Details for: FES

Gene ID: 2242

Symbol: FES

Ensembl ID: ENSG00000182511

Description: FES proto-oncogene, tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.77
    Marker Score: 2133
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.61
    Marker Score: 89981
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.47
    Marker Score: 3657
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.28
    Marker Score: 410
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.25
    Marker Score: 1276
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.19
    Marker Score: 1357.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.11
    Marker Score: 11201
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.08
    Marker Score: 596
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.08
    Marker Score: 2095
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 659
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.02
    Marker Score: 2876
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.01
    Marker Score: 4139
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1
    Marker Score: 2288
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.95
    Marker Score: 8043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.92
    Marker Score: 10678
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.91
    Marker Score: 5522
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5056
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.88
    Marker Score: 640
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.86
    Marker Score: 863
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.83
    Marker Score: 920
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.81
    Marker Score: 652
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.81
    Marker Score: 764
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.75
    Marker Score: 1909
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.74
    Marker Score: 1475
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.74
    Marker Score: 258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.73
    Marker Score: 355
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 649
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.71
    Marker Score: 1032
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.7
    Marker Score: 606
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.7
    Marker Score: 877
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2926
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.69
    Marker Score: 339
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.68
    Marker Score: 408
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.65
    Marker Score: 1690.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.63
    Marker Score: 437
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.63
    Marker Score: 16163
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 294
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.63
    Marker Score: 206
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 198
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.6
    Marker Score: 2495
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9381
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.59
    Marker Score: 534
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.59
    Marker Score: 5184
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.57
    Marker Score: 247
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.57
    Marker Score: 909
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.54
    Marker Score: 122
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.54
    Marker Score: 780
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.53
    Marker Score: 280
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.52
    Marker Score: 428
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.52
    Marker Score: 258
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.51
    Marker Score: 739
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.51
    Marker Score: 549
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.51
    Marker Score: 453
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5
    Marker Score: 854
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5
    Marker Score: 126
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.48
    Marker Score: 216
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.48
    Marker Score: 1156
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2833
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.47
    Marker Score: 470
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.46
    Marker Score: 509
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.44
    Marker Score: 153
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.44
    Marker Score: 210
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.44
    Marker Score: 299
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1004
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.42
    Marker Score: 1239
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.42
    Marker Score: 426
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.42
    Marker Score: 218
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.42
    Marker Score: 548
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.42
    Marker Score: 276
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 274
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.41
    Marker Score: 280
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.41
    Marker Score: 202
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 766
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.4
    Marker Score: 258
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4
    Marker Score: 155
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.39
    Marker Score: 158

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Other Information

**Key characteristics:** - It is a tyrosine kinase, a class of proteins that regulate cell growth, differentiation, and signaling. - It is expressed in myeloid leukocytes, dendritic cells, and endothelial cells. - It is involved in axon guidance, cell migration, and angiogenesis. **Pathways and functions:** - It is involved in the Axon guidance pathway, where it promotes axon extension and guidance. - It is also involved in the Crmps in sema3a signaling pathway, which is essential for the migration of neurons. - It is involved in the development of the nervous system, including the formation of blood-brain barrier. - It is also involved in non-membrane spanning protein tyrosine kinase (PTK) signaling and phosphatidylinositol binding. **Clinical significance:** - Mutations in the FES gene have been linked to several human diseases, including leukemia, breast cancer, and lung cancer. - Targeting the FES gene has been investigated as a therapeutic strategy for these diseases. **Additional information:** - The FES gene is located on chromosome 17q21. - It is a highly conserved gene, with a similar gene found in humans, mice, and flies. - It is a key regulator of cell migration and adhesion. - It is a promising target for cancer therapy due to its involvement in various cellular processes.

Genular Protein ID: 4273774632

Symbol: FES_HUMAN

Name: Tyrosine-protein kinase Fes/Fps

UniProtKB Accession Codes:

P07332 B2R6E6 B4DUD0 E9PC94 E9PC95 Q2VXS7 Q2VXS8 Q2VXT0 Q6GTU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 10 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 12 Rhea 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2179816

Title: Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.

PubMed ID: 2179816

PubMed ID: 4065096

Title: The structure of the human c-fes/fps proto-oncogene.

PubMed ID: 4065096

DOI: 10.1002/j.1460-2075.1985.tb04020.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2656706

Title: K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation.

PubMed ID: 2656706

DOI: 10.1016/s0021-9258(18)81796-3

PubMed ID: 7687763

Title: Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).

PubMed ID: 7687763

PubMed ID: 8955135

Title: Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.

PubMed ID: 8955135

DOI: 10.1074/jbc.271.51.32930

PubMed ID: 11339827

Title: Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking.

PubMed ID: 11339827

DOI: 10.1006/excr.2001.5217

PubMed ID: 11509660

Title: A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells.

PubMed ID: 11509660

DOI: 10.1128/mcb.21.18.6170-6180.2001

PubMed ID: 11994747

Title: Closing in on the biological functions of Fps/Fes and Fer.

PubMed ID: 11994747

DOI: 10.1038/nrm783

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 15485904

Title: The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.

PubMed ID: 15485904

DOI: 10.1128/mcb.24.21.9351-9358.2004

PubMed ID: 15867340

Title: An identity crisis for fps/fes: oncogene or tumor suppressor?

PubMed ID: 15867340

DOI: 10.1158/0008-5472.can-04-3468

PubMed ID: 15869408

Title: Expression of c-Fes protein isoforms correlates with differentiation in myeloid leukemias.

PubMed ID: 15869408

DOI: 10.1089/dna.2005.24.311

PubMed ID: 16792528

Title: The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.

PubMed ID: 16792528

DOI: 10.1042/bj20060194

PubMed ID: 16455651

Title: A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.

PubMed ID: 16455651

DOI: 10.1074/jbc.m507331200

PubMed ID: 17595334

Title: The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.

PubMed ID: 17595334

DOI: 10.1182/blood-2007-02-076471

PubMed ID: 18046454

Title: Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.

PubMed ID: 18046454

DOI: 10.1038/sj.emboj.7601943

PubMed ID: 19382747

Title: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.

PubMed ID: 19382747

DOI: 10.1021/bi900238f

PubMed ID: 19051325

Title: Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer.

PubMed ID: 19051325

DOI: 10.1002/gcc.20638

PubMed ID: 19082481

Title: Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells.

PubMed ID: 19082481

PubMed ID: 19001085

Title: Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.

PubMed ID: 19001085

DOI: 10.1128/mcb.00904-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20111072

Title: FES kinases are required for oncogenic FLT3 signaling.

PubMed ID: 20111072

DOI: 10.1038/leu.2009.301

PubMed ID: 21622225

Title: Structure and regulation of the c-Fes protein-tyrosine kinase.

PubMed ID: 21622225

DOI: 10.2741/3902

PubMed ID: 21563194

Title: Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer.

PubMed ID: 21563194

DOI: 10.1002/pros.21422

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28463229

Title: Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.

PubMed ID: 28463229

DOI: 10.1172/jci91291

PubMed ID: 15929003

Title: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes.

PubMed ID: 15929003

DOI: 10.1007/s10858-005-0946-6

PubMed ID: 18775312

Title: Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.

PubMed ID: 18775312

DOI: 10.1016/j.cell.2008.07.047

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 822
  • Mass: 93497
  • Checksum: 4C2A90555857F045
  • Sequence:
    • MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 
RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW 
QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF 
AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE 
VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE 
LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL 
QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR 
TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF 
LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK 
SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL 
KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL 
LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR 
QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP 
CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.