Details for: ETV6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 388.9544
Cell Significance Index: -60.5000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 201.9371
Cell Significance Index: -51.2200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 139.2896
Cell Significance Index: -57.3800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 130.0654
Cell Significance Index: -52.8400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 115.3804
Cell Significance Index: -59.3500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 93.5886
Cell Significance Index: -62.8000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 55.5856
Cell Significance Index: -53.0700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 49.2232
Cell Significance Index: -60.6900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 23.2707
Cell Significance Index: -50.9300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.5432
Cell Significance Index: -60.3900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.9454
Cell Significance Index: -58.1900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.4889
Cell Significance Index: -61.1200 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 15.0381
Cell Significance Index: 92.7800 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 7.7281
Cell Significance Index: 68.6000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 5.8579
Cell Significance Index: 96.5300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.3196
Cell Significance Index: 64.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.8233
Cell Significance Index: 139.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.8131
Cell Significance Index: 85.2200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.7424
Cell Significance Index: 25.0600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7335
Cell Significance Index: 312.5000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7307
Cell Significance Index: 343.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6498
Cell Significance Index: 330.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4404
Cell Significance Index: 80.8300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4095
Cell Significance Index: 173.3200 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 1.3300
Cell Significance Index: 13.3100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1519
Cell Significance Index: 1040.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1417
Cell Significance Index: 53.2300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.9845
Cell Significance Index: 446.8400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.9670
Cell Significance Index: 25.9100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9201
Cell Significance Index: 100.0800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8449
Cell Significance Index: 43.8900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7185
Cell Significance Index: 116.8600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6132
Cell Significance Index: 39.5600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4722
Cell Significance Index: 10.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4681
Cell Significance Index: 255.6400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4290
Cell Significance Index: 296.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4108
Cell Significance Index: 53.0800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3707
Cell Significance Index: 25.6400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3547
Cell Significance Index: 10.2200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3361
Cell Significance Index: 120.5700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3128
Cell Significance Index: 198.6500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2277
Cell Significance Index: 428.7200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1983
Cell Significance Index: 365.6500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1936
Cell Significance Index: 85.6100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.1905
Cell Significance Index: 19.8400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1903
Cell Significance Index: 1.1500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1574
Cell Significance Index: 6.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1536
Cell Significance Index: 29.2300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1431
Cell Significance Index: 5.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1129
Cell Significance Index: 173.8200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1055
Cell Significance Index: 2.0600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1031
Cell Significance Index: 140.2500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0542
Cell Significance Index: 9.2600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0306
Cell Significance Index: 3.0300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0018
Cell Significance Index: -0.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0151
Cell Significance Index: -0.5700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0290
Cell Significance Index: -18.1400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0296
Cell Significance Index: -0.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0364
Cell Significance Index: -4.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0392
Cell Significance Index: -29.0300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0705
Cell Significance Index: -51.7000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0739
Cell Significance Index: -55.9200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0925
Cell Significance Index: -52.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1117
Cell Significance Index: -15.3400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1382
Cell Significance Index: -7.2000 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1626
Cell Significance Index: -1.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1636
Cell Significance Index: -12.2000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1693
Cell Significance Index: -24.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1856
Cell Significance Index: -53.3900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1942
Cell Significance Index: -3.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1967
Cell Significance Index: -22.9200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2114
Cell Significance Index: -44.5200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2133
Cell Significance Index: -9.6700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2790
Cell Significance Index: -28.5000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3088
Cell Significance Index: -35.3800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3882
Cell Significance Index: -3.5800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4161
Cell Significance Index: -7.0100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4259
Cell Significance Index: -50.2300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4769
Cell Significance Index: -33.7300 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.4907
Cell Significance Index: -7.4700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5090
Cell Significance Index: -58.1000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5123
Cell Significance Index: -10.9100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5352
Cell Significance Index: -7.6900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5409
Cell Significance Index: -11.4800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5480
Cell Significance Index: -14.0000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5806
Cell Significance Index: -8.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6495
Cell Significance Index: -43.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6713
Cell Significance Index: -21.5000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6808
Cell Significance Index: -18.2100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7141
Cell Significance Index: -56.5600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7229
Cell Significance Index: -10.6700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7281
Cell Significance Index: -10.7500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7778
Cell Significance Index: -21.1700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7842
Cell Significance Index: -10.7000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8654
Cell Significance Index: -53.0600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8827
Cell Significance Index: -18.3100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.9476
Cell Significance Index: -20.2600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9575
Cell Significance Index: -60.3500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.0041
Cell Significance Index: -24.0800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0484
Cell Significance Index: -25.5800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1964543807
Symbol: ETV6_HUMAN
Name: Transcription factor ETV6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8168137
Title: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.
PubMed ID: 8168137
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8743990
Title: Genomic organization of TEL: the human ETS-variant gene 6.
PubMed ID: 8743990
DOI: 10.1101/gr.6.5.404
PubMed ID: 17344859
Title: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
PubMed ID: 17344859
DOI: 10.1038/nature05690
PubMed ID: 7731705
Title: Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.
PubMed ID: 7731705
PubMed ID: 7761424
Title: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
PubMed ID: 7761424
PubMed ID: 7780150
Title: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.
PubMed ID: 7780150
PubMed ID: 9326218
Title: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia.
PubMed ID: 9326218
PubMed ID: 10502316
Title: Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
PubMed ID: 10502316
DOI: 10.1002/(sici)1098-2264(199911)26:3<192::aid-gcc2>3.0.co;2-e
PubMed ID: 10477709
Title: Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).
PubMed ID: 10477709
PubMed ID: 12435397
Title: Functional regulation of TEL by p38-induced phosphorylation.
PubMed ID: 12435397
PubMed ID: 12203785
Title: A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome.
PubMed ID: 12203785
DOI: 10.1002/gcc.10090
PubMed ID: 12181402
Title: Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.
PubMed ID: 12181402
DOI: 10.1056/nejmoa020150
PubMed ID: 12588862
Title: The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).
PubMed ID: 12588862
PubMed ID: 12590135
Title: The histone deacetylase 9 gene encodes multiple protein isoforms.
PubMed ID: 12590135
PubMed ID: 15806161
Title: Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.
PubMed ID: 15806161
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25581430
Title: Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
PubMed ID: 25581430
DOI: 10.1038/ng.3177
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 452
- Mass: 53000
- Checksum: DEC45682ECADECBB
- Sequence:
MSETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE GKPINLSHRE DLAYMNHIMV SVSPPEEHAM PIGRIADCRL LWDYVYQLLS DSRYENFIRW EDKESKIFRI VDPNGLARLW GNHKNRTNMT YEKMSRALRH YYKLNIIRKE PGQRLLFRFM KTPDEIMSGR TDRLEHLESQ ELDEQIYQED EC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.