Details for: ELN

Gene ID: 2006

Symbol: ELN

Ensembl ID: ENSG00000049540

Description: elastin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.1516
    Cell Significance Index: -23.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.2669
    Cell Significance Index: -23.2600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.3178
    Cell Significance Index: 51.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9604
    Cell Significance Index: -23.5200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.7787
    Cell Significance Index: 22.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5962
    Cell Significance Index: 50.6700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.0383
    Cell Significance Index: 29.2700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 2.0102
    Cell Significance Index: 11.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5464
    Cell Significance Index: 24.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.2962
    Cell Significance Index: 65.5000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1709
    Cell Significance Index: 15.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7367
    Cell Significance Index: 15.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5390
    Cell Significance Index: 15.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5240
    Cell Significance Index: 187.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3513
    Cell Significance Index: 34.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3243
    Cell Significance Index: 44.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3093
    Cell Significance Index: 16.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2959
    Cell Significance Index: 267.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2748
    Cell Significance Index: 373.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2188
    Cell Significance Index: 6.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1822
    Cell Significance Index: 29.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1674
    Cell Significance Index: 31.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1596
    Cell Significance Index: 27.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1144
    Cell Significance Index: 176.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1081
    Cell Significance Index: 1.9100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0977
    Cell Significance Index: 1.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0883
    Cell Significance Index: 9.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0874
    Cell Significance Index: 55.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0753
    Cell Significance Index: 141.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0622
    Cell Significance Index: 12.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0477
    Cell Significance Index: 6.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0397
    Cell Significance Index: 73.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0325
    Cell Significance Index: 14.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0293
    Cell Significance Index: 1.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0271
    Cell Significance Index: 0.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0057
    Cell Significance Index: 0.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0111
    Cell Significance Index: -0.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0159
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0280
    Cell Significance Index: -21.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0297
    Cell Significance Index: -4.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0325
    Cell Significance Index: -23.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0357
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0371
    Cell Significance Index: -27.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0390
    Cell Significance Index: -21.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0418
    Cell Significance Index: -18.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0491
    Cell Significance Index: -27.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0505
    Cell Significance Index: -3.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0631
    Cell Significance Index: -4.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0682
    Cell Significance Index: -12.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0837
    Cell Significance Index: -3.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0871
    Cell Significance Index: -25.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1237
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1310
    Cell Significance Index: -27.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1312
    Cell Significance Index: -16.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1324
    Cell Significance Index: -3.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1633
    Cell Significance Index: -19.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1707
    Cell Significance Index: -3.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1728
    Cell Significance Index: -10.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1936
    Cell Significance Index: -6.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1940
    Cell Significance Index: -25.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1981
    Cell Significance Index: -22.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2143
    Cell Significance Index: -22.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2147
    Cell Significance Index: -21.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2269
    Cell Significance Index: -17.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2434
    Cell Significance Index: -5.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2651
    Cell Significance Index: -18.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2752
    Cell Significance Index: -7.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2823
    Cell Significance Index: -13.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2952
    Cell Significance Index: -2.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3015
    Cell Significance Index: -23.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3200
    Cell Significance Index: -21.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3263
    Cell Significance Index: -24.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3309
    Cell Significance Index: -5.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3660
    Cell Significance Index: -20.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3664
    Cell Significance Index: -17.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3849
    Cell Significance Index: -20.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3922
    Cell Significance Index: -25.3000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3990
    Cell Significance Index: -5.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4187
    Cell Significance Index: -6.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4312
    Cell Significance Index: -27.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4414
    Cell Significance Index: -9.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4475
    Cell Significance Index: -10.8400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4637
    Cell Significance Index: -4.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5034
    Cell Significance Index: -26.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5180
    Cell Significance Index: -10.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5459
    Cell Significance Index: -8.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5503
    Cell Significance Index: -15.3800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.5548
    Cell Significance Index: -6.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5574
    Cell Significance Index: -6.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5666
    Cell Significance Index: -25.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6525
    Cell Significance Index: -24.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6538
    Cell Significance Index: -24.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6637
    Cell Significance Index: -23.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6760
    Cell Significance Index: -23.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7464
    Cell Significance Index: -21.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7612
    Cell Significance Index: -20.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7737
    Cell Significance Index: -25.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7831
    Cell Significance Index: -24.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7870
    Cell Significance Index: -18.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein structure**: Elastin is a glycoprotein composed of 20-30 repeating units of amino acids, which form a coiled-coil structure that provides elasticity. 2. **Expression**: The ELN gene is widely expressed in various tissues, including skin, lung, heart, and blood vessels. 3. **Alternative splicing**: The ELN gene undergoes alternative splicing, resulting in multiple isoforms of the elastin protein. 4. **Post-translational modifications**: Elastin undergoes various post-translational modifications, including glycosylation and cross-linking, which contribute to its elasticity. **Pathways and Functions:** 1. **Extracellular matrix organization**: Elastin plays a critical role in the organization and structure of the extracellular matrix, particularly in tissues such as skin, lung, and blood vessels. 2. **Cell signaling**: Elastin interacts with various cell surface receptors, including integrins and growth factor receptors, to regulate cell signaling pathways. 3. **Stress fiber assembly**: Elastin is involved in the assembly of stress fibers, which are essential for cell migration and contraction. 4. **Regulation of smooth muscle cell proliferation**: Elastin inhibits the proliferation of smooth muscle cells, which is critical for maintaining vascular tone and preventing atherosclerosis. **Clinical Significance:** 1. **Atherosclerosis**: Mutations in the ELN gene have been associated with atherosclerosis, a leading cause of cardiovascular disease. 2. **Elastin deficiency**: Elastin deficiency, also known as Williams syndrome, is a rare genetic disorder characterized by supravalvular aortic stenosis, cardiovascular disease, and other systemic features. 3. **Pulmonary hypertension**: Elastin dysfunction has been implicated in pulmonary hypertension, a condition characterized by high blood pressure in the pulmonary arteries. 4. **Skin aging**: Elastin degradation and loss of elastic fibers contribute to skin aging, wrinkles, and age-related macular degeneration. In conclusion, the ELN gene plays a critical role in maintaining the structural integrity and function of connective tissues. Its dysfunction has been implicated in various diseases, including atherosclerosis, pulmonary hypertension, and skin aging. Further research is needed to fully understand the mechanisms underlying elastin-related diseases and to develop effective therapeutic strategies for their treatment.

Genular Protein ID: 2009052312

Symbol: ELN_HUMAN

Name: Elastin

UniProtKB Accession Codes:

P15502 B3KTS6 O15336 O15337 Q14233 Q14234 Q14235 Q14238 Q6P0L4 Q6ZWJ6 Q75MU5 Q7Z316 Q7Z3F5 Q9UMF5

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 71 Ensembl 10 ExpressionAtlas 1 GO 17 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 13 RNAct 1 Reactome 3 RefSeq 8 SASBDB 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3039501

Title: Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA.

PubMed ID: 3039501

DOI: 10.1073/pnas.84.16.5680

PubMed ID: 3171221

Title: Cloning of full-length elastin cDNAs from a human skin fibroblast recombinant cDNA library: further elucidation of alternative splicing utilizing exon-specific oligonucleotides.

PubMed ID: 3171221

DOI: 10.1111/1523-1747.ep12476591

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2722804

Title: Characterization of the complete human elastin gene. Delineation of unusual features in the 5'-flanking region.

PubMed ID: 2722804

DOI: 10.1016/s0021-9258(18)81876-2

PubMed ID: 9215670

Title: Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis.

PubMed ID: 9215670

DOI: 10.1093/hmg/6.7.1021

PubMed ID: 2831431

Title: Isolation and characterization of human elastin cDNAs, and age-associated variation in elastin gene expression in cultured skin fibroblasts.

PubMed ID: 2831431

PubMed ID: 8812460

Title: Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.

PubMed ID: 8812460

DOI: 10.1006/geno.1996.0469

PubMed ID: 8689688

Title: LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.

PubMed ID: 8689688

DOI: 10.1016/s0092-8674(00)80077-x

PubMed ID: 9873040

Title: Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN).

PubMed ID: 9873040

DOI: 10.1074/jbc.274.2.981

PubMed ID: 10942104

Title: Isolated supravalvular aortic stenosis: functional haploinsufficiency of the elastin gene as a result of nonsense-mediated decay.

PubMed ID: 10942104

DOI: 10.1007/s004390000285

PubMed ID: 15790312

Title: Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.

PubMed ID: 15790312

DOI: 10.1042/bj20050368

PubMed ID: 16078697

Title: Mass spectrometric characterization of human skin elastin peptides produced by proteolytic digestion with pepsin and thermitase.

PubMed ID: 16078697

DOI: 10.1016/j.chroma.2005.06.034

PubMed ID: 16161116

Title: Characterization of peptides resulting from digestion of human skin elastin with elastase.

PubMed ID: 16161116

DOI: 10.1002/prot.20643

PubMed ID: 17035250

Title: Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa.

PubMed ID: 17035250

DOI: 10.1093/hmg/ddl414

PubMed ID: 16478991

Title: Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.

PubMed ID: 16478991

DOI: 10.1128/mcb.26.5.1700-1709.2006

PubMed ID: 19570982

Title: Differential regulation of elastic fiber formation by fibulin-4 and -5.

PubMed ID: 19570982

DOI: 10.1074/jbc.m109.019364

PubMed ID: 17255108

Title: Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

PubMed ID: 17255108

DOI: 10.1074/jbc.m608204200

PubMed ID: 19194475

Title: An autosomal-recessive form of cutis laxa is due to homozygous elastin mutations, and the phenotype may be modified by a heterozygous fibulin 5 polymorphism.

PubMed ID: 19194475

DOI: 10.1038/jid.2008.450

Sequence Information:

  • Length: 786
  • Mass: 68398
  • Checksum: 4A128EC9EA2CC29F
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 
KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 
LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 
GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 
KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 
PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 
GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 
PGVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGAAGAGVL GGLVPGAPGA VPGVPGTGGV 
PGVGTPAAAA AKAAAKAAQF GLVPGVGVAP GVGVAPGVGV APGVGLAPGV GVAPGVGVAP 
GVGVAPGIGP GGVAAAAKSA AKVAAKAQLR AAAGLGAGIP GLGVGVGVPG LGVGAGVPGL 
GVGAGVPGFG AGADEGVRRS LSPELREGDP SSSQHLPSTP SSPRVPGALA AAKAAKYGAA 
VPGVLGGLGA LGGVGIPGGV VGAGPAAAAA AAKAAAKAAQ FGLVGAAGLG GLGVGGLGVP 
GVGGLGGIPP AAAAKAAKYG AAGLGGVLGG AGQFPLGGVA ARPGFGLSPI FPGGACLGKA 
CGRKRK

Genular Protein ID: 1026525800

Symbol: Q59H17_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H17

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 RefSeq 1

Sequence Information:

  • Length: 106
  • Mass: 11629
  • Checksum: 228761EADB87A94A
  • Sequence:
    • RRRPRGPESS CSCCPSSTPL GLEGSLGPFL VEFLEESFIQ RWGLEANLLS QFPEGLRVLA 
LGQGSAPSPQ LPFRGLWCLV EWLTLLQPIK LLRLALGLVV SQELVA

Genular Protein ID: 3523718750

Symbol: G5E950_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E950

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 643
  • Mass: 55643
  • Checksum: F9AD070710972A69
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 
KPLKPGLGAF PAVTFPGALV PGGVADAAAA YKAAKAGAGL GGVPGVGGLG VSAGAVVPQP 
GAGVKPGKVP GVGLPGVYPG GVLPGARFPG VGVLPGVPTG AGVKPKAPGV GPFGGPQPGV 
PLGYPIKAPK LPGYGPGGVA GAAGKAGYPT GTGVGPQAAA AAAAKAAAKF GAGAAGVLPG 
VGGAGVPGVP GAIPGIGGIA GVGTPAAAAA AAAAAKAAKY GAAAGLVPGG PGFGPGVVGV 
PGAGVPGVGV PGAGIPVVPG AGIPGAAVPG VVSPEAAAKA AAKAAKYGAR PGVGVGGIPT 
YGVGAGGFPG FGVGVGAEAQ AAAAAKAAKY GLVPGVGVAP GVGVAPGVGV APGVGLAPGV 
GVAPGVGVAP GVGVAPGIGP GGVAAAAKSA AKVAAKAQLR AAAGLGAGIP GLGVGVGVPG 
LGVGAGVPGL GVGAGVPGFG AVPGALAAAK AAKYGAAVPG VLGGLGALGG VGIPGGVVGA 
GPAAAAAAAK AAAKAAQFGL VGAAGLGGLG VGGLGVPGVG GLGGIPPAAA AKAAKYGAAG 
LGGVLGGAGQ FPLGGVAARP GFGLSPIFPG GACLGKACGR KRK

Genular Protein ID: 2408191927

Symbol: B4E3S4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3S4

Database IDs:

ARBA 6 Allergome 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 706
  • Mass: 61182
  • Checksum: 84D3B457CED67CA5
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 
KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 
LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 
GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 
KAGYPTGTGV GPQAVAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 
PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 
GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 
PGVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA 
PGVGVAPGVG VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL 
RAAAGLGAGI PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAVPGALAAA KAAKYGAAVP 
GVLGGLGALG GVGIPGGVVG AGPAAAAAAA KAAAKAAQFG LVGAAGLGGL GVGGLGVPGV 
GGLGGIPPAA AAKAAKYGVA ARPGFGLSPI FPGGACLGKA CGRKRK

Genular Protein ID: 2504256559

Symbol: G3V0G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V0G6

Database IDs:

ARBA 6 Allergome 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 700
  • Mass: 60721
  • Checksum: B611796F2E23E1F4
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL 
AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAAPSVP 
GAVVPQPGAG VKPGKVPGVG LPGVYPGGVL PGARFPGVGV LPGVPTGAGV KPKAPGVGGA 
FAGIPGVGPF GGPQPGVPLG YPIKAPKLPG GYGLPYTTGK LPYGYGPGGV AGAAGKAGYP 
TGTGVGPQAA AAAAAKAAAK FGAGAAGVLP GVGGAGVPGV PGAIPGIGGI AGVGTPAAAA 
AAAAAAKAAK YGAAAGLVPG GPGFGPGVVG VPGAGVPGVG VPGAGIPVVP GAGIPGAAVP 
GVVSPEAAAK AAAKAAKYGA RPGVGVGGIP TYGVGAGGFP GFGVGVGGIP GVAGVPGVGG 
VPGVGGVPGV GISPEAQAAA AAKAAKYGLV PGVGVAPGVG VAPGVGVAPG VGLAPGVGVA 
PGVGVAPGVG VAPGIGPGGV AAAAKSAAKV AAKAQLRAAA GLGAGIPGLG VGVGVPGLGV 
GAGVPGLGVG AGVPGFGAVP GALAAAKAAK YGAAVPGVLG GLGALGGVGI PGGVVGAGPA 
AAAAAAKAAA KAAQFGLVGA AGLGGLGVGG LGVPGVGGLG GIPPAAAAKA AKYGAAGLGG 
VLGGAGQFPL GGVAARPGFG LSPIFPGGAC LGKACGRKRK

Genular Protein ID: 789102575

Symbol: E7EN65_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EN65

Database IDs:

ARBA 6 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 714
  • Mass: 61923
  • Checksum: 0159DB68B68BAAFB
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL 
AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAGAVVP 
QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP GVGGAFAGIP 
GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG KAGYPTGTGV 
GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT PAAAAAAAAA 
AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP GAAVPGVVSP 
EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV PGVGGVPGVG 
GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA PGVGVAPGVG 
VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL RAAAGLGAGI 
PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAVPGALAAA KAAKYGAAVP GVLGGLGALG 
GVGIPGGVVG AGPAAAAAAA KAAAKAAQFG LVGAAGLGGL GVGGLGVPGV GGLGGIPPAA 
AAKAAKYGAA GLGGVLGGAG QFPLGGVAAR PGFGLSPIFP GGACLGKACG RKRK

Genular Protein ID: 3170167818

Symbol: B3KRT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRT8

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 3 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 617
  • Mass: 53630
  • Checksum: A5244FCC64986330
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL 
AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAGAVVP 
QPGAGVKPGK VPGVGLPGVY PGGVLPGVGP FGGPQPGVPL GYPIKAPKLP GGYGLPYTTG 
KLPYGYGPGG VAGAAGKAGY PTGTGVGPQA AAAAAAKAAA KFGAGAAGVL PGVGGAGVPG 
VPGAIPGIGG IAGVGTPAAA AAAAAAAKAA KYGAAAGLVP GGPGFGPGVV GVPGAGVPGV 
GVPGAGIPVV PGAGIPGAAV PGVVSPEAAA KAAAKAAKYG ARPGVGVGGI PTYGVGAGGF 
PGFGVGVGAE AQAAAAAKAA KYGLVPGVGV APGVGVAPGV GVAPGVGLAP GVGVAPGVGV 
APGVGVAPGI GPGGVAAAAK SAAKVAAKAQ LRAAAGLGAG IPGLGVGVGV PGLGVGAGVP 
GLGVGAGVPG FGAVPGALAA AKAAKYGAAV PGVLGGLGAL GGVGIPGGVV GAGPAAAAAA 
AKAAAKAAQF GLVGAAGLGG LGVGGLGVPG VGGLGGIPPA AAAKAAKYGV AARPGFGLSP 
IFPGGACLGK ACGRKRK

Genular Protein ID: 3168496785

Symbol: E7ENM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ENM0

Database IDs:

ARBA 6 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 706
  • Mass: 61154
  • Checksum: 34BF630B341E2F50
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 
KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG 
LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP 
GVGGAFAGIP GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG 
KAGYPTGTGV GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT 
PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP 
GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV 
PGVGGVPGVG GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA 
PGVGVAPGVG VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL 
RAAAGLGAGI PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAVPGALAAA KAAKYGAAVP 
GVLGGLGALG GVGIPGGVVG AGPAAAAAAA KAAAKAAQFG LVGAAGLGGL GVGGLGVPGV 
GGLGGIPPAA AAKAAKYGVA ARPGFGLSPI FPGGACLGKA CGRKRK

Genular Protein ID: 3888874654

Symbol: Q6ZUN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZUN2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 559
  • Mass: 53787
  • Checksum: 20938FFEC5492A01
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL 
AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAAPSVP 
GAVVPQPGAG VKPGKVPGVG LPGVYPGGVL PGARFPGVGV LPGVPTGAGV KPKAPGVGGA 
FAGIPGVGPF GGPQPGVPLG YPIKAPKLPG GYGLPYTTGK LPYGYGPGGV AGAAGKAGYP 
TGTGVGPQAA AAAAAKAAAK FGAGAAGVLP GVGGAGVPGV PGAIPGIGGI AGVGTPAAAA 
AAAAAAKAAK YGAAAGLVPG GPGFGPGVVG VPGAGVPGVG VPGAGIPVVP GAGIPGAAVP 
GVVSPEAAAK AAAKAAKYGA RPGVGVGGIP TYGVGAGGFP GFGVGVGGIP GVAGVPGVGG 
SRSRRCPGSW HFPRSSGSSC RQGCQVRVSS WCRRGSWSWR GSWCRCGSWS WLGSWSWRGS 
WSWCGSWRWR GSRHWPWWSC SCSKIRCQGG CQSPAPSCSW AWCWHPWTWS WCRRPWTWSW 
CWCSWTWSWC WCSWLRGST

Genular Protein ID: 3758280446

Symbol: Q8NBI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NBI4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 643
  • Mass: 55629
  • Checksum: FDFC042617E72A69
  • Sequence:
    • MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA LGGGALGPGG 
KPLKPGLGAF PAVTFPGALV PGGVADAAAA YKAAKAGAGL GGVPGVGGLG VSAGAVVPQP 
GAGVKPGKVP GVGLPGVYPG GVLPGARFPG VGVLPGVPTG AGVKPKAPGV GPFGGPQPGV 
PLGYPIKAPK LPGYGPGGVA GAAGKAGYPT GTGVGPQAAA AAAAKAAAKF GAGAAGVLPG 
VGGAGVPGVP GAIPGIGGIA GVGTPAAAAA AAAAAKAAKY GAAAGLVPGG PGFGPGVVGV 
PGAGVPGVGV PGAGIPVVPG AGIPGAAVPG VVSPEAAAKA AAKAAKYGAR PGVGVGGIPT 
YGVGAGGFPG FGVGVGAEAQ AAAAAKAAKY GLVPGVGVAP GVGVAPGVGV APGVGLAPGV 
GVAPGVGVAP GVGVAPGIGP GGVAAAAKSA AKVAAKAQLR AAAGLGAGIP GLGVGVGVPG 
LGVGAGVPGL GVGAGVPGFG AVPGALAAAK AANYGAAVPG VLGGLGALGG VGIPGGVVGA 
GPAAAAAAAK AAAKAAQFGL VGAAGLGGLG VGGLGVPGVG GLGGIPPAAA AKAAKYGAAG 
LGGVLGGAGQ FPLGGVAARP GFGLSPIFPG GACLGKACGR KRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.