Details for: ETS1

Gene ID: 2113

Symbol: ETS1

Ensembl ID: ENSG00000134954

Description: ETS proto-oncogene 1, transcription factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.17
    Marker Score: 8904
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.16
    Marker Score: 1579
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.12
    Marker Score: 27367
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3
    Marker Score: 1296
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.87
    Marker Score: 1002
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.86
    Marker Score: 888
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.73
    Marker Score: 27032
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.54
    Marker Score: 134322
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5
    Marker Score: 84967
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.39
    Marker Score: 2657
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.36
    Marker Score: 5744
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.31
    Marker Score: 702
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.31
    Marker Score: 2162
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.24
    Marker Score: 2391
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.21
    Marker Score: 1425
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.17
    Marker Score: 1115
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.1
    Marker Score: 3050
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.09
    Marker Score: 3742
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.09
    Marker Score: 1226
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.06
    Marker Score: 1495
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.05
    Marker Score: 2362
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.01
    Marker Score: 8616
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.01
    Marker Score: 9862
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.98
    Marker Score: 1667
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.96
    Marker Score: 1170
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.96
    Marker Score: 645
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.95
    Marker Score: 6169
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.93
    Marker Score: 606
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.93
    Marker Score: 2841
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.92
    Marker Score: 1057
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.89
    Marker Score: 812
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.89
    Marker Score: 5505
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.84
    Marker Score: 1989
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.83
    Marker Score: 1748
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.83
    Marker Score: 1436
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.82
    Marker Score: 706
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.8
    Marker Score: 586
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.79
    Marker Score: 1028
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.78
    Marker Score: 1095
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.73
    Marker Score: 2975
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.73
    Marker Score: 1267
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.72
    Marker Score: 782
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.71
    Marker Score: 397
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.67
    Marker Score: 1497
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.67
    Marker Score: 1263
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.67
    Marker Score: 2301
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.66
    Marker Score: 938
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.64
    Marker Score: 938
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.64
    Marker Score: 1759.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.63
    Marker Score: 2310.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.62
    Marker Score: 10374
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.62
    Marker Score: 1597
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.61
    Marker Score: 366
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.59
    Marker Score: 1161
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.58
    Marker Score: 4689
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.56
    Marker Score: 1369.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.53
    Marker Score: 756
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.5
    Marker Score: 3150
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.5
    Marker Score: 3381
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.5
    Marker Score: 902
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.5
    Marker Score: 413
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.47
    Marker Score: 324
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.47
    Marker Score: 1061
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.47
    Marker Score: 389
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.46
    Marker Score: 1195
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.43
    Marker Score: 1542
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.43
    Marker Score: 344
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.43
    Marker Score: 1347
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.42
    Marker Score: 795
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.42
    Marker Score: 1567
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.42
    Marker Score: 3601
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.4
    Marker Score: 340
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.39
    Marker Score: 3419.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.38
    Marker Score: 1795
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.38
    Marker Score: 1998
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.34
    Marker Score: 677
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.33
    Marker Score: 472
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.33
    Marker Score: 2652
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.32
    Marker Score: 1241
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.31
    Marker Score: 1370
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.3
    Marker Score: 2551.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.3
    Marker Score: 1257
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.3
    Marker Score: 783
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.29
    Marker Score: 1071
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.28
    Marker Score: 1593
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.26
    Marker Score: 2190
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19399
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1814
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.23
    Marker Score: 1108
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.23
    Marker Score: 3384
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.22
    Marker Score: 1086
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.22
    Marker Score: 770.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.21
    Marker Score: 1041
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.21
    Marker Score: 914
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.21
    Marker Score: 3409
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.21
    Marker Score: 1064
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.2
    Marker Score: 1306
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.2
    Marker Score: 262
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.19
    Marker Score: 1012
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.19
    Marker Score: 277

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Other Information

**Key characteristics:** * ETS1 is a member of the ETS family of transcription factors, which are involved in a variety of cellular processes, including cell cycle regulation, proliferation, and differentiation. * It is a key regulator of cellular responses to stress, such as DNA damage and hypoxia. * ETS1 is also involved in the regulation of senescence, a process by which cells stop dividing and enter a state of dormancy. * It plays a role in the regulation of immune responses, including the activation of CD8+ T cells and the regulation of regulatory T cells. **Pathways and functions:** * ETS1 is a key activator of the rna polymerase ii transcription factor, which is responsible for the transcription of a number of important genes involved in cell growth, proliferation, and differentiation. * It also plays a role in the regulation of DNA binding proteins, which are proteins that bind to DNA and regulate gene expression. * ETS1 is also involved in the regulation of cellular senescence. * It is a key regulator of immune responses, including the activation of CD8+ T cells and the regulation of regulatory T cells. **Clinical significance:** * Mutations in the ETS1 gene have been linked to a number of human cancers, including lung cancer, breast cancer, and prostate cancer. * Targeting ETS1 has been investigated as a cancer therapeutic, but it has not been successful to date. * However, research is ongoing to develop new drugs that target ETS1 and inhibit its activity.

Genular Protein ID: 1786107031

Symbol: ETS1_HUMAN

Name: Protein C-ets-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3060801

Title: Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene.

PubMed ID: 3060801

PubMed ID: 2847145

Title: Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

PubMed ID: 2847145

DOI: 10.1073/pnas.85.21.7862

PubMed ID: 19377509

Title: Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51.

PubMed ID: 19377509

DOI: 10.1038/onc.2009.72

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1614856

Title: Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.

PubMed ID: 1614856

DOI: 10.1093/nar/20.11.2699

PubMed ID: 8231246

Title: Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies.

PubMed ID: 8231246

PubMed ID: 2997781

Title: The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

PubMed ID: 2997781

DOI: 10.1073/pnas.82.21.7294

PubMed ID: 9333025

Title: Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.

PubMed ID: 9333025

DOI: 10.1038/sj.onc.1201301

PubMed ID: 10698492

Title: EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.

PubMed ID: 10698492

DOI: 10.1038/sj.onc.1203385

PubMed ID: 11909962

Title: Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

PubMed ID: 11909962

DOI: 10.1128/mcb.22.8.2687-2702.2002

PubMed ID: 15247905

Title: SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.

PubMed ID: 15247905

DOI: 10.1038/sj.onc.1207891

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15592518

Title: SP100 inhibits ETS1 activity in primary endothelial cells.

PubMed ID: 15592518

DOI: 10.1038/sj.onc.1208245

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20378371

Title: Transcription factor Ets-1 in cytokine and chemokine gene regulation.

PubMed ID: 20378371

DOI: 10.1016/j.cyto.2010.03.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8521493

Title: The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.

PubMed ID: 8521493

DOI: 10.1016/0092-8674(95)90189-2

PubMed ID: 18566588

Title: Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.

PubMed ID: 18566588

DOI: 10.1038/emboj.2008.117

Sequence Information:

  • Length: 441
  • Mass: 50408
  • Checksum: 3B66BCC464B393FB
  • Sequence:
  • MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
    QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
    VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
    ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
    TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
    KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 
    WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS 
    LLGYTPEELH AMLDVKPDAD E

Genular Protein ID: 3891433009

Symbol: A8K725_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 441
  • Mass: 50321
  • Checksum: 0EE363BE4AA3DC6F
  • Sequence:
  • MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
    QRLGIPKDPR QWTETHVRDW VTWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
    VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
    ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
    TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
    KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 
    WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKD IIHKTAGKRY VYRFVCDLQS 
    LLGYTPEELH AMLGVKPDAD E

Genular Protein ID: 1132916760

Symbol: B4DW78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 300
  • Mass: 34054
  • Checksum: 4B55706D38D9B3DE
  • Sequence:
  • MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
    QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
    VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
    ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
    TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.