Details for: FOXM1

Gene ID: 2305

Symbol: FOXM1

Ensembl ID: ENSG00000111206

Description: forkhead box M1

Associated with

  • Cell cycle
    (R-HSA-1640170)
  • Cell cycle, mitotic
    (R-HSA-69278)
  • Cyclin a/b1/b2 associated events during g2/m transition
    (R-HSA-69273)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • G2/m transition
    (R-HSA-69275)
  • Mitotic g2-g2/m phases
    (R-HSA-453274)
  • Nuclear events stimulated by alk signaling in cancer
    (R-HSA-9725371)
  • Polo-like kinase mediated events
    (R-HSA-156711)
  • Signaling by alk fusions and activated point mutants
    (R-HSA-9725370)
  • Signaling by alk in cancer
    (R-HSA-9700206)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    (GO:0006978)
  • Dna repair
    (GO:0006281)
  • G2/m transition of mitotic cell cycle
    (GO:0000086)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of stress-activated mapk cascade
    (GO:0032873)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of double-strand break repair
    (GO:2000781)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of ras protein signal transduction
    (GO:0046578)
  • Regulation of reactive oxygen species metabolic process
    (GO:2000377)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.7806
    Cell Significance Index: -7.3000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.7300
    Cell Significance Index: -3.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8721
    Cell Significance Index: -7.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9082
    Cell Significance Index: -7.5300
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 1.2447
    Cell Significance Index: 0.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8554
    Cell Significance Index: 84.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6594
    Cell Significance Index: 130.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6361
    Cell Significance Index: 69.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6307
    Cell Significance Index: 5.4200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.6217
    Cell Significance Index: 7.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5193
    Cell Significance Index: 13.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4890
    Cell Significance Index: 93.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4461
    Cell Significance Index: 51.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3781
    Cell Significance Index: 4.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3703
    Cell Significance Index: 10.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3382
    Cell Significance Index: 39.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3245
    Cell Significance Index: 18.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2763
    Cell Significance Index: 249.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2396
    Cell Significance Index: 38.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2279
    Cell Significance Index: 6.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2229
    Cell Significance Index: 15.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1817
    Cell Significance Index: 9.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1649
    Cell Significance Index: 9.9000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.1568
    Cell Significance Index: 1.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1515
    Cell Significance Index: 4.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1295
    Cell Significance Index: 2.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1132
    Cell Significance Index: 3.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1103
    Cell Significance Index: 60.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1057
    Cell Significance Index: 2.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1019
    Cell Significance Index: 2.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0997
    Cell Significance Index: 2.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0988
    Cell Significance Index: 4.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0964
    Cell Significance Index: 2.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0901
    Cell Significance Index: 3.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0637
    Cell Significance Index: 28.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0489
    Cell Significance Index: 3.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0401
    Cell Significance Index: 8.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0340
    Cell Significance Index: 6.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0332
    Cell Significance Index: 51.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0324
    Cell Significance Index: 1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0205
    Cell Significance Index: 2.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0179
    Cell Significance Index: 33.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0155
    Cell Significance Index: 29.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0096
    Cell Significance Index: 13.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0080
    Cell Significance Index: 0.9900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0053
    Cell Significance Index: 0.0400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.0053
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0027
    Cell Significance Index: -0.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0171
    Cell Significance Index: -4.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0230
    Cell Significance Index: -2.9500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0242
    Cell Significance Index: -0.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0250
    Cell Significance Index: -2.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0261
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0393
    Cell Significance Index: -8.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0460
    Cell Significance Index: -3.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0526
    Cell Significance Index: -6.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0632
    Cell Significance Index: -3.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0653
    Cell Significance Index: -4.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0661
    Cell Significance Index: -6.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0662
    Cell Significance Index: -1.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0675
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0679
    Cell Significance Index: -7.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0768
    Cell Significance Index: -0.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0799
    Cell Significance Index: -6.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0841
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0863
    Cell Significance Index: -5.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0898
    Cell Significance Index: -1.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0918
    Cell Significance Index: -7.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0927
    Cell Significance Index: -6.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0951
    Cell Significance Index: -1.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0980
    Cell Significance Index: -2.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1013
    Cell Significance Index: -7.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1053
    Cell Significance Index: -1.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1113
    Cell Significance Index: -2.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1135
    Cell Significance Index: -1.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1167
    Cell Significance Index: -3.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1210
    Cell Significance Index: -5.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1229
    Cell Significance Index: -2.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1269
    Cell Significance Index: -5.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1283
    Cell Significance Index: -6.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1323
    Cell Significance Index: -1.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1431
    Cell Significance Index: -5.4200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1452
    Cell Significance Index: -1.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1545
    Cell Significance Index: -8.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1600
    Cell Significance Index: -1.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1647
    Cell Significance Index: -5.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1716
    Cell Significance Index: -6.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1720
    Cell Significance Index: -5.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1808
    Cell Significance Index: -2.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1889
    Cell Significance Index: -2.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXM1 is a member of the forkhead box family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is highly expressed in proliferating cells, including cancer cells, and is involved in the regulation of cell cycle progression, particularly during the G2/M phase. FOXM1 is also implicated in DNA damage response, repair, and apoptosis, making it a key regulator of cellular homeostasis. **Pathways and Functions:** FOXM1 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation:** FOXM1 regulates the expression of genes involved in cell cycle progression, including cyclin A, B1, and B2, which are essential for the transition from G2 to M phase. 2. **DNA Damage Response:** FOXM1 is involved in the regulation of DNA damage response, including the expression of genes involved in DNA repair and apoptosis. 3. **Transcriptional Regulation:** FOXM1 regulates the expression of genes involved in transcriptional processes, including DNA-templated transcription and RNA polymerase II-specific transcription. 4. **Apoptosis:** FOXM1 is also involved in the regulation of apoptosis, particularly in response to DNA damage. **Clinical Significance:** Dysregulation of FOXM1 has been implicated in various cancers, including breast, prostate, and lung cancer. Its overexpression has been associated with increased cell proliferation, resistance to chemotherapy, and poor prognosis. FOXM1 is also involved in the regulation of reactive oxygen species (ROS) metabolism, which is critical for cancer progression. As a therapeutic target, FOXM1 has been the focus of several cancer therapies, including small molecule inhibitors and RNA interference. **Significantly Expressed Cells:** FOXM1 is highly expressed in various cell types, including: 1. Retinal cone cells 2. Mural cells 3. Kidney proximal convoluted tubule epithelial cells 4. Migratory enteric neural crest cells 5. Germ cells 6. Cerebral cortex GABAergic interneurons 7. Forebrain radial glial cells 8. Absorptive cells 9. Tuft cells of colon 10. BEST4+ intestinal epithelial cells **Proteins Associated with FOXM1:** Several proteins have been identified as interacting partners of FOXM1, including: 1. A0A2P9DTZ8_HUMAN 2. A8K591_HUMAN 3. A0A2P9DTZ1_HUMAN 4. A0A0D9SFF0_HUMAN In conclusion, the FOXM1 gene is a critical regulator of the cell cycle, DNA damage response, and transcriptional regulation, making it a key player in cancer progression. Its dysregulation has been implicated in various cancers, highlighting its potential as a therapeutic target. Further research is needed to fully understand the mechanisms of FOXM1 and its role in cancer progression.

Genular Protein ID: 1405678044

Symbol: FOXM1_HUMAN

Name: Forkhead box protein M1

UniProtKB Accession Codes:

Q08050 O43258 O43259 O43260 Q4ZGG7 Q9BRL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9032290

Title: Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.

PubMed ID: 9032290

DOI: 10.1128/mcb.17.3.1626

PubMed ID: 9242644

Title: Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.

PubMed ID: 9242644

DOI: 10.1074/jbc.272.32.19827

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8290587

Title: Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

PubMed ID: 8290587

DOI: 10.1073/pnas.91.2.714

PubMed ID: 17101782

Title: Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.

PubMed ID: 17101782

DOI: 10.1128/mcb.01068-06

PubMed ID: 19160488

Title: Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.

PubMed ID: 19160488

DOI: 10.1038/ncb1767

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33754036

Title: Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2.

PubMed ID: 33754036

DOI: 10.7150/thno.55672

PubMed ID: 30139873

Title: An intrinsic S/G2 checkpoint enforced by ATR.

PubMed ID: 30139873

DOI: 10.1126/science.aap9346

PubMed ID: 20360045

Title: Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

PubMed ID: 20360045

DOI: 10.1093/nar/gkq194

Sequence Information:

  • Length: 763
  • Mass: 84283
  • Checksum: 963CAC8FE7498E9B
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 
LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 
PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE 
SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE 
RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT 
PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS 
TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE 
GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQ

Genular Protein ID: 2213705062

Symbol: A0A2P9DTZ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2P9DTZ1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 748
  • Mass: 82685
  • Checksum: 3224A22B1434A531
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKQQKRP NPELRRNMTI KTELPLGARR KMKPLLPRVS 
SYLVPIQFPV NQSLVLQPSV KVPLPLAASL MSSELARHSK RVRIAPKVLL AEEGIAPLSS 
AGPGKEEKLL FGEGFSPLLP VQTIKEEEIQ PGEEMPHLAR PIKVESPPLE EWPSPAPSFK 
EESSHSWEDS SQSPTPRPKK SYSGLRSPTR CVSEMLVIQH RERRERSRSR RKQHLLPPCV 
DEPELLFSEG PSTSRWAAEL PFPADSSDPA SQLSYSQEVG GPFKTPIKET LPISSTPSKS 
VLPRTPESWR LTPPAKVGGL DFSPVQTSQG ASDPLPDPLG LMDLSTTPLQ SAPPLESPQR 
LLSSEPLDLI SVPFGNSSPS DIDVPKPGSP EPQVSGLAAN RSLTEGLVLD TMNDSLSKIL 
LDISFPGLDE DPLGPDNINW SQFIPELQ

Genular Protein ID: 3578634964

Symbol: A0A0D9SFF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D9SFF0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 748
  • Mass: 82742
  • Checksum: 78E1F5F0EAA66F95
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCDGE AAGCTINNSL 
SNIQWLRKMS SDGLGSRSIK QEMEEKENCH LEQRQVKVEE PSRPSASWQN SVSERPPYSY 
MAMIQFAINS TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 
NGKVSFWTIH PSANRYLTLD QVFKQQQKRP NPELRRNMTI KTELPLGARR KMKPLLPRVS 
SYLVPIQFPV NQSLVLQPSV KVPLPLAASL MSSELARHSK RVRIAPKVLL AEEGIAPLSS 
AGPGKEEKLL FGEGFSPLLP VQTIKEEEIQ PGEEMPHLAR PIKVESPPLE EWPSPAPSFK 
EESSHSWEDS SQSPTPRPKK SYSGLRSPTR CVSEMLVIQH RERRERSRSR RKQHLLPPCV 
DEPELLFSEG PSTSRWAAEL PFPADSSDPA SQLSYSQEVG GPFKTPIKET LPISSTPSKS 
VLPRTPESWR LTPPAKVGGL DFSPVQTSQG ASDPLPDPLG LMDLSTTPLQ SAPPLESPQR 
LLSSEPLDLI SVPFGNSSPS DIDVPKPGSP EPQVSGLAAN RSLTEGLVLD TMNDSLSKIL 
LDISFPGLDE DPLGPDNINW SQFIPELQ

Genular Protein ID: 798476021

Symbol: A0A2P9DTZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2P9DTZ8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 801
  • Mass: 88596
  • Checksum: 82416A3FA271C5D5
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS 
LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS 
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS 
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP 
LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA 
PKVFGEQVVF GYMSKFFSGD LRDFGTPITS LFNFIFLCLS VLLAEEGIAP LSSAGPGKEE 
KLLFGEGFSP LLPVQTIKEE EIQPGEEMPH LARPIKVESP PLEEWPSPAP SFKEESSHSW 
EDSSQSPTPR PKKSYSGLRS PTRCVSEMLV IQHRERRERS RSRRKQHLLP PCVDEPELLF 
SEGPSTSRWA AELPFPADSS DPASQLSYSQ EVGGPFKTPI KETLPISSTP SKSVLPRTPE 
SWRLTPPAKV GGLDFSPVQT SQGASDPLPD PLGLMDLSTT PLQSAPPLES PQRLLSSEPL 
DLISVPFGNS SPSDIDVPKP GSPEPQVSGL AANRSLTEGL VLDTMNDSLS KILLDISFPG 
LDEDPLGPDN INWSQFIPEL Q

Genular Protein ID: 3569760116

Symbol: A8K591_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K591

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 747
  • Mass: 82614
  • Checksum: 35A74D671BFE6F8A
  • Sequence:
    • MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA 
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG 
LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCDGE AAGCTINNSL 
SNIQWLRKMS SDGLGSRSIK QEMEEKENCH LEQRQVKVEE PSRPSASWQN SVSERPPYSY 
MAMIQFAINS TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 
NGKVSFWTIH PSANRYLTLD QVFKQQKRPN PELRRNMTIK TELPLGARRK MKPLLPRVSS 
YLVPIQFPVN QSLVLQPSVK VPLPLAASLM SSELARHSKR VRIAPKVLLA EEGIAPLSSA 
GPGKEEKLLF GEGFSPLLPV QTIKEEEIQP GEEMPHLARP IKVESPPLEE WPSPAPSFKE 
ESSHSWEDSS QSPTPRPKKS YSGLRSPTRC VSEMLVIQHR ERRERSRSRR KQHLLPPCVD 
EPELLFSEGP STSRWAAELP FPADSSDPAS QLSYSQEVGG PFKTPIKETL PISSTPSKSV 
LPRTPESWRL TPPAKVGGLD FSPVQTSQGA SDPLPDPLGL MDLSTTPLQS APPLESPQRL 
LSSEPLDLIS VPFGNSSPSD IDVPKPGSPE PQVSGLAANR SLTEGLVLDT MNDSLSKILL 
DISFPGLDED PLGPDNINWS QFIPELQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.