Gene FOXO3 - ENSG00000118689 | NCBI Gene ID: 2309

Details for: FOXO3

Gene ID: 2309

Symbol: FOXO3

Ensembl ID: ENSG00000118689

Description: forkhead box O3

Associated with

Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Neurodegenerative diseases
(R-HSA-8863678)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates bcl2l11 (bim) transcription
(R-HSA-8952158)
Signaling by interleukins
(R-HSA-449147)
Signaling by nodal
(R-HSA-1181150)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Antral ovarian follicle growth
(GO:0001547)
Beta-catenin binding
(GO:0008013)
Brain morphogenesis
(GO:0048854)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to corticosterone stimulus
(GO:0071386)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to oxidative stress
(GO:0034599)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Initiation of primordial ovarian follicle growth
(GO:0001544)
Mitochondrial transcription
(GO:0006390)
Mitochondrial transcription factor activity
(GO:0034246)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Ovulation from ovarian follicle
(GO:0001542)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of hydrogen peroxide-mediated programmed cell death
(GO:1901300)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of muscle atrophy
(GO:0014737)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of translation
(GO:0006417)
Response to dexamethasone
(GO:0071548)
Response to fatty acid
(GO:0070542)
Response to starvation
(GO:0042594)
Response to water-immersion restraint stress
(GO:1990785)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 5.95
Marker Score: 3916.5
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.34
Marker Score: 13360
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.34
Marker Score: 2416.5
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.62
Marker Score: 4514.5
Cell Name: contractile cell (CL0000183)
Fold Change: 3.44
Marker Score: 1862
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.33
Marker Score: 3554
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 3.22
Marker Score: 2852
Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.11
Marker Score: 4376
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.88
Marker Score: 5535
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.87
Marker Score: 64052.5
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.69
Marker Score: 3100
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.67
Marker Score: 976
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.56
Marker Score: 54731.5
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.55
Marker Score: 1771
Cell Name: fat cell (CL0000136)
Fold Change: 2.55
Marker Score: 1423
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.51
Marker Score: 85437
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.35
Marker Score: 2238
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.3
Marker Score: 34421
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.27
Marker Score: 17365
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.21
Marker Score: 3215
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.21
Marker Score: 2500
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.15
Marker Score: 1067
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.14
Marker Score: 42518
Cell Name: lactocyte (CL0002325)
Fold Change: 2.11
Marker Score: 33887
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.1
Marker Score: 79811
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.09
Marker Score: 1091
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.09
Marker Score: 541
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.07
Marker Score: 4535
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.05
Marker Score: 1226
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.04
Marker Score: 7895
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.04
Marker Score: 596
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.99
Marker Score: 9184
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.97
Marker Score: 72707
Cell Name: keratocyte (CL0002363)
Fold Change: 1.97
Marker Score: 453
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.94
Marker Score: 1020
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.93
Marker Score: 2077
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.92
Marker Score: 118038
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.92
Marker Score: 7957
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.86
Marker Score: 903.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.84
Marker Score: 1208
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.84
Marker Score: 7681
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.82
Marker Score: 1063
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.82
Marker Score: 4773
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.8
Marker Score: 673
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.79
Marker Score: 10616
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.79
Marker Score: 5858
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.78
Marker Score: 556.5
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.78
Marker Score: 1013
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.75
Marker Score: 765
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.74
Marker Score: 1307
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.73
Marker Score: 14885
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.73
Marker Score: 16274
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.73
Marker Score: 498
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.72
Marker Score: 6106.5
Cell Name: astrocyte (CL0000127)
Fold Change: 1.71
Marker Score: 1485
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.7
Marker Score: 16186
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.69
Marker Score: 614
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.68
Marker Score: 607.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.68
Marker Score: 976
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.64
Marker Score: 3748
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.64
Marker Score: 496
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.64
Marker Score: 1842
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.63
Marker Score: 525
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.63
Marker Score: 3997.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.62
Marker Score: 1617
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.61
Marker Score: 6696.5
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.6
Marker Score: 602
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.59
Marker Score: 661
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.59
Marker Score: 1081
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.57
Marker Score: 16211
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.57
Marker Score: 1678.5
Cell Name: podocyte (CL0000653)
Fold Change: 1.55
Marker Score: 574
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.55
Marker Score: 1608
Cell Name: neural cell (CL0002319)
Fold Change: 1.54
Marker Score: 742
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.52
Marker Score: 890.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.52
Marker Score: 3208
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.51
Marker Score: 3557
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.5
Marker Score: 1855
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.5
Marker Score: 370
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.5
Marker Score: 15048
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.48
Marker Score: 1280
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.47
Marker Score: 2083
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.46
Marker Score: 370.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.45
Marker Score: 689
Cell Name: neuron (CL0000540)
Fold Change: 1.45
Marker Score: 5912
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.45
Marker Score: 676.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.44
Marker Score: 2227
Cell Name: mural cell (CL0008034)
Fold Change: 1.44
Marker Score: 165403
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.44
Marker Score: 7736
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.44
Marker Score: 4936
Cell Name: acinar cell (CL0000622)
Fold Change: 1.43
Marker Score: 1011
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.43
Marker Score: 3431
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.43
Marker Score: 707.5
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.43
Marker Score: 9184.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.43
Marker Score: 1098
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.42
Marker Score: 1754
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.42
Marker Score: 2513
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.42
Marker Score: 7433.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.4
Marker Score: 4976
Cell Name: Unknown (CL0002371)
Fold Change: 1.4
Marker Score: 1485.5

Hover over a box to see details here...

**Key characteristics:** - The FOXO3 gene belongs to the forkhead box O (FOXO) family of transcription factors. - It is a key regulator of stem cell differentiation and homeostasis. - It is involved in the regulation of muscle development, differentiation, and metabolism. - It is a key regulator of cellular senescence. - It is involved in inflammation, cell growth, and tumor suppression. **Pathways and functions:** - FOXO3 is a key regulator of the cytokine signaling pathway in the immune system. - It is involved in the regulation of immune cell differentiation, activation, and survival. - It is involved in the regulation of cell growth and differentiation in various tissues. - It is involved in the regulation of apoptosis (programmed cell death). - It is involved in the regulation of cell metabolism. **Clinical significance:** - Mutations in the FOXO3 gene have been linked to various human diseases, including cancer and metabolic disorders. - FOXO3 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases. - Understanding the role of FOXO3 in health and disease is important for the development of new therapeutic strategies. **Conclusion:** The FOXO3 gene is a key regulator of various cellular processes, including development, differentiation, and survival. Its mutations have been linked to numerous human diseases, highlighting its importance in maintaining cellular homeostasis and preventing cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

FOXO3_HUMAN
A0A856PRE8_HUMAN

Genular Protein ID: 271034410

Symbol: FOXO3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43524 B4DVZ6 E1P5E6 O15171 Q5T2I7 Q9BZ04

Database IDs:

Citations:

PubMed ID: 9479491

Title: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.

PubMed ID: 9479491

DOI: 10.1006/geno.1997.5122

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9345057

Title: AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.

PubMed ID: 9345057

PubMed ID: 10102273

Title: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

PubMed ID: 10102273

DOI: 10.1016/s0092-8674(00)80595-4

PubMed ID: 11154281

Title: Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

PubMed ID: 11154281

DOI: 10.1128/mcb.21.3.952-965.2001

PubMed ID: 15084260

Title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

PubMed ID: 15084260

DOI: 10.1016/s0092-8674(04)00302-2

PubMed ID: 16751106

Title: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

PubMed ID: 16751106

DOI: 10.1016/j.cell.2006.03.046

PubMed ID: 17711846

Title: The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

PubMed ID: 17711846

DOI: 10.1074/jbc.m705325200

PubMed ID: 18593906

Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

PubMed ID: 18593906

DOI: 10.1158/0008-5472.can-08-0634

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20181828

Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

PubMed ID: 20181828

DOI: 10.1091/mbc.e09-09-0818

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21329882

Title: The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

PubMed ID: 21329882

DOI: 10.1016/j.molcel.2011.01.023

PubMed ID: 22820736

Title: Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

PubMed ID: 22820736

DOI: 10.18632/aging.100471

PubMed ID: 22313691

Title: IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death.

PubMed ID: 22313691

DOI: 10.1016/j.cellsig.2012.01.012

PubMed ID: 21841822

Title: Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

PubMed ID: 21841822

DOI: 10.1038/onc.2011.347

PubMed ID: 22761832

Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PubMed ID: 22761832

DOI: 10.1371/journal.pone.0039586

PubMed ID: 23283301

Title: A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

PubMed ID: 23283301

DOI: 10.1007/s00018-012-1244-6

PubMed ID: 23805378

Title: CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.

PubMed ID: 23805378

DOI: 10.7554/elife.00518

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29445193

Title: Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy.

PubMed ID: 29445193

DOI: 10.1038/s41419-018-0336-0

PubMed ID: 30513302

Title: AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis.

PubMed ID: 30513302

DOI: 10.1016/j.devcel.2018.11.010

PubMed ID: 17940099

Title: Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification.

PubMed ID: 17940099

DOI: 10.1093/nar/gkm703

Sequence Information:

Length: 673
Mass: 71277
Checksum: E5B4E830665A9982
Sequence:

MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE 
EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV LAPGGQDPGS GPATAAGGLS 
GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC SSRRNAWGNL SYADLITRAI ESSPDKRLTL 
SQIYEWMVRC VPYFKDKGDS NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG 
GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS 
DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS SASLSPSVSK 
PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ PSPTGGLMQR SSSFPYTTKG 
SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS SMSHYGNQTL QDLLTSDSLS 
HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT 
QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP 
VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN VVGLNVGNFT 
GAKQASSQSW VPG

Genular Protein ID: 2916850106

Symbol: A0A856PRE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A856PRE8

Database IDs:

Sequence Information:

Length: 453
Mass: 48406
Checksum: E093364532E78AE1
Sequence:

MRVQNEGTGK SSWWIINPDG GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES 
ADDSPSQLSK WPGSPTSRSS DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD 
APLSPMLYSS SASLSPSVSK PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ 
PSPTGGLMQR SSSFPYTTKG SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS 
SMSHYGNQTL QDLLTSDSLS HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA 
AQPNQGSLVN QNLLHHQHQT QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM 
QTLSDSLSGS SLYSTSANLP VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF 
NFDSLISTQN VVGLNVGNFT GAKQASSQSW VPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FOXO3

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. PubMed ID: 9479491

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. PubMed ID: 9345057

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. PubMed ID: 10102273

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). PubMed ID: 11154281

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. PubMed ID: 15084260

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. PubMed ID: 16751106

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. PubMed ID: 17711846

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. PubMed ID: 18593906

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. PubMed ID: 20181828

Initial characterization of the human central proteome. PubMed ID: 21269460

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis. PubMed ID: 21329882

Methylation by Set9 modulates FoxO3 stability and transcriptional activity. PubMed ID: 22820736

IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death. PubMed ID: 22313691

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. PubMed ID: 21841822

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PubMed ID: 22761832

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. PubMed ID: 23283301

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. PubMed ID: 23805378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. PubMed ID: 29445193

AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. PubMed ID: 30513302

Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. PubMed ID: 17940099