Details for: ERCC1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: pancreatic A cell (CL0000171)
Fold Change: 2.51
Marker Score: 2457.5 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.91
Marker Score: 4346 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.86
Marker Score: 3923.5 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.79
Marker Score: 2160 - Cell Name: neural cell (CL0002319)
Fold Change: 1.79
Marker Score: 862 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.78
Marker Score: 4354 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.66
Marker Score: 1867 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.65
Marker Score: 21730 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.62
Marker Score: 1710 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.61
Marker Score: 505.5 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.61
Marker Score: 918 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.59
Marker Score: 3323 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.58
Marker Score: 6091 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1.58
Marker Score: 1686 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.58
Marker Score: 508 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.57
Marker Score: 6407 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.56
Marker Score: 1727 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.56
Marker Score: 1572 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.55
Marker Score: 976 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.53
Marker Score: 3591 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.51
Marker Score: 6494.5 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.51
Marker Score: 13081 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.51
Marker Score: 1004.5 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.5
Marker Score: 1409 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.48
Marker Score: 605 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.47
Marker Score: 50108 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.46
Marker Score: 1568 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.45
Marker Score: 1536 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.45
Marker Score: 1547 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.44
Marker Score: 9389 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.44
Marker Score: 2453 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.43
Marker Score: 1680 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.41
Marker Score: 398 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.4
Marker Score: 688 - Cell Name: basal cell (CL0000646)
Fold Change: 1.4
Marker Score: 1801 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.39
Marker Score: 5148 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.37
Marker Score: 2668 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.37
Marker Score: 2488 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.36
Marker Score: 3206 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.36
Marker Score: 2004 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.36
Marker Score: 483 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.35
Marker Score: 712 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.34
Marker Score: 3660 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.34
Marker Score: 736 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.33
Marker Score: 14990.5 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.31
Marker Score: 1499 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.31
Marker Score: 13175.5 - Cell Name: club cell (CL0000158)
Fold Change: 1.3
Marker Score: 1523 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20257 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.29
Marker Score: 302 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.29
Marker Score: 450 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.28
Marker Score: 2433 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.27
Marker Score: 1570 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.25
Marker Score: 413 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.25
Marker Score: 906.5 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.25
Marker Score: 12676 - Cell Name: ciliated cell (CL0000064)
Fold Change: 1.25
Marker Score: 4293.5 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.25
Marker Score: 2210 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.24
Marker Score: 359 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.24
Marker Score: 307 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.24
Marker Score: 539 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.24
Marker Score: 3237 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.23
Marker Score: 396 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.23
Marker Score: 2151.5 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.23
Marker Score: 778 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.23
Marker Score: 42489 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.22
Marker Score: 578 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.22
Marker Score: 3048 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.22
Marker Score: 731 - Cell Name: blood cell (CL0000081)
Fold Change: 1.21
Marker Score: 14071 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.21
Marker Score: 288 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.2
Marker Score: 67062 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.2
Marker Score: 658 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.19
Marker Score: 1956.5 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.19
Marker Score: 993 - Cell Name: radial glial cell (CL0000681)
Fold Change: 1.19
Marker Score: 437 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.18
Marker Score: 933 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.18
Marker Score: 1009 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.18
Marker Score: 491 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.18
Marker Score: 802 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.17
Marker Score: 745 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.17
Marker Score: 1805 - Cell Name: enteric neuron (CL0007011)
Fold Change: 1.17
Marker Score: 621 - Cell Name: Unknown (CL0002371)
Fold Change: 1.15
Marker Score: 1222 - Cell Name: motor neuron (CL0000100)
Fold Change: 1.15
Marker Score: 682 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.15
Marker Score: 386 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.15
Marker Score: 544 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.14
Marker Score: 2149 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.13
Marker Score: 658 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.13
Marker Score: 390 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.13
Marker Score: 846 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.11
Marker Score: 244 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.11
Marker Score: 444 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.1
Marker Score: 2960 - Cell Name: peptic cell (CL0000155)
Fold Change: 1.1
Marker Score: 461 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.09
Marker Score: 742.5 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.09
Marker Score: 533.5 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.09
Marker Score: 8133 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.09
Marker Score: 380 - Cell Name: mature B cell (CL0000785)
Fold Change: 1.09
Marker Score: 797
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Other Information
Genular Protein ID: 3682969689
Symbol: ERCC1_HUMAN
Name: DNA excision repair protein ERCC-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2420469
Title: Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.
PubMed ID: 2420469
PubMed ID: 3034490
Title: Identification of DNA repair genes in the human genome.
PubMed ID: 3034490
PubMed ID: 9360634
Title: A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues.
PubMed ID: 9360634
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24036546
Title: ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform.
PubMed ID: 24036546
DOI: 10.4161/cc.26309
PubMed ID: 23514287
Title: ERCC1 isoform expression and DNA repair in non-small-cell lung cancer.
PubMed ID: 23514287
PubMed ID: 25538220
Title: USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.
PubMed ID: 25538220
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 32034146
Title: Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
PubMed ID: 32034146
PubMed ID: 16076955
Title: Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
PubMed ID: 16076955
PubMed ID: 16338413
Title: The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.
PubMed ID: 16338413
PubMed ID: 17273966
Title: First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
PubMed ID: 17273966
DOI: 10.1086/512486
PubMed ID: 23623389
Title: Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia.
PubMed ID: 23623389
Sequence Information:
- Length: 297
- Mass: 32562
- Checksum: 6FCE3615732349E5
- Sequence:
MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS IIVSPRQRGN PVLKFVRNVP WEFGDVIPDY VLGQSTCALF LSLRYHNLHP DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KARRLFDVLH EPFLKVP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.