Details for: ELK3

Gene ID: 2004

Symbol: ELK3

Ensembl ID: ENSG00000111145

Description: ETS transcription factor ELK3

Associated with

  • Angiogenesis
    (GO:0001525)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Purine-rich negative regulatory element binding
    (GO:0032422)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction
    (GO:0007165)
  • Wound healing
    (GO:0042060)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.9325
    Cell Significance Index: -34.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.0180
    Cell Significance Index: -31.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.6083
    Cell Significance Index: -34.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.5619
    Cell Significance Index: -28.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.0048
    Cell Significance Index: -33.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.1459
    Cell Significance Index: -34.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9243
    Cell Significance Index: -28.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.9369
    Cell Significance Index: -34.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4680
    Cell Significance Index: -33.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.4647
    Cell Significance Index: -27.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7556
    Cell Significance Index: -34.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6441
    Cell Significance Index: -26.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.8945
    Cell Significance Index: 254.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.3035
    Cell Significance Index: 48.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.6645
    Cell Significance Index: 52.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.5661
    Cell Significance Index: 27.6800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2398
    Cell Significance Index: 7.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7740
    Cell Significance Index: 153.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7642
    Cell Significance Index: 21.9100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6224
    Cell Significance Index: 4.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5598
    Cell Significance Index: 66.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5437
    Cell Significance Index: 53.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5412
    Cell Significance Index: 3.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5406
    Cell Significance Index: 10.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5279
    Cell Significance Index: 476.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3609
    Cell Significance Index: 16.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3249
    Cell Significance Index: 52.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2888
    Cell Significance Index: 7.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2497
    Cell Significance Index: 29.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2201
    Cell Significance Index: 23.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2020
    Cell Significance Index: 40.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1882
    Cell Significance Index: 1.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1779
    Cell Significance Index: 97.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1435
    Cell Significance Index: 17.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1224
    Cell Significance Index: 84.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0841
    Cell Significance Index: 37.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0775
    Cell Significance Index: 14.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0694
    Cell Significance Index: 8.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0601
    Cell Significance Index: 113.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0585
    Cell Significance Index: 8.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0545
    Cell Significance Index: 3.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0344
    Cell Significance Index: 0.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0265
    Cell Significance Index: 3.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0017
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0101
    Cell Significance Index: -0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0117
    Cell Significance Index: -2.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0122
    Cell Significance Index: -22.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0165
    Cell Significance Index: -5.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0239
    Cell Significance Index: -32.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0261
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0268
    Cell Significance Index: -19.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0357
    Cell Significance Index: -20.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0385
    Cell Significance Index: -6.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0399
    Cell Significance Index: -29.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0413
    Cell Significance Index: -31.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0564
    Cell Significance Index: -25.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0600
    Cell Significance Index: -1.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0816
    Cell Significance Index: -3.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0871
    Cell Significance Index: -6.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0979
    Cell Significance Index: -28.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1232
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1305
    Cell Significance Index: -27.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1590
    Cell Significance Index: -8.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1617
    Cell Significance Index: -4.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1694
    Cell Significance Index: -24.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1960
    Cell Significance Index: -20.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1983
    Cell Significance Index: -22.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2005
    Cell Significance Index: -11.2500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2028
    Cell Significance Index: -1.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2059
    Cell Significance Index: -9.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2206
    Cell Significance Index: -3.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2436
    Cell Significance Index: -17.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2715
    Cell Significance Index: -28.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2871
    Cell Significance Index: -32.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2973
    Cell Significance Index: -4.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3090
    Cell Significance Index: -23.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3095
    Cell Significance Index: -16.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3149
    Cell Significance Index: -8.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3497
    Cell Significance Index: -9.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3588
    Cell Significance Index: -24.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3732
    Cell Significance Index: -24.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3733
    Cell Significance Index: -6.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3734
    Cell Significance Index: -22.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3906
    Cell Significance Index: -17.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3971
    Cell Significance Index: -31.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4413
    Cell Significance Index: -6.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4520
    Cell Significance Index: -12.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4859
    Cell Significance Index: -14.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5059
    Cell Significance Index: -10.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5152
    Cell Significance Index: -19.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5409
    Cell Significance Index: -7.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5555
    Cell Significance Index: -14.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5648
    Cell Significance Index: -35.6000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.6343
    Cell Significance Index: -6.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6619
    Cell Significance Index: -21.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6924
    Cell Significance Index: -36.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELK3 is a member of the ETS family of transcription factors, characterized by the presence of an ETS domain, which is crucial for DNA binding and transcriptional regulation. The ELK3 protein is primarily expressed in endothelial cells, fibroblasts, and immune cells, suggesting its involvement in various cellular processes, including angiogenesis and cell differentiation. ELK3 is also involved in the regulation of transcription by RNA polymerase II, indicating its role in gene expression and transcriptional control. **Pathways and Functions:** ELK3 is involved in several key pathways, including: 1. **Angiogenesis**: ELK3 promotes angiogenesis by regulating the expression of genes involved in vascular endothelial cell growth and differentiation. 2. **Cell Differentiation**: ELK3 plays a crucial role in the differentiation of various cell types, including endothelial cells, fibroblasts, and immune cells. 3. **Transcriptional Regulation**: ELK3 regulates transcription by interacting with RNA polymerase II and other transcription factors, influencing the expression of genes involved in various cellular processes. 4. **Wound Healing**: ELK3 is involved in the regulation of wound healing by promoting the expression of genes involved in angiogenesis and tissue repair. **Clinical Significance:** The ELK3 gene has been implicated in various immunological disorders, including: 1. **Cancer**: ELK3 is overexpressed in several types of cancer, including lung, breast, and prostate cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Vascular Diseases**: ELK3 is involved in the pathogenesis of vascular diseases, including atherosclerosis and hypertension, by regulating angiogenesis and endothelial cell function. 3. **Immune Disorders**: ELK3 is involved in the regulation of immune cell function and differentiation, suggesting its role in autoimmune and inflammatory disorders. 4. **Neurological Disorders**: ELK3 is implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, by regulating transcriptional programs involved in neuronal differentiation and survival. In conclusion, the ELK3 gene plays a crucial role in immunological regulation and disease pathogenesis, particularly in the context of angiogenesis, cell differentiation, and transcriptional regulation. Further research is necessary to elucidate the specific mechanisms by which ELK3 contributes to immunological disorders and to explore potential therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 4154422307

Symbol: ELK3_HUMAN

Name: ETS domain-containing protein Elk-3

UniProtKB Accession Codes:

P41970 B2R6S6 Q6FG57 Q6GU29 Q9UD17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7958835

Title: Net, a new ets transcription factor that is activated by Ras.

PubMed ID: 7958835

DOI: 10.1101/gad.8.13.1502

PubMed ID: 7540136

Title: Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

PubMed ID: 7540136

DOI: 10.1002/j.1460-2075.1995.tb07257.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 407
  • Mass: 44240
  • Checksum: DD4515270ECED1E3
  • Sequence:
    • MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS 
RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI SRESLLLQDS DCKASPEGRE 
AHKHGLAALR STSRNEYIHS GLYSSFTINS LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR 
TVIRFVTNKT DKHVTRPVVS LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS 
SRSPSLSPNS PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS 
APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI HFWSSLSPVA 
PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL SSNSQKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.