Gene ETS2 - ENSG00000157557 | NCBI Gene ID: 2114

Details for: ETS2

Gene ID: 2114

Symbol: ETS2

Ensembl ID: ENSG00000157557

Description: ETS proto-oncogene 2, transcription factor

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Oncogene induced senescence
(R-HSA-2559585)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Ectodermal cell fate commitment
(GO:0001712)
Mesoderm development
(GO:0007498)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Primitive streak formation
(GO:0090009)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal system development
(GO:0001501)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.59
Marker Score: 31470
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 3.36
Marker Score: 2978
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.23
Marker Score: 8216
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.13
Marker Score: 4542
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.93
Marker Score: 3347
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.92
Marker Score: 7120
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.84
Marker Score: 3429
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.7
Marker Score: 3914
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.64
Marker Score: 5279
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.58
Marker Score: 2223
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.52
Marker Score: 1505
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.39
Marker Score: 3521
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.38
Marker Score: 2500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.37
Marker Score: 919
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.31
Marker Score: 781
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.27
Marker Score: 2419
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.23
Marker Score: 3774
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.22
Marker Score: 1750
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.19
Marker Score: 2205
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.17
Marker Score: 3566
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.17
Marker Score: 6813
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.12
Marker Score: 1899
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.04
Marker Score: 4932
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.04
Marker Score: 1737
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.03
Marker Score: 13227
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.01
Marker Score: 20388
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.95
Marker Score: 1866
Cell Name: stem cell (CL0000034)
Fold Change: 1.94
Marker Score: 4605
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.94
Marker Score: 845
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.88
Marker Score: 48194
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.88
Marker Score: 782
Cell Name: enterocyte (CL0000584)
Fold Change: 1.87
Marker Score: 8952
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.86
Marker Score: 4087
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.86
Marker Score: 1860.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.86
Marker Score: 11845
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.84
Marker Score: 1984
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.83
Marker Score: 4751.5
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.81
Marker Score: 384
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.8
Marker Score: 1624
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.78
Marker Score: 6594
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.78
Marker Score: 2828
Cell Name: basal cell (CL0000646)
Fold Change: 1.77
Marker Score: 2281
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.74
Marker Score: 432
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.73
Marker Score: 650
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.71
Marker Score: 10369
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.7
Marker Score: 12663
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.69
Marker Score: 1152
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.69
Marker Score: 8293
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.69
Marker Score: 983
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.68
Marker Score: 1679
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.67
Marker Score: 3779
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.66
Marker Score: 480
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.65
Marker Score: 384
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.65
Marker Score: 2925
Cell Name: microglial cell (CL0000129)
Fold Change: 1.65
Marker Score: 3000
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.64
Marker Score: 395
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.64
Marker Score: 6328
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.58
Marker Score: 384
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.56
Marker Score: 1668.5
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.56
Marker Score: 636
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.54
Marker Score: 391
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.53
Marker Score: 1110
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.52
Marker Score: 6550
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.51
Marker Score: 8144
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.51
Marker Score: 17043
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.51
Marker Score: 1517
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.5
Marker Score: 738
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.49
Marker Score: 7853
Cell Name: lactocyte (CL0002325)
Fold Change: 1.48
Marker Score: 23789
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.47
Marker Score: 1229
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.46
Marker Score: 751
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.46
Marker Score: 2961
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.45
Marker Score: 2231
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.44
Marker Score: 49109
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.43
Marker Score: 460
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.43
Marker Score: 364
Cell Name: stromal cell (CL0000499)
Fold Change: 1.42
Marker Score: 1667
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.42
Marker Score: 354
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.42
Marker Score: 9115
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.41
Marker Score: 732
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.41
Marker Score: 354
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.4
Marker Score: 1321
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.4
Marker Score: 581
Cell Name: club cell (CL0000158)
Fold Change: 1.39
Marker Score: 1626
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.39
Marker Score: 400
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.38
Marker Score: 2225
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.37
Marker Score: 5695
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.37
Marker Score: 753
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.36
Marker Score: 298
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.36
Marker Score: 346
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.35
Marker Score: 473
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.34
Marker Score: 74815
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.33
Marker Score: 925
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.33
Marker Score: 1502
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.31
Marker Score: 2995
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.31
Marker Score: 377
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.31
Marker Score: 3256
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.3
Marker Score: 407
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.29
Marker Score: 1525.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.29
Marker Score: 11102

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**Key characteristics** * ETS2 is a member of the ETS family of transcription factors, which are important for regulating cell fate and differentiation. * It is a key regulator of epithelial cell growth and differentiation. * It is also involved in the development of the cardiovascular system and the regulation of inflammation. **Pathways and functions** * ETS2 is a key regulator of cell differentiation. It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is essential for the development of the skin, lung, and prostate. * It is also involved in the regulation of inflammation and the development of the cardiovascular system. **Clinical significance** * Mutations in the ETS2 gene are linked to a number of human cancers. * ETS2 inhibitors are being investigated as a treatment for cancer. **Other relevant information** * ETS2 is a highly conserved gene, with a similar gene found in other vertebrates. * It is a key target for cancer therapy. * It is a promising target for the treatment of cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein C-ets-2

Genular Protein ID: 4051148905

Symbol: ETS2_HUMAN

Name: Protein C-ets-2

UniProtKB Accession Codes:

P15036 A6NM68 D3DSH6 Q53Y89

Database IDs:

Citations:

PubMed ID: 2847145

Title: Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

PubMed ID: 2847145

DOI: 10.1073/pnas.85.21.7862

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2250910

Title: Molecular organization and differential polyadenylation sites of the human ETS2 gene.

PubMed ID: 2250910

PubMed ID: 2997781

Title: The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

PubMed ID: 2997781

DOI: 10.1073/pnas.82.21.7294

PubMed ID: 11909962

Title: Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

PubMed ID: 11909962

DOI: 10.1128/mcb.22.8.2687-2702.2002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 24218572

Title: CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.

PubMed ID: 24218572

DOI: 10.1073/pnas.1306814110

Sequence Information:

Length: 469
Mass: 53001
Checksum: 5944EC4B5AAB553E
Sequence:

MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS 
HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN 
EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE 
NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP 
KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS 
SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS 
GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG 
LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ETS2

Associated with

Cells (max top 100)

Other Information

Mammalian ets-1 and ets-2 genes encode highly conserved proteins. PubMed ID: 2847145

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular organization and differential polyadenylation sites of the human ETS2 gene. PubMed ID: 2250910

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active. PubMed ID: 2997781

Sp100 interacts with ETS-1 and stimulates its transcriptional activity. PubMed ID: 11909962

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. PubMed ID: 24218572