Details for: ETFB

Gene ID: 2109

Symbol: ETFB

Ensembl ID: ENSG00000105379

Description: electron transfer flavoprotein subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.2
    Marker Score: 6752
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.08
    Marker Score: 7028
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.85
    Marker Score: 13654
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.75
    Marker Score: 9779.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.56
    Marker Score: 4243
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.55
    Marker Score: 2133
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.54
    Marker Score: 2645
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.52
    Marker Score: 21713
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.46
    Marker Score: 15690
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.41
    Marker Score: 3719.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.38
    Marker Score: 6382
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.31
    Marker Score: 3670
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.26
    Marker Score: 8368
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.25
    Marker Score: 17590
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.22
    Marker Score: 885
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.19
    Marker Score: 2097
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.15
    Marker Score: 5422
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8768
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.09
    Marker Score: 72464
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.08
    Marker Score: 4949
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.05
    Marker Score: 8061.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.05
    Marker Score: 3014.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.04
    Marker Score: 2290
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.01
    Marker Score: 4556.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2
    Marker Score: 2420
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.96
    Marker Score: 1307
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.92
    Marker Score: 1058
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.91
    Marker Score: 713
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.88
    Marker Score: 5904
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.88
    Marker Score: 618
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.87
    Marker Score: 11980
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.87
    Marker Score: 3008
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.87
    Marker Score: 1667
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.84
    Marker Score: 7934
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.81
    Marker Score: 2566
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.81
    Marker Score: 680
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.81
    Marker Score: 607
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.8
    Marker Score: 1828
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.79
    Marker Score: 1900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.77
    Marker Score: 3144
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.77
    Marker Score: 399
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.76
    Marker Score: 1860
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.76
    Marker Score: 3570
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.74
    Marker Score: 15143
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.73
    Marker Score: 499
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.71
    Marker Score: 6610
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.71
    Marker Score: 853
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.69
    Marker Score: 11023.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.69
    Marker Score: 2042
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.67
    Marker Score: 1577
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.67
    Marker Score: 3483
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.66
    Marker Score: 413
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.66
    Marker Score: 1129
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.65
    Marker Score: 2197
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.64
    Marker Score: 8629
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.63
    Marker Score: 1631
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.62
    Marker Score: 381
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.62
    Marker Score: 1614
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.61
    Marker Score: 835
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.61
    Marker Score: 764
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.61
    Marker Score: 794
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.61
    Marker Score: 1717
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.59
    Marker Score: 2053
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.59
    Marker Score: 1106
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.58
    Marker Score: 18389
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.58
    Marker Score: 40439
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.57
    Marker Score: 652
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.55
    Marker Score: 449
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.55
    Marker Score: 371
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.53
    Marker Score: 17185
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.52
    Marker Score: 1583
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.52
    Marker Score: 1101
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.52
    Marker Score: 1598.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.51
    Marker Score: 4183
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.51
    Marker Score: 373
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.51
    Marker Score: 4466
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.5
    Marker Score: 774
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.5
    Marker Score: 14881
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.5
    Marker Score: 2815
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.49
    Marker Score: 83204
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.48
    Marker Score: 2820
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.48
    Marker Score: 1051
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.48
    Marker Score: 1488
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.47
    Marker Score: 641
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.46
    Marker Score: 1703
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.45
    Marker Score: 678
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.45
    Marker Score: 2648
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.45
    Marker Score: 860
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.45
    Marker Score: 370
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.44
    Marker Score: 382
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165441
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.44
    Marker Score: 392.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.44
    Marker Score: 980
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.43
    Marker Score: 410
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.42
    Marker Score: 3471
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.41
    Marker Score: 1061
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.41
    Marker Score: 486
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.4
    Marker Score: 1512

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Other Information

**Key characteristics:** * The ETFB gene is located on chromosome 15q21.1. * It is a large gene, encoding for a protein of 1,270 amino acids. * The protein is a flavoprotein, which means that it contains a flavin domain. * ETFB is a key enzyme in the citric acid (tca) cycle and the respiratory electron transport chain. **Pathways and functions:** * The ETFB protein is involved in the electron transport chain, which is a series of electron carriers that carry electrons from NADH and FADH2 to oxygen. * The ETFB protein is also involved in the citric acid cycle, which is a series of chemical reactions that break down glucose to produce energy. * The ETFB protein is a key regulator of cellular metabolism. It can control the flow of electrons in the electron transport chain and the citric acid cycle, which can affect the production of energy and the synthesis of proteins and lipids. **Clinical significance:** Mutations in the ETFB gene have been linked to several human diseases, including Niemann-Pick disease, which is an inherited disorder that causes the accumulation of a protein called Niemann-Pick A in the brain. Niemann-Pick disease is a fatal disease that can lead to brain damage and death. The ETFB gene is also involved in the pathogenesis of several types of cancer. For example, mutations in the ETFB gene have been linked to the development of lung cancer, breast cancer, and colon cancer.

Genular Protein ID: 295474810

Symbol: ETFB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P38117 A8K766 B3KNY2 Q6IBH7 Q71RF6 Q9Y3S7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8504797

Title: cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.

PubMed ID: 8504797

DOI: 10.1111/j.1432-1033.1993.tb17847.x

PubMed ID: 12815589

Title: Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency.

PubMed ID: 12815589

DOI: 10.1002/humu.10226

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7912128

Title: Mutations and polymorphisms of the gene encoding the beta-subunit of the electron transfer flavoprotein in three patients with glutaric acidemia type II.

PubMed ID: 7912128

DOI: 10.1093/hmg/3.3.429

PubMed ID: 17941859

Title: Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.

PubMed ID: 17941859

DOI: 10.1111/j.1742-4658.2007.06107.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25023281

Title: Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.

PubMed ID: 25023281

DOI: 10.1074/jbc.m114.580464

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25416781

Title: Human METTL20 is a mitochondrial lysine methyltransferase that targets the beta subunit of electron transfer flavoprotein (ETFbeta) and modulates its activity.

PubMed ID: 25416781

DOI: 10.1074/jbc.m114.614115

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27499296

Title: Mitochondrial protein interaction mapping identifies regulators of respiratory chain function.

PubMed ID: 27499296

DOI: 10.1016/j.molcel.2016.06.033

PubMed ID: 8962055

Title: Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution.

PubMed ID: 8962055

DOI: 10.1073/pnas.93.25.14355

PubMed ID: 15159392

Title: Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain acyl-CoA dehydrogenase complex.

PubMed ID: 15159392

DOI: 10.1074/jbc.m404884200

PubMed ID: 15975918

Title: Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein.

PubMed ID: 15975918

DOI: 10.1074/jbc.m505562200

PubMed ID: 10356313

Title: A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-chain acyl-CoA dehydrogenase-deficient patients with mild childhood presentation.

PubMed ID: 10356313

DOI: 10.1006/mgme.1999.2856

Sequence Information:

  • Length: 255
  • Mass: 27844
  • Checksum: 47E6EAEF50EB2C80
  • Sequence:
    • MAELRVLVAV KRVIDYAVKI RVKPDRTGVV TDGVKHSMNP FCEIAVEEAV RLKEKKLVKE 
VIAVSCGPAQ CQETIRTALA MGADRGIHVE VPPAEAERLG PLQVARVLAK LAEKEKVDLV 
LLGKQAIDDD CNQTGQMTAG FLDWPQGTFA SQVTLEGDKL KVEREIDGGL ETLRLKLPAV 
VTADLRLNEP RYATLPNIMK AKKKKIEVIK PGDLGVDLTS KLSVISVEDP PQRTAGVKVE 
TTEDLVAKLK EIGRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.