Details for: FZD2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 37.1979
Cell Significance Index: -9.4400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 27.3578
Cell Significance Index: -11.2700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 21.3080
Cell Significance Index: -10.0600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 16.7628
Cell Significance Index: -6.8100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.5185
Cell Significance Index: -9.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.0821
Cell Significance Index: 66.6900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3735
Cell Significance Index: 28.7500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0845
Cell Significance Index: 37.6900 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.9312
Cell Significance Index: 6.7700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.9162
Cell Significance Index: 9.9600 - Cell Name: sensory neuron (CL0000101)
Fold Change: 0.6738
Cell Significance Index: 3.8300 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.5207
Cell Significance Index: 3.1200 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.3769
Cell Significance Index: 5.9800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.3684
Cell Significance Index: 10.8500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3603
Cell Significance Index: 20.2200 - Cell Name: chondroblast (CL0000058)
Fold Change: 0.2862
Cell Significance Index: 1.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2610
Cell Significance Index: 42.4500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2561
Cell Significance Index: 3.2800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2002
Cell Significance Index: 19.8100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1902
Cell Significance Index: 11.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1894
Cell Significance Index: 36.0500 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1797
Cell Significance Index: 2.5200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1748
Cell Significance Index: 24.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0599
Cell Significance Index: 32.7300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0533
Cell Significance Index: 1.1400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0514
Cell Significance Index: 5.9900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0485
Cell Significance Index: 5.2700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0179
Cell Significance Index: 0.3000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0152
Cell Significance Index: 0.3800 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0112
Cell Significance Index: 0.1800 - Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0008
Cell Significance Index: 0.0000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0004
Cell Significance Index: 0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0016
Cell Significance Index: -3.0900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0066
Cell Significance Index: -4.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0079
Cell Significance Index: -14.5000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0097
Cell Significance Index: -14.8600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0121
Cell Significance Index: -0.3500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0145
Cell Significance Index: -11.0100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0146
Cell Significance Index: -0.7600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0159
Cell Significance Index: -1.1000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0181
Cell Significance Index: -13.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0183
Cell Significance Index: -2.3400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0202
Cell Significance Index: -9.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0209
Cell Significance Index: -0.5600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0230
Cell Significance Index: -12.9600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0291
Cell Significance Index: -8.3800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0291
Cell Significance Index: -0.6300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0322
Cell Significance Index: -11.5500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0329
Cell Significance Index: -2.1200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0371
Cell Significance Index: -6.6800 - Cell Name: glioblast (CL0000030)
Fold Change: -0.0382
Cell Significance Index: -0.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0383
Cell Significance Index: -7.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0415
Cell Significance Index: -4.2400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0472
Cell Significance Index: -2.9000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0472
Cell Significance Index: -0.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0495
Cell Significance Index: -8.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0517
Cell Significance Index: -10.3700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0536
Cell Significance Index: -6.5900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0548
Cell Significance Index: -2.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0555
Cell Significance Index: -11.6800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0557
Cell Significance Index: -8.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0632
Cell Significance Index: -2.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0718
Cell Significance Index: -9.2800 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.0751
Cell Significance Index: -0.4700 - Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.0767
Cell Significance Index: -0.4700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0781
Cell Significance Index: -9.2200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0837
Cell Significance Index: -3.7900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0876
Cell Significance Index: -5.3700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0897
Cell Significance Index: -9.3400 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.0983
Cell Significance Index: -0.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1027
Cell Significance Index: -2.8700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1028
Cell Significance Index: -11.7800 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1082
Cell Significance Index: -0.9200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1140
Cell Significance Index: -2.9300 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1239
Cell Significance Index: -1.4600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1324
Cell Significance Index: -9.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1368
Cell Significance Index: -10.5000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1406
Cell Significance Index: -6.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1491
Cell Significance Index: -3.9200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1493
Cell Significance Index: -2.7600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1496
Cell Significance Index: -9.4300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1500
Cell Significance Index: -2.2600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1607
Cell Significance Index: -6.5800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1648
Cell Significance Index: -8.3300 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: -0.1691
Cell Significance Index: -0.8900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1745
Cell Significance Index: -3.7300 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1774
Cell Significance Index: -2.4900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1776
Cell Significance Index: -11.9400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1917
Cell Significance Index: -9.9600 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2094
Cell Significance Index: -3.0400 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.2160
Cell Significance Index: -2.1400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2288
Cell Significance Index: -10.6700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2309
Cell Significance Index: -6.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2335
Cell Significance Index: -12.2600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2356
Cell Significance Index: -10.4200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.2408
Cell Significance Index: -3.7300 - Cell Name: mesangial cell (CL0000650)
Fold Change: -0.2498
Cell Significance Index: -3.1600 - Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.2559
Cell Significance Index: -3.0400 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.2580
Cell Significance Index: -3.5800 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.2592
Cell Significance Index: -1.2400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1825035963
Symbol: FZD2_HUMAN
Name: Frizzled-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7558010
Title: A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.
PubMed ID: 7558010
PubMed ID: 9813155
Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.
PubMed ID: 9813155
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9707618
Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.
PubMed ID: 9707618
PubMed ID: 25759469
Title: A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.
PubMed ID: 25759469
DOI: 10.1093/hmg/ddv088
PubMed ID: 27680706
Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
PubMed ID: 27680706
DOI: 10.1038/nature19799
PubMed ID: 31233493
Title: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B.
PubMed ID: 31233493
PubMed ID: 29748286
Title: Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.
PubMed ID: 29748286
PubMed ID: 29230162
Title: A novel de novo FZD2 mutation in a patient with autosomal dominant omodysplasia.
PubMed ID: 29230162
DOI: 10.1159/000479721
PubMed ID: 29383834
Title: Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes.
PubMed ID: 29383834
DOI: 10.1002/ajmg.a.38623
PubMed ID: 29276006
Title: WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome.
PubMed ID: 29276006
PubMed ID: 30455931
Title: Two unrelated patients with autosomal dominant omodysplasia and FRIZZLED2 mutations.
PubMed ID: 30455931
DOI: 10.1002/ccr3.1818
Sequence Information:
- Length: 565
- Mass: 63554
- Checksum: AA387876A1DDE063
- Sequence:
MRPRSALPRL LLPLLLLPAA GPAQFHGEKG ISIPDHGFCQ PISIPLCTDI AYNQTIMPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLEQAIPPC RSICERARQG CEALMNKFGF QWPERLRCEH FPRHGAEQIC VGQNHSEDGA PALLTTAPPP GLQPGAGGTP GGPGGGGAPP RYATLEHPFH CPRVLKVPSY LSYKFLGERD CAAPCEPARP DGSMFFSQEE TRFARLWILT WSVLCCASTF FTVTTYLVDM QRFRYPERPI IFLSGCYTMV SVAYIAGFVL QERVVCNERF SEDGYRTVVQ GTKKEGCTIL FMMLYFFSMA SSIWWVILSL TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AVKTITILAM GQIDGDLLSG VCFVGLNSLD PLRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLERLMV RIGVFSVLYT VPATIVIACY FYEQAFREHW ERSWVSQHCK SLAIPCPAHY TPRMSPDFTV YMIKYLMTLI VGITSGFWIW SGKTLHSWRK FYTRLTNSRH GETTV
Genular Protein ID: 272383377
Symbol: Q86UZ8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 641
- Mass: 71488
- Checksum: 120BCF98F673DA29
- Sequence:
ARGVSGCSVR PRQASGQAHR PLPRPASPTL RPRVKFAKRR GRRQPQRGGG GEEAQSPGWG RGRGGRQGAG WGAAASMRPR SALPRLLLPL LLLPAAGPAQ FHGEKGISIP DHGFCQPISI PLCTDIAYNQ TIMPNLLGHT NQEDAGLEVH QFYPLVKVQC SPELRFFLCS MYAPVCTVLE QAIPPCRSIC ERARQGCEAL MNKFGFQWPE RLRCEHFPRH GAEQICVGQN HSEDGAPALL TTAPPPGLQP GAGGTPGGPG GGGAPPRYAT LEHPFHCPRV LKVPSYLSYK FLGERDCAAP CEPARPDGSM FFSQEETRFA RLWILTWSVL CCASTFFTVT TYLVDMQRFR YPERPIIFLS GCYTMVSVAY IAGFVLQERV VCNERFSEDG YRTVVQGTKK EGCTILFMML YFFSMASSIW WVILSLTWFL AAGMKWGHEA IEANSQYFHL AAWAVPAVKT ITILAMGQID GDLLSGVCFV GLNSLDPLRG FVLAPLFVYL FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LERLMVRIGV FSVLYTVPAT IVIACYFYEQ AFREHWERSW VSQHCKSLAI PCPAHYTPRM SPDFTVYMIK YLMTLIVGIT SGFWIWSGKT LHSWRKFYTR LTNSRHGETT V
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.