RPL36 | ENSG00000130255 | NCBI 25873

Details for: RPL36

Gene ID: 25873

Symbol: RPL36

Ensembl ID: ENSG00000130255

Description: ribosomal protein L36

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 720.8441
Cell Significance Index: -296.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 638.9796
Cell Significance Index: -259.5900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 572.1183
Cell Significance Index: -270.1100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 564.4408
Cell Significance Index: -290.3400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 404.4799
Cell Significance Index: -271.4200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 276.3414
Cell Significance Index: -263.8400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 48.7969
Cell Significance Index: -130.7200
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 20.6909
Cell Significance Index: 314.2500
Cell Name: abnormal cell (CL0001061)
Fold Change: 15.5613
Cell Significance Index: 1589.5800
Cell Name: theca cell (CL0000503)
Fold Change: 14.5497
Cell Significance Index: 85.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: 14.2701
Cell Significance Index: 364.5600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 13.9991
Cell Significance Index: 657.9500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 12.6287
Cell Significance Index: 337.8100
Cell Name: granulosa cell (CL0000501)
Fold Change: 12.6268
Cell Significance Index: 332.0200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 11.7346
Cell Significance Index: 336.3800
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 11.4670
Cell Significance Index: 70.5700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 10.2872
Cell Significance Index: 131.7500
Cell Name: lactocyte (CL0002325)
Fold Change: 10.0463
Cell Significance Index: 1297.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 9.7310
Cell Significance Index: 171.9600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.3989
Cell Significance Index: 664.7300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.1284
Cell Significance Index: 1253.5800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 8.4043
Cell Significance Index: 1515.0300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 8.2889
Cell Significance Index: 173.5000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.2736
Cell Significance Index: 1017.3200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.2038
Cell Significance Index: 611.4200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 8.1100
Cell Significance Index: 378.1300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 7.9976
Cell Significance Index: 3535.9200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 7.7849
Cell Significance Index: 88.4400
Cell Name: peg cell (CL4033014)
Fold Change: 7.7326
Cell Significance Index: 178.6500
Cell Name: cell in vitro (CL0001034)
Fold Change: 7.6417
Cell Significance Index: 4173.3400
Cell Name: odontoblast (CL0000060)
Fold Change: 7.0162
Cell Significance Index: 899.4400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 6.8597
Cell Significance Index: 808.9700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 6.7397
Cell Significance Index: 183.4500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.6717
Cell Significance Index: 72.5300
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 6.0433
Cell Significance Index: 51.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.4724
Cell Significance Index: 934.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 5.3163
Cell Significance Index: 240.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.9222
Cell Significance Index: 144.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.5377
Cell Significance Index: 292.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 4.2175
Cell Significance Index: 121.5200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 4.0034
Cell Significance Index: 396.0200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.8974
Cell Significance Index: 35.8900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.6199
Cell Significance Index: 188.5600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.4108
Cell Significance Index: 63.0400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.2583
Cell Significance Index: 2942.0000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 3.1817
Cell Significance Index: 2408.3200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.1626
Cell Significance Index: 166.0500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.8170
Cell Significance Index: 97.8900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1013
Cell Significance Index: 417.0100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9538
Cell Significance Index: 52.1700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1928
Cell Significance Index: 227.0000
Cell Name: kidney cell (CL1000497)
Fold Change: 0.9907
Cell Significance Index: 7.9100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.6195
Cell Significance Index: 454.2500
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.5121
Cell Significance Index: 10.6800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5116
Cell Significance Index: 26.5800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0674
Cell Significance Index: -126.8900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1067
Cell Significance Index: -79.0400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1482
Cell Significance Index: -273.3100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1875
Cell Significance Index: -288.6500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1916
Cell Significance Index: -119.6500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2357
Cell Significance Index: -132.9300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2457
Cell Significance Index: -334.0600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2634
Cell Significance Index: -42.8400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2836
Cell Significance Index: -101.7100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3417
Cell Significance Index: -217.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.3514
Cell Significance Index: -70.5000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.5124
Cell Significance Index: -232.5800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5711
Cell Significance Index: -120.2900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.7260
Cell Significance Index: -208.9100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7427
Cell Significance Index: -58.8200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9389
Cell Significance Index: -30.0700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1424
Cell Significance Index: -70.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1919
Cell Significance Index: -136.5500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.2066
Cell Significance Index: -7.2900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.2948
Cell Significance Index: -22.3200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.3517
Cell Significance Index: -93.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.5620
Cell Significance Index: -98.4500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.7031
Cell Significance Index: -25.5200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.7143
Cell Significance Index: -249.2000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.7680
Cell Significance Index: -201.8200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.8178
Cell Significance Index: -45.4400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.9790
Cell Significance Index: -33.1200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.5871
Cell Significance Index: -269.3800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -3.0914
Cell Significance Index: -185.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -3.2952
Cell Significance Index: -184.9100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -3.4954
Cell Significance Index: -47.6900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.6295
Cell Significance Index: -127.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.7428
Cell Significance Index: -229.4700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -3.8422
Cell Significance Index: -258.3500
Cell Name: Sertoli cell (CL0000216)
Fold Change: -3.8912
Cell Significance Index: -54.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.8924
Cell Significance Index: -298.7000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.5249
Cell Significance Index: -98.0300
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -5.2688
Cell Significance Index: -28.7300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.5079
Cell Significance Index: -162.2300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -5.5243
Cell Significance Index: -148.0300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -5.5459
Cell Significance Index: -39.8300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -6.2169
Cell Significance Index: -106.5400
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -6.7052
Cell Significance Index: -86.3500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -6.9015
Cell Significance Index: -253.3500
Cell Name: perivascular cell (CL4033054)
Fold Change: -6.9257
Cell Significance Index: -31.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Ribosomal Protein L36**: RPL36 is a 60S ribosomal protein, which is essential for the assembly and functioning of the 60S ribosomal subunit. 2. **Cellular Expression**: RPL36 is significantly expressed in various cell types, including epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, malignant cells, and immune cells such as activated CD8-positive, alpha-beta T cells. 3. **Function**: RPL36 is involved in protein synthesis, translation, and cell survival, making it a crucial component of the translational machinery. **Pathways and Functions:** 1. **Translation Initiation**: RPL36 is involved in the initiation of translation, interacting with initiation factors and other ribosomal proteins to facilitate the binding of mRNA to the ribosome. 2. **Eukaryotic Translation Elongation**: RPL36 plays a role in the elongation phase of translation, helping to maintain the fidelity of protein synthesis by preventing non-templated additions of amino acids. 3. **Cellular Responses to Stimuli**: RPL36 is involved in the regulation of cellular responses to stress, starvation, and other stimuli, ensuring the proper functioning of the translational machinery. 4. **Immune Response**: RPL36 is expressed in immune cells, where it plays a role in the regulation of protein synthesis and cell survival, influencing the immune response to pathogens and tumors. 5. **Viral Infection**: RPL36 is also involved in the translation of viral mRNAs, making it a target for antiviral therapies. **Clinical Significance:** 1. **Cancer Research**: RPL36 has been implicated in the development and progression of various cancers, including pancreatic cancer, where it is overexpressed. 2. **Immunological Disorders**: Alterations in RPL36 expression have been linked to autoimmune diseases, such as rheumatoid arthritis, where it plays a role in the regulation of protein synthesis and cell survival. 3. **Neurological Disorders**: RPL36 has been implicated in neurological disorders, including Alzheimer's disease, where it is involved in the regulation of protein synthesis and cell survival. 4. **Antiviral Therapies**: Targeting RPL36 has been proposed as a potential strategy for antiviral therapies, particularly against influenza viruses. In conclusion, RPL36 is a multifunctional protein that plays a critical role in various cellular processes, including translation, cell survival, and immune responses. Its clinical significance is evident in its involvement in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully elucidate the role of RPL36 in human health and disease, with potential therapeutic implications for the development of novel treatments.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L36

Genular Protein ID: 1490846234

Symbol: RL36_HUMAN

Name: 60S ribosomal protein L36

UniProtKB Accession Codes:

Q9Y3U8 B2R4Y1 D6W634 Q6FIG1 Q9UQF6

Database IDs:

Citations:

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 105
Mass: 12254
Checksum: FEE8850A62080EB3
Sequence:

MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF APYERRAMEL 
LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA AAKKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPL36

Associated with

Cells (max top 100)

Other Information

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. PubMed ID: 12962325

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of actively translating human ribosomes. PubMed ID: 25957688

Structure of the human 80S ribosome. PubMed ID: 25901680

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547