Details for: FDFT1

Gene ID: 2222

Symbol: FDFT1

Ensembl ID: ENSG00000079459

Description: farnesyl-diphosphate farnesyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 343.8871
    Cell Significance Index: -53.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.6901
    Cell Significance Index: -47.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.6247
    Cell Significance Index: -57.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.3006
    Cell Significance Index: -61.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.6915
    Cell Significance Index: -59.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.5901
    Cell Significance Index: -62.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.9651
    Cell Significance Index: -55.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.3287
    Cell Significance Index: -49.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.2355
    Cell Significance Index: -60.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4024
    Cell Significance Index: -41.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5254
    Cell Significance Index: -16.4700
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 5.2403
    Cell Significance Index: 6.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.9573
    Cell Significance Index: 45.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.8023
    Cell Significance Index: 128.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.3675
    Cell Significance Index: 98.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4567
    Cell Significance Index: 127.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4521
    Cell Significance Index: 442.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3205
    Cell Significance Index: 61.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2739
    Cell Significance Index: 119.3900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1261
    Cell Significance Index: 26.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8274
    Cell Significance Index: 224.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7870
    Cell Significance Index: 83.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7738
    Cell Significance Index: 352.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6570
    Cell Significance Index: 43.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6262
    Cell Significance Index: 34.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5603
    Cell Significance Index: 93.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5463
    Cell Significance Index: 844.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1962
    Cell Significance Index: 239.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0847
    Cell Significance Index: 50.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0788
    Cell Significance Index: 30.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0645
    Cell Significance Index: 137.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0279
    Cell Significance Index: 66.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9137
    Cell Significance Index: 68.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8010
    Cell Significance Index: 94.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5686
    Cell Significance Index: 251.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5205
    Cell Significance Index: 29.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4963
    Cell Significance Index: 63.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4761
    Cell Significance Index: 11.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4626
    Cell Significance Index: 31.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4534
    Cell Significance Index: 162.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3965
    Cell Significance Index: 11.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3497
    Cell Significance Index: 15.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3308
    Cell Significance Index: 11.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3300
    Cell Significance Index: 8.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3241
    Cell Significance Index: 44.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3136
    Cell Significance Index: 51.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2882
    Cell Significance Index: 542.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1969
    Cell Significance Index: 37.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1946
    Cell Significance Index: 13.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1334
    Cell Significance Index: 13.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1290
    Cell Significance Index: 97.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1278
    Cell Significance Index: 88.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1027
    Cell Significance Index: 3.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1025
    Cell Significance Index: 17.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0814
    Cell Significance Index: 110.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0435
    Cell Significance Index: 66.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0264
    Cell Significance Index: 16.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0240
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0168
    Cell Significance Index: 30.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0114
    Cell Significance Index: 0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0346
    Cell Significance Index: -25.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0418
    Cell Significance Index: -30.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0421
    Cell Significance Index: -2.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0827
    Cell Significance Index: -46.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0873
    Cell Significance Index: -8.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1123
    Cell Significance Index: -70.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1306
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1639
    Cell Significance Index: -47.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2184
    Cell Significance Index: -31.7500
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.2233
    Cell Significance Index: -1.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2523
    Cell Significance Index: -19.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2627
    Cell Significance Index: -6.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2668
    Cell Significance Index: -31.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3091
    Cell Significance Index: -65.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3312
    Cell Significance Index: -34.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3349
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3538
    Cell Significance Index: -40.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3821
    Cell Significance Index: -2.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3869
    Cell Significance Index: -8.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4280
    Cell Significance Index: -10.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4758
    Cell Significance Index: -15.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6074
    Cell Significance Index: -38.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6327
    Cell Significance Index: -9.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6455
    Cell Significance Index: -51.1200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6736
    Cell Significance Index: -4.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7689
    Cell Significance Index: -10.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7788
    Cell Significance Index: -20.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8630
    Cell Significance Index: -23.0900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9150
    Cell Significance Index: -11.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9206
    Cell Significance Index: -40.7200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.9730
    Cell Significance Index: -6.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9835
    Cell Significance Index: -60.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9866
    Cell Significance Index: -40.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0175
    Cell Significance Index: -29.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0370
    Cell Significance Index: -17.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0909
    Cell Significance Index: -41.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1056
    Cell Significance Index: -38.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1359
    Cell Significance Index: -37.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1468
    Cell Significance Index: -42.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subcellular Localization:** FDFT1 is primarily found in the endoplasmic reticulum membrane, where it plays a pivotal role in regulating cholesterol biosynthesis. 2. **Enzymatic Activity:** FDFT1 exhibits farnesyl-diphosphate farnesyltransferase activity, facilitating the conversion of farnesyl diphosphate and isopentenyl pyrophosphate into squalene. 3. **Regulatory Mechanisms:** FDFT1 is modulated by several transcription factors, including SREBP (Sterol Regulatory Element Binding Protein) and PPARα (Peroxisome Proliferator-Activated Receptor alpha), which play significant roles in regulating lipid metabolism. 4. **Expression Patterns:** FDFT1 is significantly expressed in various cell types, including cortical cells of the adrenal gland, hepatoblasts, pancreatic acinar cells, and immune cells such as CD4-positive, alpha-beta memory T cells. **Pathways and Functions:** 1. **Cholesterol Biosynthesis:** FDFT1 is a critical enzyme in the cholesterol biosynthetic pathway, catalyzing the formation of squalene from farnesyl diphosphate and isopentenyl pyrophosphate. 2. **Lipid Metabolism:** FDFT1 regulates lipid metabolism by modulating the synthesis and degradation of cholesterol and other lipids. 3. **Steroid Biosynthesis:** FDFT1 is involved in the biosynthesis of various steroids, including cholesterol, steroid hormones, and bile acids. 4. **Endoplasmic Reticulum Function:** FDFT1 contributes to the maintenance of endoplasmic reticulum function and structure, particularly in the context of lipid metabolism. **Clinical Significance:** Dysregulation of FDFT1 has been implicated in various diseases, including: 1. **Atherosclerosis:** Abnormal cholesterol biosynthesis and lipid metabolism contribute to the development of atherosclerosis. 2. **Xenograft Rejection:** Immune cells expressing high levels of FDFT1 may be resistant to rejection in xenotransplantation. 3. **Cancer:** Altered lipid metabolism and cholesterol biosynthesis have been linked to cancer development and progression. 4. **Metabolic Disorders:** FDFT1 dysregulation may contribute to metabolic disorders, such as obesity and insulin resistance. In conclusion, FDFT1 is a crucial enzyme in the regulation of cholesterol biosynthesis and lipid metabolism. Its dysregulation has significant implications for various physiological and pathological processes, highlighting the need for further research into the mechanisms underlying FDFT1 function and its clinical applications.

Genular Protein ID: 4054647806

Symbol: FDFT_HUMAN

Name: Squalene synthase

UniProtKB Accession Codes:

P37268 B3KQ95 B4DJE5 B4DT56 B7Z1J3 Q96GT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 36 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 16 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 32 PIR 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 12 Rhea 10 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8474436

Title: Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.

PubMed ID: 8474436

DOI: 10.1128/mcb.13.5.2706-2717.1993

PubMed ID: 7685352

Title: Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.

PubMed ID: 7685352

DOI: 10.1016/s0021-9258(18)31461-3

PubMed ID: 8294001

Title: Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase.

PubMed ID: 8294001

DOI: 10.1016/0378-1119(93)90462-c

PubMed ID: 7864626

Title: Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems.

PubMed ID: 7864626

DOI: 10.1006/abbi.1995.1095

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29909962

Title: Squalene synthase deficiency: clinical, biochemical, and molecular characterization of a defect in cholesterol biosynthesis.

PubMed ID: 29909962

DOI: 10.1016/j.ajhg.2018.05.004

PubMed ID: 10896663

Title: Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

PubMed ID: 10896663

DOI: 10.1074/jbc.m004132200

PubMed ID: 24531458

Title: Structural insights into the catalytic mechanism of human squalene synthase.

PubMed ID: 24531458

DOI: 10.1107/s1399004713026230

PubMed ID: 18350552

Title: K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population.

PubMed ID: 18350552

DOI: 10.1002/humu.20702

Sequence Information:

  • Length: 417
  • Mass: 48115
  • Checksum: D36CBC8382F827EC
  • Sequence:
    • MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA 
LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ 
VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG 
IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV 
KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL 
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR 
QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH

Genular Protein ID: 1050176898

Symbol: B7Z9R8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9R8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 28 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 6 Gene3D 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 8 RuleBase 1 SFLD 2 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 353
  • Mass: 40754
  • Checksum: 45C1DF579F179D2B
  • Sequence:
    • MRNAVCIFYL VLRALDTLED DMTISVEKKV PLLHNFHSFL YQPDWRFMES KEKDRQVLED 
FPTISLEFRN LAEKYQTVIA DICRRMGIGM AEFLDKHVTS EQEWDKYCHY VAGLVGIGLS 
RLFSASEFED PLVGEDTERA NSMGLFLQKT NIIRDYLEDQ QGGREFWPQE VWSRYVKKLG 
DFAKPENIDL AVQCLNELIT NALHHIPDVI TYLSRLRNQS VFNFCAIPQV MAIATLAACY 
NNQQVFKGAV KIRKGQAVTL MMDATNMPAV KAIIYQYMEE IYHRIPDSDP SSSKTRQIIS 
TIRTQNLPNC QLISRSHYSP IYLSFVMPLA ALSWQYLTTL SQVTEDYVQT GEH

Genular Protein ID: 3298542456

Symbol: B4DWP0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWP0

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 16 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 6 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 250
  • Mass: 28529
  • Checksum: E37F827A1D5D439D
  • Sequence:
    • MPWPPRRVLQ PGALPDRGQA EASEFEDPLV GEDTERANSM GLFLQKTNII RDYLEDQQGG 
REFWPQEVWS RYVKKLGDFA KPENIDLAVQ CLNELITNAL HHIPDVITYL SRLRNQSVFN 
FCAIPQVMAI ATLAACYNNQ QVFKGAVKIR KGQAVTLMMD ATNMPAVKAI IYQYMEEIYH 
RIPDSDPSSS KTRQIISTIR TQNLPNCQLI SRSHYSPIYL SFVMLLAALS WQYLTTLSQV 
TEDYVQTGEH

Genular Protein ID: 86579480

Symbol: B4DND3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DND3

Database IDs:

ARBA 9 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 28 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 2 GO 5 Gene3D 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 8 RuleBase 1 SFLD 2 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 474
  • Mass: 53405
  • Checksum: 82E726FC8132DEC2
  • Sequence:
    • MAAAACGTKA MALFKRTLVL SPAAAPRGPG AGTAPRGCCL PPAAWPCKDW PRGEGGRLWS 
RLPQSHSHSH SHSHSCSSTS PTAVCVVCPQ DSLSSSLKTC YKYLNQTSRS FAAVIQALDG 
EMRNAVCIFY LVLRALDTLE DDMTISVEKK VPLLHNFHSF LYQPDWRFME SKEKDRQVLE 
DFPTISLEFR NLAEKYQTVI ADICRRMGIG MAEFLDKHVT SEQEWDKYCH YVAGLVGIGL 
SRLFSASEFE DPLVGEDTER ANSMGLFLQK TNIIRDYLED QQGGREFWPQ EVWSRYVKKL 
GDFAKPENID LAVQCLNELI TNALHHIPDV ITYLSRLRNQ SVFNFCAIPQ VMAIATLAAC 
YNNQQVFKGA VKIRKGQAVT LMMDATNMPA VKAIIYQYME EIYHRIPDSD PSSSKTRQII 
STIRTQNLPN CQLISRSHYS PIYLSFVMLL AALSWQYLTT LSQVTEDYVQ TGEH

Genular Protein ID: 2015382974

Symbol: A0A1W2PQ47_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1W2PQ47

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 8 RuleBase 1 SAM 1 SFLD 2 SMR 1 SUPFAM 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 476
  • Mass: 53629
  • Checksum: B9EC08472E44D84D
  • Sequence:
    • MAAAACGTKA MALFKRTLVL SPAAAPRGPG AGTAPRGCCL PPAAWPCKDW PRGEGGRLWS 
RLPQSHSHSH SHSHSHSCSS TSPTAVCVVC PQDSLSSSLK TCYKYLNQTS RSFAAVIQAL 
DGEMRNAVCI FYLVLRALDT LEDDMTISVE KKVPLLHNFH SFLYQPDWRF MESKEKDRQV 
LEDFPTISLE FRNLAEKYQT VIADICRRMG IGMAEFLDKH VTSEQEWDKY CHYVAGLVGI 
GLSRLFSASE FEDPLVGEDT ERANSMGLFL QKTNIIRDYL EDQQGGREFW PQEVWSRYVK 
KLGDFAKPEN IDLAVQCLNE LITNALHHIP DVITYLSRLR NQSVFNFCAI PQVMAIATLA 
ACYNNQQVFK GAVKIRKGQA VTLMMDATNM PAVKAIIYQY MEEIYHRIPD SDPSSSKTRQ 
IISTIRTQNL PNCQLISRSH YSPIYLSFVM LLAALSWQYL TTLSQVTEDY VQTGEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.