FOXO3 | ENSG00000118689 | NCBI 2309

Details for: FOXO3

Gene ID: 2309

Symbol: FOXO3

Ensembl ID: ENSG00000118689

Description: forkhead box O3

Associated with

Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Mitochondrial unfolded protein response (uprmt)
(R-HSA-9841251)
Neurodegenerative diseases
(R-HSA-8863678)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates bcl2l11 (bim) transcription
(R-HSA-8952158)
Signaling by interleukins
(R-HSA-449147)
Signaling by nodal
(R-HSA-1181150)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Antral ovarian follicle growth
(GO:0001547)
Beta-catenin binding
(GO:0008013)
Brain morphogenesis
(GO:0048854)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to corticosterone stimulus
(GO:0071386)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to oxidative stress
(GO:0034599)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Initiation of primordial ovarian follicle growth
(GO:0001544)
Mitochondrial transcription
(GO:0006390)
Mitochondrial transcription factor activity
(GO:0034246)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Ovulation from ovarian follicle
(GO:0001542)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of hydrogen peroxide-mediated programmed cell death
(GO:1901300)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of muscle atrophy
(GO:0014737)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of translation
(GO:0006417)
Response to dexamethasone
(GO:0071548)
Response to fatty acid
(GO:0070542)
Response to starvation
(GO:0042594)
Response to water-immersion restraint stress
(GO:1990785)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 570.6379
Cell Significance Index: -88.7600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 354.7106
Cell Significance Index: -89.9700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 211.5318
Cell Significance Index: -87.1400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 201.9391
Cell Significance Index: -95.3400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 194.0766
Cell Significance Index: -78.8500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 175.6271
Cell Significance Index: -90.3400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 142.2755
Cell Significance Index: -95.4700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 82.7867
Cell Significance Index: -79.0400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 71.0244
Cell Significance Index: -87.5700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 33.6524
Cell Significance Index: -90.1500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 27.7881
Cell Significance Index: -85.3500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 26.9717
Cell Significance Index: -59.0300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.0747
Cell Significance Index: -95.0000
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 14.7251
Cell Significance Index: 99.7700
Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.4124
Cell Significance Index: 107.6600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.0564
Cell Significance Index: 68.3300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.0337
Cell Significance Index: 77.9800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.0332
Cell Significance Index: 232.7600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3428
Cell Significance Index: 464.9300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.2161
Cell Significance Index: 794.8800
Cell Name: type II muscle cell (CL0002212)
Fold Change: 2.1717
Cell Significance Index: 35.0400
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.1130
Cell Significance Index: 26.6100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9731
Cell Significance Index: 395.8000
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.9214
Cell Significance Index: 37.5000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.8901
Cell Significance Index: 106.0600
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.6188
Cell Significance Index: 14.3700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4267
Cell Significance Index: 39.8700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.3530
Cell Significance Index: 19.4300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2124
Cell Significance Index: 34.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8641
Cell Significance Index: 140.5500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8563
Cell Significance Index: 109.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7519
Cell Significance Index: 81.7800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5928
Cell Significance Index: 410.0200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5899
Cell Significance Index: 72.5400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5846
Cell Significance Index: 105.3800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5623
Cell Significance Index: 34.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5355
Cell Significance Index: 292.4400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5263
Cell Significance Index: 334.2300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4173
Cell Significance Index: 184.5000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3552
Cell Significance Index: 16.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3499
Cell Significance Index: 59.7400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3256
Cell Significance Index: 5.5800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3175
Cell Significance Index: 597.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2627
Cell Significance Index: 7.5700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1827
Cell Significance Index: 82.9400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1796
Cell Significance Index: 4.4900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1779
Cell Significance Index: 160.6600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1423
Cell Significance Index: 6.4500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1334
Cell Significance Index: 18.3200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1264
Cell Significance Index: 8.7400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0945
Cell Significance Index: 4.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0810
Cell Significance Index: 149.4800
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0503
Cell Significance Index: 0.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0465
Cell Significance Index: 71.5700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0410
Cell Significance Index: 55.8000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0350
Cell Significance Index: 1.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0212
Cell Significance Index: 1.0000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0038
Cell Significance Index: 0.4800
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0126
Cell Significance Index: -1.2500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0275
Cell Significance Index: -1.0400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0386
Cell Significance Index: -24.0800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0404
Cell Significance Index: -29.6300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0598
Cell Significance Index: -44.2800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0611
Cell Significance Index: -6.9700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0617
Cell Significance Index: -1.6800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1029
Cell Significance Index: -77.8500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1198
Cell Significance Index: -67.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1605
Cell Significance Index: -16.3900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1940
Cell Significance Index: -10.1100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2065
Cell Significance Index: -15.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.2514
Cell Significance Index: -47.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2714
Cell Significance Index: -39.4600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2801
Cell Significance Index: -59.0000
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2870
Cell Significance Index: -2.3400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2875
Cell Significance Index: -82.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3022
Cell Significance Index: -8.0700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3125
Cell Significance Index: -16.4100
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3408
Cell Significance Index: -5.0300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3949
Cell Significance Index: -5.8300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4719
Cell Significance Index: -54.9900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5031
Cell Significance Index: -32.4600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5453
Cell Significance Index: -34.3700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5702
Cell Significance Index: -65.3300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6610
Cell Significance Index: -22.9700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6972
Cell Significance Index: -49.3100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7103
Cell Significance Index: -36.9000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7114
Cell Significance Index: -83.9000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7354
Cell Significance Index: -76.5700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8435
Cell Significance Index: -56.7200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.8676
Cell Significance Index: -14.5200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.8771
Cell Significance Index: -18.7500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.9461
Cell Significance Index: -22.6900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9514
Cell Significance Index: -75.3500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.1514
Cell Significance Index: -16.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2788
Cell Significance Index: -78.4000
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.3126
Cell Significance Index: -34.5200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.3197
Cell Significance Index: -28.5900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.3823
Cell Significance Index: -29.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.5364
Cell Significance Index: -49.2100
Cell Name: peg cell (CL4033014)
Fold Change: -1.5859
Cell Significance Index: -36.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FOXO3 is a member of the forkhead box (FOX) family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. FOXO3 is a transcription factor that belongs to the FOXO subfamily and is primarily localized in the nucleus. It is activated by phosphorylation, which allows it to translocate to the nucleus and regulate the expression of target genes. FOXO3 has several key characteristics that distinguish it from other transcription factors: 1. **Phosphorylation-dependent regulation**: FOXO3 is activated by phosphorylation, which allows it to translocate to the nucleus and regulate gene expression. 2. **DNA-binding specificity**: FOXO3 binds to specific DNA sequences, which are often located in the promoter regions of target genes. 3. **Regulation of cell cycle and apoptosis**: FOXO3 regulates the expression of genes involved in cell cycle progression and apoptosis. 4. **Metabolic regulation**: FOXO3 regulates the expression of genes involved in glucose and lipid metabolism. **Pathways and Functions** FOXO3 is involved in several signaling pathways, including: 1. **Akt signaling pathway**: FOXO3 is phosphorylated and inactivated by Akt, which allows it to translocate to the cytoplasm and regulate gene expression. 2. **Wnt/β-catenin signaling pathway**: FOXO3 negatively regulates the Wnt/β-catenin signaling pathway, which is involved in cell proliferation and differentiation. 3. **Mitochondrial stress response**: FOXO3 regulates the expression of genes involved in mitochondrial stress response, including genes involved in oxidative stress and apoptosis. 4. **Autophagy regulation**: FOXO3 regulates the expression of genes involved in autophagy, a cellular process involved in the degradation and recycling of cellular components. FOXO3 has several functions, including: 1. **Regulation of cell cycle**: FOXO3 regulates the expression of genes involved in cell cycle progression, including genes involved in DNA repair and replication. 2. **Apoptosis regulation**: FOXO3 regulates the expression of genes involved in apoptosis, including genes involved in mitochondrial stress response and autophagy. 3. **Metabolic regulation**: FOXO3 regulates the expression of genes involved in glucose and lipid metabolism, including genes involved in insulin signaling and glucose uptake. 4. **Stress response**: FOXO3 regulates the expression of genes involved in stress response, including genes involved in oxidative stress and hypoxia. **Clinical Significance** FOXO3 has been implicated in various diseases, including: 1. **Metabolic disorders**: FOXO3 has been linked to metabolic disorders, including type 2 diabetes and obesity. 2. **Cancer**: FOXO3 has been implicated in the development and progression of various cancers, including breast cancer and colon cancer. 3. **Neurodegenerative diseases**: FOXO3 has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: FOXO3 has been implicated in the development of cardiovascular disease, including atherosclerosis and heart failure. In conclusion, FOXO3 is a crucial transcription factor involved in various cellular processes, including metabolism, stress response, and apoptosis. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

FOXO3_HUMAN
A0A856PRE8_HUMAN

Genular Protein ID: 271034410

Symbol: FOXO3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43524 B4DVZ6 E1P5E6 O15171 Q5T2I7 Q9BZ04

Database IDs:

Citations:

PubMed ID: 9479491

Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.

PubMed ID: 9479491

DOI: 10.1006/geno.1997.5122

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9345057

Title: AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.

PubMed ID: 9345057

PubMed ID: 10102273

Title: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

PubMed ID: 10102273

DOI: 10.1016/s0092-8674(00)80595-4

PubMed ID: 11154281

Title: Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

PubMed ID: 11154281

DOI: 10.1128/mcb.21.3.952-965.2001

PubMed ID: 15084260

Title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

PubMed ID: 15084260

DOI: 10.1016/s0092-8674(04)00302-2

PubMed ID: 16751106

Title: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

PubMed ID: 16751106

DOI: 10.1016/j.cell.2006.03.046

PubMed ID: 17711846

Title: The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

PubMed ID: 17711846

DOI: 10.1074/jbc.m705325200

PubMed ID: 18593906

Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

PubMed ID: 18593906

DOI: 10.1158/0008-5472.can-08-0634

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20181828

Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

PubMed ID: 20181828

DOI: 10.1091/mbc.e09-09-0818

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21329882

Title: The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

PubMed ID: 21329882

DOI: 10.1016/j.molcel.2011.01.023

PubMed ID: 22820736

Title: Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

PubMed ID: 22820736

DOI: 10.18632/aging.100471

PubMed ID: 22313691

Title: IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death.

PubMed ID: 22313691

DOI: 10.1016/j.cellsig.2012.01.012

PubMed ID: 21841822

Title: Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

PubMed ID: 21841822

DOI: 10.1038/onc.2011.347

PubMed ID: 22761832

Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PubMed ID: 22761832

DOI: 10.1371/journal.pone.0039586

PubMed ID: 23283301

Title: A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

PubMed ID: 23283301

DOI: 10.1007/s00018-012-1244-6

PubMed ID: 23805378

Title: CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.

PubMed ID: 23805378

DOI: 10.7554/elife.00518

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29445193

Title: Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

PubMed ID: 29445193

DOI: 10.1038/s41419-018-0336-0

PubMed ID: 30513302

Title: AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis.

PubMed ID: 30513302

DOI: 10.1016/j.devcel.2018.11.010

PubMed ID: 17940099

Title: Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification.

PubMed ID: 17940099

DOI: 10.1093/nar/gkm703

Sequence Information:

Length: 673
Mass: 71277
Checksum: E5B4E830665A9982
Sequence:

MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE 
EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV LAPGGQDPGS GPATAAGGLS 
GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC SSRRNAWGNL SYADLITRAI ESSPDKRLTL 
SQIYEWMVRC VPYFKDKGDS NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG 
GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS 
DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS SASLSPSVSK 
PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ PSPTGGLMQR SSSFPYTTKG 
SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS SMSHYGNQTL QDLLTSDSLS 
HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT 
QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP 
VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN VVGLNVGNFT 
GAKQASSQSW VPG

Genular Protein ID: 2916850106

Symbol: A0A856PRE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A856PRE8

Database IDs:

Sequence Information:

Length: 453
Mass: 48406
Checksum: E093364532E78AE1
Sequence:

MRVQNEGTGK SSWWIINPDG GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES 
ADDSPSQLSK WPGSPTSRSS DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD 
APLSPMLYSS SASLSPSVSK PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ 
PSPTGGLMQR SSSFPYTTKG SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS 
SMSHYGNQTL QDLLTSDSLS HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA 
AQPNQGSLVN QNLLHHQHQT QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM 
QTLSDSLSGS SLYSTSANLP VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF 
NFDSLISTQN VVGLNVGNFT GAKQASSQSW VPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOXO3

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. PubMed ID: 9479491

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. PubMed ID: 9345057

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. PubMed ID: 10102273

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). PubMed ID: 11154281

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. PubMed ID: 15084260

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. PubMed ID: 16751106

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. PubMed ID: 17711846

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. PubMed ID: 18593906

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. PubMed ID: 20181828

Initial characterization of the human central proteome. PubMed ID: 21269460

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. PubMed ID: 21329882

Methylation by Set9 modulates FoxO3 stability and transcriptional activity. PubMed ID: 22820736

IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death. PubMed ID: 22313691

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. PubMed ID: 21841822

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PubMed ID: 22761832

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. PubMed ID: 23283301

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. PubMed ID: 23805378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. PubMed ID: 29445193

AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. PubMed ID: 30513302

Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. PubMed ID: 17940099