Details for: FZD2

Gene ID: 2535

Symbol: FZD2

Ensembl ID: ENSG00000180340

Description: frizzled class receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.1979
    Cell Significance Index: -9.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 27.3578
    Cell Significance Index: -11.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.3080
    Cell Significance Index: -10.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.7628
    Cell Significance Index: -6.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5185
    Cell Significance Index: -9.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0821
    Cell Significance Index: 66.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3735
    Cell Significance Index: 28.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0845
    Cell Significance Index: 37.6900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.9312
    Cell Significance Index: 6.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9162
    Cell Significance Index: 9.9600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6738
    Cell Significance Index: 3.8300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.5207
    Cell Significance Index: 3.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3769
    Cell Significance Index: 5.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3684
    Cell Significance Index: 10.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3603
    Cell Significance Index: 20.2200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2862
    Cell Significance Index: 1.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2610
    Cell Significance Index: 42.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2561
    Cell Significance Index: 3.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2002
    Cell Significance Index: 19.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1902
    Cell Significance Index: 11.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1894
    Cell Significance Index: 36.0500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1797
    Cell Significance Index: 2.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1748
    Cell Significance Index: 24.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0599
    Cell Significance Index: 32.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0533
    Cell Significance Index: 1.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0514
    Cell Significance Index: 5.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0485
    Cell Significance Index: 5.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0179
    Cell Significance Index: 0.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0152
    Cell Significance Index: 0.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0112
    Cell Significance Index: 0.1800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0008
    Cell Significance Index: 0.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0004
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0079
    Cell Significance Index: -14.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0121
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -11.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0146
    Cell Significance Index: -0.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0159
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0183
    Cell Significance Index: -2.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0209
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0230
    Cell Significance Index: -12.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0291
    Cell Significance Index: -8.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0291
    Cell Significance Index: -0.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0322
    Cell Significance Index: -11.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0329
    Cell Significance Index: -2.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0371
    Cell Significance Index: -6.6800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0382
    Cell Significance Index: -0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0383
    Cell Significance Index: -7.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0415
    Cell Significance Index: -4.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0472
    Cell Significance Index: -2.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0472
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0495
    Cell Significance Index: -8.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0517
    Cell Significance Index: -10.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0536
    Cell Significance Index: -6.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0548
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0555
    Cell Significance Index: -11.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0557
    Cell Significance Index: -8.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0632
    Cell Significance Index: -2.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0718
    Cell Significance Index: -9.2800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0751
    Cell Significance Index: -0.4700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0767
    Cell Significance Index: -0.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0781
    Cell Significance Index: -9.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0837
    Cell Significance Index: -3.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0876
    Cell Significance Index: -5.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0897
    Cell Significance Index: -9.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0983
    Cell Significance Index: -0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1027
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1028
    Cell Significance Index: -11.7800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1082
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1140
    Cell Significance Index: -2.9300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1239
    Cell Significance Index: -1.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1324
    Cell Significance Index: -9.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1368
    Cell Significance Index: -10.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1406
    Cell Significance Index: -6.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1491
    Cell Significance Index: -3.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1493
    Cell Significance Index: -2.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1496
    Cell Significance Index: -9.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1500
    Cell Significance Index: -2.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1607
    Cell Significance Index: -6.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1648
    Cell Significance Index: -8.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1691
    Cell Significance Index: -0.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1745
    Cell Significance Index: -3.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1774
    Cell Significance Index: -2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1776
    Cell Significance Index: -11.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1917
    Cell Significance Index: -9.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2094
    Cell Significance Index: -3.0400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2160
    Cell Significance Index: -2.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2288
    Cell Significance Index: -10.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2309
    Cell Significance Index: -6.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2335
    Cell Significance Index: -12.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2356
    Cell Significance Index: -10.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2408
    Cell Significance Index: -3.7300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2498
    Cell Significance Index: -3.1600
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.2559
    Cell Significance Index: -3.0400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2580
    Cell Significance Index: -3.5800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2592
    Cell Significance Index: -1.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FZD2 is a transmembrane receptor that belongs to the Frizzled family, which is characterized by the presence of a seven-transmembrane domain and a cytoplasmic tail. FZD2 is a ligand-binding receptor that interacts with Wnt proteins, which are secreted signaling molecules. The binding of Wnt proteins to FZD2 triggers a series of downstream signaling events that regulate various cellular processes. FZD2 is also known for its involvement in planar cell polarity (PCP) signaling, which is essential for the establishment of tissue polarity and the development of the nervous system. **Pathways and Functions** FZD2 is involved in several signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FZD2 interacts with Wnt proteins to activate the canonical Wnt signaling pathway, which regulates cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt signaling pathway**: FZD2 also interacts with Wnt proteins to activate the non-canonical Wnt signaling pathway, which regulates cell migration, adhesion, and polarity. 3. **PCP pathway**: FZD2 is involved in the establishment of tissue polarity and the development of the nervous system through the PCP pathway. 4. **Ca2+ pathway**: FZD2 interacts with Wnt proteins to regulate the Ca2+ pathway, which is involved in cell signaling and differentiation. **Clinical Significance** FZD2 has been implicated in several diseases, including: 1. **Cancer**: FZD2 has been found to be overexpressed in several types of cancer, including colorectal cancer, breast cancer, and lung cancer. 2. **Cardiovascular disease**: FZD2 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac fibrosis. 3. **Neurological disorders**: FZD2 has been implicated in the development of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Immunological disorders**: FZD2 has been implicated in the development of immunological disorders, including autoimmune diseases and inflammatory disorders. In conclusion, FZD2 is a critical receptor in the Wnt signaling pathway, which regulates various cellular processes, including cell differentiation, proliferation, and survival. Its dysregulation has been implicated in several diseases, highlighting the importance of FZD2 in human health and disease. Further research is needed to fully understand the role of FZD2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1825035963

Symbol: FZD2_HUMAN

Name: Frizzled-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7558010

Title: A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.

PubMed ID: 7558010

DOI: 10.1006/geno.1995.1060

PubMed ID: 9813155

Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

PubMed ID: 9813155

DOI: 10.1006/bbrc.1998.9607

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 25759469

Title: A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.

PubMed ID: 25759469

DOI: 10.1093/hmg/ddv088

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

PubMed ID: 31233493

Title: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B.

PubMed ID: 31233493

DOI: 10.1371/journal.pbio.3000311

PubMed ID: 29748286

Title: Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.

PubMed ID: 29748286

DOI: 10.1126/science.aar1999

PubMed ID: 29230162

Title: A novel de novo FZD2 mutation in a patient with autosomal dominant omodysplasia.

PubMed ID: 29230162

DOI: 10.1159/000479721

PubMed ID: 29383834

Title: Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes.

PubMed ID: 29383834

DOI: 10.1002/ajmg.a.38623

PubMed ID: 29276006

Title: WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome.

PubMed ID: 29276006

DOI: 10.1016/j.ajhg.2017.10.002

PubMed ID: 30455931

Title: Two unrelated patients with autosomal dominant omodysplasia and FRIZZLED2 mutations.

PubMed ID: 30455931

DOI: 10.1002/ccr3.1818

Sequence Information:

  • Length: 565
  • Mass: 63554
  • Checksum: AA387876A1DDE063
  • Sequence:
  • MRPRSALPRL LLPLLLLPAA GPAQFHGEKG ISIPDHGFCQ PISIPLCTDI AYNQTIMPNL 
    LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLEQAIPPC RSICERARQG 
    CEALMNKFGF QWPERLRCEH FPRHGAEQIC VGQNHSEDGA PALLTTAPPP GLQPGAGGTP 
    GGPGGGGAPP RYATLEHPFH CPRVLKVPSY LSYKFLGERD CAAPCEPARP DGSMFFSQEE 
    TRFARLWILT WSVLCCASTF FTVTTYLVDM QRFRYPERPI IFLSGCYTMV SVAYIAGFVL 
    QERVVCNERF SEDGYRTVVQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL TWFLAAGMKW 
    GHEAIEANSQ YFHLAAWAVP AVKTITILAM GQIDGDLLSG VCFVGLNSLD PLRGFVLAPL 
    FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLERLMV RIGVFSVLYT VPATIVIACY 
    FYEQAFREHW ERSWVSQHCK SLAIPCPAHY TPRMSPDFTV YMIKYLMTLI VGITSGFWIW 
    SGKTLHSWRK FYTRLTNSRH GETTV

Genular Protein ID: 272383377

Symbol: Q86UZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 641
  • Mass: 71488
  • Checksum: 120BCF98F673DA29
  • Sequence:
  • ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG GEEAQSPGWG 
    RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ FHGEKGISIP DHGFCQPISI 
    PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH QFYPLVKVQC SPELRFFLCS MYAPVCTVLE 
    QAIPPCRSIC ERARQGCEAL MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL 
    TTAPPPGLQP GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP 
    CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR YPERPIIFLS 
    GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK EGCTILFMML YFFSMASSIW 
    WVILSLTWFL AAGMKWGHEA IEANSQYFHL AAWAVPAVKT ITILAMGQID GDLLSGVCFV 
    GLNSLDPLRG FVLAPLFVYL FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV 
    FSVLYTVPAT IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK 
    YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.