Details for: ETS2

Gene ID: 2114

Symbol: ETS2

Ensembl ID: ENSG00000157557

Description: ETS proto-oncogene 2, transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 339.9011
    Cell Significance Index: -52.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.7690
    Cell Significance Index: -47.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.7561
    Cell Significance Index: -59.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.8840
    Cell Significance Index: -49.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 117.7025
    Cell Significance Index: -55.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.3818
    Cell Significance Index: -55.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.5010
    Cell Significance Index: -55.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.6998
    Cell Significance Index: -49.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.4809
    Cell Significance Index: -53.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.6786
    Cell Significance Index: -55.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1269
    Cell Significance Index: -43.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.7327
    Cell Significance Index: -54.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3922
    Cell Significance Index: -29.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.2615
    Cell Significance Index: 378.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 6.8394
    Cell Significance Index: 49.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.2061
    Cell Significance Index: 55.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.0779
    Cell Significance Index: 107.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.1780
    Cell Significance Index: 140.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.9516
    Cell Significance Index: 83.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.7287
    Cell Significance Index: 53.7200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.7091
    Cell Significance Index: 14.0100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.6816
    Cell Significance Index: 8.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.8334
    Cell Significance Index: 81.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7845
    Cell Significance Index: 126.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7483
    Cell Significance Index: 142.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5420
    Cell Significance Index: 2295.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0920
    Cell Significance Index: 125.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0794
    Cell Significance Index: 134.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0115
    Cell Significance Index: 247.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9331
    Cell Significance Index: 41.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.9225
    Cell Significance Index: 27.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6972
    Cell Significance Index: 117.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5199
    Cell Significance Index: 273.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1642
    Cell Significance Index: 86.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1272
    Cell Significance Index: 31.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1110
    Cell Significance Index: 180.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1068
    Cell Significance Index: 219.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9903
    Cell Significance Index: 198.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7602
    Cell Significance Index: 98.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6734
    Cell Significance Index: 10.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6179
    Cell Significance Index: 16.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6102
    Cell Significance Index: 21.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6035
    Cell Significance Index: 329.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5997
    Cell Significance Index: 28.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5878
    Cell Significance Index: 80.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5120
    Cell Significance Index: 226.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5018
    Cell Significance Index: 35.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4829
    Cell Significance Index: 12.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2818
    Cell Significance Index: 36.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2814
    Cell Significance Index: 53.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2673
    Cell Significance Index: 26.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2582
    Cell Significance Index: 1.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2463
    Cell Significance Index: 3.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2241
    Cell Significance Index: 80.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2168
    Cell Significance Index: 6.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0661
    Cell Significance Index: 30.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0273
    Cell Significance Index: 20.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0247
    Cell Significance Index: 0.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0168
    Cell Significance Index: 1.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0069
    Cell Significance Index: 0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0128
    Cell Significance Index: -24.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0144
    Cell Significance Index: -1.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0316
    Cell Significance Index: -23.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0397
    Cell Significance Index: -53.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0411
    Cell Significance Index: -0.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0470
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0519
    Cell Significance Index: -8.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0533
    Cell Significance Index: -33.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0544
    Cell Significance Index: -39.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0563
    Cell Significance Index: -35.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0678
    Cell Significance Index: -38.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1274
    Cell Significance Index: -18.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1305
    Cell Significance Index: -1.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1454
    Cell Significance Index: -41.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1851
    Cell Significance Index: -38.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2195
    Cell Significance Index: -25.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2241
    Cell Significance Index: -3.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2296
    Cell Significance Index: -5.7400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.2448
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2469
    Cell Significance Index: -28.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2957
    Cell Significance Index: -19.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3035
    Cell Significance Index: -34.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4343
    Cell Significance Index: -9.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4392
    Cell Significance Index: -11.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4405
    Cell Significance Index: -51.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4769
    Cell Significance Index: -49.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5451
    Cell Significance Index: -13.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6060
    Cell Significance Index: -30.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6261
    Cell Significance Index: -49.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6557
    Cell Significance Index: -40.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7749
    Cell Significance Index: -31.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8507
    Cell Significance Index: -52.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8753
    Cell Significance Index: -12.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8891
    Cell Significance Index: -56.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9356
    Cell Significance Index: -49.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9448
    Cell Significance Index: -8.7000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.9631
    Cell Significance Index: -15.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ETS2 is a transcription factor that belongs to the ETS family, which is characterized by the presence of an ETS domain. This domain is responsible for DNA binding and transcriptional activation. ETS2 is a dimeric transcription factor that binds to specific DNA sequences, regulating the expression of target genes involved in various cellular processes. The gene is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions:** The ETS2 gene is involved in various signaling pathways, including: 1. **Cell differentiation**: ETS2 regulates the expression of genes involved in cell fate commitment, differentiation, and survival. It is essential for the development of various cell types, including endothelial cells, epithelial cells, and immune cells. 2. **Cellular responses to stimuli**: ETS2 is activated in response to various stimuli, including growth factors, cytokines, and stress signals. It regulates the expression of genes involved in cell survival, proliferation, and differentiation. 3. **Chromatin remodeling**: ETS2 interacts with chromatin remodeling complexes, regulating the expression of genes involved in cell differentiation and survival. 4. **DNA binding**: ETS2 binds to specific DNA sequences, regulating the expression of target genes involved in various cellular processes. **Clinical Significance:** Dysregulation of the ETS2 gene has been implicated in various diseases, including: 1. **Cancer**: ETS2 is overexpressed in various types of cancer, including lung, prostate, and breast cancer. It is involved in tumor progression, metastasis, and poor prognosis. 2. **Cardiovascular disorders**: ETS2 is involved in the regulation of endothelial cell function, and its dysregulation has been implicated in cardiovascular disorders, including atherosclerosis and hypertension. 3. **Autoimmune diseases**: ETS2 is involved in the regulation of immune cell function, and its dysregulation has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, the ETS2 gene is a transcription factor that plays a crucial role in regulating various cellular processes, including cell differentiation, proliferation, and survival. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and autoimmune diseases. Further research is necessary to fully understand the mechanisms by which ETS2 regulates cellular processes and to develop therapeutic strategies for its dysregulation. **Significantly expressed cells:** * Lung endothelial cell * Basal epithelial cell of prostatic duct * Alveolar capillary type 1 endothelial cell * Endothelial cell of vascular tree * Lung macrophage * Basal cell of prostate epithelium * Myeloid leukocyte * Alveolar capillary type 2 endothelial cell * Endothelial cell of uterus * Pulmonary artery endothelial cell **Proteins:** * ETS2_HUMAN (Protein C-ets-2)

Genular Protein ID: 4051148905

Symbol: ETS2_HUMAN

Name: Protein C-ets-2

UniProtKB Accession Codes:

P15036 A6NM68 D3DSH6 Q53Y89

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2847145

Title: Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

PubMed ID: 2847145

DOI: 10.1073/pnas.85.21.7862

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2250910

Title: Molecular organization and differential polyadenylation sites of the human ETS2 gene.

PubMed ID: 2250910

PubMed ID: 2997781

Title: The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

PubMed ID: 2997781

DOI: 10.1073/pnas.82.21.7294

PubMed ID: 11909962

Title: Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

PubMed ID: 11909962

DOI: 10.1128/mcb.22.8.2687-2702.2002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 24218572

Title: CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.

PubMed ID: 24218572

DOI: 10.1073/pnas.1306814110

Sequence Information:

  • Length: 469
  • Mass: 53001
  • Checksum: 5944EC4B5AAB553E
  • Sequence:
    • MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS 
HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN 
EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE 
NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP 
KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS 
SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS 
GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG 
LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.