Gene FGF2 - ENSG00000138685 | NCBI Gene ID: 2247

Details for: FGF2

Gene ID: 2247

Symbol: FGF2

Ensembl ID: ENSG00000138685

Description: fibroblast growth factor 2

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Extracellular matrix organization
(R-HSA-1474244)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1b ligand binding and activation
(R-HSA-190370)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2b ligand binding and activation
(R-HSA-190377)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Formation of intermediate mesoderm
(R-HSA-9761174)
Formation of the nephric duct
(R-HSA-9830364)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Gastrulation
(R-HSA-9758941)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Insulin receptor signalling cascade
(R-HSA-74751)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Kidney development
(R-HSA-9830369)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Pou5f1 (oct4), sox2, nanog activate genes related to proliferation
(R-HSA-2892247)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Syndecan interactions
(R-HSA-3000170)
Transcriptional regulation of pluripotent stem cells
(R-HSA-452723)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Chemoattractant activity
(GO:0042056)
Chemokine binding
(GO:0019956)
Cytokine activity
(GO:0005125)
Fibroblast growth factor receptor binding
(GO:0005104)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Nuclear receptor coactivator activity
(GO:0030374)
Organ induction
(GO:0001759)
Osteoblast differentiation
(GO:0001649)
Protein binding
(GO:0005515)
Receptor-receptor interaction
(GO:0090722)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.57
Marker Score: 2193
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.49
Marker Score: 53113
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.37
Marker Score: 988
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.98
Marker Score: 1978
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.91
Marker Score: 475
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.89
Marker Score: 475
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.86
Marker Score: 1226
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.77
Marker Score: 8706.5
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.64
Marker Score: 2045
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.63
Marker Score: 55329
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1157
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168808
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.35
Marker Score: 859
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.29
Marker Score: 2822
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 844
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.22
Marker Score: 708
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 481
Cell Name: fat cell (CL0000136)
Fold Change: 1.15
Marker Score: 644.5
Cell Name: retinal cone cell (CL0000573)
Fold Change: 1.15
Marker Score: 3299
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4790
Cell Name: astrocyte (CL0000127)
Fold Change: 1.12
Marker Score: 969
Cell Name: keratocyte (CL0002363)
Fold Change: 1.1
Marker Score: 253
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.08
Marker Score: 1457
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.08
Marker Score: 496
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.04
Marker Score: 329.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 786
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71796
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48021
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.98
Marker Score: 287
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.96
Marker Score: 608
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5341
Cell Name: stromal cell (CL0000499)
Fold Change: 0.92
Marker Score: 1079
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.92
Marker Score: 14383
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.91
Marker Score: 323
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.9
Marker Score: 1085.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.83
Marker Score: 459
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.81
Marker Score: 930
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.79
Marker Score: 168
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.78
Marker Score: 1495
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.78
Marker Score: 1578
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1253
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.77
Marker Score: 440
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 692
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.72
Marker Score: 422
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.69
Marker Score: 7768
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.69
Marker Score: 4130
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.68
Marker Score: 2525
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.67
Marker Score: 160
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.66
Marker Score: 300
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.65
Marker Score: 695
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.64
Marker Score: 993
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.62
Marker Score: 409.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.6
Marker Score: 358
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 378
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.57
Marker Score: 233
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.55
Marker Score: 559
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.55
Marker Score: 678
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.54
Marker Score: 20502
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.54
Marker Score: 238
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.54
Marker Score: 664
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.53
Marker Score: 1428
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.53
Marker Score: 4553
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.52
Marker Score: 215
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.51
Marker Score: 1011
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.5
Marker Score: 129
Cell Name: fibroblast (CL0000057)
Fold Change: 0.5
Marker Score: 480
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.49
Marker Score: 2071
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.49
Marker Score: 470
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.49
Marker Score: 530
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.49
Marker Score: 275
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 469
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.48
Marker Score: 177
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.48
Marker Score: 107
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.47
Marker Score: 116
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.46
Marker Score: 156
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.45
Marker Score: 1069
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.45
Marker Score: 1181
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.45
Marker Score: 4656
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.44
Marker Score: 214
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.43
Marker Score: 822
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 386
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.43
Marker Score: 205
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.43
Marker Score: 113
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.42
Marker Score: 108
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 130
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.41
Marker Score: 215
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.39
Marker Score: 137
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.39
Marker Score: 126
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.39
Marker Score: 360

Hover over a box to see details here...

**Key characteristics**: - FGF2 is a transmembrane protein with a molecular weight of approximately 180 kDa. - It is a member of the fibroblast growth factor family of proteins. - It is highly expressed in various cell types, including fibroblasts, astrocytes, and enterocytes. - It is involved in cell signaling pathways that are important for tissue development, differentiation, and survival. **Pathways and functions**: - FGF2 signaling is involved in cell proliferation, migration, and differentiation. - It is essential for the development of the cardiovascular, skeletal, and central nervous systems. - It is involved in wound healing and tissue repair. - It plays a role in the regulation of cell cycle progression and apoptosis. - It is involved in the regulation of inflammation and fibrosis. **Clinical significance**: - Mutations in FGF2 have been linked to several human diseases, including cancer, cardiovascular disease, and developmental disorders. - FGF2 inhibitors are being investigated as potential treatments for these diseases. - FGF2 is a promising target for cancer immunotherapy. **Additional notes**: - FGF2 is a highly conserved protein with significant expression in mammalian tissues. - It is a key factor in maintaining the integrity and function of the ECM. - Mutations in FGF2 have been linked to a number of human diseases, highlighting its critical role in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 2

Genular Protein ID: 721456115

Symbol: FGF2_HUMAN

Name: Fibroblast growth factor 2

UniProtKB Accession Codes:

P09038 A4LBB8 O00527 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6

Database IDs:

Citations:

PubMed ID: 3472745

Title: Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells.

PubMed ID: 3472745

DOI: 10.1101/sqb.1986.051.01.078

PubMed ID: 3780670

Title: Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

PubMed ID: 3780670

DOI: 10.1002/j.1460-2075.1986.tb04530.x

PubMed ID: 2538817

Title: High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

PubMed ID: 2538817

DOI: 10.1073/pnas.86.6.1836

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 1785797

Title: Basic fibroblast growth factor gene expression.

PubMed ID: 1785797

DOI: 10.1111/j.1749-6632.1991.tb49022.x

PubMed ID: 2435575

Title: Cloning and expression of cDNA encoding human basic fibroblast growth factor.

PubMed ID: 2435575

DOI: 10.1016/0014-5793(87)81489-8

PubMed ID: 1721615

Title: Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.

PubMed ID: 1721615

DOI: 10.1111/j.1349-7006.1991.tb01791.x

PubMed ID: 8564983

Title: Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor.

PubMed ID: 8564983

PubMed ID: 3579930

Title: A form of human basic fibroblast growth factor with an extended amino terminus.

PubMed ID: 3579930

DOI: 10.1016/s0006-291x(87)80001-3

PubMed ID: 2435284

Title: Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue.

PubMed ID: 2435284

DOI: 10.1016/0006-291x(87)91471-9

PubMed ID: 3964259

Title: Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.

PubMed ID: 3964259

DOI: 10.1016/0006-291x(86)90028-8

PubMed ID: 3732516

Title: Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

PubMed ID: 3732516

DOI: 10.1016/0014-5793(86)80812-2

PubMed ID: 1417798

Title: Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients.

PubMed ID: 1417798

DOI: 10.1016/0006-291x(92)90434-m

PubMed ID: 1885605

Title: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

PubMed ID: 1885605

DOI: 10.1016/s0021-9258(18)55368-0

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 10358027

Title: High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan.

PubMed ID: 10358027

DOI: 10.1074/jbc.274.24.16831

PubMed ID: 11509569

Title: Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.

PubMed ID: 11509569

DOI: 10.1074/jbc.m104933200

PubMed ID: 11964394

Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

PubMed ID: 11964394

DOI: 10.1074/jbc.m112193200

PubMed ID: 16257968

Title: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.

PubMed ID: 16257968

DOI: 10.1074/jbc.m510754200

PubMed ID: 18669637

Title: Effect of FGF-binding protein 3 on vascular permeability.

PubMed ID: 18669637

DOI: 10.1074/jbc.m802144200

PubMed ID: 20230531

Title: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.

PubMed ID: 20230531

DOI: 10.1111/j.1600-0854.2010.01059.x

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 22321063

Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.

PubMed ID: 22321063

DOI: 10.1111/j.1600-0854.2012.01341.x

PubMed ID: 23469107

Title: A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis.

PubMed ID: 23469107

DOI: 10.1371/journal.pone.0057927

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28302677

Title: The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.

PubMed ID: 28302677

DOI: 10.1042/bsr20170173

PubMed ID: 29501879

Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

PubMed ID: 29501879

DOI: 10.1016/j.exer.2018.02.025

PubMed ID: 1769963

Title: Crystal structure of basic fibroblast growth factor at 1.6-A resolution.

PubMed ID: 1769963

DOI: 10.1093/oxfordjournals.jbchem.a123586

PubMed ID: 1707542

Title: Three-dimensional structure of human basic fibroblast growth factor.

PubMed ID: 1707542

DOI: 10.1073/pnas.88.8.3441

PubMed ID: 1849658

Title: Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta.

PubMed ID: 1849658

DOI: 10.1073/pnas.88.8.3446

PubMed ID: 1702556

Title: Three-dimensional structures of acidic and basic fibroblast growth factors.

PubMed ID: 1702556

DOI: 10.1126/science.1702556

PubMed ID: 7691311

Title: Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution.

PubMed ID: 7691311

DOI: 10.1002/pro.5560020810

PubMed ID: 11390973

Title: Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.

PubMed ID: 11390973

DOI: 10.1073/pnas.121183798

PubMed ID: 8885834

Title: High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy.

PubMed ID: 8885834

DOI: 10.1021/bi961260p

Sequence Information:

Length: 288
Mass: 30770
Checksum: EAE98552A39D5E19
Sequence:

MVGVGGGDVE DVTPRPGGCQ ISGRGARGCN GIPGAAAWEA ALPRRRPRRH PSVNPRSRAA 
GSPRTRGRRT EERPSGSRLG DRGRGRALPG GRLGGRGRGR APERVGGRGR GRGTAAPRAA 
PAARGSRPGP AGTMAAGSIT TLPALPEDGG SGAFPPGHFK DPKRLYCKNG GFFLRIHPDG 
RVDGVREKSD PHIKLQLQAE ERGVVSIKGV CANRYLAMKE DGRLLASKCV TDECFFFERL 
ESNNYNTYRS RKYTSWYVAL KRTGQYKLGS KTGPGQKAIL FLPMSAKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF2

Associated with

Cells (max top 100)

Other Information

Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells. PubMed ID: 3472745

Human basic fibroblast growth factor: nucleotide sequence and genomic organization. PubMed ID: 3780670

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. PubMed ID: 2538817

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Basic fibroblast growth factor gene expression. PubMed ID: 1785797

Cloning and expression of cDNA encoding human basic fibroblast growth factor. PubMed ID: 2435575

Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis. PubMed ID: 1721615

Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor. PubMed ID: 8564983

A form of human basic fibroblast growth factor with an extended amino terminus. PubMed ID: 3579930

Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue. PubMed ID: 2435284

Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities. PubMed ID: 3964259

Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors. PubMed ID: 3732516

Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients. PubMed ID: 1417798

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. PubMed ID: 1885605

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. PubMed ID: 10358027

Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. PubMed ID: 11509569

Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. PubMed ID: 11964394

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. PubMed ID: 16257968

Effect of FGF-binding protein 3 on vascular permeability. PubMed ID: 18669637

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. PubMed ID: 20230531

Cellular signaling by fibroblast growth factor receptors. PubMed ID: 15863030

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. PubMed ID: 22321063

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. PubMed ID: 23469107

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. PubMed ID: 28302677

Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. PubMed ID: 29501879

Crystal structure of basic fibroblast growth factor at 1.6-A resolution. PubMed ID: 1769963

Three-dimensional structure of human basic fibroblast growth factor. PubMed ID: 1707542

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. PubMed ID: 1849658

Three-dimensional structures of acidic and basic fibroblast growth factors. PubMed ID: 1702556

Refinement of the structure of human basic fibroblast growth factor at 1.6-A resolution and analysis of presumed heparin binding sites by selenate substitution. PubMed ID: 7691311

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. PubMed ID: 11390973

High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. PubMed ID: 8885834