Details for: FZD2

Gene ID: 2535

Symbol: FZD2

Ensembl ID: ENSG00000180340

Description: frizzled class receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1992
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.34
    Marker Score: 2728.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.23
    Marker Score: 1490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.14
    Marker Score: 627
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15698
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.98
    Marker Score: 1038
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.83
    Marker Score: 315
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8
    Marker Score: 395
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.8
    Marker Score: 10508
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 682
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 486
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.71
    Marker Score: 1337.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.69
    Marker Score: 1175
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.69
    Marker Score: 2876.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.67
    Marker Score: 1573
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.56
    Marker Score: 1167
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.54
    Marker Score: 218
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 301
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5
    Marker Score: 3237
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.47
    Marker Score: 504
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 223
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.45
    Marker Score: 116
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 213
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 412
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 123
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 401
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.38
    Marker Score: 2238
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.37
    Marker Score: 1447
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.37
    Marker Score: 349
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.36
    Marker Score: 438
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.35
    Marker Score: 3993
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.35
    Marker Score: 235
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.34
    Marker Score: 213
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 150
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 131
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 83
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.31
    Marker Score: 247
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3
    Marker Score: 1124
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.3
    Marker Score: 117
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 544
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.29
    Marker Score: 97
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.29
    Marker Score: 71
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.27
    Marker Score: 63
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.27
    Marker Score: 2742
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.24
    Marker Score: 254
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 156
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 85
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.23
    Marker Score: 314
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.22
    Marker Score: 338
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 78
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.21
    Marker Score: 161
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.2
    Marker Score: 504
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.2
    Marker Score: 129
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.19
    Marker Score: 214
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.19
    Marker Score: 129
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 303
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.19
    Marker Score: 511
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.18
    Marker Score: 205
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 158
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.18
    Marker Score: 123
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 203
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 174

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Other Information

**Key characteristics:** - FZD2 is a transmembrane receptor that is expressed in a variety of cell types. - It is a key regulator of epithelial cell migration and differentiation. - Its overexpression has been linked to cancer. - It is a member of the frizzled family of receptors. - It is a ligand for the Wnt receptor. **Pathways and functions:** - FZD2 is involved in the asymmetric localization of pcp proteins. - It is also involved in the Beta-catenin independent wnt signaling pathway. - It is involved in the Ca2+ pathway. - It is involved in the Class b/2 (secretin family receptors) pathway. - It is involved in the disassembly of the destruction complex and recruitment of axin to the membrane. - It is involved in the Gpcr ligand binding pathway. - It is involved in the G protein-coupled receptor activity pathway. - It is involved in the Pcp/ce pathway. - It is involved in the Pdz domain binding pathway. - It is involved in the Protein binding pathway. - It is involved in the Signaling by gpcr pathway. - It is involved in the Signaling by wnt pathway. - It is involved in the Signal transduction pathway. - It is involved in the Tcf dependent signaling in response to wnt. - It is involved in the Wnt-protein binding pathway. - It is involved in the Wnt5a-dependent internalization of fzd2, fzd5 and ror2. - It is involved in the Wnt receptor activity. **Clinical significance:** FZD2 is a key regulator of epithelial cell migration and differentiation. Mutations in FZD2 have been linked to cancer. Targeting FZD2 has been shown to be a promising therapeutic strategy for cancer.

Genular Protein ID: 1825035963

Symbol: FZD2_HUMAN

Name: Frizzled-2

UniProtKB Accession Codes:

Q14332 Q0VG82

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 3 EPD 1 Ensembl 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7558010

Title: A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.

PubMed ID: 7558010

DOI: 10.1006/geno.1995.1060

PubMed ID: 9813155

Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

PubMed ID: 9813155

DOI: 10.1006/bbrc.1998.9607

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 25759469

Title: A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.

PubMed ID: 25759469

DOI: 10.1093/hmg/ddv088

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

PubMed ID: 31233493

Title: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B.

PubMed ID: 31233493

DOI: 10.1371/journal.pbio.3000311

PubMed ID: 29748286

Title: Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.

PubMed ID: 29748286

DOI: 10.1126/science.aar1999

PubMed ID: 29230162

Title: A novel de novo FZD2 mutation in a patient with autosomal dominant omodysplasia.

PubMed ID: 29230162

DOI: 10.1159/000479721

PubMed ID: 29383834

Title: Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes.

PubMed ID: 29383834

DOI: 10.1002/ajmg.a.38623

PubMed ID: 29276006

Title: WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome.

PubMed ID: 29276006

DOI: 10.1016/j.ajhg.2017.10.002

PubMed ID: 30455931

Title: Two unrelated patients with autosomal dominant omodysplasia and FRIZZLED2 mutations.

PubMed ID: 30455931

DOI: 10.1002/ccr3.1818

Sequence Information:

  • Length: 565
  • Mass: 63554
  • Checksum: AA387876A1DDE063
  • Sequence:
    • MRPRSALPRL LLPLLLLPAA GPAQFHGEKG ISIPDHGFCQ PISIPLCTDI AYNQTIMPNL 
LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLEQAIPPC RSICERARQG 
CEALMNKFGF QWPERLRCEH FPRHGAEQIC VGQNHSEDGA PALLTTAPPP GLQPGAGGTP 
GGPGGGGAPP RYATLEHPFH CPRVLKVPSY LSYKFLGERD CAAPCEPARP DGSMFFSQEE 
TRFARLWILT WSVLCCASTF FTVTTYLVDM QRFRYPERPI IFLSGCYTMV SVAYIAGFVL 
QERVVCNERF SEDGYRTVVQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL TWFLAAGMKW 
GHEAIEANSQ YFHLAAWAVP AVKTITILAM GQIDGDLLSG VCFVGLNSLD PLRGFVLAPL 
FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLERLMV RIGVFSVLYT VPATIVIACY 
FYEQAFREHW ERSWVSQHCK SLAIPCPAHY TPRMSPDFTV YMIKYLMTLI VGITSGFWIW 
SGKTLHSWRK FYTRLTNSRH GETTV

Genular Protein ID: 272383377

Symbol: Q86UZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86UZ8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 641
  • Mass: 71488
  • Checksum: 120BCF98F673DA29
  • Sequence:
    • ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG GEEAQSPGWG 
RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ FHGEKGISIP DHGFCQPISI 
PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH QFYPLVKVQC SPELRFFLCS MYAPVCTVLE 
QAIPPCRSIC ERARQGCEAL MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL 
TTAPPPGLQP GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP 
CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR YPERPIIFLS 
GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK EGCTILFMML YFFSMASSIW 
WVILSLTWFL AAGMKWGHEA IEANSQYFHL AAWAVPAVKT ITILAMGQID GDLLSGVCFV 
GLNSLDPLRG FVLAPLFVYL FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV 
FSVLYTVPAT IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK 
YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.