Details for: EPRS1

Gene ID: 2058

Symbol: EPRS1

Ensembl ID: ENSG00000136628

Description: glutamyl-prolyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.0448
    Cell Significance Index: -37.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.4652
    Cell Significance Index: -39.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.2121
    Cell Significance Index: -53.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.6288
    Cell Significance Index: -44.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.7416
    Cell Significance Index: -51.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.0912
    Cell Significance Index: -44.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.9633
    Cell Significance Index: -48.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8154
    Cell Significance Index: -50.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8283
    Cell Significance Index: -36.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3165
    Cell Significance Index: -20.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5247
    Cell Significance Index: 71.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2617
    Cell Significance Index: 253.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2443
    Cell Significance Index: 1123.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2285
    Cell Significance Index: 151.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2114
    Cell Significance Index: 11.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2078
    Cell Significance Index: 239.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1804
    Cell Significance Index: 212.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9968
    Cell Significance Index: 136.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8441
    Cell Significance Index: 43.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7590
    Cell Significance Index: 414.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7311
    Cell Significance Index: 47.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7095
    Cell Significance Index: 254.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6628
    Cell Significance Index: 34.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6106
    Cell Significance Index: 269.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5890
    Cell Significance Index: 41.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5345
    Cell Significance Index: 15.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5320
    Cell Significance Index: 367.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4972
    Cell Significance Index: 58.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4895
    Cell Significance Index: 11.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4637
    Cell Significance Index: 3.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4240
    Cell Significance Index: 10.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3140
    Cell Significance Index: 19.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2927
    Cell Significance Index: 13.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2483
    Cell Significance Index: 31.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2406
    Cell Significance Index: 12.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2230
    Cell Significance Index: 10.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2005
    Cell Significance Index: 32.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1894
    Cell Significance Index: 10.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1862
    Cell Significance Index: 31.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1580
    Cell Significance Index: 4.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1471
    Cell Significance Index: 4.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1403
    Cell Significance Index: 3.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1391
    Cell Significance Index: 17.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1225
    Cell Significance Index: 6.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1224
    Cell Significance Index: 23.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1073
    Cell Significance Index: 3.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0622
    Cell Significance Index: 4.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0184
    Cell Significance Index: 1.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0178
    Cell Significance Index: 13.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0170
    Cell Significance Index: 31.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0135
    Cell Significance Index: 0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0078
    Cell Significance Index: 5.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0245
    Cell Significance Index: -11.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0636
    Cell Significance Index: -47.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0741
    Cell Significance Index: -7.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0824
    Cell Significance Index: -46.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0938
    Cell Significance Index: -58.6000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1242
    Cell Significance Index: -1.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1533
    Cell Significance Index: -44.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1553
    Cell Significance Index: -17.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1589
    Cell Significance Index: -5.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1719
    Cell Significance Index: -24.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1959
    Cell Significance Index: -14.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2050
    Cell Significance Index: -4.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2159
    Cell Significance Index: -3.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2338
    Cell Significance Index: -23.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2434
    Cell Significance Index: -6.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2454
    Cell Significance Index: -7.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2714
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2723
    Cell Significance Index: -57.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3031
    Cell Significance Index: -5.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3311
    Cell Significance Index: -8.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3511
    Cell Significance Index: -15.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3832
    Cell Significance Index: -8.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4378
    Cell Significance Index: -16.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4553
    Cell Significance Index: -47.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4691
    Cell Significance Index: -7.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4848
    Cell Significance Index: -12.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5155
    Cell Significance Index: -40.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6221
    Cell Significance Index: -6.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6231
    Cell Significance Index: -13.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6853
    Cell Significance Index: -9.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7247
    Cell Significance Index: -15.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7299
    Cell Significance Index: -44.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7543
    Cell Significance Index: -21.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7884
    Cell Significance Index: -32.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8152
    Cell Significance Index: -21.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9580
    Cell Significance Index: -30.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9893
    Cell Significance Index: -29.1400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0075
    Cell Significance Index: -21.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0132
    Cell Significance Index: -12.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0171
    Cell Significance Index: -33.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0201
    Cell Significance Index: -12.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0479
    Cell Significance Index: -30.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0600
    Cell Significance Index: -20.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0970
    Cell Significance Index: -40.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EPRS1 is a bifunctional enzyme that exhibits two distinct activities: glutamyl-tRNA aminoacylation and prolyl-tRNA aminoacylation. It is a member of the aminoacyl-tRNA synthetase family, which is responsible for the accurate transfer of amino acids to their corresponding tRNA molecules during protein synthesis. EPRS1 is a cytosolic enzyme that interacts with its substrates, glutamate and proline, and facilitates their incorporation into tRNA molecules. **Pathways and Functions** EPRS1 is involved in various cellular processes, including: 1. **Protein synthesis**: EPRS1 plays a crucial role in the incorporation of glutamate and proline into their corresponding tRNA molecules, which are then used to synthesize proteins. 2. **Cellular response to insulin stimulus**: EPRS1 has been implicated in the regulation of glucose metabolism and insulin signaling pathways. 3. **Cellular response to type II interferon**: EPRS1 has been shown to interact with type II interferon receptors, suggesting its involvement in the regulation of immune responses. 4. **Metabolism of amino acids and derivatives**: EPRS1 is involved in the metabolism of glutamate and proline, which are essential amino acids for various cellular processes. 5. **Regulation of translation**: EPRS1 has been shown to regulate translation initiation and elongation, suggesting its involvement in the regulation of protein synthesis. **Clinical Significance** EPRS1 has been implicated in various diseases, including: 1. **Cancer**: EPRS1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Metabolic disorders**: EPRS1 has been implicated in the regulation of glucose metabolism and insulin signaling pathways, suggesting its potential role in the development of metabolic disorders, such as type 2 diabetes. 3. **Neurological disorders**: EPRS1 has been shown to interact with neurotrophic factors, suggesting its potential role in the regulation of neuronal function and development. In conclusion, EPRS1 is a bifunctional enzyme that plays a crucial role in the post-translational modification of proteins. Its involvement in various cellular processes, including protein synthesis, cellular response to insulin stimulus, and metabolism of amino acids and derivatives, suggests its potential role in the development of various diseases. Further research is needed to fully elucidate the function and clinical significance of EPRS1.

Genular Protein ID: 1878299415

Symbol: SYEP_HUMAN

Name: Bifunctional aminoacyl-tRNA synthetase

UniProtKB Accession Codes:

P07814 A0AVA9 B9EGH3 Q05BP6 Q05DF8 Q5DSM1 Q5H9S5 Q6PD57 Q86X73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CORUM 1 CPTAC 2 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 22 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 32 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 7 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1988429

Title: The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors.

PubMed ID: 1988429

DOI: 10.1016/s0021-9258(18)52315-2

PubMed ID: 3290852

Title: The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes.

PubMed ID: 3290852

DOI: 10.1093/nar/16.12.5391

PubMed ID: 1556743

Title: Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase.

PubMed ID: 1556743

DOI: 10.1007/bf00163851

PubMed ID: 10791971

Title: Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.

PubMed ID: 10791971

DOI: 10.1083/jcb.149.3.567

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15479637

Title: Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.

PubMed ID: 15479637

DOI: 10.1016/j.cell.2004.09.030

PubMed ID: 15994936

Title: A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.

PubMed ID: 15994936

DOI: 10.1158/0008-5472.can-05-0600

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131329

Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.

PubMed ID: 19131329

DOI: 10.1074/jbc.m809636200

PubMed ID: 19289464

Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.

PubMed ID: 19289464

DOI: 10.1074/jbc.m900480200

PubMed ID: 19647514

Title: Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity.

PubMed ID: 19647514

DOI: 10.1016/j.molcel.2009.05.028

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21220307

Title: Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.

PubMed ID: 21220307

DOI: 10.1073/pnas.1011275108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23071094

Title: Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

PubMed ID: 23071094

DOI: 10.1128/mcb.01168-12

PubMed ID: 24312579

Title: Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.

PubMed ID: 24312579

DOI: 10.1371/journal.pone.0081734

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28178239

Title: EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.

PubMed ID: 28178239

DOI: 10.1038/nature21380

PubMed ID: 29576217

Title: Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy.

PubMed ID: 29576217

DOI: 10.1016/j.ajhg.2018.02.011

PubMed ID: 11123902

Title: Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats.

PubMed ID: 11123902

DOI: 10.1021/bi001393h

PubMed ID: 24100331

Title: Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.

PubMed ID: 24100331

DOI: 10.1107/s0907444913020556

PubMed ID: 23263184

Title: ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.

PubMed ID: 23263184

DOI: 10.1038/nature11774

PubMed ID: 26472928

Title: Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains.

PubMed ID: 26472928

DOI: 10.1074/jbc.m115.690867

PubMed ID: 29273753

Title: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.

PubMed ID: 29273753

DOI: 10.1038/s41467-017-02201-z

PubMed ID: 37212275

Title: Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.

PubMed ID: 37212275

DOI: 10.15252/emmm.202216940

Sequence Information:

  • Length: 1512
  • Mass: 170591
  • Checksum: 2CE4311076719403
  • Sequence:
    • MATLSLTVNS GDPPLGALLA VEHVKDDVSI SVEEGKENIL HVSENVIFTD VNSILRYLAR 
VATTAGLYGS NLMEHTEIDH WLEFSATKLS SCDSFTSTIN ELNHCLSLRT YLVGNSLSLA 
DLCVWATLKG NAAWQEQLKQ KKAPVHVKRW FGFLEAQQAF QSVGTKWDVS TTKARVAPEK 
KQDVGKFVEL PGAEMGKVTV RFPPEASGYL HIGHAKAALL NQHYQVNFKG KLIMRFDDTN 
PEKEKEDFEK VILEDVAMLH IKPDQFTYTS DHFETIMKYA EKLIQEGKAY VDDTPAEQMK 
AEREQRIDSK HRKNPIEKNL QMWEEMKKGS QFGQSCCLRA KIDMSSNNGC MRDPTLYRCK 
IQPHPRTGNK YNVYPTYDFA CPIVDSIEGV THALRTTEYH DRDEQFYWII EALGIRKPYI 
WEYSRLNLNN TVLSKRKLTW FVNEGLVDGW DDPRFPTVRG VLRRGMTVEG LKQFIAAQGS 
SRSVVNMEWD KIWAFNKKVI DPVAPRYVAL LKKEVIPVNV PEAQEEMKEV AKHPKNPEVG 
LKPVWYSPKV FIEGADAETF SEGEMVTFIN WGNLNITKIH KNADGKIISL DAKLNLENKD 
YKKTTKVTWL AETTHALPIP VICVTYEHLI TKPVLGKDED FKQYVNKNSK HEELMLGDPC 
LKDLKKGDII QLQRRGFFIC DQPYEPVSPY SCKEAPCVLI YIPDGHTKEM PTSGSKEKTK 
VEATKNETSA PFKERPTPSL NNNCTTSEDS LVLYNRVAVQ GDVVRELKAK KAPKEDVDAA 
VKQLLSLKAE YKEKTGQEYK PGNPPAEIGQ NISSNSSASI LESKSLYDEV AAQGEVVRKL 
KAEKSPKAKI NEAVECLLSL KAQYKEKTGK EYIPGQPPLS QSSDSSPTRN SEPAGLETPE 
AKVLFDKVAS QGEVVRKLKT EKAPKDQVDI AVQELLQLKA QYKSLIGVEY KPVSATGAED 
KDKKKKEKEN KSEKQNKPQK QNDGQRKDPS KNQGGGLSSS GAGEGQGPKK QTRLGLEAKK 
EENLADWYSQ VITKSEMIEY HDISGCYILR PWAYAIWEAI KDFFDAEIKK LGVENCYFPM 
FVSQSALEKE KTHVADFAPE VAWVTRSGKT ELAEPIAIRP TSETVMYPAY AKWVQSHRDL 
PIKLNQWCNV VRWEFKHPQP FLRTREFLWQ EGHSAFATME EAAEEVLQIL DLYAQVYEEL 
LAIPVVKGRK TEKEKFAGGD YTTTIEAFIS ASGRAIQGGT SHHLGQNFSK MFEIVFEDPK 
IPGEKQFAYQ NSWGLTTRTI GVMTMVHGDN MGLVLPPRVA CVQVVIIPCG ITNALSEEDK 
EALIAKCNDY RRRLLSVNIR VRADLRDNYS PGWKFNHWEL KGVPIRLEVG PRDMKSCQFV 
AVRRDTGEKL TVAENEAETK LQAILEDIQV TLFTRASEDL KTHMVVANTM EDFQKILDSG 
KIVQIPFCGE IDCEDWIKKT TARDQDLEPG APSMGAKSLC IPFKPLCELQ PGAKCVCGKN 
PAKYYTLFGR SY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.