Details for: FUT4

Gene ID: 2526

Symbol: FUT4

Ensembl ID: ENSG00000196371

Description: fucosyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.5278
    Cell Significance Index: -6.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.8380
    Cell Significance Index: -6.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 15.0385
    Cell Significance Index: -7.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 10.5809
    Cell Significance Index: -7.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3935
    Cell Significance Index: -6.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7437
    Cell Significance Index: -7.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1364
    Cell Significance Index: 347.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8320
    Cell Significance Index: 39.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6979
    Cell Significance Index: -6.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6649
    Cell Significance Index: 164.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2702
    Cell Significance Index: 138.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2057
    Cell Significance Index: 54.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9376
    Cell Significance Index: 109.2700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.7545
    Cell Significance Index: 10.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7535
    Cell Significance Index: 11.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7145
    Cell Significance Index: 645.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6751
    Cell Significance Index: 46.6900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.6105
    Cell Significance Index: 4.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5504
    Cell Significance Index: 9.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5184
    Cell Significance Index: 11.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4745
    Cell Significance Index: 13.6700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3963
    Cell Significance Index: 2.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3712
    Cell Significance Index: 9.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3612
    Cell Significance Index: 23.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2450
    Cell Significance Index: 8.6100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1984
    Cell Significance Index: 2.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1678
    Cell Significance Index: 2.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1671
    Cell Significance Index: 8.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1605
    Cell Significance Index: 4.3000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1534
    Cell Significance Index: 1.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1512
    Cell Significance Index: 7.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1508
    Cell Significance Index: 28.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1380
    Cell Significance Index: 2.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1288
    Cell Significance Index: 8.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1101
    Cell Significance Index: 3.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0863
    Cell Significance Index: 9.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0700
    Cell Significance Index: 1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0692
    Cell Significance Index: 43.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0570
    Cell Significance Index: 0.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0541
    Cell Significance Index: 10.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0452
    Cell Significance Index: 7.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0410
    Cell Significance Index: 14.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0349
    Cell Significance Index: 1.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0302
    Cell Significance Index: 4.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0272
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0236
    Cell Significance Index: 12.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0202
    Cell Significance Index: 5.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0168
    Cell Significance Index: 3.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0140
    Cell Significance Index: 0.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0105
    Cell Significance Index: 4.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0084
    Cell Significance Index: 0.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0009
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0042
    Cell Significance Index: -0.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0052
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0091
    Cell Significance Index: -1.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0102
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0167
    Cell Significance Index: -3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0318
    Cell Significance Index: -1.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0560
    Cell Significance Index: -4.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0565
    Cell Significance Index: -3.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0566
    Cell Significance Index: -6.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0586
    Cell Significance Index: -3.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0630
    Cell Significance Index: -1.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0649
    Cell Significance Index: -4.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0656
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0846
    Cell Significance Index: -1.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0881
    Cell Significance Index: -3.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0922
    Cell Significance Index: -7.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0925
    Cell Significance Index: -4.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1050
    Cell Significance Index: -2.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1094
    Cell Significance Index: -2.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1200
    Cell Significance Index: -6.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1393
    Cell Significance Index: -4.8400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1394
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1444
    Cell Significance Index: -5.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1480
    Cell Significance Index: -2.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1483
    Cell Significance Index: -3.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1558
    Cell Significance Index: -5.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1578
    Cell Significance Index: -4.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1626
    Cell Significance Index: -4.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1630
    Cell Significance Index: -5.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1716
    Cell Significance Index: -6.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1740
    Cell Significance Index: -2.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1857
    Cell Significance Index: -1.7100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2142
    Cell Significance Index: -3.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2166
    Cell Significance Index: -6.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2170
    Cell Significance Index: -4.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2196
    Cell Significance Index: -3.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2208
    Cell Significance Index: -4.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2280
    Cell Significance Index: -2.5900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2340
    Cell Significance Index: -3.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2342
    Cell Significance Index: -4.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2364
    Cell Significance Index: -3.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2455
    Cell Significance Index: -4.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FUT4 is a type II transmembrane glycoprotein, consisting of a large extracellular domain and a small cytoplasmic domain. The enzyme exhibits a high degree of specificity for the transfer of fucose moieties to specific carbohydrate structures, including globoside, Lewis X, and Lewis Y. FUT4 is primarily expressed on the surface of immune cells, including lymphocytes, neutrophils, and epithelial cells, where it plays a crucial role in regulating immune responses. **Pathways and Functions:** FUT4 is involved in several key pathways, including: 1. **Fucosylation**: FUT4 catalyzes the transfer of fucose moieties to specific carbohydrate structures, resulting in the formation of complex glycoconjugates that modulate immune responses. 2. **Blood group systems biosynthesis**: FUT4 is involved in the biosynthesis of Lewis blood group antigens, which are critical for determining blood type and compatibility. 3. **Inflammatory response**: FUT4 expression is induced in response to inflammatory stimuli, where it contributes to the recruitment of immune cells to sites of inflammation. 4. **Cell signaling**: FUT4 glycoconjugates can interact with specific receptors, modulating signaling pathways that regulate immune cell function and cytokine production. **Clinical Significance:** Dysregulation of FUT4 expression and activity has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Abnormal FUT4 expression has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the dysregulation of immune responses. 2. **Cancer**: FUT4 expression is often upregulated in cancer cells, where it contributes to the formation of tumor-associated antigens and the evasion of immune surveillance. 3. **Infectious diseases**: FUT4 expression is induced in response to infectious stimuli, where it contributes to the recruitment of immune cells to sites of infection. 4. **Transplantation**: Abnormal FUT4 expression has been linked to transplant rejection, where it contributes to the dysregulation of immune responses. In conclusion, FUT4 is a critical enzyme involved in the regulation of immune responses and the biosynthesis of fucosylated glycans. Dysregulation of FUT4 expression and activity has been implicated in various immune-related disorders, highlighting the importance of this enzyme in maintaining immune homeostasis. Further research is needed to fully elucidate the mechanisms by which FUT4 regulates immune responses and to explore its therapeutic potential in immune-related disorders.

Genular Protein ID: 218749432

Symbol: FUT4_HUMAN

Name: Alpha-(1,3)-fucosyltransferase 4

UniProtKB Accession Codes:

P22083 B2RMS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 20 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1702034

Title: ELFT: a gene that directs the expression of an ELAM-1 ligand.

PubMed ID: 1702034

DOI: 10.1016/0092-8674(90)90430-m

PubMed ID: 1716630

Title: Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion.

PubMed ID: 1716630

DOI: 10.1016/s0021-9258(19)47396-1

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1718983

Title: Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants.

PubMed ID: 1718983

DOI: 10.1016/s0021-9258(18)54704-9

PubMed ID: 11278338

Title: CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.

PubMed ID: 11278338

DOI: 10.1074/jbc.m007272200

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

Sequence Information:

  • Length: 530
  • Mass: 59084
  • Checksum: B10C1C3C67BE1562
  • Sequence:
    • MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW ASWPAHLALA 
ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL QHESRCRSST PADAWRAEAA 
LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP WTVCVLAAAG LTCTALITYA CWGQLPPLPW 
ASPTPSRPVG VLLWWEPFGG RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR 
DLVKGPPDWP PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP 
SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL SRKQGLVAWV 
VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL LHTVARYKFY LAFENSQHLD 
YITEKLWRNA LLAGAVPVVL GPDRANYERF VPRGAFIHVD DFPSASSLAS YLLFLDRNPA 
VYRRYFHWRR SYAVHITSFW DEPWCRVCQA VQRAGDRPKS IRNLASWFER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.