Details for: FNTA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 296.9233
Cell Significance Index: -46.1900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 157.1498
Cell Significance Index: -39.8600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 124.4818
Cell Significance Index: -51.2800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 107.3873
Cell Significance Index: -50.7000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 94.2679
Cell Significance Index: -48.4900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 75.8395
Cell Significance Index: -50.8900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.8173
Cell Significance Index: -47.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.0284
Cell Significance Index: -37.5800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.3364
Cell Significance Index: -48.6800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.2585
Cell Significance Index: -34.5800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.3975
Cell Significance Index: -16.1900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.1784
Cell Significance Index: 219.8100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6361
Cell Significance Index: 98.2200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3950
Cell Significance Index: 37.9700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2886
Cell Significance Index: 1163.5300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1498
Cell Significance Index: 157.9000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.1345
Cell Significance Index: 39.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.9565
Cell Significance Index: 44.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9252
Cell Significance Index: 59.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9137
Cell Significance Index: 164.7200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9133
Cell Significance Index: 183.2100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8800
Cell Significance Index: 480.6100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8552
Cell Significance Index: 17.9000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8203
Cell Significance Index: 100.8600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8021
Cell Significance Index: 102.8200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7686
Cell Significance Index: 275.6800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7404
Cell Significance Index: 327.3500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6921
Cell Significance Index: 48.9500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6786
Cell Significance Index: 18.1200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5406
Cell Significance Index: 107.2900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5203
Cell Significance Index: 13.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.5124
Cell Significance Index: 147.4300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4580
Cell Significance Index: 59.1700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4519
Cell Significance Index: 21.0700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4406
Cell Significance Index: 4.7900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4274
Cell Significance Index: 295.6000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4100
Cell Significance Index: 23.0100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3474
Cell Significance Index: 40.9700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3160
Cell Significance Index: 9.1100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3042
Cell Significance Index: 19.1700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2859
Cell Significance Index: 12.9600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2818
Cell Significance Index: 45.8300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2609
Cell Significance Index: 3.1100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2333
Cell Significance Index: 39.8400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2250
Cell Significance Index: 17.2700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1538
Cell Significance Index: 4.4100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0964
Cell Significance Index: 5.9300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0921
Cell Significance Index: 9.1100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0912
Cell Significance Index: 4.7400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0827
Cell Significance Index: 6.1700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0521
Cell Significance Index: 1.8300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0143
Cell Significance Index: 2.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0075
Cell Significance Index: -14.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0114
Cell Significance Index: -8.4800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0174
Cell Significance Index: -10.8900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0234
Cell Significance Index: -17.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0250
Cell Significance Index: -46.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0267
Cell Significance Index: -41.0800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0347
Cell Significance Index: -0.5800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0354
Cell Significance Index: -26.7700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0357
Cell Significance Index: -48.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0434
Cell Significance Index: -27.5800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0519
Cell Significance Index: -0.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0626
Cell Significance Index: -35.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0748
Cell Significance Index: -7.6400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0818
Cell Significance Index: -37.1300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0821
Cell Significance Index: -2.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1358
Cell Significance Index: -28.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1365
Cell Significance Index: -7.1700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1381
Cell Significance Index: -16.0900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1458
Cell Significance Index: -16.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1569
Cell Significance Index: -17.9800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1689
Cell Significance Index: -24.5500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1986
Cell Significance Index: -5.5500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2495
Cell Significance Index: -12.6100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3605
Cell Significance Index: -9.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3858
Cell Significance Index: -41.9600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3958
Cell Significance Index: -3.6500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4270
Cell Significance Index: -2.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4454
Cell Significance Index: -19.7000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4603
Cell Significance Index: -47.9300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4732
Cell Significance Index: -10.9300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4887
Cell Significance Index: -13.1000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4895
Cell Significance Index: -10.4600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5052
Cell Significance Index: -40.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5169
Cell Significance Index: -19.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5690
Cell Significance Index: -38.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5719
Cell Significance Index: -12.3900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6555
Cell Significance Index: -21.0000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6555
Cell Significance Index: -13.9600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.6581
Cell Significance Index: -8.4300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6729
Cell Significance Index: -18.0000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6833
Cell Significance Index: -41.8900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6846
Cell Significance Index: -9.3400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.8112
Cell Significance Index: -14.3400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9329
Cell Significance Index: -23.3200 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.9481
Cell Significance Index: -7.5700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9933
Cell Significance Index: -36.4700 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -1.0300
Cell Significance Index: -13.9000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.0320
Cell Significance Index: -24.7500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2406832826
Symbol: FNTA_HUMAN
Name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8276393
Title: cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.
PubMed ID: 8276393
PubMed ID: 8419339
Title: Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role.
PubMed ID: 8419339
PubMed ID: 8494894
Title: Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.
PubMed ID: 8494894
DOI: 10.1021/bi00070a028
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 11687658
Title: The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
PubMed ID: 11687658
PubMed ID: 12036349
Title: 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
PubMed ID: 12036349
DOI: 10.1021/jm010531d
PubMed ID: 12825937
Title: Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
PubMed ID: 12825937
DOI: 10.1021/jm020587n
PubMed ID: 15170324
Title: Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.
PubMed ID: 15170324
DOI: 10.1021/bi049723b
PubMed ID: 15451670
Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
PubMed ID: 15451670
PubMed ID: 16893176
Title: Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
PubMed ID: 16893176
DOI: 10.1021/bi060295e
PubMed ID: 19246009
Title: Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
PubMed ID: 19246009
Sequence Information:
- Length: 379
- Mass: 44409
- Checksum: E933CBA874AB92B9
- Sequence:
MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG RSLQSKHSTE NDSPTNVQQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.