Details for: ELK3

Gene ID: 2004

Symbol: ELK3

Ensembl ID: ENSG00000111145

Description: ETS transcription factor ELK3

Associated with

  • Angiogenesis
    (GO:0001525)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Purine-rich negative regulatory element binding
    (GO:0032422)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction
    (GO:0007165)
  • Wound healing
    (GO:0042060)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.94
    Marker Score: 25795
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.41
    Marker Score: 1361
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.32
    Marker Score: 6656
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.26
    Marker Score: 3290
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.08
    Marker Score: 1185
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.04
    Marker Score: 4083
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.85
    Marker Score: 449
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.65
    Marker Score: 1948
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.6
    Marker Score: 1503
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.57
    Marker Score: 13609
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.56
    Marker Score: 489
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.56
    Marker Score: 1410
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.54
    Marker Score: 371
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167763
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.44
    Marker Score: 899
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.44
    Marker Score: 1290
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.37
    Marker Score: 1466
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.35
    Marker Score: 288
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.32
    Marker Score: 6496.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.32
    Marker Score: 1040
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3
    Marker Score: 44254
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.29
    Marker Score: 2450
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.27
    Marker Score: 756
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.26
    Marker Score: 294
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.26
    Marker Score: 294
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.23
    Marker Score: 1290
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.22
    Marker Score: 2071
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.21
    Marker Score: 826
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.2
    Marker Score: 468
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.2
    Marker Score: 1034
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.18
    Marker Score: 4053
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18396
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.16
    Marker Score: 579
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.12
    Marker Score: 1203
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.1
    Marker Score: 341
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.09
    Marker Score: 516
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.08
    Marker Score: 536
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.08
    Marker Score: 296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.04
    Marker Score: 624
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.04
    Marker Score: 2635
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1
    Marker Score: 1075
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71679
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47902
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 848
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5537
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.91
    Marker Score: 2709
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.9
    Marker Score: 1238
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.9
    Marker Score: 565
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.89
    Marker Score: 2175.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.89
    Marker Score: 896
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.89
    Marker Score: 981
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.89
    Marker Score: 194
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.88
    Marker Score: 443
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.87
    Marker Score: 428
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1641
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.85
    Marker Score: 354
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4778
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.83
    Marker Score: 791
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.82
    Marker Score: 7036
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.82
    Marker Score: 2005
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 262
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.81
    Marker Score: 1015.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.79
    Marker Score: 1218
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.78
    Marker Score: 918
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.78
    Marker Score: 1127
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.77
    Marker Score: 1371
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 644
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 362
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.75
    Marker Score: 10056
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.74
    Marker Score: 1201
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.74
    Marker Score: 166
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.73
    Marker Score: 193
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.71
    Marker Score: 775
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.71
    Marker Score: 2979
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.71
    Marker Score: 39702
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2975
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 915
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.71
    Marker Score: 288
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 848
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.7
    Marker Score: 177
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.7
    Marker Score: 173
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.69
    Marker Score: 223
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.68
    Marker Score: 162
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.68
    Marker Score: 459
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.68
    Marker Score: 652
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.67
    Marker Score: 510
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.67
    Marker Score: 155
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.67
    Marker Score: 479

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Other Information

**Key characteristics:** * ELK3 is a transcription factor belonging to the ETS family of proteins. * It is a key regulator of gene expression, modulating the activity of other transcription factors. * ELK3 is involved in the regulation of vascular development, cell migration, and inflammation. * It is a key regulator of angiogenesis, promoting the formation of new blood vessels and the growth of new tissues. * It is also involved in cell differentiation, promoting the development of specific cell types. * ELK3 is a key regulator of inflammation, promoting the production of inflammatory cytokines and chemokines. **Pathways and functions:** * ELK3 is a key regulator of angiogenesis. It promotes the formation of new blood vessels by binding to specific DNA sequences in the promoters of endothelial genes. * It also regulates cell migration and invasion by promoting the activation of pro-angiogenic transcription factors. * ELK3 is involved in the regulation of cell differentiation. It promotes the development of endothelial cells from progenitor cells and suppresses the development of other cell types. * It is also involved in the regulation of inflammation. It promotes the production of inflammatory cytokines and chemokines, and it inhibits the production of anti-inflammatory cytokines. **Clinical significance:** * Mutations in the ELK3 gene have been linked to various human diseases, including cancer, cardiovascular disease, and inflammatory diseases. * The development of anti-ELK3 antibodies is being investigated as a potential treatment for these diseases. **Additional notes:** * ELK3 is a highly conserved protein, with similar genes found in other species. * It is a key regulator of angiogenesis, making it a potential target for cancer therapy. * ELK3 is a complex protein that interacts with a variety of other transcription factors.

Genular Protein ID: 4154422307

Symbol: ELK3_HUMAN

Name: ETS domain-containing protein Elk-3

UniProtKB Accession Codes:

P41970 B2R6S6 Q6FG57 Q6GU29 Q9UD17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7958835

Title: Net, a new ets transcription factor that is activated by Ras.

PubMed ID: 7958835

DOI: 10.1101/gad.8.13.1502

PubMed ID: 7540136

Title: Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

PubMed ID: 7540136

DOI: 10.1002/j.1460-2075.1995.tb07257.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 407
  • Mass: 44240
  • Checksum: DD4515270ECED1E3
  • Sequence:
    • MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS 
RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI SRESLLLQDS DCKASPEGRE 
AHKHGLAALR STSRNEYIHS GLYSSFTINS LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR 
TVIRFVTNKT DKHVTRPVVS LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS 
SRSPSLSPNS PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS 
APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI HFWSSLSPVA 
PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL SSNSQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.