Details for: EXTL2

Gene ID: 2135

Symbol: EXTL2

Ensembl ID: ENSG00000162694

Description: exostosin like glycosyltransferase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1
    Marker Score: 8260.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.73
    Marker Score: 1859
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15569
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.5
    Marker Score: 6236.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.44
    Marker Score: 25644
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50053
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.24
    Marker Score: 16357
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.23
    Marker Score: 1310.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.22
    Marker Score: 1888
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.18
    Marker Score: 2473
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.14
    Marker Score: 323
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2292
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.13
    Marker Score: 426
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1967
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.13
    Marker Score: 10584
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.12
    Marker Score: 2646
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.11
    Marker Score: 1709
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68009
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.08
    Marker Score: 1157
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.06
    Marker Score: 10686
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.06
    Marker Score: 2875
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.04
    Marker Score: 1774
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.02
    Marker Score: 957
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47988
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.98
    Marker Score: 6360.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8346.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.93
    Marker Score: 3582
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.91
    Marker Score: 751
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14064
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.88
    Marker Score: 587
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5008
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.86
    Marker Score: 18298
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9455.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.83
    Marker Score: 934
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.82
    Marker Score: 1668
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12227
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.82
    Marker Score: 430
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.81
    Marker Score: 580
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8
    Marker Score: 3462
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.8
    Marker Score: 1103
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.79
    Marker Score: 3644
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.78
    Marker Score: 29705
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.77
    Marker Score: 524
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.77
    Marker Score: 6675
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.75
    Marker Score: 7164
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.75
    Marker Score: 470
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.74
    Marker Score: 174
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.74
    Marker Score: 4438
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.73
    Marker Score: 404
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.73
    Marker Score: 2698
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3050
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.73
    Marker Score: 14453
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 434
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.72
    Marker Score: 887
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 655
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.71
    Marker Score: 2761.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.71
    Marker Score: 246
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.71
    Marker Score: 1860
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.69
    Marker Score: 4073.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.68
    Marker Score: 156
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.67
    Marker Score: 1118
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1578
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.65
    Marker Score: 4981
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.62
    Marker Score: 600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 524
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6
    Marker Score: 2606.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.6
    Marker Score: 1143
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6
    Marker Score: 3846
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 687
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.6
    Marker Score: 497
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.59
    Marker Score: 1116
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.59
    Marker Score: 2017
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.57
    Marker Score: 699
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 811
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.55
    Marker Score: 1398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.54
    Marker Score: 2213
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.54
    Marker Score: 1441
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.53
    Marker Score: 287
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 682
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 345
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.52
    Marker Score: 175

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - EXTL2 is a transmembrane protein with a predicted molecular weight of approximately 120 kDa. - It is localized to the cell surface and is associated with various cell types. - It is a glycosyltransferase enzyme that catalyzes the transfer of a glucuronic acid residue from UDP-glucuronic acid to galactose residues on specific proteins. **Pathways and functions:** - EXTL2 is involved in several important cellular processes, including cell migration, cell adhesion, cell signaling, and tissue development. - It is a key regulator of angiogenesis, as it is expressed in high levels in endothelial cells and is required for the formation of new blood vessels. - It is also involved in cell migration, as it is expressed in cells that are migrating through the extracellular matrix. - EXTL2 is also involved in cell signaling, as it is a receptor for the growth factor GDNF. - It plays a role in tissue development, as it is expressed in developing brain structures such as the placenta and the nervous system. **Clinical significance:** - Mutations in the EXTL2 gene have been linked to several human diseases, including cerebral palsy, epilepsy, and autism. - Exostosin-like glycoprotein 2 (EXTL2) is a promising target for the treatment of these disorders, as it is involved in the pathogenesis of these conditions. - Small molecule inhibitors of EXTL2 have been shown to be effective in inhibiting tumor growth and migration, suggesting that EXTL2 could be a potential therapeutic agent for cancer.

Genular Protein ID: 2267400315

Symbol: EXTL2_HUMAN

Name: Exostosin-like 2

UniProtKB Accession Codes:

Q9UBQ6 B2R795 D3DT60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 28 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9450183

Title: Identification and characterization of a novel member of the EXT gene family, EXTL2.

PubMed ID: 9450183

PubMed ID: 9473480

Title: Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.

PubMed ID: 9473480

DOI: 10.1006/bbrc.1997.8062

PubMed ID: 10639137

Title: The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.

PubMed ID: 10639137

DOI: 10.1073/pnas.97.2.668

PubMed ID: 10318803

Title: The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.

PubMed ID: 10318803

DOI: 10.1074/jbc.274.20.13933

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 330
  • Mass: 37466
  • Checksum: 6976BE7EC6F588C8
  • Sequence:
    • MRCCHICKLP GRVMGIRVLR LSLVVILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK 
STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIVVWN NIGEKAPDEL WNSLGPHPIP 
VIFKQQTANR MRNRLQVFPE LETNAVLMVD DDTLISTPDL VFAFSVWQQF PDQIVGFVPR 
KHVSTSSGIY SYGSFEMQAP GSGNGDQYSM VLIGASFFNS KYLELFQRQP AAVHALIDDT 
QNCDDIAMNF IIAKHIGKTS GIFVKPVNMD NLEKETNSGY SGMWHRAEHA LQRSYCINKL 
VNIYDSMPLR YSNIMISQFG FPYANYKRKI

Genular Protein ID: 2983089596

Symbol: Q8N8F1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N8F1

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CAZy 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 2 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 329
  • Mass: 37395
  • Checksum: 7CE07064474BE340
  • Sequence:
    • MRCCHICKLP GRVMGIRVLR LSLVVILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK 
STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIVVWN NIGEKAPDEL WNSLGPHPIP 
VIFKQQTANR MRNRLQVFPE LETNVLMVDD DTLISTPDLV FAFSVWQQFP DQIVGFVPRK 
HVSTSSGIYS YGSFEMQAPG SGNGDQYSMV LIGASFFNSK YLELFQRQPA AVHALIDDTQ 
NCDDIAMNFI IAKHIGKTSG IFVKPVNMDN LEKETNSGYS GMWHRAEHAL QRSYCINKLV 
NIYDSMPLRY SNIMISQFGF PYANYKRKI

Genular Protein ID: 1859259076

Symbol: F5GZK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GZK1

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 147
  • Mass: 16751
  • Checksum: 8E9DC29F7E68F006
  • Sequence:
    • MRCCHICKLP GRVMGIRVLR LSLVVILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK 
STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIVVWN NIGEKAPDEL WNSLGPHPIP 
VIFKQQTANR MRNRLQVFPE LETNAIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.