Details for: FOXM1

Gene ID: 2305

Symbol: FOXM1

Ensembl ID: ENSG00000111206

Description: forkhead box M1

Associated with

  • Cell cycle
    (R-HSA-1640170)
  • Cell cycle, mitotic
    (R-HSA-69278)
  • Cyclin a/b1/b2 associated events during g2/m transition
    (R-HSA-69273)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • G2/m transition
    (R-HSA-69275)
  • Mitotic g2-g2/m phases
    (R-HSA-453274)
  • Nuclear events stimulated by alk signaling in cancer
    (R-HSA-9725371)
  • Polo-like kinase mediated events
    (R-HSA-156711)
  • Signaling by alk fusions and activated point mutants
    (R-HSA-9725370)
  • Signaling by alk in cancer
    (R-HSA-9700206)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    (GO:0006978)
  • Dna repair
    (GO:0006281)
  • G2/m transition of mitotic cell cycle
    (GO:0000086)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of stress-activated mapk cascade
    (GO:0032873)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of double-strand break repair
    (GO:2000781)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of ras protein signal transduction
    (GO:0046578)
  • Regulation of reactive oxygen species metabolic process
    (GO:2000377)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.4
    Marker Score: 6879
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169512
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.47
    Marker Score: 3038
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.07
    Marker Score: 1010
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.06
    Marker Score: 1853
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5185
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.83
    Marker Score: 588
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.8
    Marker Score: 2186
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.76
    Marker Score: 807
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3049
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 464.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1326
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.64
    Marker Score: 853
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 298
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.62
    Marker Score: 455
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.6
    Marker Score: 295
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9098
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.58
    Marker Score: 1712
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.56
    Marker Score: 1053
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.54
    Marker Score: 918
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.54
    Marker Score: 650
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 386
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.5
    Marker Score: 315
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.5
    Marker Score: 602
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.5
    Marker Score: 157
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.47
    Marker Score: 595
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.47
    Marker Score: 236
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.47
    Marker Score: 675
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.46
    Marker Score: 152
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.45
    Marker Score: 1751
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.43
    Marker Score: 315
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.41
    Marker Score: 240
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.41
    Marker Score: 1113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.41
    Marker Score: 409
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 240
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.4
    Marker Score: 288
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.38
    Marker Score: 911
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.38
    Marker Score: 190
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.38
    Marker Score: 211
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.37
    Marker Score: 185
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 841
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.36
    Marker Score: 189
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.35
    Marker Score: 98
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.34
    Marker Score: 102
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.34
    Marker Score: 144
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.34
    Marker Score: 321
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 706
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 163
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.34
    Marker Score: 794
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.33
    Marker Score: 449
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.32
    Marker Score: 80
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.32
    Marker Score: 330
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.31
    Marker Score: 205.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.3
    Marker Score: 4089
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3
    Marker Score: 315
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.29
    Marker Score: 311.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 121
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.29
    Marker Score: 403
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.29
    Marker Score: 324
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.29
    Marker Score: 178
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.28
    Marker Score: 77
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.27
    Marker Score: 173
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.26
    Marker Score: 1024
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.25
    Marker Score: 1065
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.25
    Marker Score: 125
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.24
    Marker Score: 133
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 152
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.23
    Marker Score: 948
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 78

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Other Information

**Key characteristics:** - FOXM1 is a transcription factor that is highly expressed in certain cell types, including retinal cone cells, mural cells, kidney proximal convoluted tubule epithelial cells, and cancer cells. - It is a key regulator of the G2/M transition in mammalian cells. - FOXM1 binds to DNA sequences known as the Rna polymerase ii transcription regulatory region (RR2) and regulates the expression of several downstream genes involved in cell cycle progression, DNA repair, and apoptosis. - It is a target for mutations in many human cancers. **Pathways and functions:** - FOXM1 regulates the expression of genes involved in the G2/M transition, including CDK inhibitors, cyclin-dependent kinases (CDKs), and cell cycle checkpoints. - It also regulates the expression of genes involved in DNA repair, such as DNA repair proteins and DNA damage response genes. - FOXM1 is involved in the regulation of cell proliferation, apoptosis, and tumor growth. - In cancer cells, FOXM1 is often mutated or overexpressed, leading to uncontrolled cell growth and tumor formation. **Clinical significance:** - FOXM1 mutations are associated with several human cancers, including retinoblastoma, breast cancer, and lung cancer. - Targeting FOXM1 has been explored as a therapeutic strategy for cancer treatment. - Clinical trials are currently investigating the use of FOXM1 inhibitors to inhibit tumor growth and metastasis.

Genular Protein ID: 1405678044

Symbol: FOXM1_HUMAN

Name: Forkhead box protein M1

UniProtKB Accession Codes:

Q08050 O43258 O43259 O43260 Q4ZGG7 Q9BRL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9032290

Title: Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.

PubMed ID: 9032290

DOI: 10.1128/mcb.17.3.1626

PubMed ID: 9242644

Title: Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.

PubMed ID: 9242644

DOI: 10.1074/jbc.272.32.19827

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8290587

Title: Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

PubMed ID: 8290587

DOI: 10.1073/pnas.91.2.714

PubMed ID: 17101782

Title: Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.

PubMed ID: 17101782

DOI: 10.1128/mcb.01068-06

PubMed ID: 19160488

Title: Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.

PubMed ID: 19160488

DOI: 10.1038/ncb1767

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33754036

Title: Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2.

PubMed ID: 33754036

DOI: 10.7150/thno.55672

PubMed ID: 20360045

Title: Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

PubMed ID: 20360045

DOI: 10.1093/nar/gkq194

Sequence Information:

  • Length: 763
  • Mass: 84283
  • Checksum: 963CAC8FE7498E9B
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 
LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 
PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE 
SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE 
RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT 
PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS 
TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE 
GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ

Genular Protein ID: 798476021

Symbol: A0A2P9DTZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2P9DTZ8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 801
  • Mass: 88596
  • Checksum: 82416A3FA271C5D5
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 
LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 
PKVFGEQVVF GYMSKFFSGD LRDFGTPITS LFNFIFLCLS VLLAEEGIAP LSSAGPGKEE 
KLLFGEGFSP LLPVQTIKEE EIQPGEEMPH LARPIKVESP PLEEWPSPAP SFKEESSHSW 
EDSSQSPTPR PKKSYSGLRS PTRCVSEMLV IQHRERRERS RSRRKQHLLP PCVDEPELLF 
SEGPSTSRWA AELPFPADSS DPASQLSYSQ EVGGPFKTPI KETLPISSTP SKSVLPRTPE 
SWRLTPPAKV GGLDFSPVQT SQGASDPLPD PLGLMDLSTT PLQSAPPLES PQRLLSSEPL 
DLISVPFGNS SPSDIDVPKP GSPEPQVSGL AANRSLTEGL VLDTMNDSLS KILLDISFPG 
LDEDPLGPDN INWSQFIPEL Q

Genular Protein ID: 3569760116

Symbol: A8K591_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K591

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 747
  • Mass: 82614
  • Checksum: 35A74D671BFE6F8A
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCDGE AAGCTINNSL 
SNIQWLRKMS SDGLGSRSIK QEMEEKENCH LEQRQVKVEE PSRPSASWQN SVSERPPYSY 
MAMIQFAINS TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 
NGKVSFWTIH PSANRYLTLD QVFKQQKRPN PELRRNMTIK TELPLGARRK MKPLLPRVSS 
YLVPIQFPVN QSLVLQPSVK VPLPLAASLM SSELARHSKR VRIAPKVLLA EEGIAPLSSA 
GPGKEEKLLF GEGFSPLLPV QTIKEEEIQP GEEMPHLARP IKVESPPLEE WPSPAPSFKE 
ESSHSWEDSS QSPTPRPKKS YSGLRSPTRC VSEMLVIQHR ERRERSRSRR KQHLLPPCVD 
EPELLFSEGP STSRWAAELP FPADSSDPAS QLSYSQEVGG PFKTPIKETL PISSTPSKSV 
LPRTPESWRL TPPAKVGGLD FSPVQTSQGA SDPLPDPLGL MDLSTTPLQS APPLESPQRL 
LSSEPLDLIS VPFGNSSPSD IDVPKPGSPE PQVSGLAANR SLTEGLVLDT MNDSLSKILL 
DISFPGLDED PLGPDNINWS QFIPELQ

Genular Protein ID: 2213705062

Symbol: A0A2P9DTZ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2P9DTZ1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 748
  • Mass: 82685
  • Checksum: 3224A22B1434A531
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKQQKRP NPELRRNMTI KTELPLGARR KMKPLLPRVS 
SYLVPIQFPV NQSLVLQPSV KVPLPLAASL MSSELARHSK RVRIAPKVLL AEEGIAPLSS 
AGPGKEEKLL FGEGFSPLLP VQTIKEEEIQ PGEEMPHLAR PIKVESPPLE EWPSPAPSFK 
EESSHSWEDS SQSPTPRPKK SYSGLRSPTR CVSEMLVIQH RERRERSRSR RKQHLLPPCV 
DEPELLFSEG PSTSRWAAEL PFPADSSDPA SQLSYSQEVG GPFKTPIKET LPISSTPSKS 
VLPRTPESWR LTPPAKVGGL DFSPVQTSQG ASDPLPDPLG LMDLSTTPLQ SAPPLESPQR 
LLSSEPLDLI SVPFGNSSPS DIDVPKPGSP EPQVSGLAAN RSLTEGLVLD TMNDSLSKIL 
LDISFPGLDE DPLGPDNINW SQFIPELQ

Genular Protein ID: 3578634964

Symbol: A0A0D9SFF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D9SFF0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 748
  • Mass: 82742
  • Checksum: 78E1F5F0EAA66F95
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCDGE AAGCTINNSL 
SNIQWLRKMS SDGLGSRSIK QEMEEKENCH LEQRQVKVEE PSRPSASWQN SVSERPPYSY 
MAMIQFAINS TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 
NGKVSFWTIH PSANRYLTLD QVFKQQQKRP NPELRRNMTI KTELPLGARR KMKPLLPRVS 
SYLVPIQFPV NQSLVLQPSV KVPLPLAASL MSSELARHSK RVRIAPKVLL AEEGIAPLSS 
AGPGKEEKLL FGEGFSPLLP VQTIKEEEIQ PGEEMPHLAR PIKVESPPLE EWPSPAPSFK 
EESSHSWEDS SQSPTPRPKK SYSGLRSPTR CVSEMLVIQH RERRERSRSR RKQHLLPPCV 
DEPELLFSEG PSTSRWAAEL PFPADSSDPA SQLSYSQEVG GPFKTPIKET LPISSTPSKS 
VLPRTPESWR LTPPAKVGGL DFSPVQTSQG ASDPLPDPLG LMDLSTTPLQ SAPPLESPQR 
LLSSEPLDLI SVPFGNSSPS DIDVPKPGSP EPQVSGLAAN RSLTEGLVLD TMNDSLSKIL 
LDISFPGLDE DPLGPDNINW SQFIPELQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.