Details for: ETV6

Gene ID: 2120

Symbol: ETV6

Ensembl ID: ENSG00000139083

Description: ETS variant transcription factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 388.9544
    Cell Significance Index: -60.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.9371
    Cell Significance Index: -51.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.2896
    Cell Significance Index: -57.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.0654
    Cell Significance Index: -52.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.3804
    Cell Significance Index: -59.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 93.5886
    Cell Significance Index: -62.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.5856
    Cell Significance Index: -53.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.2232
    Cell Significance Index: -60.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.2707
    Cell Significance Index: -50.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.5432
    Cell Significance Index: -60.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.9454
    Cell Significance Index: -58.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4889
    Cell Significance Index: -61.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 15.0381
    Cell Significance Index: 92.7800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.7281
    Cell Significance Index: 68.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.8579
    Cell Significance Index: 96.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3196
    Cell Significance Index: 64.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8233
    Cell Significance Index: 139.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8131
    Cell Significance Index: 85.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7424
    Cell Significance Index: 25.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7335
    Cell Significance Index: 312.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7307
    Cell Significance Index: 343.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6498
    Cell Significance Index: 330.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4404
    Cell Significance Index: 80.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4095
    Cell Significance Index: 173.3200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.3300
    Cell Significance Index: 13.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1519
    Cell Significance Index: 1040.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1417
    Cell Significance Index: 53.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9845
    Cell Significance Index: 446.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9670
    Cell Significance Index: 25.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9201
    Cell Significance Index: 100.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8449
    Cell Significance Index: 43.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7185
    Cell Significance Index: 116.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6132
    Cell Significance Index: 39.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4722
    Cell Significance Index: 10.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4681
    Cell Significance Index: 255.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4290
    Cell Significance Index: 296.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4108
    Cell Significance Index: 53.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3707
    Cell Significance Index: 25.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3547
    Cell Significance Index: 10.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3361
    Cell Significance Index: 120.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3128
    Cell Significance Index: 198.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2277
    Cell Significance Index: 428.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1983
    Cell Significance Index: 365.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1936
    Cell Significance Index: 85.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1905
    Cell Significance Index: 19.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1903
    Cell Significance Index: 1.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1574
    Cell Significance Index: 6.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1536
    Cell Significance Index: 29.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1431
    Cell Significance Index: 5.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1129
    Cell Significance Index: 173.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1055
    Cell Significance Index: 2.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1031
    Cell Significance Index: 140.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0542
    Cell Significance Index: 9.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0306
    Cell Significance Index: 3.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0018
    Cell Significance Index: -0.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0151
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0290
    Cell Significance Index: -18.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0296
    Cell Significance Index: -0.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0364
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0392
    Cell Significance Index: -29.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0705
    Cell Significance Index: -51.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0739
    Cell Significance Index: -55.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0925
    Cell Significance Index: -52.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1117
    Cell Significance Index: -15.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1382
    Cell Significance Index: -7.2000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1626
    Cell Significance Index: -1.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1636
    Cell Significance Index: -12.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1693
    Cell Significance Index: -24.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1856
    Cell Significance Index: -53.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1942
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1967
    Cell Significance Index: -22.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2114
    Cell Significance Index: -44.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2133
    Cell Significance Index: -9.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2790
    Cell Significance Index: -28.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3088
    Cell Significance Index: -35.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3882
    Cell Significance Index: -3.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4161
    Cell Significance Index: -7.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4259
    Cell Significance Index: -50.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4769
    Cell Significance Index: -33.7300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4907
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5090
    Cell Significance Index: -58.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5123
    Cell Significance Index: -10.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5352
    Cell Significance Index: -7.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5409
    Cell Significance Index: -11.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5480
    Cell Significance Index: -14.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5806
    Cell Significance Index: -8.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6495
    Cell Significance Index: -43.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6713
    Cell Significance Index: -21.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6808
    Cell Significance Index: -18.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7141
    Cell Significance Index: -56.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7229
    Cell Significance Index: -10.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7281
    Cell Significance Index: -10.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7778
    Cell Significance Index: -21.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7842
    Cell Significance Index: -10.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8654
    Cell Significance Index: -53.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8827
    Cell Significance Index: -18.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9476
    Cell Significance Index: -20.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9575
    Cell Significance Index: -60.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0041
    Cell Significance Index: -24.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0484
    Cell Significance Index: -25.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** ETV6 is a transcription factor that regulates gene expression by binding to specific DNA sequences and influencing the activity of RNA polymerase II. 2. **Cell Type Specificity:** ETV6 is expressed in various cell types, including epithelial cells, immune cells, and hematopoietic stem cells, suggesting its importance in different cellular processes. 3. **Signaling Pathways:** ETV6 is involved in multiple signaling pathways, including Flt3 signaling, PDGFR signaling, and neurogenesis, which regulate cell proliferation, differentiation, and survival. 4. **Protein Binding:** ETV6 interacts with various proteins, including PDGFR, Flt3, and other transcription factors, to modulate gene expression and cellular processes. **Pathways and Functions:** 1. **Flt3 Signaling:** ETV6 is involved in Flt3 signaling, which regulates hematopoietic stem cell proliferation and differentiation. 2. **PDGFR Signaling:** ETV6 interacts with PDGFR to regulate cell proliferation, migration, and survival in various cell types. 3. **Neurogenesis:** ETV6 is involved in neurogenesis, regulating the development and maintenance of neurons. 4. **Cell Differentiation:** ETV6 regulates cell differentiation by controlling the expression of genes involved in cellular development and maturation. 5. **Apoptosis:** ETV6 modulates apoptosis by regulating the expression of genes involved in cell death and survival. **Clinical Significance:** 1. **Hematological Disorders:** ETV6 mutations have been implicated in hematological disorders, including acute myeloid leukemia and lymphoma. 2. **Neurological Disorders:** ETV6 is involved in neurological disorders, including neurodevelopmental disorders and neurodegenerative diseases. 3. **Cancer:** ETV6 is overexpressed in various cancers, including breast, lung, and colon cancer, suggesting its potential as a tumor suppressor. 4. **Immunological Disorders:** ETV6 is involved in immunological disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, the ETV6 gene plays a crucial role in regulating cellular processes, including cell differentiation, proliferation, and survival. Its involvement in multiple signaling pathways and its expression in various cell types make it an important regulator of immune function and disease. Further research is needed to fully understand the functional significance of ETV6 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1964543807

Symbol: ETV6_HUMAN

Name: Transcription factor ETV6

UniProtKB Accession Codes:

P41212 A3QVP6 A8K076 Q9UMF6 Q9UMF7 Q9UMG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8168137

Title: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.

PubMed ID: 8168137

DOI: 10.1016/0092-8674(94)90322-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8743990

Title: Genomic organization of TEL: the human ETS-variant gene 6.

PubMed ID: 8743990

DOI: 10.1101/gr.6.5.404

PubMed ID: 17344859

Title: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

PubMed ID: 17344859

DOI: 10.1038/nature05690

PubMed ID: 7731705

Title: Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

PubMed ID: 7731705

PubMed ID: 7761424

Title: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

PubMed ID: 7761424

DOI: 10.1073/pnas.92.11.4917

PubMed ID: 7780150

Title: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

PubMed ID: 7780150

PubMed ID: 9326218

Title: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia.

PubMed ID: 9326218

PubMed ID: 10502316

Title: Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).

PubMed ID: 10502316

DOI: 10.1002/(sici)1098-2264(199911)26:3<192::aid-gcc2>3.0.co;2-e

PubMed ID: 10477709

Title: Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).

PubMed ID: 10477709

PubMed ID: 12435397

Title: Functional regulation of TEL by p38-induced phosphorylation.

PubMed ID: 12435397

DOI: 10.1016/s0006-291x(02)02588-3

PubMed ID: 12203785

Title: A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome.

PubMed ID: 12203785

DOI: 10.1002/gcc.10090

PubMed ID: 12181402

Title: Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.

PubMed ID: 12181402

DOI: 10.1056/nejmoa020150

PubMed ID: 12588862

Title: The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).

PubMed ID: 12588862

DOI: 10.1074/jbc.m300592200

PubMed ID: 12590135

Title: The histone deacetylase 9 gene encodes multiple protein isoforms.

PubMed ID: 12590135

DOI: 10.1074/jbc.m212935200

PubMed ID: 15806161

Title: Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.

PubMed ID: 15806161

DOI: 10.1038/sj.onc.1208588

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25581430

Title: Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.

PubMed ID: 25581430

DOI: 10.1038/ng.3177

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 452
  • Mass: 53000
  • Checksum: DEC45682ECADECBB
  • Sequence:
    • MSETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY 
WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI 
LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH 
RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM 
ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE 
GKPINLSHRE DLAYMNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW 
EDKESKIFRI VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM 
KTPDEIMSGR TDRLEHLESQ ELDEQIYQED EC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.