FGF2 | ENSG00000138685 | NCBI 2247

Details for: FGF2

Gene ID: 2247

Symbol: FGF2

Ensembl ID: ENSG00000138685

Description: fibroblast growth factor 2

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Extracellular matrix organization
(R-HSA-1474244)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Formation of intermediate mesoderm
(R-HSA-9761174)
Formation of the nephric duct
(R-HSA-9830364)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Gastrulation
(R-HSA-9758941)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Insulin receptor signalling cascade
(R-HSA-74751)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Kidney development
(R-HSA-9830369)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Pou5f1 (oct4), sox2, nanog activate genes related to proliferation
(R-HSA-2892247)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Syndecan interactions
(R-HSA-3000170)
Tgfbr3 regulates fgf2 signaling
(R-HSA-9839397)
Transcriptional regulation of pluripotent stem cells
(R-HSA-452723)
Chemoattractant activity
(GO:0042056)
Chemokine binding
(GO:0019956)
Cytokine activity
(GO:0005125)
Fibroblast growth factor receptor binding
(GO:0005104)
Growth factor activity
(GO:0008083)
H3k9me3 modified histone binding
(GO:0062072)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Nuclear receptor coactivator activity
(GO:0030374)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 76.6036
Cell Significance Index: -19.4300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 38.8916
Cell Significance Index: -15.8000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 38.8035
Cell Significance Index: -18.3200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 2.5802
Cell Significance Index: 36.0800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.0798
Cell Significance Index: 59.6200
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.5398
Cell Significance Index: 19.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4056
Cell Significance Index: 267.5000
Cell Name: keratocyte (CL0002363)
Fold Change: 1.1138
Cell Significance Index: 17.6700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9183
Cell Significance Index: 90.8500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8462
Cell Significance Index: 764.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8271
Cell Significance Index: 46.4100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7711
Cell Significance Index: 15.0500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6894
Cell Significance Index: 22.0800
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.5561
Cell Significance Index: 6.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5414
Cell Significance Index: 107.4400
Cell Name: peg cell (CL4033014)
Fold Change: 0.4701
Cell Significance Index: 10.8600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4622
Cell Significance Index: 75.1800
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.3992
Cell Significance Index: 4.4100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3900
Cell Significance Index: 53.5600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3451
Cell Significance Index: 37.5400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.2593
Cell Significance Index: 3.7300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2336
Cell Significance Index: 26.6600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1762
Cell Significance Index: 12.1900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1583
Cell Significance Index: 56.7700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1533
Cell Significance Index: 97.3700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1391
Cell Significance Index: 7.0300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0869
Cell Significance Index: 39.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0818
Cell Significance Index: 150.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0652
Cell Significance Index: 40.7000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0645
Cell Significance Index: 99.3300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0446
Cell Significance Index: 2.8100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0329
Cell Significance Index: 62.0100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0200
Cell Significance Index: 1.2000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0172
Cell Significance Index: 23.3300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0161
Cell Significance Index: 0.7600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0111
Cell Significance Index: 0.3200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0106
Cell Significance Index: 2.1300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0006
Cell Significance Index: 0.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0011
Cell Significance Index: -0.8300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0093
Cell Significance Index: -0.1600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0104
Cell Significance Index: -7.7000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0116
Cell Significance Index: -0.2900
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: -0.0125
Cell Significance Index: -0.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0144
Cell Significance Index: -8.1300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0219
Cell Significance Index: -9.6700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0253
Cell Significance Index: -19.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0280
Cell Significance Index: -15.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0342
Cell Significance Index: -1.5500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0346
Cell Significance Index: -0.7500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0399
Cell Significance Index: -5.8000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0468
Cell Significance Index: -1.2500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0500
Cell Significance Index: -10.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0502
Cell Significance Index: -5.7500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0510
Cell Significance Index: -14.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0515
Cell Significance Index: -8.7900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0573
Cell Significance Index: -1.2200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0627
Cell Significance Index: -8.1000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0654
Cell Significance Index: -8.3900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0846
Cell Significance Index: -15.2500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1018
Cell Significance Index: -12.5200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1201
Cell Significance Index: -7.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1267
Cell Significance Index: -12.9400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1531
Cell Significance Index: -11.7500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1594
Cell Significance Index: -18.5800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1613
Cell Significance Index: -16.7900
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1635
Cell Significance Index: -0.9700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1654
Cell Significance Index: -19.5000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1725
Cell Significance Index: -13.6600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2109
Cell Significance Index: -3.5300
Cell Name: mature astrocyte (CL0002627)
Fold Change: -0.2232
Cell Significance Index: -2.4800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2342
Cell Significance Index: -3.5300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2451
Cell Significance Index: -18.2700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2471
Cell Significance Index: -16.6200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2693
Cell Significance Index: -14.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2982
Cell Significance Index: -18.2800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3746
Cell Significance Index: -10.4700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3773
Cell Significance Index: -19.8100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3902
Cell Significance Index: -10.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3905
Cell Significance Index: -13.5700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4085
Cell Significance Index: -21.2200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4110
Cell Significance Index: -19.1700
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.4164
Cell Significance Index: -13.1700
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.4279
Cell Significance Index: -6.5100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4467
Cell Significance Index: -6.4200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4501
Cell Significance Index: -19.9100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4636
Cell Significance Index: -11.2300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4744
Cell Significance Index: -9.9300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5049
Cell Significance Index: -16.5300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5056
Cell Significance Index: -3.0600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5139
Cell Significance Index: -13.2100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5165
Cell Significance Index: -19.5600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5200
Cell Significance Index: -19.0900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5487
Cell Significance Index: -13.1600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5494
Cell Significance Index: -19.2500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5616
Cell Significance Index: -16.0300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5631
Cell Significance Index: -9.6500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5829
Cell Significance Index: -10.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5879
Cell Significance Index: -15.4600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5911
Cell Significance Index: -14.7400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6038
Cell Significance Index: -19.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure:** FGF2 is a 22-kDa protein composed of 154 amino acids, with a single polypeptide chain. 2. **Expression:** FGF2 is highly expressed in various tissues, including the prostate, mammary gland, liver, and kidney. 3. **Receptor Binding:** FGF2 binds to the fibroblast growth factor receptors (FGFRs), specifically FGFR1, FGFR2, FGFR3, and FGFR4. 4. **Signaling Pathways:** FGF2 activates various signaling pathways, including the PI3K/AKT, MAPK, and JAK/STAT pathways. 5. **Function:** FGF2 promotes cell proliferation, differentiation, and survival, as well as angiogenesis and wound healing. **Pathways and Functions:** 1. **Cell Proliferation and Differentiation:** FGF2 stimulates the proliferation of fibroblasts, endothelial cells, and other cell types. 2. **Angiogenesis:** FGF2 promotes the formation of new blood vessels, essential for tissue growth and development. 3. **Wound Healing:** FGF2 plays a crucial role in wound healing by stimulating the proliferation of fibroblasts and endothelial cells. 4. **Development:** FGF2 is involved in various developmental processes, including kidney development and organ induction. 5. **Cancer:** FGF2 has been implicated in cancer development and progression, particularly in the prostate and breast. **Clinical Significance:** 1. **Cancer Therapy:** FGF2 has been investigated as a potential therapeutic target for cancer treatment, particularly in the prostate and breast. 2. **Wound Healing:** FGF2 has been used to promote wound healing in various clinical settings, including burn patients and diabetic foot ulcers. 3. **Regenerative Medicine:** FGF2 has been used to promote tissue regeneration in various clinical settings, including orthopedic and cardiovascular applications. 4. **Neurological Disorders:** FGF2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Immunology:** FGF2 has been shown to modulate immune responses, particularly in the context of cancer and autoimmune diseases. In conclusion, FGF2 is a multifunctional protein that plays a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immunological disorders. Further research is needed to fully understand the mechanisms of FGF2 signaling and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 2

Genular Protein ID: 721456115

Symbol: FGF2_HUMAN

Name: Fibroblast growth factor 2

UniProtKB Accession Codes:

P09038 A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6

Database IDs:

Citations:

PubMed ID: 3472745

Title: Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells.

PubMed ID: 3472745

DOI: 10.1101/sqb.1986.051.01.078

PubMed ID: 3780670

Title: Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

PubMed ID: 3780670

DOI: 10.1002/j.1460-2075.1986.tb04530.x

PubMed ID: 2538817

Title: High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

PubMed ID: 2538817

DOI: 10.1073/pnas.86.6.1836

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1785797

Title: Basic fibroblast growth factor gene expression.

PubMed ID: 1785797

DOI: 10.1111/j.1749-6632.1991.tb49022.x

PubMed ID: 2435575

Title: Cloning and expression of cDNA encoding human basic fibroblast growth factor.

PubMed ID: 2435575

DOI: 10.1016/0014-5793(87)81489-8

PubMed ID: 1721615

Title: Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.

PubMed ID: 1721615

DOI: 10.1111/j.1349-7006.1991.tb01791.x

PubMed ID: 8564983

Title: Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor.

PubMed ID: 8564983

PubMed ID: 3579930

Title: A form of human basic fibroblast growth factor with an extended amino terminus.

PubMed ID: 3579930

DOI: 10.1016/s0006-291x(87)80001-3

PubMed ID: 2435284

Title: Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue.

PubMed ID: 2435284

DOI: 10.1016/0006-291x(87)91471-9

PubMed ID: 3964259

Title: Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.

PubMed ID: 3964259

DOI: 10.1016/0006-291x(86)90028-8

PubMed ID: 3732516

Title: Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

PubMed ID: 3732516

DOI: 10.1016/0014-5793(86)80812-2

PubMed ID: 1417798

Title: Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients.

PubMed ID: 1417798

DOI: 10.1016/0006-291x(92)90434-m

PubMed ID: 1885605

Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

PubMed ID: 1885605

DOI: 10.1016/s0021-9258(18)55368-0

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 10358027

Title: High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan.

PubMed ID: 10358027

DOI: 10.1074/jbc.274.24.16831

PubMed ID: 11509569

Title: Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.

PubMed ID: 11509569

DOI: 10.1074/jbc.m104933200

PubMed ID: 11964394

Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

PubMed ID: 11964394

DOI: 10.1074/jbc.m112193200

PubMed ID: 16257968

Title: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.

PubMed ID: 16257968

DOI: 10.1074/jbc.m510754200

PubMed ID: 18669637

Title: Effect of FGF-binding protein 3 on vascular permeability.

PubMed ID: 18669637

DOI: 10.1074/jbc.m802144200

PubMed ID: 20230531

Title: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.

PubMed ID: 20230531

DOI: 10.1111/j.1600-0854.2010.01059.x

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 22321063

Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.

PubMed ID: 22321063

DOI: 10.1111/j.1600-0854.2012.01341.x

PubMed ID: 23469107

Title: A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

PubMed ID: 23469107

DOI: 10.1371/journal.pone.0057927

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28302677

Title: The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.

PubMed ID: 28302677

DOI: 10.1042/bsr20170173

PubMed ID: 29501879

Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

PubMed ID: 29501879

DOI: 10.1016/j.exer.2018.02.025

PubMed ID: 1769963

Title: Crystal structure of basic fibroblast growth factor at 1.6-A resolution.

PubMed ID: 1769963

DOI: 10.1093/oxfordjournals.jbchem.a123586

PubMed ID: 1707542

Title: Three-dimensional structure of human basic fibroblast growth factor.

PubMed ID: 1707542

DOI: 10.1073/pnas.88.8.3441

PubMed ID: 1849658

Title: Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

PubMed ID: 1849658

DOI: 10.1073/pnas.88.8.3446

PubMed ID: 1702556

Title: Three-dimensional structures of acidic and basic fibroblast growth factors.

PubMed ID: 1702556

DOI: 10.1126/science.1702556

PubMed ID: 7691311

Title: Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution.

PubMed ID: 7691311

DOI: 10.1002/pro.5560020810

PubMed ID: 11390973

Title: Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.

PubMed ID: 11390973

DOI: 10.1073/pnas.121183798

PubMed ID: 8885834

Title: High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy.

PubMed ID: 8885834

DOI: 10.1021/bi961260p

Sequence Information:

Length: 288
Mass: 30770
Checksum: EAE98552A39D5E19
Sequence:

MVGVGGGDVE DVTPRPGGCQ ISGRGARGCN GIPGAAAWEA ALPRRRPRRH PSVNPRSRAA 
GSPRTRGRRT EERPSGSRLG DRGRGRALPG GRLGGRGRGR APERVGGRGR GRGTAAPRAA 
PAARGSRPGP AGTMAAGSIT TLPALPEDGG SGAFPPGHFK DPKRLYCKNG GFFLRIHPDG 
RVDGVREKSD PHIKLQLQAE ERGVVSIKGV CANRYLAMKE DGRLLASKCV TDECFFFERL 
ESNNYNTYRS RKYTSWYVAL KRTGQYKLGS KTGPGQKAIL FLPMSAKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF2

Associated with

Cells (max top 100)

Other Information

Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells. PubMed ID: 3472745

Human basic fibroblast growth factor: nucleotide sequence and genomic organization. PubMed ID: 3780670

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. PubMed ID: 2538817

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Basic fibroblast growth factor gene expression. PubMed ID: 1785797

Cloning and expression of cDNA encoding human basic fibroblast growth factor. PubMed ID: 2435575

Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis. PubMed ID: 1721615

Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor. PubMed ID: 8564983

A form of human basic fibroblast growth factor with an extended amino terminus. PubMed ID: 3579930

Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue. PubMed ID: 2435284

Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities. PubMed ID: 3964259

Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors. PubMed ID: 3732516

Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients. PubMed ID: 1417798

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. PubMed ID: 1885605

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. PubMed ID: 10358027

Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. PubMed ID: 11509569

Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. PubMed ID: 11964394

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. PubMed ID: 16257968

Effect of FGF-binding protein 3 on vascular permeability. PubMed ID: 18669637

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. PubMed ID: 20230531

Cellular signaling by fibroblast growth factor receptors. PubMed ID: 15863030

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. PubMed ID: 22321063

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PubMed ID: 23469107

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. PubMed ID: 28302677

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. PubMed ID: 29501879

Crystal structure of basic fibroblast growth factor at 1.6-A resolution. PubMed ID: 1769963

Three-dimensional structure of human basic fibroblast growth factor. PubMed ID: 1707542

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. PubMed ID: 1849658

Three-dimensional structures of acidic and basic fibroblast growth factors. PubMed ID: 1702556

Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution. PubMed ID: 7691311

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. PubMed ID: 11390973

High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. PubMed ID: 8885834