Details for: GBP2

Gene ID: 2634

Symbol: GBP2

Ensembl ID: ENSG00000162645

Description: guanylate binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.44
    Marker Score: 4330
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.08
    Marker Score: 13329
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.02
    Marker Score: 2161
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2930
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.96
    Marker Score: 697
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.85
    Marker Score: 4558.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.79
    Marker Score: 17687
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.77
    Marker Score: 1509
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.69
    Marker Score: 3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.68
    Marker Score: 3964
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.64
    Marker Score: 91909
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.64
    Marker Score: 436
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.64
    Marker Score: 3954
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.62
    Marker Score: 7001
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167209
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.44
    Marker Score: 7088.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.44
    Marker Score: 16729.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.43
    Marker Score: 328
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.36
    Marker Score: 1501
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.36
    Marker Score: 3956
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.33
    Marker Score: 504
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.33
    Marker Score: 5114
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.32
    Marker Score: 762
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.32
    Marker Score: 3217.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.26
    Marker Score: 2773
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.25
    Marker Score: 3947
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.25
    Marker Score: 1049.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.24
    Marker Score: 65735.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.24
    Marker Score: 726
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.24
    Marker Score: 278
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.24
    Marker Score: 431
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.18
    Marker Score: 3266
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.18
    Marker Score: 774
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.16
    Marker Score: 279
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.15
    Marker Score: 445
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.14
    Marker Score: 2976
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.13
    Marker Score: 1061
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38494
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.11
    Marker Score: 1882.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.1
    Marker Score: 804
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.1
    Marker Score: 1065
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.1
    Marker Score: 1514
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.1
    Marker Score: 2069
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.09
    Marker Score: 338
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.08
    Marker Score: 1204
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.08
    Marker Score: 846
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.07
    Marker Score: 686
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.06
    Marker Score: 1886
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.05
    Marker Score: 296
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.04
    Marker Score: 252
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.04
    Marker Score: 2927
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.04
    Marker Score: 26673
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.04
    Marker Score: 923
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.04
    Marker Score: 518
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.03
    Marker Score: 1276
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.03
    Marker Score: 514
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.03
    Marker Score: 445
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.02
    Marker Score: 1571
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.02
    Marker Score: 2035
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.01
    Marker Score: 839
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.01
    Marker Score: 1467
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71641
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47867
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.99
    Marker Score: 414
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.98
    Marker Score: 341
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.97
    Marker Score: 239
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.97
    Marker Score: 293
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.97
    Marker Score: 2501
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.96
    Marker Score: 1487
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.96
    Marker Score: 1366
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.96
    Marker Score: 209
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.96
    Marker Score: 694
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.96
    Marker Score: 692
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.96
    Marker Score: 571
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.95
    Marker Score: 4071
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.94
    Marker Score: 744
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.94
    Marker Score: 812
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.94
    Marker Score: 911
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.94
    Marker Score: 10609
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2389
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.94
    Marker Score: 1165
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.93
    Marker Score: 833
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.93
    Marker Score: 964
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.93
    Marker Score: 608
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.91
    Marker Score: 1498.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.91
    Marker Score: 502
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.91
    Marker Score: 231
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.91
    Marker Score: 295
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.91
    Marker Score: 976
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2685
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.89
    Marker Score: 209
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.89
    Marker Score: 1154
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.89
    Marker Score: 335
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.88
    Marker Score: 1979
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.88
    Marker Score: 289

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Other Information

**Key characteristics:** * GBP2 is a protein of the immunoglobulin superfamily. * It is expressed in a variety of cell types, including epithelial cells of the mammary gland, immune cells, and fibroblasts. * GBP2 is a key regulator of the innate immune response, and its expression is often upregulated in response to infection. * GBP2 is a multi-functional protein that can act as an enzyme, a protein-protein interaction partner, and a signaling molecule. **Pathways and functions:** * GBP2 is involved in the activation of innate immune response. * It is a key regulator of the inflammatory response to bacterial and viral infection. * GBP2 is also involved in the regulation of cell migration and adhesion. **Clinical significance:** * GBP2 is a potential therapeutic target for inflammatory diseases. * Inhibition of GBP2 has been shown to reduce inflammation and improve disease outcomes in animal models of inflammatory diseases. * GBP2 is a promising target for the development of new drugs for inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and sepsis. **Additional information:** * The gene encoding GBP2 is located on chromosome 17q21.1. * GBP2 is a secreted protein that is found in the plasma and urine. * GBP2 is a highly conserved protein that is found in mammals and birds.

Genular Protein ID: 2534682353

Symbol: GBP2_HUMAN

Name: Guanylate-binding protein 2

UniProtKB Accession Codes:

P32456 Q6GPH0 Q6IAU2 Q86TB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1715024

Title: Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

PubMed ID: 1715024

DOI: 10.1128/mcb.11.9.4717-4725.1991

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706832

Title: GTPase properties of the interferon-induced human guanylate-binding protein 2.

PubMed ID: 8706832

DOI: 10.1016/0014-5793(96)00628-x

PubMed ID: 17266443

Title: Unique features of different members of the human guanylate-binding protein family.

PubMed ID: 17266443

DOI: 10.1089/jir.2007.0086

PubMed ID: 21151871

Title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

PubMed ID: 21151871

DOI: 10.1371/journal.pone.0014246

PubMed ID: 29024643

Title: GBPs inhibit motility of Shigella flexneri but are targeted for degradation by the bacterial ubiquitin ligase IpaH9.8.

PubMed ID: 29024643

DOI: 10.1016/j.chom.2017.09.007

PubMed ID: 29144452

Title: Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

PubMed ID: 29144452

DOI: 10.1038/nature24467

PubMed ID: 31091448

Title: Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins.

PubMed ID: 31091448

DOI: 10.1016/j.celrep.2019.04.063

PubMed ID: 33876762

Title: Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.

PubMed ID: 33876762

DOI: 10.1073/pnas.2022269118

Sequence Information:

  • Length: 591
  • Mass: 67209
  • Checksum: B09B3C2F3C3E1EA2
  • Sequence:
    • MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 
KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI 
LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL 
RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA 
PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN 
AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER 
EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV 
KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL 
SEKEKAIEVE RIKAESAEAA KKMLEEIQKK NEEMMEQKEK SYQEHVKQLT EKMERDRAQL 
MAEQEKTLAL KLQEQERLLK EGFENESKRL QKDIWDIQMR SKSLEPICNI L

Genular Protein ID: 4076545227

Symbol: Q8TCE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TCE5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 481
  • Mass: 54035
  • Checksum: 2F8B66BEA92EED87
  • Sequence:
    • MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 
KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI 
LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL 
RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA 
PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN 
AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER 
EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV 
KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.