Details for: EMD

Gene ID: 2010

Symbol: EMD

Ensembl ID: ENSG00000102119

Description: emerin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 195.1201
    Cell Significance Index: -30.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.5627
    Cell Significance Index: -33.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.4679
    Cell Significance Index: -37.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.1123
    Cell Significance Index: -35.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.2501
    Cell Significance Index: -38.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.5659
    Cell Significance Index: -38.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.4656
    Cell Significance Index: -35.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.0927
    Cell Significance Index: -35.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5422
    Cell Significance Index: -30.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4018
    Cell Significance Index: -37.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1097
    Cell Significance Index: -27.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6514
    Cell Significance Index: -10.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2629
    Cell Significance Index: 66.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.9954
    Cell Significance Index: 25.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8913
    Cell Significance Index: 51.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1887
    Cell Significance Index: 163.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1738
    Cell Significance Index: 138.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0584
    Cell Significance Index: 14.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9605
    Cell Significance Index: 20.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9509
    Cell Significance Index: 103.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9208
    Cell Significance Index: 10.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7409
    Cell Significance Index: 91.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7405
    Cell Significance Index: 47.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7156
    Cell Significance Index: 53.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6187
    Cell Significance Index: 32.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5870
    Cell Significance Index: 75.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5840
    Cell Significance Index: 27.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5789
    Cell Significance Index: 255.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5629
    Cell Significance Index: 307.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5557
    Cell Significance Index: 100.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5195
    Cell Significance Index: 24.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4997
    Cell Significance Index: 35.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4492
    Cell Significance Index: 31.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3767
    Cell Significance Index: 19.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3332
    Cell Significance Index: 42.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3263
    Cell Significance Index: 8.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2632
    Cell Significance Index: 7.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2559
    Cell Significance Index: 4.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2489
    Cell Significance Index: 7.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2391
    Cell Significance Index: 1.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2205
    Cell Significance Index: 44.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1931
    Cell Significance Index: 36.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1399
    Cell Significance Index: 8.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1340
    Cell Significance Index: 3.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1188
    Cell Significance Index: 11.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1133
    Cell Significance Index: 78.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1030
    Cell Significance Index: 1.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0921
    Cell Significance Index: 83.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0643
    Cell Significance Index: 120.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0607
    Cell Significance Index: 1.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0578
    Cell Significance Index: 11.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0577
    Cell Significance Index: 20.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0552
    Cell Significance Index: 2.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0055
    Cell Significance Index: 4.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0010
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0008
    Cell Significance Index: 0.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0055
    Cell Significance Index: -0.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0349
    Cell Significance Index: -15.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0416
    Cell Significance Index: -30.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0581
    Cell Significance Index: -32.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0638
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0646
    Cell Significance Index: -40.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0832
    Cell Significance Index: -9.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1066
    Cell Significance Index: -2.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1318
    Cell Significance Index: -37.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1543
    Cell Significance Index: -3.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1702
    Cell Significance Index: -19.8400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1746
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1858
    Cell Significance Index: -39.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1991
    Cell Significance Index: -6.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2248
    Cell Significance Index: -7.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2309
    Cell Significance Index: -17.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2564
    Cell Significance Index: -5.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2830
    Cell Significance Index: -29.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3226
    Cell Significance Index: -6.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3464
    Cell Significance Index: -2.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3492
    Cell Significance Index: -8.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3862
    Cell Significance Index: -30.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3975
    Cell Significance Index: -3.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3997
    Cell Significance Index: -6.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4206
    Cell Significance Index: -28.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4235
    Cell Significance Index: -26.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4879
    Cell Significance Index: -27.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5348
    Cell Significance Index: -32.7900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6052
    Cell Significance Index: -6.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6176
    Cell Significance Index: -18.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6228
    Cell Significance Index: -11.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6795
    Cell Significance Index: -8.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6884
    Cell Significance Index: -30.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7498
    Cell Significance Index: -12.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7709
    Cell Significance Index: -19.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8004
    Cell Significance Index: -30.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8420
    Cell Significance Index: -30.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: Emerin is a transmembrane protein with a long N-terminal tail and a short C-terminal tail, which anchors it to the nuclear outer membrane. 2. **Nuclear envelope localization**: Emerin is specifically localized to the nuclear outer membrane, where it interacts with various proteins to maintain the nuclear envelope's structure and function. 3. **Actin and beta-tubulin binding**: Emerin interacts with actin and beta-tubulin, which are essential components of the cytoskeleton, to regulate nuclear envelope dynamics. 4. **Cadherin binding**: Emerin interacts with cadherins, which are cell adhesion molecules, to regulate cell-cell interactions and maintain tissue architecture. 5. **Cell cycle regulation**: Emerin plays a role in regulating the cell cycle, particularly during mitosis, by interacting with proteins involved in the mitotic process. **Pathways and Functions:** 1. **Cell cycle regulation**: Emerin interacts with proteins involved in the cell cycle, including cyclins and cyclin-dependent kinases, to regulate the transition from G1 to S phase. 2. **Apoptosis regulation**: Emerin interacts with proteins involved in apoptosis, including Bcl-2 family members, to regulate programmed cell death. 3. **Immune responses**: Emerin is expressed in immune cells, including myeloid dendritic cells and T cells, where it regulates immune responses and cell signaling. 4. **Muscle development and contraction**: Emerin is expressed in skeletal muscle cells, where it regulates muscle development and contraction. 5. **Nuclear envelope dynamics**: Emerin interacts with proteins involved in nuclear envelope dynamics, including actin and beta-tubulin, to regulate nuclear envelope structure and function. **Clinical Significance:** 1. **Nuclear envelope disorders**: Mutations in the EMD gene have been associated with nuclear envelope disorders, including Emery-Dreifuss muscular dystrophy and nuclear membrane disease. 2. **Immune system disorders**: Emerin deficiency has been linked to immune system disorders, including autoimmune diseases and immunodeficiency syndromes. 3. **Cancer**: Emerin has been implicated in cancer development and progression, particularly in breast cancer and other epithelial cancers. 4. **Muscle disorders**: Emerin deficiency has been associated with muscle disorders, including muscular dystrophy and myopathy. 5. **Neurological disorders**: Emerin has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the emerin gene plays a critical role in maintaining the structural and functional integrity of the nuclear envelope, regulating cell cycle, apoptosis, and immune responses. Mutations in the EMD gene have been associated with various disorders, highlighting the importance of emerin in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms by which emerin regulates nuclear envelope dynamics and to understand the clinical significance of emerin deficiency in various diseases.

Genular Protein ID: 609188175

Symbol: EMD_HUMAN

Name: Emerin

UniProtKB Accession Codes:

P50402 Q6FI02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7894480

Title: Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy.

PubMed ID: 7894480

DOI: 10.1038/ng1294-323

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 8655156

Title: A novel emerin mutation in a Japanese patient with Emery-Dreifuss muscular dystrophy.

PubMed ID: 8655156

DOI: 10.1007/bf02281886

PubMed ID: 8595407

Title: Identification of new mutations in the Emery-Dreifuss muscular dystrophy gene and evidence for genetic heterogeneity of the disease.

PubMed ID: 8595407

DOI: 10.1093/hmg/4.10.1859

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9673989

Title: Immunocytochemical detection of emerin within the nuclear matrix.

PubMed ID: 9673989

DOI: 10.1016/s0960-8966(98)00031-5

PubMed ID: 9472006

Title: Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype.

PubMed ID: 9472006

DOI: 10.1242/jcs.111.6.781

PubMed ID: 11792822

Title: BAF is required for emerin assembly into the reforming nuclear envelope.

PubMed ID: 11792822

DOI: 10.1242/jcs.114.24.4575

PubMed ID: 12755701

Title: Emerin interacts in vitro with the splicing-associated factor, YT521-B.

PubMed ID: 12755701

DOI: 10.1046/j.1432-1033.2003.03617.x

PubMed ID: 12493765

Title: Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro.

PubMed ID: 12493765

DOI: 10.1074/jbc.m208811200

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15009215

Title: Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy.

PubMed ID: 15009215

DOI: 10.1111/j.1432-1033.2004.04007.x

PubMed ID: 15328537

Title: Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PubMed ID: 15328537

DOI: 10.1371/journal.pbio.0020231

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16858403

Title: The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

PubMed ID: 16858403

DOI: 10.1038/sj.emboj.7601230

PubMed ID: 16972941

Title: The Emery-Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A.

PubMed ID: 16972941

DOI: 10.1111/j.1742-4658.2006.05464.x

PubMed ID: 16680152

Title: The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity.

PubMed ID: 16680152

DOI: 10.1038/nature04682

PubMed ID: 17785515

Title: A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane.

PubMed ID: 17785515

DOI: 10.1083/jcb.200702026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19323649

Title: Emerin-prelamin A interplay in human fibroblasts.

PubMed ID: 19323649

DOI: 10.1042/bc20080175

PubMed ID: 19167377

Title: Involvement of an inner nuclear membrane protein, Nemp1, in Xenopus neural development through an interaction with the chromatin protein BAF.

PubMed ID: 19167377

DOI: 10.1016/j.ydbio.2008.12.038

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21610090

Title: Samp1 is functionally associated with the LINC complex and A-type lamina networks.

PubMed ID: 21610090

DOI: 10.1242/jcs.078923

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32923640

Title: The NEMP family supports metazoan fertility and nuclear envelope stiffness.

PubMed ID: 32923640

DOI: 10.1126/sciadv.abb4591

PubMed ID: 11470279

Title: Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy.

PubMed ID: 11470279

DOI: 10.1016/s0014-5793(01)02649-7

PubMed ID: 11435115

Title: Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.

PubMed ID: 11435115

DOI: 10.1016/s0969-2126(01)00611-6

PubMed ID: 10323252

Title: Changes at P183 of emerin weaken its protein-protein interactions resulting in X-linked Emery-Dreifuss muscular dystrophy.

PubMed ID: 10323252

DOI: 10.1007/s004390050946

PubMed ID: 11587540

Title: How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?

PubMed ID: 11587540

DOI: 10.1006/bbrc.2001.5708

Sequence Information:

  • Length: 254
  • Mass: 28994
  • Checksum: EB62EDD59B7A044F
  • Sequence:
    • MDNYADLSDT ELTTLLRRYN IPHGPVVGST RRLYEKKIFE YETQRRRLSP PSSSAASSYS 
FSDLNSTRGD ADMYDLPKKE DALLYQSKGY NDDYYEESYF TTRTYGEPES AGPSRAVRQS 
VTSFPDADAF HHQVHDDDLL SSSEEECKDR ERPMYGRDSA YQSITHYRPV SASRSSLDLS 
YYPTSSSTSF MSSSSSSSSW LTRRAIRPEN RAPGAGLGQD RQVPLWGQLL LFLVFVIVLF 
FIYHFMQAEE GNPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.