Details for: EIF4G1

Gene ID: 1981

Symbol: EIF4G1

Ensembl ID: ENSG00000114867

Description: eukaryotic translation initiation factor 4 gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 258.8958
    Cell Significance Index: -40.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.2140
    Cell Significance Index: -42.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 106.5581
    Cell Significance Index: -43.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.2269
    Cell Significance Index: -49.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.8571
    Cell Significance Index: -49.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.1555
    Cell Significance Index: -49.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.7924
    Cell Significance Index: -43.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.5358
    Cell Significance Index: -46.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4477
    Cell Significance Index: -46.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2315
    Cell Significance Index: -40.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1210
    Cell Significance Index: -47.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1832
    Cell Significance Index: 237.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1060
    Cell Significance Index: 56.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9435
    Cell Significance Index: 52.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5518
    Cell Significance Index: 80.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4289
    Cell Significance Index: 66.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3805
    Cell Significance Index: 36.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3752
    Cell Significance Index: 36.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3388
    Cell Significance Index: 241.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2429
    Cell Significance Index: 35.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2216
    Cell Significance Index: 63.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1958
    Cell Significance Index: 147.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1823
    Cell Significance Index: 234.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1423
    Cell Significance Index: 79.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0415
    Cell Significance Index: 27.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0124
    Cell Significance Index: 45.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0031
    Cell Significance Index: 547.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9685
    Cell Significance Index: 72.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9393
    Cell Significance Index: 8.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8961
    Cell Significance Index: 22.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8824
    Cell Significance Index: 41.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5911
    Cell Significance Index: 533.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5815
    Cell Significance Index: 16.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5709
    Cell Significance Index: 73.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5513
    Cell Significance Index: 75.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5437
    Cell Significance Index: 240.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5324
    Cell Significance Index: 12.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4882
    Cell Significance Index: 83.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4834
    Cell Significance Index: 57.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4621
    Cell Significance Index: 92.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3807
    Cell Significance Index: 29.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3254
    Cell Significance Index: 32.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3176
    Cell Significance Index: 22.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2868
    Cell Significance Index: 18.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2289
    Cell Significance Index: 82.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1770
    Cell Significance Index: 22.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1701
    Cell Significance Index: 27.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1580
    Cell Significance Index: 2.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1565
    Cell Significance Index: 29.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1268
    Cell Significance Index: 87.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0799
    Cell Significance Index: 4.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0367
    Cell Significance Index: 27.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0079
    Cell Significance Index: 14.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0069
    Cell Significance Index: 5.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0176
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0264
    Cell Significance Index: -16.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0281
    Cell Significance Index: -38.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0333
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0465
    Cell Significance Index: -21.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0581
    Cell Significance Index: -0.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0624
    Cell Significance Index: -35.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1115
    Cell Significance Index: -12.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1155
    Cell Significance Index: -24.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1422
    Cell Significance Index: -40.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1751
    Cell Significance Index: -2.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1781
    Cell Significance Index: -2.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1897
    Cell Significance Index: -27.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2142
    Cell Significance Index: -6.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2222
    Cell Significance Index: -7.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2563
    Cell Significance Index: -29.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2599
    Cell Significance Index: -1.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2799
    Cell Significance Index: -32.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3017
    Cell Significance Index: -2.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3181
    Cell Significance Index: -17.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3268
    Cell Significance Index: -10.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3421
    Cell Significance Index: -17.9600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3607
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4208
    Cell Significance Index: -28.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4286
    Cell Significance Index: -44.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4536
    Cell Significance Index: -27.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4714
    Cell Significance Index: -10.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4805
    Cell Significance Index: -12.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4814
    Cell Significance Index: -30.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4972
    Cell Significance Index: -39.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5663
    Cell Significance Index: -34.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6434
    Cell Significance Index: -9.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6533
    Cell Significance Index: -12.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6554
    Cell Significance Index: -14.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6746
    Cell Significance Index: -14.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6803
    Cell Significance Index: -17.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7059
    Cell Significance Index: -12.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7981
    Cell Significance Index: -32.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8379
    Cell Significance Index: -24.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8640
    Cell Significance Index: -38.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9353
    Cell Significance Index: -26.6900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9612
    Cell Significance Index: -12.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EIF4G1 is a member of the eukaryotic translation initiation factor 4 (eIF4) family, which plays a central role in the initiation of translation. The protein encoded by EIF4G1 is a gamma subunit that associates with the eIF4E protein to form the eIF4E-eIF4G complex, which is essential for the recruitment of the 43S ribosomal subunit to the mRNA cap. EIF4G1 also interacts with other proteins, such as eIF4A and eIF3, to regulate the translation of specific mRNAs. The EIF4G1 protein has several key characteristics that distinguish it from other eIF4 family members. These include: * High affinity for the mRNA cap, which is essential for the recruitment of the 43S ribosomal subunit * Ability to interact with eIF4E and eIF3 to regulate translation initiation * Role in regulating the translation of specific mRNAs, including those involved in immune responses and neuronal development **Pathways and Functions** EIF4G1 is involved in multiple cellular pathways and processes, including: 1. **Translation initiation**: EIF4G1 plays a critical role in the assembly of the eukaryotic translation initiation complex, which is responsible for translating mRNA into proteins. 2. **Antiviral mechanism**: EIF4G1 is involved in the regulation of antiviral gene expression, including the translation of interferon-stimulated genes (ISGs) that are activated in response to viral infections. 3. **Immune response**: EIF4G1 is highly expressed in immune cells, such as plasmablasts and goblet cells, where it plays a role in regulating the translation of immune-related mRNAs. 4. **Neurogenesis**: EIF4G1 is involved in the regulation of neuronal development and differentiation, including the translation of mRNAs that are essential for neuronal growth and survival. 5. **Cellular stress response**: EIF4G1 is involved in the regulation of cellular stress response, including the translation of mRNAs that are activated in response to endoplasmic reticulum stress. **Clinical Significance** Dysregulation of EIF4G1 has been implicated in various diseases, including: 1. **Cancer**: EIF4G1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it is thought to contribute to tumorigenesis. 2. **Neurological disorders**: EIF4G1 is involved in the regulation of neuronal development and function, and dysregulation of this gene has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: EIF4G1 is involved in the regulation of antiviral gene expression, and dysregulation of this gene has been implicated in viral infections such as HIV and influenza. In conclusion, EIF4G1 is a critical gene that plays a central role in regulating protein synthesis and cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and response to environmental stimuli.

Genular Protein ID: 2017758663

Symbol: IF4G1_HUMAN

Name: Eukaryotic translation initiation factor 4 gamma 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1429670

Title: Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma.

PubMed ID: 1429670

DOI: 10.1016/s0021-9258(18)50080-6

PubMed ID: 9857202

Title: A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.

PubMed ID: 9857202

DOI: 10.1093/emboj/17.24.7480

PubMed ID: 9418880

Title: A novel functional human eukaryotic translation initiation factor 4G.

PubMed ID: 9418880

DOI: 10.1128/mcb.18.1.334

PubMed ID: 12052860

Title: Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons.

PubMed ID: 12052860

DOI: 10.1128/mcb.22.13.4499-4511.2002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9755181

Title: Rotavirus RNA binding protein NSP3, interacts with eIF-4GI and evicts the poly(A) binding protein from eIF4F.

PubMed ID: 9755181

DOI: 10.1093/emboj/17.19.5811

PubMed ID: 9372926

Title: Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.

PubMed ID: 9372926

DOI: 10.1128/mcb.17.12.6940

PubMed ID: 7651417

Title: The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.

PubMed ID: 7651417

DOI: 10.1128/mcb.15.9.4990

PubMed ID: 8396129

Title: Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

PubMed ID: 8396129

DOI: 10.1016/s0021-9258(19)36499-3

PubMed ID: 7935836

Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

PubMed ID: 7935836

DOI: 10.1038/371762a0

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 8961935

Title: A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases.

PubMed ID: 8961935

DOI: 10.1021/bi961864t

PubMed ID: 9755863

Title: Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex.

PubMed ID: 9755863

DOI: 10.1016/s0014-5793(98)01027-8

PubMed ID: 10872469

Title: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

PubMed ID: 10872469

DOI: 10.1146/annurev.biochem.68.1.913

PubMed ID: 9878069

Title: Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.

PubMed ID: 9878069

DOI: 10.1093/emboj/18.1.270

PubMed ID: 10996799

Title: Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation.

PubMed ID: 10996799

DOI: 10.1016/s0960-9822(00)00701-6

PubMed ID: 10970864

Title: Multiple portions of poly(A)-binding protein stimulate translation in vivo.

PubMed ID: 10970864

DOI: 10.1093/emboj/19.17.4723

PubMed ID: 11034318

Title: Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro.

PubMed ID: 11034318

DOI: 10.1016/s0014-5793(00)01928-1

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 15314025

Title: Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting.

PubMed ID: 15314025

DOI: 10.1101/gad.1212504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16513844

Title: Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18.

PubMed ID: 16513844

DOI: 10.1093/nar/gkj519

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17284590

Title: Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.

PubMed ID: 17284590

DOI: 10.1073/pnas.0611015104

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18799579

Title: Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

PubMed ID: 18799579

DOI: 10.1128/jvi.00872-08

PubMed ID: 17984221

Title: Proline-rich transcript in brain protein induces stress granule formation.

PubMed ID: 17984221

DOI: 10.1128/mcb.01226-07

PubMed ID: 18025107

Title: SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.

PubMed ID: 18025107

DOI: 10.1128/mcb.01500-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21576361

Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.

PubMed ID: 21576361

DOI: 10.1128/mcb.05589-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22872150

Title: DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.

PubMed ID: 22872150

DOI: 10.1038/emboj.2012.220

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24423872

Title: AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.

PubMed ID: 24423872

DOI: 10.1093/nar/gkt1379

PubMed ID: 29062139

Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

PubMed ID: 29062139

DOI: 10.1038/s41598-017-14262-7

PubMed ID: 29987188

Title: Dynamic interaction of eukaryotic initiation factor 4G1 (eIF4G1) with eIF4E and eIF1 underlies scanning-dependent and -independent translation.

PubMed ID: 29987188

DOI: 10.1128/mcb.00139-18

PubMed ID: 31403400

Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.

PubMed ID: 31403400

DOI: 10.7554/elife.46681

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 26740508

Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.

PubMed ID: 26740508

DOI: 10.1136/jmedgenet-2015-103568

PubMed ID: 12086624

Title: Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.

PubMed ID: 12086624

DOI: 10.1016/s1097-2765(02)00555-5

PubMed ID: 16698552

Title: Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.

PubMed ID: 16698552

DOI: 10.1016/j.str.2006.03.012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21907011

Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.

PubMed ID: 21907011

DOI: 10.1016/j.ajhg.2011.08.009

Sequence Information:

  • Length: 1599
  • Mass: 175491
  • Checksum: 324088B60863DA34
  • Sequence:
  • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH FYPSRAQPPS 
    SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ GAYYIPGQGR STYVVPTQQY 
    PVQPGAPGFY PGASPTEFGT YAGAYYPAQG VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI 
    RIRDPNQGGK DITEEIMSGA RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI 
    IADRPGLPGP EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES 
    TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP LASHTVEIHE 
    PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP EELLNGAPSP PAVDLSPVSE 
    PEEQAKEVTA SMAPPTIPSA TPATAPSATS PAQEEEMEEE EEEEEGEAGE AGEAESEKGG 
    EELLPPESTP IPANLSQNLE AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA 
    VPEVENQPPA GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ 
    WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR PLDPTRLQGI 
    NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG PRRSQQGPRK EPRKIIATVL 
    MTEDIKLNKA EKAWKPSSKR TAADKDRGEE DADGSKTQDL FRRVRSILNK LTPQMFQQLM 
    KQVTQLAIDT EERLKGVIDL IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR 
    KLLLNRCQKE FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK 
    FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK AKPRMDQYFN 
    QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK TIDQIHKEAE MEEHREHIKV 
    QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG GWNTVPISKG SRPIDTSRLT KITKPGSIDS 
    NNQLFAPGGR LSWGKGSSGG SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV 
    VQRSSLSRER GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ 
    PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII EEYLHLNDMK 
    EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL LHQLLCAGHL STAQYYQGLY 
    EILELAEDME IDIPHVWLYL AELVTPILQE GGVPMGELFR EITKPLRPLG KAASLLLEIL 
    GLLCKSMGPK KVGTLWREAG LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS 
    EELNRQLEKL LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD 
    VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY DEDVVKEDAF 
    YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN

Genular Protein ID: 2417510356

Symbol: B2RU06_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1606
  • Mass: 176175
  • Checksum: 0A8B1B889D6D7A8D
  • Sequence:
  • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP 
    SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ ISYPASQGAY YIPGQGRSTY 
    VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP 
    KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD 
    DRSQGAIIAD RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
    QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS PLQAPTPLAS 
    HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP IAPTAQPEEL LNGAPSPPAV 
    DLSPVSEPEE QAKEVTASVA PPTIPSATPA TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE 
    AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA 
    FKEANPAVPE VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
    YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK ANKTPLRPLD 
    PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP RGPAGLGPRR SQQGPRKEPR 
    KIIATVLMTE DIKLNKAEKA WKPSSKRTAA DKDRGEEDAD GSKTQDLFRR VRSILNKLTP 
    QMFQQLMKQV TQLAIDTEER LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP 
    TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
    RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFEKAKP 
    RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR RGDQGPKTID QIHKEAEMEE 
    HREHIKVQQL MAKGSDKRRG GPPGPPISRG LPLVDDGGWN TVPISKGSRP IDTSRLTKIT 
    KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE 
    STDNRRVVQR SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
    SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE KKSKAIIEEY 
    LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA REHMGQLLHQ LLCAGHLSTA 
    QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL VTPILQEGGV PMGELFREIT KPLRPLGKAA 
    SLLLEILGLL CKSMGPKKVG TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP 
    GQRALPSEEL NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
    ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR MFFDALYDED 
    VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE EESDHN

Genular Protein ID: 3361545984

Symbol: O95065_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 230
  • Mass: 24382
  • Checksum: 9082E3BF75E07BBF
  • Sequence:
  • PEPGVPGWGV GTPRPKQLAP FVIREPGASE TWNFRSGWSG APRSQVDTLT SQPQALGCPE 
    PVGRTVDLFL IEGHFYPSRA QPPSSAASRV QSAAPARPGP AAHVYPAGSQ VMMIPSQISY 
    PASQGAYYIP GQGRSTYVVP TQQYPVQPGA PGFYPGASPT EFGTYAGAYY PAQGVQQFPT 
    GVAPAPVLMN QPPQIAPKRE RKTIRIRDPN QGGKDITEEI MSGARTASTP

Genular Protein ID: 2922594711

Symbol: B4DSI9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1512
  • Mass: 166582
  • Checksum: 790466ADA55CBC6D
  • Sequence:
  • MMIPSQISYP ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP GFYPGASPTE FGTYAGAYYP 
    AQGVQQFPTG VAPAPVLMNQ PPQIAPKRER KTIRIRDPNQ GGKDITEEIM SGARTASTPT 
    PPQTGGGLEP QANGETPQVA VIVRPDDRSQ GAIIADRPGL PGPEHSPSES QPSSPSPTPS 
    PSPVLEPGSE PNLAVLSIPG DTMTTIQMSV EESTPISRET GEPYRLSPEP TPLAEPILEV 
    EVTLSKPVPE SEFSSSPLQA PTPLASHTVE IHEPNGMVPS EDLEPEVESS PELAPPPACP 
    SESPVPIAPT AQPEELLNGA PSPPAVDLSP VSEPEEQAKE VTASMAPPTI PSATPATAPS 
    ATSPAQEEEM EEEEEEEEGE AGEAGEAESE KGGEELLPPE STPIPANLSQ NLEAAAATQV 
    AVSVPKRRRK IKELNKKEAV GDLLDAFKEA NPAVPEVENQ PPAGSNPGPE SEGSGVPPRP 
    EEADETWDSK EDKIHNAENI QPGEQKYEYK SDQWKPLNLE EKKRYDREFL LGFQFIFASM 
    QKPEGLPHIS DVVLDKANKT PLRPLDPTRL QGINCGPDFT PSFANLGRTT LSTRGPPRGG 
    PGGELPRGPA GLGPRRSQQG PRKEPRKIIA TVLMTEDIKL NKAEKAWKPS SKRTPADKDR 
    GEEDADGSKT QDLFRRVRSI LNKLTPQMFQ QLMKQVTQLA IDTEERLKGV IDLIFEKAIS 
    EPNFSVAYAN MCRCLMALKV PTTEKPTVTV NFRKLLLNRC QKEFEKDKDD DEVFEKKQKE 
    MDEAATAEER GRLKEELEEA RDIARRRSLG NIKFIGELFK LKMLTEAIMH DCVVKLLKNH 
    DEESLECLCR LLTTIGKDLD FEKAKPRMDQ YFNQMEKIIK EKKTSSRIRF MLQDVLNLRG 
    SNWVPRRGDQ GPKTIDQIHK EAEMEEHREH IKVQQLMAKG SDKRRGGPPG PPISRGLPLV 
    DDGGWNTVPI SKGSRPIDTS RLTKITKPGS IDSNNQLFAP GGRLSWGKGS SGGSGAKPSD 
    AASEAARPAT STLNRFSALQ QAVPTESTDN RRVVQRSSLS RERGEKAGDR GDRLERSERG 
    GDRGDRLDRA RTPATKRSFS KEVEERSRER PSQPEGLRKA ASLTEDRDRG RDAVKREAAL 
    PPVSPLKAAL SEEELEKKSK AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGVESTL 
    ERSAIAREHM GQLLHQLLCA GHLSTAQYYQ GLYEILELAE DVEIDIPHVW LYLAELVTPI 
    LQEGGVPMGE LFREITKPLR PLGKAASLLL EILGLLCKSM GPKKVGTLWR EAGLSWKEFL 
    PEGQDIGAFV AEQKVEYTLG EESEAPGQRA LPSEELNRQL EKLLKEGSSN QRVFDWIEAN 
    LSEQQIVSNT LVRALMTAVC YSAIIFETPL RVDVAVLKAR AKLLQKYLCD EQKELQALYA 
    LQALVVTLEQ PPNLLRMFFD ALYDEDVVKE DAFYSWESSK DPAEQQGKGV ALKSVTAFFK 
    WLREAEEESD HN

Genular Protein ID: 1213909839

Symbol: Q96I65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 645
  • Mass: 72201
  • Checksum: DD257232574A45B8
  • Sequence:
  • MDQYFNQMEK IIKEKKTSSR IRFMLQDVLD LRGSNWVPRR GDQGPKTIDQ IHKEAEMEEH 
    REHIKVQQLM AKGSDKRRGG PPGPPISRGL PLVDDGGWNT VPISKGSRPI DTSRLTKITK 
    PGSIDSNNQL FAPGGRLSWG KGSSGGSGAK PSDAASEAAR PATSTLNRFS ALQQAVPTES 
    TDNRRVVQRS SLSRERGEKA GDRGDRLERS ERGGDRGDRL DRARTPATKR SFSKEVEERS 
    RERPSQPEGL RKAASLTEDR DRGRDAVKRE AALPPVSPLK AALSEEELEK KSKAIIEEYL 
    HLNDMKEAVQ CVQELASPSL LFIFVRHGVE STLERSAIAR EHMGQLLHQL LCAGHLSTAQ 
    YYQGLYEILE LAEDMEIDIP HVWLYLAELV TPILQEGGVP MGELFREITK PLRPLGKAAS 
    LLLEILGLLC KSMGPKKVGT LWREAGLSWK EFLPEGQDIG AFVAEQKVEY TLGEESEAPG 
    QRALPSEELN RQLEKLLKEG SSNQRVFDWI EANLSEQQIV SNTLVRALMT AVCYSAIIFE 
    TPLRVDVAVL KARAKLLQKY LCDEQKELQA LYALQALVVT LEQPPNLLRM FFDALYDEDV 
    VKEDAFYSWE SSKDPAEQQG KGVALKSVTA FFKWLREAEE ESDHN

Genular Protein ID: 596026238

Symbol: B2RU10_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1606
  • Mass: 176207
  • Checksum: FD3BD97634837A9D
  • Sequence:
  • MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG GFRSLQHFYP 
    SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ ISYPASQGAY YIPGQGRSTY 
    VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP 
    KRERKTIRIR DPNQGGKDIT EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD 
    DRSQGAIIAD RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
    QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS PLQAPTPLAS 
    HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP IAPTAQPEEL LNGAPSPPAV 
    DLSPVSEPEE QAKEVTASMA PPTIPSATPA TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE 
    AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA 
    FKEANPAVPE VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
    YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK ANKTPLRPLD 
    PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP RGPAGLGPRR SQQGPRKEPR 
    KIIATVLMTE DIKLNKAEKA WKPSSKRTAA DKDRGEEDAD GSKTQDLFRR VRSILNKLTP 
    QMFQQLMKQV TQLAIDTEER LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP 
    TVTVNFRKLL LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
    RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFEKAKP 
    RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR RGDQGPKTID QIHKEAEMEE 
    HREHIKVQQL MAKGSDKRRG GPPGPPISRG LPLVDDGGWN TVPISKGSRP IDTSRLTKIT 
    KPGSIDSNNQ LFAPGGRLSW GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE 
    STDNRRVVQR SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
    SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE KKSKAIIEEY 
    LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA REHMGQLLHQ LLCAGHLSTA 
    QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL VTPILQEGGV PMGELFREIT KPLRPLGKAA 
    SLLLEILGLL CKSMGPKKVG TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP 
    GQRALPSEEL NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
    ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR MFFDALYDED 
    VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE EESDHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.