Details for: FNTA

Gene ID: 2339

Symbol: FNTA

Ensembl ID: ENSG00000168522

Description: farnesyltransferase, CAAX box, subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 296.9233
    Cell Significance Index: -46.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.1498
    Cell Significance Index: -39.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 124.4818
    Cell Significance Index: -51.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 107.3873
    Cell Significance Index: -50.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.2679
    Cell Significance Index: -48.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.8395
    Cell Significance Index: -50.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.8173
    Cell Significance Index: -47.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0284
    Cell Significance Index: -37.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3364
    Cell Significance Index: -48.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2585
    Cell Significance Index: -34.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3975
    Cell Significance Index: -16.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1784
    Cell Significance Index: 219.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6361
    Cell Significance Index: 98.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3950
    Cell Significance Index: 37.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2886
    Cell Significance Index: 1163.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1498
    Cell Significance Index: 157.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1345
    Cell Significance Index: 39.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9565
    Cell Significance Index: 44.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9252
    Cell Significance Index: 59.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9137
    Cell Significance Index: 164.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9133
    Cell Significance Index: 183.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8800
    Cell Significance Index: 480.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8552
    Cell Significance Index: 17.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8203
    Cell Significance Index: 100.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8021
    Cell Significance Index: 102.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7686
    Cell Significance Index: 275.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7404
    Cell Significance Index: 327.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6921
    Cell Significance Index: 48.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6786
    Cell Significance Index: 18.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5406
    Cell Significance Index: 107.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5203
    Cell Significance Index: 13.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5124
    Cell Significance Index: 147.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4580
    Cell Significance Index: 59.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4519
    Cell Significance Index: 21.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4406
    Cell Significance Index: 4.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4274
    Cell Significance Index: 295.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4100
    Cell Significance Index: 23.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3474
    Cell Significance Index: 40.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3160
    Cell Significance Index: 9.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3042
    Cell Significance Index: 19.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2859
    Cell Significance Index: 12.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2818
    Cell Significance Index: 45.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2609
    Cell Significance Index: 3.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2333
    Cell Significance Index: 39.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2250
    Cell Significance Index: 17.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1538
    Cell Significance Index: 4.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0964
    Cell Significance Index: 5.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0921
    Cell Significance Index: 9.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0912
    Cell Significance Index: 4.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0827
    Cell Significance Index: 6.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0521
    Cell Significance Index: 1.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0143
    Cell Significance Index: 2.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0174
    Cell Significance Index: -10.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0234
    Cell Significance Index: -17.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0250
    Cell Significance Index: -46.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0267
    Cell Significance Index: -41.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0354
    Cell Significance Index: -26.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0357
    Cell Significance Index: -48.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0434
    Cell Significance Index: -27.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0519
    Cell Significance Index: -0.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0626
    Cell Significance Index: -35.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0748
    Cell Significance Index: -7.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0818
    Cell Significance Index: -37.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0821
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1358
    Cell Significance Index: -28.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1365
    Cell Significance Index: -7.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1381
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1458
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1569
    Cell Significance Index: -17.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1689
    Cell Significance Index: -24.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1986
    Cell Significance Index: -5.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2495
    Cell Significance Index: -12.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3605
    Cell Significance Index: -9.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3858
    Cell Significance Index: -41.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3958
    Cell Significance Index: -3.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4270
    Cell Significance Index: -2.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4454
    Cell Significance Index: -19.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4603
    Cell Significance Index: -47.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4732
    Cell Significance Index: -10.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4887
    Cell Significance Index: -13.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4895
    Cell Significance Index: -10.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5052
    Cell Significance Index: -40.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5169
    Cell Significance Index: -19.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5690
    Cell Significance Index: -38.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5719
    Cell Significance Index: -12.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6555
    Cell Significance Index: -21.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6555
    Cell Significance Index: -13.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6581
    Cell Significance Index: -8.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6729
    Cell Significance Index: -18.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6833
    Cell Significance Index: -41.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6846
    Cell Significance Index: -9.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8112
    Cell Significance Index: -14.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9329
    Cell Significance Index: -23.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.9481
    Cell Significance Index: -7.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9933
    Cell Significance Index: -36.4700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.0300
    Cell Significance Index: -13.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0320
    Cell Significance Index: -24.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic activity**: FNTA is a farnesyltransferase and geranylgeranyltransferase, responsible for the post-translational modification of proteins by adding a farnesyl or geranylgeranyl group to a C-terminal CAAX motif. 2. **Subunit of the farnesyltransferase complex**: FNTA is a subunit of the farnesyltransferase and geranylgeranyltransferase complex, which also includes other subunits, such as FNTB and FNTC. 3. **Cellular expression**: FNTA is expressed in various cell types, including placental villous trophoblast, epithelial cells, and immune cells, such as CD14-positive classical monocytes. 4. **Pathway involvement**: FNTA is involved in numerous signaling pathways, including alpha-tubulin binding, apoptosis, and MAPK signaling cascades. **Pathways and Functions** 1. **Protein farnesylation and geranylgeranylation**: FNTA catalyzes the post-translational modification of proteins by adding a farnesyl or geranylgeranyl group to a C-terminal CAAX motif. 2. **Signal transduction**: FNTA is involved in various signal transduction pathways, including alpha-tubulin binding, apoptosis, and MAPK signaling cascades. 3. **Cell growth and differentiation**: FNTA plays a role in regulating cell growth and differentiation by modifying proteins involved in these processes. 4. **Immune response**: FNTA is expressed in immune cells, such as CD14-positive classical monocytes, and is involved in the regulation of immune responses. **Clinical Significance** 1. **Cancer**: FNTA has been implicated in the development and progression of various cancers, including leukemia and lymphoma, due to its role in regulating cell growth and differentiation. 2. **Neurological disorders**: FNTA has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its involvement in protein farnesylation and geranylgeranylation. 3. **Infectious diseases**: FNTA has been identified as a potential therapeutic target for SARS-CoV infections, as it plays a role in regulating the host cell response to viral infections. 4. **Immunological disorders**: FNTA has been implicated in immunological disorders, such as multiple sclerosis, due to its role in regulating immune responses. In conclusion, FNTA is a crucial gene that plays a vital role in various cellular processes, including protein farnesylation and geranylgeranylation, signal transduction, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, infectious diseases, and immunological disorders, highlighting the importance of further research into the functions and clinical significance of FNTA.

Genular Protein ID: 2406832826

Symbol: FNTA_HUMAN

Name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8276393

Title: cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.

PubMed ID: 8276393

DOI: 10.1006/geno.1993.1432

PubMed ID: 8419339

Title: Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role.

PubMed ID: 8419339

DOI: 10.1016/s0021-9258(18)54087-4

PubMed ID: 8494894

Title: Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.

PubMed ID: 8494894

DOI: 10.1021/bi00070a028

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 11687658

Title: The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.

PubMed ID: 11687658

DOI: 10.1073/pnas.241407898

PubMed ID: 12036349

Title: 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

PubMed ID: 12036349

DOI: 10.1021/jm010531d

PubMed ID: 12825937

Title: Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

PubMed ID: 12825937

DOI: 10.1021/jm020587n

PubMed ID: 15170324

Title: Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.

PubMed ID: 15170324

DOI: 10.1021/bi049723b

PubMed ID: 15451670

Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

PubMed ID: 15451670

DOI: 10.1016/j.jmb.2004.08.056

PubMed ID: 16893176

Title: Conversion of protein farnesyltransferase to a geranylgeranyltransferase.

PubMed ID: 16893176

DOI: 10.1021/bi060295e

PubMed ID: 19246009

Title: Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.

PubMed ID: 19246009

DOI: 10.1016/j.chembiol.2009.01.014

Sequence Information:

  • Length: 379
  • Mass: 44409
  • Checksum: E933CBA874AB92B9
  • Sequence:
  • MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS 
    PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT 
    RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR 
    DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR 
    YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL 
    DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG 
    RSLQSKHSTE NDSPTNVQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.