rich elements in the 5' UTR of mRNA and destabilizes it, promoting translation initiation. * It is involved in various cellular processes, including immune responses, development, and metabolism. ## Pathways and functions * EIF4G1 is involved in the Auf1 (hnrnp d0) binding and destabilizing of mRNA. * It is essential for axon guidance in neurons. * It plays a role in cytokine signaling in the immune system. * It is involved in dedenylation-dependent mRNA decay and degradation. * It regulates the expression of genes involved in developmental biology, metabolism, and cancer. * It is involved in the regulation of the maternal-to-zygotic transition (mzt) during fertilization. * It regulates protein translation through the mtorc1-mediated and mtor signaling pathways. * It is involved in nervous system development and the regulation of gene expression in neurons. ## Clinical significance * Mutations in EIF4G1 have been linked to several human diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. * Targeting EIF4G1 has emerged as a potential therapeutic strategy for these disorders.

Genular Protein ID: 2017758663

Symbol: IF4G1_HUMAN

Name: Eukaryotic translation initiation factor 4 gamma 1

UniProtKB Accession Codes:

Q04637 D3DNT2 D3DNT4 D3DNT5 E9PFM1 G5E9S1 O43177 O95066 Q5HYG0 Q6ZN21 Q8N102

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 18 EMDB 3 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 13 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 14 RefSeq 4 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1429670

Title: Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma.

PubMed ID: 1429670

DOI: 10.1016/s0021-9258(18)50080-6

PubMed ID: 9857202

Title: A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.

PubMed ID: 9857202

DOI: 10.1093/emboj/17.24.7480

PubMed ID: 9418880

Title: A novel functional human eukaryotic translation initiation factor 4G.

PubMed ID: 9418880

DOI: 10.1128/mcb.18.1.334

PubMed ID: 12052860

Title: Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons.

PubMed ID: 12052860

DOI: 10.1128/mcb.22.13.4499-4511.2002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9755181

Title: Rotavirus RNA binding protein NSP3, interacts with eIF-4GI and evicts the poly(A) binding protein from eIF4F.

PubMed ID: 9755181

DOI: 10.1093/emboj/17.19.5811

PubMed ID: 9372926

Title: Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.

PubMed ID: 9372926

DOI: 10.1128/mcb.17.12.6940

PubMed ID: 7651417

Title: The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.

PubMed ID: 7651417

DOI: 10.1128/mcb.15.9.4990

PubMed ID: 8396129

Title: Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

PubMed ID: 8396129

DOI: 10.1016/s0021-9258(19)36499-3

PubMed ID: 7935836

Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

PubMed ID: 7935836

DOI: 10.1038/371762a0

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 8961935

Title: A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases.

PubMed ID: 8961935

DOI: 10.1021/bi961864t

PubMed ID: 9755863

Title: Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex.

PubMed ID: 9755863

DOI: 10.1016/s0014-5793(98)01027-8

PubMed ID: 10872469

Title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

PubMed ID: 10872469

DOI: 10.1146/annurev.biochem.68.1.913

PubMed ID: 9878069

Title: Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PubMed ID: 9878069

DOI: 10.1093/emboj/18.1.270

PubMed ID: 10996799

Title: Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation.

PubMed ID: 10996799

DOI: 10.1016/s0960-9822(00)00701-6

PubMed ID: 10970864

Title: Multiple portions of poly(A)-binding protein stimulate translation in vivo.

PubMed ID: 10970864

DOI: 10.1093/emboj/19.17.4723

PubMed ID: 11034318

Title: Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro.

PubMed ID: 11034318

DOI: 10.1016/s0014-5793(00)01928-1

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 15314025

Title: Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting.

PubMed ID: 15314025

DOI: 10.1101/gad.1212504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16513844

Title: Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18.

PubMed ID: 16513844

DOI: 10.1093/nar/gkj519

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17284590

Title: Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.

PubMed ID: 17284590

DOI: 10.1073/pnas.0611015104

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18799579

Title: Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

PubMed ID: 18799579

DOI: 10.1128/jvi.00872-08

PubMed ID: 17984221

Title: Proline-rich transcript in brain protein induces stress granule formation.

PubMed ID: 17984221

DOI: 10.1128/mcb.01226-07

PubMed ID: 18025107

Title: SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.

PubMed ID: 18025107

DOI: 10.1128/mcb.01500-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21576361

Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.

PubMed ID: 21576361

DOI: 10.1128/mcb.05589-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22872150

Title: DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.

PubMed ID: 22872150

DOI: 10.1038/emboj.2012.220

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24423872

Title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.

PubMed ID: 24423872

DOI: 10.1093/nar/gkt1379

PubMed ID: 29062139

Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

PubMed ID: 29062139

DOI: 10.1038/s41598-017-14262-7

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 26740508

Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.

PubMed ID: 26740508

DOI: 10.1136/jmedgenet-2015-103568

PubMed ID: 12086624

Title: Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.

PubMed ID: 12086624

DOI: 10.1016/s1097-2765(02)00555-5

PubMed ID: 16698552

Title: Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.

PubMed ID: 16698552

DOI: 10.1016/j.str.2006.03.012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21907011

Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.

PubMed ID: 21907011

DOI: 10.1016/j.ajhg.2011.08.009

Sequence Information:

  • Length: 1599
  • Mass: 175491
  • Checksum: 324088B60863DA34
  • Sequence:
    • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH FYPSRAQPPS 
SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ GAYYIPGQGR STYVVPTQQY 
PVQPGAPGFY PGASPTEFGT YAGAYYPAQG VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI 
RIRDPNQGGK DITEEIMSGA RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI 
IADRPGLPGP EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES 
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP LASHTVEIHE 
PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP EELLNGAPSP PAVDLSPVSE 
PEEQAKEVTA SMAPPTIPSA TPATAPSATS PAQEEEMEEE EEEEEGEAGE AGEAESEKGG 
EELLPPESTP IPANLSQNLE AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA 
VPEVENQPPA GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ 
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR PLDPTRLQGI 
NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG PRRSQQGPRK EPRKIIATVL 
MTEDIKLNKA EKAWKPSSKR TAADKDRGEE DADGSKTQDL FRRVRSILNK LTPQMFQQLM 
KQVTQLAIDT EERLKGVIDL IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR 
KLLLNRCQKE FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK 
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK AKPRMDQYFN 
QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK TIDQIHKEAE MEEHREHIKV 
QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG GWNTVPISKG SRPIDTSRLT KITKPGSIDS 
NNQLFAPGGR LSWGKGSSGG SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV 
VQRSSLSRER GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ 
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII EEYLHLNDMK 
EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL LHQLLCAGHL STAQYYQGLY 
EILELAEDME IDIPHVWLYL AELVTPILQE GGVPMGELFR EITKPLRPLG KAASLLLEIL 
GLLCKSMGPK KVGTLWREAG LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS 
EELNRQLEKL LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD 
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY DEDVVKEDAF 
YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN

Genular Protein ID: 1213909839

Symbol: Q96I65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96I65

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 1 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 645
  • Mass: 72201
  • Checksum: DD257232574A45B8
  • Sequence:
    • MDQYFNQMEK IIKEKKTSSR IRFMLQDVLD LRGSNWVPRR GDQGPKTIDQ IHKEAEMEEH 
REHIKVQQLM AKGSDKRRGG PPGPPISRGL PLVDDGGWNT VPISKGSRPI DTSRLTKITK 
PGSIDSNNQL FAPGGRLSWG KGSSGGSGAK PSDAASEAAR PATSTLNRFS ALQQAVPTES 
TDNRRVVQRS SLSRERGEKA GDRGDRLERS ERGGDRGDRL DRARTPATKR SFSKEVEERS 
RERPSQPEGL RKAASLTEDR DRGRDAVKRE AALPPVSPLK AALSEEELEK KSKAIIEEYL 
HLNDMKEAVQ CVQELASPSL LFIFVRHGVE STLERSAIAR EHMGQLLHQL LCAGHLSTAQ 
YYQGLYEILE LAEDMEIDIP HVWLYLAELV TPILQEGGVP MGELFREITK PLRPLGKAAS 
LLLEILGLLC KSMGPKKVGT LWREAGLSWK EFLPEGQDIG AFVAEQKVEY TLGEESEAPG 
QRALPSEELN RQLEKLLKEG SSNQRVFDWI EANLSEQQIV SNTLVRALMT AVCYSAIIFE 
TPLRVDVAVL KARAKLLQKY LCDEQKELQA LYALQALVVT LEQPPNLLRM FFDALYDEDV 
VKEDAFYSWE SSKDPAEQQG KGVALKSVTA FFKWLREAEE ESDHN

Genular Protein ID: 2417510356

Symbol: B2RU06_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RU06

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 5 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1606
  • Mass: 176175
  • Checksum: 0A8B1B889D6D7A8D
  • Sequence:
    • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP 
SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ ISYPASQGAY YIPGQGRSTY 
VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP 
KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD 
DRSQGAIIAD RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS PLQAPTPLAS 
HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP IAPTAQPEEL LNGAPSPPAV 
DLSPVSEPEE QAKEVTASVA PPTIPSATPA TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE 
AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA 
FKEANPAVPE VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK ANKTPLRPLD 
PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP RGPAGLGPRR SQQGPRKEPR 
KIIATVLMTE DIKLNKAEKA WKPSSKRTAA DKDRGEEDAD GSKTQDLFRR VRSILNKLTP 
QMFQQLMKQV TQLAIDTEER LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP 
TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFEKAKP 
RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR RGDQGPKTID QIHKEAEMEE 
HREHIKVQQL MAKGSDKRRG GPPGPPISRG LPLVDDGGWN TVPISKGSRP IDTSRLTKIT 
KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE 
STDNRRVVQR SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE KKSKAIIEEY 
LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA REHMGQLLHQ LLCAGHLSTA 
QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL VTPILQEGGV PMGELFREIT KPLRPLGKAA 
SLLLEILGLL CKSMGPKKVG TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP 
GQRALPSEEL NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR MFFDALYDED 
VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE EESDHN

Genular Protein ID: 596026238

Symbol: B2RU10_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RU10

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 2 SAM 1 SMART 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1606
  • Mass: 176207
  • Checksum: FD3BD97634837A9D
  • Sequence:
    • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP 
SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ ISYPASQGAY YIPGQGRSTY 
VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP 
KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD 
DRSQGAIIAD RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS PLQAPTPLAS 
HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP IAPTAQPEEL LNGAPSPPAV 
DLSPVSEPEE QAKEVTASMA PPTIPSATPA TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE 
AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA 
FKEANPAVPE VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK ANKTPLRPLD 
PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP RGPAGLGPRR SQQGPRKEPR 
KIIATVLMTE DIKLNKAEKA WKPSSKRTAA DKDRGEEDAD GSKTQDLFRR VRSILNKLTP 
QMFQQLMKQV TQLAIDTEER LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP 
TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFEKAKP 
RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR RGDQGPKTID QIHKEAEMEE 
HREHIKVQQL MAKGSDKRRG GPPGPPISRG LPLVDDGGWN TVPISKGSRP IDTSRLTKIT 
KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE 
STDNRRVVQR SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE KKSKAIIEEY 
LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA REHMGQLLHQ LLCAGHLSTA 
QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL VTPILQEGGV PMGELFREIT KPLRPLGKAA 
SLLLEILGLL CKSMGPKKVG TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP 
GQRALPSEEL NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR MFFDALYDED 
VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE EESDHN

Genular Protein ID: 2922594711

Symbol: B4DSI9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DSI9

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 3 RefSeq 1 SAM 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1512
  • Mass: 166582
  • Checksum: 790466ADA55CBC6D
  • Sequence:
    • MMIPSQISYP ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP GFYPGASPTE FGTYAGAYYP 
AQGVQQFPTG VAPAPVLMNQ PPQIAPKRER KTIRIRDPNQ GGKDITEEIM SGARTASTPT 
PPQTGGGLEP QANGETPQVA VIVRPDDRSQ GAIIADRPGL PGPEHSPSES QPSSPSPTPS 
PSPVLEPGSE PNLAVLSIPG DTMTTIQMSV EESTPISRET GEPYRLSPEP TPLAEPILEV 
EVTLSKPVPE SEFSSSPLQA PTPLASHTVE IHEPNGMVPS EDLEPEVESS PELAPPPACP 
SESPVPIAPT AQPEELLNGA PSPPAVDLSP VSEPEEQAKE VTASMAPPTI PSATPATAPS 
ATSPAQEEEM EEEEEEEEGE AGEAGEAESE KGGEELLPPE STPIPANLSQ NLEAAAATQV 
AVSVPKRRRK IKELNKKEAV GDLLDAFKEA NPAVPEVENQ PPAGSNPGPE SEGSGVPPRP 
EEADETWDSK EDKIHNAENI QPGEQKYEYK SDQWKPLNLE EKKRYDREFL LGFQFIFASM 
QKPEGLPHIS DVVLDKANKT PLRPLDPTRL QGINCGPDFT PSFANLGRTT LSTRGPPRGG 
PGGELPRGPA GLGPRRSQQG PRKEPRKIIA TVLMTEDIKL NKAEKAWKPS SKRTPADKDR 
GEEDADGSKT QDLFRRVRSI LNKLTPQMFQ QLMKQVTQLA IDTEERLKGV IDLIFEKAIS 
EPNFSVAYAN MCRCLMALKV PTTEKPTVTV NFRKLLLNRC QKEFEKDKDD DEVFEKKQKE 
MDEAATAEER GRLKEELEEA RDIARRRSLG NIKFIGELFK LKMLTEAIMH DCVVKLLKNH 
DEESLECLCR LLTTIGKDLD FEKAKPRMDQ YFNQMEKIIK EKKTSSRIRF MLQDVLNLRG 
SNWVPRRGDQ GPKTIDQIHK EAEMEEHREH IKVQQLMAKG SDKRRGGPPG PPISRGLPLV 
DDGGWNTVPI SKGSRPIDTS RLTKITKPGS IDSNNQLFAP GGRLSWGKGS SGGSGAKPSD 
AASEAARPAT STLNRFSALQ QAVPTESTDN RRVVQRSSLS RERGEKAGDR GDRLERSERG 
GDRGDRLDRA RTPATKRSFS KEVEERSRER PSQPEGLRKA ASLTEDRDRG RDAVKREAAL 
PPVSPLKAAL SEEELEKKSK AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGVESTL 
ERSAIAREHM GQLLHQLLCA GHLSTAQYYQ GLYEILELAE DVEIDIPHVW LYLAELVTPI 
LQEGGVPMGE LFREITKPLR PLGKAASLLL EILGLLCKSM GPKKVGTLWR EAGLSWKEFL 
PEGQDIGAFV AEQKVEYTLG EESEAPGQRA LPSEELNRQL EKLLKEGSSN QRVFDWIEAN 
LSEQQIVSNT LVRALMTAVC YSAIIFETPL RVDVAVLKAR AKLLQKYLCD EQKELQALYA 
LQALVVTLEQ PPNLLRMFFD ALYDEDVVKE DAFYSWESSK DPAEQQGKGV ALKSVTAFFK 
WLREAEEESD HN

Genular Protein ID: 3361545984

Symbol: O95065_HUMAN

Name: N/A

UniProtKB Accession Codes:

O95065

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 IntAct 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1 SMR 1

Sequence Information:

  • Length: 230
  • Mass: 24382
  • Checksum: 9082E3BF75E07BBF
  • Sequence:
    • PEPGVPGWGV GTPRPKQLAP FVIREPGASE TWNFRSGWSG APRSQVDTLT SQPQALGCPE 
PVGRTVDLFL IEGHFYPSRA QPPSSAASRV QSAAPARPGP AAHVYPAGSQ VMMIPSQISY 
PASQGAYYIP GQGRSTYVVP TQQYPVQPGA PGFYPGASPT EFGTYAGAYY PAQGVQQFPT 
GVAPAPVLMN QPPQIAPKRE RKTIRIRDPN QGGKDITEEI MSGARTASTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.