Details for: FES

Gene ID: 2242

Symbol: FES

Ensembl ID: ENSG00000182511

Description: FES proto-oncogene, tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.2047
    Cell Significance Index: -10.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.1411
    Cell Significance Index: -10.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.4171
    Cell Significance Index: -12.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.3677
    Cell Significance Index: -12.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.2540
    Cell Significance Index: -4.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3748
    Cell Significance Index: -10.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.9541
    Cell Significance Index: -11.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7255
    Cell Significance Index: -9.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8839
    Cell Significance Index: -11.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.7251
    Cell Significance Index: 44.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4740
    Cell Significance Index: 145.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3389
    Cell Significance Index: 21.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3111
    Cell Significance Index: 35.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1965
    Cell Significance Index: 22.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1214
    Cell Significance Index: 72.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9806
    Cell Significance Index: 159.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7329
    Cell Significance Index: 79.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5949
    Cell Significance Index: 30.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4773
    Cell Significance Index: 8.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4326
    Cell Significance Index: 25.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4099
    Cell Significance Index: 28.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3407
    Cell Significance Index: 4.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.2987
    Cell Significance Index: 6.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2565
    Cell Significance Index: 11.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2461
    Cell Significance Index: 48.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2250
    Cell Significance Index: 6.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1290
    Cell Significance Index: 17.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1279
    Cell Significance Index: 24.3400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1204
    Cell Significance Index: 0.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1064
    Cell Significance Index: 12.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0745
    Cell Significance Index: 0.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0720
    Cell Significance Index: 1.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0599
    Cell Significance Index: 0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0507
    Cell Significance Index: 2.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0502
    Cell Significance Index: 6.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0454
    Cell Significance Index: 5.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0354
    Cell Significance Index: 1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0350
    Cell Significance Index: 7.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0205
    Cell Significance Index: 0.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0197
    Cell Significance Index: 0.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0188
    Cell Significance Index: 0.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0143
    Cell Significance Index: 0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0110
    Cell Significance Index: 4.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0066
    Cell Significance Index: 4.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0052
    Cell Significance Index: 0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0130
    Cell Significance Index: -7.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0144
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0233
    Cell Significance Index: -10.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0253
    Cell Significance Index: -9.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0282
    Cell Significance Index: -1.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0299
    Cell Significance Index: -8.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0338
    Cell Significance Index: -0.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0347
    Cell Significance Index: -0.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0368
    Cell Significance Index: -4.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0502
    Cell Significance Index: -1.3400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0513
    Cell Significance Index: -0.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0524
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0527
    Cell Significance Index: -9.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0591
    Cell Significance Index: -8.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0602
    Cell Significance Index: -12.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0676
    Cell Significance Index: -7.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0855
    Cell Significance Index: -1.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1010
    Cell Significance Index: -7.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1055
    Cell Significance Index: -4.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1060
    Cell Significance Index: -11.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1070
    Cell Significance Index: -7.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1110
    Cell Significance Index: -8.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1226
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1263
    Cell Significance Index: -2.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1307
    Cell Significance Index: -2.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1433
    Cell Significance Index: -4.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1436
    Cell Significance Index: -11.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1512
    Cell Significance Index: -9.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1610
    Cell Significance Index: -4.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1649
    Cell Significance Index: -9.2600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1731
    Cell Significance Index: -2.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1786
    Cell Significance Index: -10.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1792
    Cell Significance Index: -12.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1886
    Cell Significance Index: -11.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2036
    Cell Significance Index: -1.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2142
    Cell Significance Index: -6.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2160
    Cell Significance Index: -11.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2199
    Cell Significance Index: -9.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2201
    Cell Significance Index: -7.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2249
    Cell Significance Index: -3.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2279
    Cell Significance Index: -9.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2332
    Cell Significance Index: -6.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The FES proto-oncogene is characterized by its ability to bind to phosphatidylinositol, regulate microtubule polymerization, and interact with various signaling molecules, including semaphorins and integrins. It is a member of the src family of tyrosine kinases, which are known for their role in regulating cell growth, differentiation, and survival. The FES proto-oncogene is also involved in the regulation of cell adhesion, which is critical for the proper functioning of immune cells. **Pathways and Functions** The FES proto-oncogene is involved in several signaling pathways, including: 1. **Axon guidance**: FES interacts with semaphorins, which are proteins that regulate axon guidance during neural development. 2. **Cardiac muscle cell proliferation**: FES regulates the proliferation of cardiac muscle cells, which is essential for heart development and function. 3. **Myeloid cell differentiation**: FES is involved in the differentiation of myeloid cells, including monocytes and macrophages, which are critical for immune function. 4. **Cell adhesion**: FES regulates the adhesion of immune cells to the extracellular matrix, which is essential for their proper functioning. 5. **Signaling by receptor tyrosine kinases**: FES interacts with various signaling molecules, including semaphorins and integrins, to regulate cell growth, differentiation, and survival. **Clinical Significance** The FES proto-oncogene has been implicated in several diseases, including: 1. **Leukemia**: FES is overexpressed in certain types of leukemia, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 2. **Immune system disorders**: FES is involved in the regulation of immune cell function, and its dysregulation may contribute to immune system disorders, such as autoimmune diseases. 3. **Neurological disorders**: FES is involved in axon guidance during neural development, and its dysregulation may contribute to neurological disorders, such as autism and schizophrenia. In conclusion, the FES proto-oncogene is a critical regulator of immune cell function and is involved in several signaling pathways that are essential for cell growth, differentiation, and survival. Its dysregulation may contribute to various diseases, including leukemia, immune system disorders, and neurological disorders. Further research is needed to fully understand the role of FES in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 4273774632

Symbol: FES_HUMAN

Name: Tyrosine-protein kinase Fes/Fps

UniProtKB Accession Codes:

P07332 B2R6E6 B4DUD0 E9PC94 E9PC95 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 12 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2179816

Title: Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.

PubMed ID: 2179816

PubMed ID: 4065096

Title: The structure of the human c-fes/fps proto-oncogene.

PubMed ID: 4065096

DOI: 10.1002/j.1460-2075.1985.tb04020.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2656706

Title: K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation.

PubMed ID: 2656706

DOI: 10.1016/s0021-9258(18)81796-3

PubMed ID: 7687763

Title: Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).

PubMed ID: 7687763

PubMed ID: 8955135

Title: Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.

PubMed ID: 8955135

DOI: 10.1074/jbc.271.51.32930

PubMed ID: 11339827

Title: Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking.

PubMed ID: 11339827

DOI: 10.1006/excr.2001.5217

PubMed ID: 11509660

Title: A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells.

PubMed ID: 11509660

DOI: 10.1128/mcb.21.18.6170-6180.2001

PubMed ID: 11994747

Title: Closing in on the biological functions of Fps/Fes and Fer.

PubMed ID: 11994747

DOI: 10.1038/nrm783

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 15485904

Title: The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.

PubMed ID: 15485904

DOI: 10.1128/mcb.24.21.9351-9358.2004

PubMed ID: 15867340

Title: An identity crisis for fps/fes: oncogene or tumor suppressor?

PubMed ID: 15867340

DOI: 10.1158/0008-5472.can-04-3468

PubMed ID: 15869408

Title: Expression of c-Fes protein isoforms correlates with differentiation in myeloid leukemias.

PubMed ID: 15869408

DOI: 10.1089/dna.2005.24.311

PubMed ID: 16792528

Title: The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.

PubMed ID: 16792528

DOI: 10.1042/bj20060194

PubMed ID: 16455651

Title: A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.

PubMed ID: 16455651

DOI: 10.1074/jbc.m507331200

PubMed ID: 17595334

Title: The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.

PubMed ID: 17595334

DOI: 10.1182/blood-2007-02-076471

PubMed ID: 18046454

Title: Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.

PubMed ID: 18046454

DOI: 10.1038/sj.emboj.7601943

PubMed ID: 19382747

Title: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.

PubMed ID: 19382747

DOI: 10.1021/bi900238f

PubMed ID: 19051325

Title: Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer.

PubMed ID: 19051325

DOI: 10.1002/gcc.20638

PubMed ID: 19082481

Title: Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells.

PubMed ID: 19082481

PubMed ID: 19001085

Title: Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.

PubMed ID: 19001085

DOI: 10.1128/mcb.00904-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20111072

Title: FES kinases are required for oncogenic FLT3 signaling.

PubMed ID: 20111072

DOI: 10.1038/leu.2009.301

PubMed ID: 21622225

Title: Structure and regulation of the c-Fes protein-tyrosine kinase.

PubMed ID: 21622225

DOI: 10.2741/3902

PubMed ID: 21563194

Title: Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer.

PubMed ID: 21563194

DOI: 10.1002/pros.21422

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28463229

Title: Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.

PubMed ID: 28463229

DOI: 10.1172/jci91291

PubMed ID: 15929003

Title: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes.

PubMed ID: 15929003

DOI: 10.1007/s10858-005-0946-6

PubMed ID: 18775312

Title: Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.

PubMed ID: 18775312

DOI: 10.1016/j.cell.2008.07.047

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 822
  • Mass: 93497
  • Checksum: 4C2A90555857F045
  • Sequence:
    • MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 
RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW 
QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF 
AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE 
VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE 
LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL 
QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR 
TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF 
LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK 
SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL 
KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL 
LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR 
QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP 
CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.