ETS1 | ENSG00000134954 | NCBI 2113

Details for: ETS1

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Oncogene induced senescence
(R-HSA-2559585)
Cell differentiation
(GO:0030154)
Cell motility
(GO:0048870)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body organization
(GO:0030578)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of leukocyte adhesion to vascular endothelial cell
(GO:1904996)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of angiogenesis
(GO:0045765)
Regulation of apoptotic process
(GO:0042981)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to antibiotic
(GO:0046677)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription corepressor binding
(GO:0001222)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD4-positive helper T cell CL0000492

CSI 45.21

rCSI 34.2%

PRS 72.7
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 41.93

rCSI 31.44%

PRS 85.7
mature T cell CL0002419

CSI 33.34

rCSI 25.93%

PRS 76.8
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 31.91

rCSI 21.27%

PRS 79.45
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 28.57

rCSI 16.88%

PRS 76.1
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 26.63

rCSI 33.47%

PRS 86.2
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 23.9

rCSI 16.78%

PRS 77.68
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 23.67

rCSI 28.68%

PRS 47.2
double negative thymocyte CL0002489

CSI 21.13

rCSI 14.69%

PRS 69.68
activated type II NK T cell CL0000931

CSI 18.48

rCSI 20.79%

PRS 75.23
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 17.52

rCSI 53.97%

PRS 68.3
pro-B cell CL0000826

CSI 16.59

rCSI 13.74%

PRS 60.64
mature NK T cell CL0000814

CSI 16.3

rCSI 20.84%

PRS 81.48
enteroendocrine cell CL0000164

CSI 15.7

rCSI 21.46%

PRS 60.72
endothelial cell of placenta CL0009092

CSI 15.3

rCSI 75.4%

PRS 70.18
naive B cell CL0000788

CSI 13.39

rCSI 11.49%

PRS 67.24
T follicular helper cell CL0002038

CSI 13.36

rCSI 10%

PRS 73.82
T-helper 17 cell CL0000899

CSI 13.22

rCSI 10.49%

PRS 80.43
regulatory T cell CL0000815

CSI 12.86

rCSI 14.91%

PRS 70.9
extravillous trophoblast CL0008036

CSI 12.65

rCSI 15.64%

PRS 55.09
immature B cell CL0000816

CSI 12.64

rCSI 9.39%

PRS 72.18
naive T cell CL0000898

CSI 12.45

rCSI 8.66%

PRS 73.9
helper T cell CL0000912

CSI 12.11

rCSI 17.12%

PRS 64.73
cerebral cortex endothelial cell CL1001602

CSI 11.1

rCSI 19.19%

PRS 49.08
skin fibroblast CL0002620

CSI 11.06

rCSI 9.54%

PRS 64.86
kidney connecting tubule epithelial cell CL1000768

CSI 10.94

rCSI 27.75%

PRS 48.45
memory B cell CL0000787

CSI 10.07

rCSI 9.94%

PRS 83.68
inhibitory interneuron CL0000498

CSI 9.82

rCSI 22.66%

PRS 48.35
conjunctival epithelial cell CL1000432

CSI 9.75

rCSI 14.89%

PRS 59.47
cardiac neuron CL0010022

CSI 9.01

rCSI 28.83%

PRS 56.59
precursor B cell CL0000817

CSI 8.95

rCSI 7.84%

PRS 68.89
fibroblast of cardiac tissue CL0002548

CSI 8.67

rCSI 41.52%

PRS 59.11
lung pericyte CL0009089

CSI 8.53

rCSI 22.5%

PRS 67.77
intraepithelial lymphocyte CL0002496

CSI 8.41

rCSI 22.89%

PRS 88.03
gamma-delta T cell CL0000798

CSI 8.12

rCSI 9.54%

PRS 85.83
contractile cell CL0000183

CSI 8.11

rCSI 23.92%

PRS 57.78
bronchus fibroblast of lung CL2000093

CSI 8.08

rCSI 6.56%

PRS 59.47
mucosal invariant T cell CL0000940

CSI 8.04

rCSI 6.5%

PRS 69.52
capillary endothelial cell CL0002144

CSI 7.47

rCSI 13.69%

PRS 72.36
transitional stage B cell CL0000818

CSI 7.31

rCSI 23.93%

PRS 85.14
B cell CL0000236

CSI 7.26

rCSI 9.72%

PRS 79.1
common dendritic progenitor CL0001029

CSI 7.2

rCSI 9.04%

PRS 69.24
T cell CL0000084

CSI 7.11

rCSI 13.89%

PRS 89.85
IgG plasma cell CL0000985

CSI 7.07

rCSI 8.47%

PRS 76.32
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 6.9

rCSI 9.4%

PRS 83.4
endothelial cell of arteriole CL1000412

CSI 6.22

rCSI 34.5%

PRS 74.6
cardiac blood vessel endothelial cell CL0010006

CSI 6.22

rCSI 43.97%

PRS 51.16
activated CD4-positive, alpha-beta T cell CL0000896

CSI 6.1

rCSI 5.64%

PRS 78.57
mature alpha-beta T cell CL0000791

CSI 5.88

rCSI 21.28%

PRS 78.39
adipocyte CL0000136

CSI 5.77

rCSI 7.41%

PRS 52.05
vascular leptomeningeal cell CL4023051

CSI 5.76

rCSI 10.09%

PRS 51.02
class switched memory B cell CL0000972

CSI 5.6

rCSI 4.18%

PRS 75.8
alpha-beta T cell CL0000789

CSI 5.46

rCSI 6.4%

PRS 75.38
early lymphoid progenitor CL0000936

CSI 5.46

rCSI 4.79%

PRS 64.18
endothelial cell of lymphatic vessel CL0002138

CSI 5.44

rCSI 10.79%

PRS 73.95
retinal blood vessel endothelial cell CL0002585

CSI 5.34

rCSI 8.53%

PRS 62.91
vein endothelial cell of respiratory system CL4033008

CSI 5.33

rCSI 36.62%

PRS 72.32
respiratory basal cell CL0002633

CSI 5.32

rCSI 5.51%

PRS 64.31
pancreatic D cell CL0000173

CSI 5.21

rCSI 5.12%

PRS 61.52
thymocyte CL0000893

CSI 5.13

rCSI 18.24%

PRS 88.88
group 3 innate lymphoid cell CL0001071

CSI 5.06

rCSI 3.81%

PRS 63.97
perivascular cell CL4033054

CSI 4.98

rCSI 6.81%

PRS 64.71
endothelial cell of artery CL1000413

CSI 4.97

rCSI 7.28%

PRS 78.4
unswitched memory B cell CL0000970

CSI 4.94

rCSI 4.15%

PRS 76.14
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 4.83

rCSI 9.63%

PRS 76.62
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 4.83

rCSI 12.49%

PRS 84.88
pulmonary capillary endothelial cell CL4028001

CSI 4.78

rCSI 9.12%

PRS 74.11
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 4.57

rCSI 4.48%

PRS 74.63
goblet cell CL0000160

CSI 4.56

rCSI 4.31%

PRS 58.47
basophil CL0000767

CSI 4.49

rCSI 9.51%

PRS 77.29
double-positive, alpha-beta thymocyte CL0000809

CSI 4.47

rCSI 4.56%

PRS 72.19
hepatic stellate cell CL0000632

CSI 4.4

rCSI 16.5%

PRS 51.13
pvalb GABAergic cortical interneuron CL4023018

CSI 4.34

rCSI 5.39%

PRS 39.05
fibroblast of lung CL0002553

CSI 4.29

rCSI 3.99%

PRS 59.19
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.2

rCSI 10.87%

PRS 53.88
Schwann cell CL0002573

CSI 4.2

rCSI 11.94%

PRS 57.24
cardiac endothelial cell CL0010008

CSI 4.15

rCSI 16.76%

PRS 57.74
CD8-positive, alpha-beta memory T cell CL0000909

CSI 4.06

rCSI 4.24%

PRS 81.75
vein endothelial cell CL0002543

CSI 3.97

rCSI 10.84%

PRS 77.77
vascular associated smooth muscle cell CL0000359

CSI 3.95

rCSI 12.81%

PRS 59.68
mononuclear phagocyte CL0000113

CSI 3.93

rCSI 8.65%

PRS 62.94
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.92

rCSI 19.68%

PRS 71.32
chondrocyte CL0000138

CSI 3.91

rCSI 6.22%

PRS 51.26
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 3.86

rCSI 5.3%

PRS 78.59
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.76

rCSI 3.7%

PRS 80.84
granulocyte CL0000094

CSI 3.66

rCSI 5.6%

PRS 68.12
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.66

rCSI 3.33%

PRS 73.58
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.63

rCSI 2.76%

PRS 71.68
intestinal tuft cell CL0019032

CSI 3.61

rCSI 5.51%

PRS 63.18
melanocyte CL0000148

CSI 3.59

rCSI 2.66%

PRS 51.62
blood vessel endothelial cell CL0000071

CSI 3.58

rCSI 7.43%

PRS 56.17
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.49

rCSI 2.79%

PRS 79.43
renal principal cell CL0005009

CSI 3.35

rCSI 8.69%

PRS 62.83
T-helper 1 cell CL0000545

CSI 3.29

rCSI 5.94%

PRS 81.12
endocardial cell CL0002350

CSI 3.23

rCSI 15.47%

PRS 58.02
alveolar adventitial fibroblast CL4028006

CSI 3.22

rCSI 5.08%

PRS 60.88
vasa recta ascending limb cell CL1001131

CSI 3.09

rCSI 14%

PRS 76.97
enteroglial cell CL4040002

CSI 3.02

rCSI 15.85%

PRS 64.81
mesodermal cell CL0000222

CSI 3.01

rCSI 3.62%

PRS 56.9
lung microvascular endothelial cell CL2000016

CSI 2.97

rCSI 57.41%

PRS 75.2

mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.3%

PRS 72.0%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.3

rCSI 3.0%

PRS 85.4%
NKp44-positive group 3 innate lymphoid cell, human CL0001079

CSI 0.3

rCSI 4.4%

PRS 96.5%
cytotoxic T cell CL0000910

CSI 0.4

rCSI 2.0%

PRS 68.5%
eosinophil CL0000771

CSI 0.4

rCSI 2.4%

PRS 85.4%
immature alpha-beta T cell CL0000790

CSI 0.5

rCSI 6.8%

PRS 94.5%
blood vessel smooth muscle cell CL0019018

CSI 0.5

rCSI 4.2%

PRS 52.2%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.6

rCSI 2.2%

PRS 79.2%
endothelial cell of venule CL1000414

CSI 0.6

rCSI 5.1%

PRS 77.3%
type EC enteroendocrine cell CL0000577

CSI 0.7

rCSI 2.3%

PRS 68.3%
megakaryocyte CL0000556

CSI 0.7

rCSI 2.9%

PRS 71.9%
IgM plasma cell CL0000986

CSI 0.7

rCSI 3.2%

PRS 89.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.7

rCSI 1.2%

PRS 41.0%
Hofbauer cell CL3000001

CSI 0.8

rCSI 1.4%

PRS 69.5%
erythroid lineage cell CL0000764

CSI 0.8

rCSI 5.1%

PRS 76.8%
parietal epithelial cell CL1000452

CSI 0.8

rCSI 2.1%

PRS 50.3%
mesangial cell CL0000650

CSI 0.8

rCSI 3.4%

PRS 70.8%
small intestine goblet cell CL1000495

CSI 0.8

rCSI 1.8%

PRS 67.5%
large pre-B-II cell CL0000957

CSI 0.9

rCSI 2.7%

PRS 71.0%
intrahepatic cholangiocyte CL0002538

CSI 1.0

rCSI 2.4%

PRS 70.3%
enteroendocrine cell of small intestine CL0009006

CSI 1.1

rCSI 2.4%

PRS 72.2%
skeletal muscle satellite stem cell CL0008011

CSI 1.1

rCSI 4.8%

PRS 77.5%
group 2 innate lymphoid cell CL0001069

CSI 1.1

rCSI 6.0%

PRS 87.0%
paneth cell of epithelium of small intestine CL1000343

CSI 1.1

rCSI 3.1%

PRS 70.8%
type B pancreatic cell CL0000169

CSI 1.1

rCSI 2.5%

PRS 56.8%
memory T cell CL0000813

CSI 1.1

rCSI 2.2%

PRS 85.0%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.2

rCSI 2.8%

PRS 89.7%
dendritic cell, human CL0001056

CSI 1.2

rCSI 1.8%

PRS 67.6%
basal cell of prostate epithelium CL0002341

CSI 1.2

rCSI 3.5%

PRS 71.9%
microcirculation associated smooth muscle cell CL0008035

CSI 1.3

rCSI 3.7%

PRS 60.4%
pancreatic ductal cell CL0002079

CSI 1.3

rCSI 2.5%

PRS 61.6%
intermediate monocyte CL0002393

CSI 1.3

rCSI 1.9%

PRS 62.7%
natural T-regulatory cell CL0000903

CSI 1.4

rCSI 2.6%

PRS 87.8%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.5

rCSI 2.7%

PRS 51.2%
renal interstitial pericyte CL1001318

CSI 1.5

rCSI 4.2%

PRS 54.9%
stem cell CL0000034

CSI 1.6

rCSI 1.5%

PRS 49.4%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.6

rCSI 2.3%

PRS 55.2%
endothelial cell of vascular tree CL0002139

CSI 1.6

rCSI 9.0%

PRS 58.3%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.7

rCSI 7.9%

PRS 70.8%
myeloid dendritic cell CL0000782

CSI 1.8

rCSI 2.6%

PRS 75.0%
pancreatic acinar cell CL0002064

CSI 1.8

rCSI 2.4%

PRS 65.1%
mature B cell CL0000785

CSI 1.9

rCSI 1.7%

PRS 69.4%
adventitial cell CL0002503

CSI 1.9

rCSI 4.6%

PRS 67.9%
sst GABAergic cortical interneuron CL4023017

CSI 1.9

rCSI 2.5%

PRS 42.2%
small pre-B-II cell CL0000954

CSI 2.0

rCSI 1.9%

PRS 80.9%
basal-myoepithelial cell of mammary gland CL0002324

CSI 2.0

rCSI 3.8%

PRS 78.0%
erythrocyte CL0000232

CSI 2.0

rCSI 4.6%

PRS 63.1%
BEST4+ enteroycte CL4030026

CSI 2.1

rCSI 2.6%

PRS 60.9%
pancreatic stellate cell CL0002410

CSI 2.1

rCSI 12.1%

PRS 68.3%
pulmonary artery endothelial cell CL1001568

CSI 2.1

rCSI 2.9%

PRS 70.7%
interstitial cell of Cajal CL0002088

CSI 2.2

rCSI 2.8%

PRS 65.3%
basal cell CL0000646

CSI 2.2

rCSI 2.9%

PRS 59.2%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.3

rCSI 1.7%

PRS 73.2%
exhausted T cell CL0011025

CSI 2.4

rCSI 39.9%

PRS 82.2%
alveolar type 1 fibroblast cell CL4028004

CSI 2.4

rCSI 2.6%

PRS 62.9%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.4

rCSI 2.9%

PRS 78.6%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.5

rCSI 1.7%

PRS 71.8%
hepatic pit cell CL2000054

CSI 2.6

rCSI 35.0%

PRS 86.3%
pancreatic A cell CL0000171

CSI 2.6

rCSI 2.7%

PRS 62.4%
prostate gland microvascular endothelial cell CL2000059

CSI 2.6

rCSI 62.7%

PRS 77.6%
plasmablast CL0000980

CSI 2.6

rCSI 2.1%

PRS 65.5%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 2.7

rCSI 4.6%

PRS 77.2%
germinal center B cell CL0000844

CSI 2.7

rCSI 8.0%

PRS 77.2%
innate lymphoid cell CL0001065

CSI 2.7

rCSI 5.7%

PRS 61.2%
endothelial cell of uterus CL0009095

CSI 2.8

rCSI 20.1%

PRS 76.6%
neural crest cell CL0011012

CSI 2.8

rCSI 2.2%

PRS 45.8%
keratinocyte CL0000312

CSI 2.8

rCSI 2.4%

PRS 63.5%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.9

rCSI 4.5%

PRS 83.1%
collagen secreting cell CL0000667

CSI 2.9

rCSI 16.4%

PRS 75.0%
respiratory suprabasal cell CL4033048

CSI 2.9

rCSI 3.7%

PRS 63.6%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.9

rCSI 8.3%

PRS 78.4%
lung microvascular endothelial cell CL2000016

CSI 3.0

rCSI 57.4%

PRS 75.2%
mesodermal cell CL0000222

CSI 3.0

rCSI 3.6%

PRS 56.9%
enteroglial cell CL4040002

CSI 3.0

rCSI 15.9%

PRS 64.8%
vasa recta ascending limb cell CL1001131

CSI 3.1

rCSI 14.0%

PRS 77.0%
alveolar adventitial fibroblast CL4028006

CSI 3.2

rCSI 5.1%

PRS 60.9%
endocardial cell CL0002350

CSI 3.2

rCSI 15.5%

PRS 58.0%
T-helper 1 cell CL0000545

CSI 3.3

rCSI 5.9%

PRS 81.1%
renal principal cell CL0005009

CSI 3.4

rCSI 8.7%

PRS 62.8%
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.5

rCSI 2.8%

PRS 79.4%
blood vessel endothelial cell CL0000071

CSI 3.6

rCSI 7.4%

PRS 56.2%
melanocyte CL0000148

CSI 3.6

rCSI 2.7%

PRS 51.6%
intestinal tuft cell CL0019032

CSI 3.6

rCSI 5.5%

PRS 63.2%
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.6

rCSI 2.8%

PRS 71.7%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.7

rCSI 3.3%

PRS 73.6%
granulocyte CL0000094

CSI 3.7

rCSI 5.6%

PRS 68.1%
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.8

rCSI 3.7%

PRS 80.8%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 3.9

rCSI 5.3%

PRS 78.6%
chondrocyte CL0000138

CSI 3.9

rCSI 6.2%

PRS 51.3%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.9

rCSI 19.7%

PRS 71.3%
mononuclear phagocyte CL0000113

CSI 3.9

rCSI 8.7%

PRS 62.9%
vascular associated smooth muscle cell CL0000359

CSI 4.0

rCSI 12.8%

PRS 59.7%
vein endothelial cell CL0002543

CSI 4.0

rCSI 10.8%

PRS 77.8%
CD8-positive, alpha-beta memory T cell CL0000909

CSI 4.1

rCSI 4.2%

PRS 81.8%
cardiac endothelial cell CL0010008

CSI 4.2

rCSI 16.8%

PRS 57.7%
Schwann cell CL0002573

CSI 4.2

rCSI 11.9%

PRS 57.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.2

rCSI 10.9%

PRS 53.9%
fibroblast of lung CL0002553

CSI 4.3

rCSI 4.0%

PRS 59.2%
pvalb GABAergic cortical interneuron CL4023018

CSI 4.3

rCSI 5.4%

PRS 39.1%
hepatic stellate cell CL0000632

CSI 4.4

rCSI 16.5%

PRS 51.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ETS1](/details-gene/2113) (ETS proto-oncogene 1) is a protein-coding gene located on chromosome 11q24.3 that encodes a crucial transcription factor. As a member of the E26 transformation-specific (ETS) family of proteins, [ETS1](/details-gene/2113) plays a fundamental role in regulating the expression of genes involved in a wide array of cellular processes. Expression data reveals its profound significance within the immune system, where it stands out as a key marker for numerous lymphocyte populations, including [CD4-positive helper T cell](/details-cell/CL0000492) and various natural killer (NK) cell subsets. Its function is pleiotropic, extending from cell differentiation and motility to the regulation of angiogenesis and immune responses. Clinically, [ETS1](/details-gene/2113) is recognized as a proto-oncogene ([OMIM: [164720](https://omim.org/entry/164720)]), and its dysregulation has been noted in hematologic malignancies ([Link](https://pubmed.ncbi.nlm.nih.gov/8231246/)). ## Cellular Roles and Expression Landscape The expression profile of [ETS1](/details-gene/2113) strongly establishes its role as a master regulator in the hematopoietic and, specifically, the lymphoid lineage. **Overall**, the gene shows its highest significance in mature and developing lymphocytes. It is a top marker for [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 45.21), [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938) (CSI: 41.93), and [mature T cell](/details-cell/CL0002419) (CSI: 33.34). Its importance spans various stages of T cell development and differentiation, from [double negative thymocyte](/details-cell/CL0002489) to naive ([naive thymus-derived CD4-positive, alpha-beta T cell](/details-cell/CL0000895)) and memory subsets ([central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904)), underscoring a continuous requirement for its activity in establishing and maintaining T cell identity. Beyond the T cell and NK cell compartments, [ETS1](/details-gene/2113) is also significant in early B cell development, as shown by its expression in [pro-B cell](/details-cell/CL0000826). This suggests a broader role in lymphocyte lineage commitment. Interestingly, [ETS1](/details-gene/2113) also demonstrates notable significance in specific non-immune cell types, particularly endothelial cells such as [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022) and [endothelial cell of placenta](/details-cell/CL0009092). This dual expression pattern points towards a role in coordinating processes that involve both immune cells and the vasculature, such as inflammation and angiogenesis. ## Pathways and Molecular Function Functionally, [ETS1](/details-gene/2113) operates as a DNA-binding transcription factor, as supported by its annotation in multiple related molecular functions, including '[Dna-binding transcription factor activity, rna polymerase ii-specific](/details-cell/GO:0000981)' and '[Rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-cell/GO:0000978)'. It is localized to the '[Nucleus](/details-cell/GO:0005634)' and '[Chromatin](/details-cell/GO:0000785)', consistent with its role in gene regulation. Its activity can be modulated through protein-protein interactions, as it is known to bind co-repressors and co-activators ([Link](https://doi.org/10.1038/sj.onc.1203385); [Link](https://doi.org/10.1128/mcb.22.8.2687-2702.2002)). The biological processes associated with [ETS1](/details-gene/2113) align closely with its cellular expression profile. Its high significance in lymphocytes is explained by its involvement in the '[Immune response](/details-cell/GO:0006955)' and '[Cell differentiation](/details-cell/GO:0030154)'. The expression in endothelial cells is consistent with its role in '[Positive regulation of angiogenesis](/details-cell/GO:0045766)' and '[Positive regulation of blood vessel endothelial cell migration](/details-cell/GO:0043536)'. Furthermore, its classification as a proto-oncogene is reflected in its participation in pathways like '[Oncogene induced senescence](/details-cell/R-HSA-2559585)' and its function in the '[Negative regulation of cell population proliferation](/details-cell/GO:0008285)', suggesting that its dysregulation can lead to uncontrolled cell growth. ## Research Directions The expression and functional data for [ETS1](/details-gene/2113) highlight its central role in both immunology and oncology. Its dual function in regulating lymphocyte biology and angiogenesis presents compelling avenues for future research, particularly in the context of the tumor microenvironment. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis:** [ETS1](/details-gene/2113) is indispensable for T cell lineage fidelity. Its depletion during hematopoietic development will lead to a severe block in T cell maturation at the [double negative thymocyte](/details-cell/CL0002489) stage and/or aberrant lineage skewing towards other hematopoietic fates. 2. **Hypothesis:** In inflammatory settings or within a tumor, [ETS1](/details-gene/2113) acts as a master coordinator, simultaneously promoting angiogenesis in endothelial cells and directing the chemotaxis and activation of T cells and NK cells, thereby shaping the tissue microenvironment. To investigate the first hypothesis, a key experiment could be proposed: * **Experimental Approach:** Generate a conditional knockout mouse model where [ETS1](/details-gene/2113) is specifically deleted in hematopoietic stem cells (e.g., using a Vav1-Cre system). Analyze thymic and peripheral lymphoid organ development using high-dimensional flow cytometry. Single-cell RNA sequencing (scRNA-seq) of thymocytes from knockout and wild-type mice could then be used to pinpoint the exact developmental stage at which maturation is arrested and to identify the downstream transcriptional programs that are dysregulated by the loss of [ETS1](/details-gene/2113). **Therapeutic Potential:** As a transcription factor and a proto-oncogene, [ETS1](/details-gene/2113) presents a challenging but potentially valuable therapeutic target. Direct inhibition of transcription factors is notoriously difficult; however, its activity is modulated by protein-protein interactions with cofactors such as SP100 ([Link](https://doi.org/10.1038/sj.onc.1208245)). This suggests that developing small molecules or biologics to disrupt these regulatory interactions could be a viable strategy for **inhibition**. Such an approach would be particularly relevant in hematologic malignancies where [ETS1](/details-gene/2113) expression is altered, or in solid tumors where it may drive angiogenesis and immune modulation. Targeting its downstream effector genes, once clearly elucidated, could provide an alternative therapeutic route.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1786107031

Symbol: ETS1_HUMAN

Name: Protein C-ets-1

UniProtKB Accession Codes:

P14921 A9UL17 F5GYX9 Q14278 Q16080 Q6N087 Q96AC5

Database IDs:

Citations:

PubMed ID: 3060801

Title: Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene.

PubMed ID: 3060801

PubMed ID: 2847145

Title: Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

PubMed ID: 2847145

DOI: 10.1073/pnas.85.21.7862

PubMed ID: 19377509

Title: Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51.

PubMed ID: 19377509

DOI: 10.1038/onc.2009.72

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1614856

Title: Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter.

PubMed ID: 1614856

DOI: 10.1093/nar/20.11.2699

PubMed ID: 8231246

Title: Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies.

PubMed ID: 8231246

PubMed ID: 2997781

Title: The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

PubMed ID: 2997781

DOI: 10.1073/pnas.82.21.7294

PubMed ID: 9333025

Title: Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.

PubMed ID: 9333025

DOI: 10.1038/sj.onc.1201301

PubMed ID: 10698492

Title: EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.

PubMed ID: 10698492

DOI: 10.1038/sj.onc.1203385

PubMed ID: 11909962

Title: Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

PubMed ID: 11909962

DOI: 10.1128/mcb.22.8.2687-2702.2002

PubMed ID: 15247905

Title: SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.

PubMed ID: 15247905

DOI: 10.1038/sj.onc.1207891

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15592518

Title: SP100 inhibits ETS1 activity in primary endothelial cells.

PubMed ID: 15592518

DOI: 10.1038/sj.onc.1208245

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20378371

Title: Transcription factor Ets-1 in cytokine and chemokine gene regulation.

PubMed ID: 20378371

DOI: 10.1016/j.cyto.2010.03.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8521493

Title: The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation.

PubMed ID: 8521493

DOI: 10.1016/0092-8674(95)90189-2

PubMed ID: 18566588

Title: Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.

PubMed ID: 18566588

DOI: 10.1038/emboj.2008.117

Sequence Information:

Length: 441
Mass: 50408
Checksum: 3B66BCC464B393FB
Sequence:

MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 
WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS 
LLGYTPEELH AMLDVKPDAD E

Genular Protein ID: 1132916760

Symbol: B4DW78_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DW78

Database IDs:

Sequence Information:

Length: 300
Mass: 34054
Checksum: 4B55706D38D9B3DE
Sequence:

MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP

Genular Protein ID: 3891433009

Symbol: A8K725_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K725

Database IDs:

Sequence Information:

Length: 441
Mass: 50321
Checksum: 0EE363BE4AA3DC6F
Sequence:

MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ 
QRLGIPKDPR QWTETHVRDW VTWAVNEFSL KGVDFQKFCM NGAALCALGK DCFLELAPDF 
VGDILWEHLE ILQKEDVKPY QVNGVNPAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF 
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ NDYFAIKQEV VTPDNMCMGR 
TSRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP 
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG 
WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKD IIHKTAGKRY VYRFVCDLQS 
LLGYTPEELH AMLGVKPDAD E

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Type 1 diabetes mellitus MONDO0005147
	Type 2 diabetes mellitus MONDO0005148
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: ETS1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene. PubMed ID: 3060801

Mammalian ets-1 and ets-2 genes encode highly conserved proteins. PubMed ID: 2847145

Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51. PubMed ID: 19377509

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter. PubMed ID: 1614856

Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. PubMed ID: 8231246

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. PubMed ID: 2997781

Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme. PubMed ID: 9333025

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. PubMed ID: 10698492

Sp100 interacts with ETS-1 and stimulates its transcriptional activity. PubMed ID: 11909962

SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. PubMed ID: 15247905

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

SP100 inhibits ETS1 activity in primary endothelial cells. PubMed ID: 15592518

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Transcription factor Ets-1 in cytokine and chemokine gene regulation. PubMed ID: 20378371

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation. PubMed ID: 8521493

Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. PubMed ID: 18566588

PubMed ID: 3060801

PubMed ID: 2847145

PubMed ID: 19377509

PubMed ID: 17974005

PubMed ID: 16554811

PubMed ID: 15489334

PubMed ID: 1614856

PubMed ID: 8231246

PubMed ID: 2997781

PubMed ID: 9333025

PubMed ID: 10698492

PubMed ID: 11909962

PubMed ID: 15247905

PubMed ID: 15592455

PubMed ID: 15592518

PubMed ID: 19690332

PubMed ID: 19608861

PubMed ID: 20378371

PubMed ID: 23186163

PubMed ID: 25755297

PubMed ID: 28112733

PubMed ID: 8521493

PubMed ID: 18566588