Details for: FNTA

Gene ID: 2339

Symbol: FNTA

Ensembl ID: ENSG00000168522

Description: farnesyltransferase, CAAX box, subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.84
    Marker Score: 7220
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.67
    Marker Score: 7186
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.66
    Marker Score: 3467
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.64
    Marker Score: 791
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.58
    Marker Score: 2677
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.53
    Marker Score: 2707
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.53
    Marker Score: 85415
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.52
    Marker Score: 20088
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.5
    Marker Score: 1591
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5
    Marker Score: 6125.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.49
    Marker Score: 12810
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.47
    Marker Score: 1566
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.47
    Marker Score: 1570
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.46
    Marker Score: 1378
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49478
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.43
    Marker Score: 1788.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.41
    Marker Score: 5233
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.39
    Marker Score: 1403
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.39
    Marker Score: 6837
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.38
    Marker Score: 869
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.38
    Marker Score: 8989.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.38
    Marker Score: 921
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.38
    Marker Score: 13972
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.38
    Marker Score: 46839.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.37
    Marker Score: 10702
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.37
    Marker Score: 781
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.36
    Marker Score: 3689
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.35
    Marker Score: 1521
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.33
    Marker Score: 14925
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.32
    Marker Score: 375
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.32
    Marker Score: 726
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.3
    Marker Score: 1224
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.3
    Marker Score: 68679
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.29
    Marker Score: 4996.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.29
    Marker Score: 938
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.29
    Marker Score: 1074
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.27
    Marker Score: 9746
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.27
    Marker Score: 12785
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.27
    Marker Score: 366
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.25
    Marker Score: 3060
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.25
    Marker Score: 1793.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.25
    Marker Score: 2936
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.24
    Marker Score: 1322.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.23
    Marker Score: 1329
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.22
    Marker Score: 629
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.22
    Marker Score: 1873
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.21
    Marker Score: 573
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2
    Marker Score: 286
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73447
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.18
    Marker Score: 11201.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.18
    Marker Score: 10094.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.17
    Marker Score: 2339
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.16
    Marker Score: 23164
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.16
    Marker Score: 390
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.16
    Marker Score: 286
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.15
    Marker Score: 232
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.15
    Marker Score: 1692.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.15
    Marker Score: 402
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.15
    Marker Score: 3114.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.14
    Marker Score: 15351
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.14
    Marker Score: 607.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43299.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1183
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.14
    Marker Score: 1223
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.14
    Marker Score: 463
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.13
    Marker Score: 672
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.13
    Marker Score: 41626.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.13
    Marker Score: 750
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.13
    Marker Score: 11158
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.13
    Marker Score: 620
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 264
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.12
    Marker Score: 2690
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.12
    Marker Score: 8330
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.12
    Marker Score: 1009
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.11
    Marker Score: 6569
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.11
    Marker Score: 2629.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 755
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.11
    Marker Score: 1295
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.09
    Marker Score: 976.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.09
    Marker Score: 377
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.08
    Marker Score: 4401
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.08
    Marker Score: 10148.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.08
    Marker Score: 1040.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.08
    Marker Score: 2456.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.08
    Marker Score: 376
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.08
    Marker Score: 16099.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.07
    Marker Score: 27531
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.07
    Marker Score: 381
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.07
    Marker Score: 961
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.07
    Marker Score: 2013
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.07
    Marker Score: 283
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 837.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.06
    Marker Score: 1156
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.06
    Marker Score: 1847
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.06
    Marker Score: 22596
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.05
    Marker Score: 6742.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.05
    Marker Score: 1627
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.05
    Marker Score: 241.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1352

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Other Information

**Key characteristics:** * The FNTA gene is located on chromosome 17q21.1. * It is a large gene with a molecular weight of approximately 110 kDa. * The protein contains a CAAX box, a conserved region that is involved in protein-protein interactions. * FNTA is expressed in a variety of cell types, including placental cells, epithelial cells, and neural cells. **Pathways and functions:** * The FNTA gene is involved in the regulation of the phototransduction cascade of visual perception. * The cascade is initiated by the binding of farnesyl phosphate to the FNP1 and FNP2 proteins. * Farnesyl phosphate is then converted to retinal farnesyl phosphate by the action of farnesyltransferase. * Retinal farnesyl phosphate is a key regulator of the function of photoreceptors in the retina. **Clinical significance:** * Mutations in the FNTA gene have been linked to several eye diseases, including retinitis pigmentosa and age-related macular degeneration. * These mutations can disrupt the normal functioning of the phototransduction cascade, leading to the development of these eye diseases. * Therefore, FNTA is a promising target for the development of new therapies for eye diseases. **Additional notes:** * FNTA is a highly conserved protein, with a similar gene found in other vertebrates. * The expression of FNTA is regulated by a variety of factors, including light, hormones, and genetic variants. * Mutations in the FNTA gene can also be associated with other developmental disorders, such as autism and schizophrenia.

Genular Protein ID: 2406832826

Symbol: FNTA_HUMAN

Name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

UniProtKB Accession Codes:

P49354 A6NJW0 Q53XJ9 Q9UDC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 12 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 14 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8276393

Title: cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.

PubMed ID: 8276393

DOI: 10.1006/geno.1993.1432

PubMed ID: 8419339

Title: Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role.

PubMed ID: 8419339

DOI: 10.1016/s0021-9258(18)54087-4

PubMed ID: 8494894

Title: Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.

PubMed ID: 8494894

DOI: 10.1021/bi00070a028

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 11687658

Title: The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.

PubMed ID: 11687658

DOI: 10.1073/pnas.241407898

PubMed ID: 12036349

Title: 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

PubMed ID: 12036349

DOI: 10.1021/jm010531d

PubMed ID: 12825937

Title: Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

PubMed ID: 12825937

DOI: 10.1021/jm020587n

PubMed ID: 15170324

Title: Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.

PubMed ID: 15170324

DOI: 10.1021/bi049723b

PubMed ID: 15451670

Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

PubMed ID: 15451670

DOI: 10.1016/j.jmb.2004.08.056

PubMed ID: 16893176

Title: Conversion of protein farnesyltransferase to a geranylgeranyltransferase.

PubMed ID: 16893176

DOI: 10.1021/bi060295e

PubMed ID: 19246009

Title: Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.

PubMed ID: 19246009

DOI: 10.1016/j.chembiol.2009.01.014

Sequence Information:

  • Length: 379
  • Mass: 44409
  • Checksum: E933CBA874AB92B9
  • Sequence:
    • MAATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS 
PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT 
RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR 
DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR 
YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL 
DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG 
RSLQSKHSTE NDSPTNVQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.