Details for: FUT4

Gene ID: 2526

Symbol: FUT4

Ensembl ID: ENSG00000196371

Description: fucosyltransferase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.33
    Marker Score: 1917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 523
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 649
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.68
    Marker Score: 274
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1324
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.63
    Marker Score: 2646
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.63
    Marker Score: 156
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4006
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 542
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.61
    Marker Score: 770.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.57
    Marker Score: 298
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 584
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.55
    Marker Score: 2663
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8291
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.52
    Marker Score: 501
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.51
    Marker Score: 1985
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5
    Marker Score: 499
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.49
    Marker Score: 1164
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.49
    Marker Score: 122
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1122
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.44
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.44
    Marker Score: 142
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.43
    Marker Score: 4349
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.42
    Marker Score: 101
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.41
    Marker Score: 2732.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.41
    Marker Score: 930
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.37
    Marker Score: 237
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.37
    Marker Score: 139
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 94
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.35
    Marker Score: 793
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.34
    Marker Score: 19175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 643.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.33
    Marker Score: 233
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.32
    Marker Score: 139
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.31
    Marker Score: 1274
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.3
    Marker Score: 953
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 144
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.3
    Marker Score: 291
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.29
    Marker Score: 1731
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.28
    Marker Score: 137
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 493
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.27
    Marker Score: 667
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.27
    Marker Score: 653
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.25
    Marker Score: 246
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.25
    Marker Score: 155
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.24
    Marker Score: 180
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 380
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.23
    Marker Score: 164
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.23
    Marker Score: 7835
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.23
    Marker Score: 479
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.23
    Marker Score: 124
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.22
    Marker Score: 221
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.21
    Marker Score: 773
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 244
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.21
    Marker Score: 1257
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1695
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.2
    Marker Score: 5032
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 240
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.19
    Marker Score: 141
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.19
    Marker Score: 325
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.18
    Marker Score: 148
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 42
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.18
    Marker Score: 220

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Other Information

**Key characteristics:** * The FUT4 gene is located on chromosome 15q26.1. * It is a large gene with a molecular weight of approximately 1.8 million Da. * It contains 13 exons and 12 introns. * It is expressed in a variety of cell types, including respiratory cells, neurons, and immune cells. **Pathways and functions:** * The FUT4 gene is involved in multiple pathways, including: * Blood group systems biosynthesis * Carbohydrate metabolic process * Fucosylation * Regulation of leukocyte cell-cell adhesion * It is essential for the synthesis of Lewis blood group antigens, which are expressed on the surface of red blood cells. * It also plays a role in the metabolism of carbohydrates and in the regulation of immune responses. **Clinical significance:** * Mutations in the FUT4 gene have been linked to several human diseases, including: * Hemolytic anemia * Thrombotic disorders * Immune disorders * FUT4 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * The FUT4 gene is also known as FCGR2B, CD112, and ITGA2. * It is a highly conserved gene, with a similar gene found in mice and rats. * It is expressed in high levels in cells of the immune system, including macrophages, dendritic cells, and lymphocytes.

Genular Protein ID: 218749432

Symbol: FUT4_HUMAN

Name: Alpha-(1,3)-fucosyltransferase 4

UniProtKB Accession Codes:

P22083 B2RMS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 20 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1702034

Title: ELFT: a gene that directs the expression of an ELAM-1 ligand.

PubMed ID: 1702034

DOI: 10.1016/0092-8674(90)90430-m

PubMed ID: 1716630

Title: Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion.

PubMed ID: 1716630

DOI: 10.1016/s0021-9258(19)47396-1

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1718983

Title: Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants.

PubMed ID: 1718983

DOI: 10.1016/s0021-9258(18)54704-9

PubMed ID: 11278338

Title: CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.

PubMed ID: 11278338

DOI: 10.1074/jbc.m007272200

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

Sequence Information:

  • Length: 530
  • Mass: 59084
  • Checksum: B10C1C3C67BE1562
  • Sequence:
    • MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW ASWPAHLALA 
ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL QHESRCRSST PADAWRAEAA 
LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP WTVCVLAAAG LTCTALITYA CWGQLPPLPW 
ASPTPSRPVG VLLWWEPFGG RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR 
DLVKGPPDWP PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP 
SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL SRKQGLVAWV 
VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL LHTVARYKFY LAFENSQHLD 
YITEKLWRNA LLAGAVPVVL GPDRANYERF VPRGAFIHVD DFPSASSLAS YLLFLDRNPA 
VYRRYFHWRR SYAVHITSFW DEPWCRVCQA VQRAGDRPKS IRNLASWFER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.