Details for: ETFB

Gene ID: 2109

Symbol: ETFB

Ensembl ID: ENSG00000105379

Description: electron transfer flavoprotein subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 258.4457
    Cell Significance Index: -40.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.8037
    Cell Significance Index: -42.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.8917
    Cell Significance Index: -58.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.6768
    Cell Significance Index: -56.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.7487
    Cell Significance Index: -47.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.8156
    Cell Significance Index: -54.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.6187
    Cell Significance Index: -56.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.5476
    Cell Significance Index: -48.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.6593
    Cell Significance Index: -53.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4246
    Cell Significance Index: -56.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0813
    Cell Significance Index: -43.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5221
    Cell Significance Index: -33.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 5.2583
    Cell Significance Index: 855.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7900
    Cell Significance Index: 223.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4325
    Cell Significance Index: 35.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.7676
    Cell Significance Index: 31.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4151
    Cell Significance Index: 22.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2707
    Cell Significance Index: 52.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9902
    Cell Significance Index: 358.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9069
    Cell Significance Index: 234.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7770
    Cell Significance Index: 93.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7193
    Cell Significance Index: 50.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6667
    Cell Significance Index: 86.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5699
    Cell Significance Index: 857.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5381
    Cell Significance Index: 198.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4716
    Cell Significance Index: 202.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4605
    Cell Significance Index: 66.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4413
    Cell Significance Index: 286.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4268
    Cell Significance Index: 21.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4142
    Cell Significance Index: 625.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3478
    Cell Significance Index: 95.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2906
    Cell Significance Index: 127.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1724
    Cell Significance Index: 87.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1183
    Cell Significance Index: 30.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0140
    Cell Significance Index: 119.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9660
    Cell Significance Index: 123.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8201
    Cell Significance Index: 52.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7793
    Cell Significance Index: 36.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7400
    Cell Significance Index: 668.1900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.6708
    Cell Significance Index: 13.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6069
    Cell Significance Index: 31.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4195
    Cell Significance Index: 11.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3495
    Cell Significance Index: 5.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3372
    Cell Significance Index: 10.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2745
    Cell Significance Index: 52.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2211
    Cell Significance Index: 17.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2069
    Cell Significance Index: 151.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2047
    Cell Significance Index: 2.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1764
    Cell Significance Index: 6.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1379
    Cell Significance Index: 8.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0827
    Cell Significance Index: 62.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0825
    Cell Significance Index: 16.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0550
    Cell Significance Index: 9.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0404
    Cell Significance Index: 1.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0091
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0129
    Cell Significance Index: -24.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0298
    Cell Significance Index: -55.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0347
    Cell Significance Index: -53.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0363
    Cell Significance Index: -49.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0459
    Cell Significance Index: -4.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0466
    Cell Significance Index: -29.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0581
    Cell Significance Index: -43.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0621
    Cell Significance Index: -22.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0702
    Cell Significance Index: -5.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0812
    Cell Significance Index: -45.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1012
    Cell Significance Index: -63.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1030
    Cell Significance Index: -46.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1346
    Cell Significance Index: -15.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1520
    Cell Significance Index: -10.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1540
    Cell Significance Index: -44.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1560
    Cell Significance Index: -4.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1655
    Cell Significance Index: -9.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1805
    Cell Significance Index: -5.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1812
    Cell Significance Index: -4.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1991
    Cell Significance Index: -3.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2012
    Cell Significance Index: -29.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2244
    Cell Significance Index: -25.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2354
    Cell Significance Index: -6.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2680
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2821
    Cell Significance Index: -59.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3083
    Cell Significance Index: -6.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3246
    Cell Significance Index: -19.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3420
    Cell Significance Index: -3.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3626
    Cell Significance Index: -39.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3951
    Cell Significance Index: -5.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4988
    Cell Significance Index: -10.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5411
    Cell Significance Index: -56.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6271
    Cell Significance Index: -18.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6971
    Cell Significance Index: -42.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7340
    Cell Significance Index: -12.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7562
    Cell Significance Index: -50.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7669
    Cell Significance Index: -19.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8293
    Cell Significance Index: -13.9700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.8938
    Cell Significance Index: -7.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9045
    Cell Significance Index: -24.2000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.9214
    Cell Significance Index: -7.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9946
    Cell Significance Index: -14.6800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.0447
    Cell Significance Index: -11.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0720
    Cell Significance Index: -47.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0860
    Cell Significance Index: -23.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ETFB gene is a single gene encoding for the beta subunit of the ETF complex, which is composed of two subunits (alpha and beta). The ETF complex is a flavoprotein that participates in the transfer of electrons during the respiratory electron transport chain. ETFB is a small protein with a molecular weight of approximately 15 kDa and is highly conserved across species. Its expression is tissue-specific, with significant levels observed in cells involved in energy metabolism, such as pancreatic acinar cells and enterocytes. **Pathways and Functions:** ETFB is involved in various metabolic pathways, including: 1. **Fatty acid beta-oxidation**: ETFB plays a crucial role in the beta-oxidation of fatty acids, which is essential for energy production in cells. 2. **Amino acid catabolism**: ETFB is involved in the catabolism of amino acids, such as leucine and isoleucine, which are essential for protein synthesis. 3. **Protein metabolism**: ETFB is also involved in the metabolism of proteins, including the degradation of proteins and the synthesis of new proteins. 4. **Electron transfer activity**: ETFB participates in the transfer of electrons during the respiratory electron transport chain, which is essential for the production of ATP in cells. **Clinical Significance:** Dysregulation of ETFB has been implicated in various diseases, including: 1. **Mitochondrial disorders**: ETFB mutations have been associated with mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Metabolic disorders**: ETFB dysregulation has been linked to metabolic disorders, such as fatty acid oxidation disorders and amino acid disorders. 3. **Cancer**: ETFB expression has been observed in various types of cancer, including pancreatic cancer and colorectal cancer. 4. **Neurological disorders**: ETFB has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ETFB is a critical gene involved in various metabolic processes, including fatty acid beta-oxidation, amino acid catabolism, and protein metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of ETFB in human health and disease.

Genular Protein ID: 295474810

Symbol: ETFB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P38117 A8K766 B3KNY2 Q6IBH7 Q71RF6 Q9Y3S7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8504797

Title: cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.

PubMed ID: 8504797

DOI: 10.1111/j.1432-1033.1993.tb17847.x

PubMed ID: 12815589

Title: Clear relationship between ETF/ETFDH genotype and phenotype in patients with multiple acyl-CoA dehydrogenation deficiency.

PubMed ID: 12815589

DOI: 10.1002/humu.10226

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7912128

Title: Mutations and polymorphisms of the gene encoding the beta-subunit of the electron transfer flavoprotein in three patients with glutaric acidemia type II.

PubMed ID: 7912128

DOI: 10.1093/hmg/3.3.429

PubMed ID: 17941859

Title: Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.

PubMed ID: 17941859

DOI: 10.1111/j.1742-4658.2007.06107.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25023281

Title: Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.

PubMed ID: 25023281

DOI: 10.1074/jbc.m114.580464

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25416781

Title: Human METTL20 is a mitochondrial lysine methyltransferase that targets the beta subunit of electron transfer flavoprotein (ETFbeta) and modulates its activity.

PubMed ID: 25416781

DOI: 10.1074/jbc.m114.614115

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27499296

Title: Mitochondrial protein interaction mapping identifies regulators of respiratory chain function.

PubMed ID: 27499296

DOI: 10.1016/j.molcel.2016.06.033

PubMed ID: 8962055

Title: Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution.

PubMed ID: 8962055

DOI: 10.1073/pnas.93.25.14355

PubMed ID: 15159392

Title: Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain acyl-CoA dehydrogenase complex.

PubMed ID: 15159392

DOI: 10.1074/jbc.m404884200

PubMed ID: 15975918

Title: Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein.

PubMed ID: 15975918

DOI: 10.1074/jbc.m505562200

PubMed ID: 10356313

Title: A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-chain acyl-CoA dehydrogenase-deficient patients with mild childhood presentation.

PubMed ID: 10356313

DOI: 10.1006/mgme.1999.2856

Sequence Information:

  • Length: 255
  • Mass: 27844
  • Checksum: 47E6EAEF50EB2C80
  • Sequence:
    • MAELRVLVAV KRVIDYAVKI RVKPDRTGVV TDGVKHSMNP FCEIAVEEAV RLKEKKLVKE 
VIAVSCGPAQ CQETIRTALA MGADRGIHVE VPPAEAERLG PLQVARVLAK LAEKEKVDLV 
LLGKQAIDDD CNQTGQMTAG FLDWPQGTFA SQVTLEGDKL KVEREIDGGL ETLRLKLPAV 
VTADLRLNEP RYATLPNIMK AKKKKIEVIK PGDLGVDLTS KLSVISVEDP PQRTAGVKVE 
TTEDLVAKLK EIGRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.