Details for: NARF

Gene ID: 26502

Symbol: NARF

Ensembl ID: ENSG00000141562

Description: nuclear prelamin A recognition factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.7274
    Cell Significance Index: -34.6800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.3649
    Cell Significance Index: -18.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.8765
    Cell Significance Index: -40.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.5517
    Cell Significance Index: -44.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.0415
    Cell Significance Index: -36.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.9121
    Cell Significance Index: -41.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.6491
    Cell Significance Index: -36.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9296
    Cell Significance Index: -31.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4419
    Cell Significance Index: -33.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1276
    Cell Significance Index: -43.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0506
    Cell Significance Index: -30.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9582
    Cell Significance Index: -13.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6052
    Cell Significance Index: 1449.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1947
    Cell Significance Index: 239.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1284
    Cell Significance Index: 33.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1200
    Cell Significance Index: 182.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0688
    Cell Significance Index: 116.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0629
    Cell Significance Index: 68.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0169
    Cell Significance Index: 52.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0114
    Cell Significance Index: 12.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8382
    Cell Significance Index: 50.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7971
    Cell Significance Index: 27.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6987
    Cell Significance Index: 82.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6942
    Cell Significance Index: 137.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6910
    Cell Significance Index: 377.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6807
    Cell Significance Index: 35.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6476
    Cell Significance Index: 232.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6372
    Cell Significance Index: 28.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5557
    Cell Significance Index: 15.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5268
    Cell Significance Index: 24.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5141
    Cell Significance Index: 92.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5042
    Cell Significance Index: 34.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5016
    Cell Significance Index: 10.5000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4801
    Cell Significance Index: 3.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4788
    Cell Significance Index: 61.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4407
    Cell Significance Index: 27.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3986
    Cell Significance Index: 275.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3557
    Cell Significance Index: 27.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3482
    Cell Significance Index: 42.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3407
    Cell Significance Index: 46.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3296
    Cell Significance Index: 620.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3223
    Cell Significance Index: 31.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2923
    Cell Significance Index: 55.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2602
    Cell Significance Index: 115.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2313
    Cell Significance Index: 10.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1917
    Cell Significance Index: 8.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1666
    Cell Significance Index: 9.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1437
    Cell Significance Index: 5.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1079
    Cell Significance Index: 3.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0785
    Cell Significance Index: 2.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0317
    Cell Significance Index: 48.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0310
    Cell Significance Index: 57.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0280
    Cell Significance Index: 17.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0067
    Cell Significance Index: 9.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0065
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0319
    Cell Significance Index: -23.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0361
    Cell Significance Index: -4.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0367
    Cell Significance Index: -27.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0478
    Cell Significance Index: -35.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0682
    Cell Significance Index: -38.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0708
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0775
    Cell Significance Index: -48.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0911
    Cell Significance Index: -1.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0964
    Cell Significance Index: -5.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1025
    Cell Significance Index: -29.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1352
    Cell Significance Index: -19.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1373
    Cell Significance Index: -9.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1437
    Cell Significance Index: -9.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1542
    Cell Significance Index: -4.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1760
    Cell Significance Index: -4.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1996
    Cell Significance Index: -5.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2183
    Cell Significance Index: -16.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2209
    Cell Significance Index: -46.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2324
    Cell Significance Index: -14.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2440
    Cell Significance Index: -28.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2640
    Cell Significance Index: -2.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2865
    Cell Significance Index: -6.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2961
    Cell Significance Index: -33.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3134
    Cell Significance Index: -32.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3487
    Cell Significance Index: -9.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3758
    Cell Significance Index: -4.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3776
    Cell Significance Index: -4.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3826
    Cell Significance Index: -8.1500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4471
    Cell Significance Index: -2.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4689
    Cell Significance Index: -37.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5322
    Cell Significance Index: -11.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6265
    Cell Significance Index: -38.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6358
    Cell Significance Index: -11.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6413
    Cell Significance Index: -18.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6584
    Cell Significance Index: -9.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6727
    Cell Significance Index: -10.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7069
    Cell Significance Index: -22.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7501
    Cell Significance Index: -18.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7578
    Cell Significance Index: -19.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7923
    Cell Significance Index: -22.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8041
    Cell Significance Index: -7.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8822
    Cell Significance Index: -25.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** NARF is highly expressed in a wide range of cell types, including those with distinct developmental and functional roles, such as GABAergic neurons and erythroid progenitor cells. 2. **Lamin Binding:** NARF interacts with lamin A, a key component of the nuclear lamina, suggesting its role in regulating nuclear architecture and maintaining the structural integrity of the nucleus. 3. **Nuclear Filament Formation:** NARF is involved in the formation of nuclear filaments, which are essential for maintaining the organization and structure of the nucleus. 4. **Nucleolar Organization:** NARF also plays a role in regulating nucleolar organization, which is critical for ribosome biogenesis and cellular homeostasis. **Pathways and Functions:** 1. **Lamin Binding Pathway:** NARF interacts with lamin A, leading to the formation of nuclear filaments and the maintenance of nuclear architecture. 2. **Nuclear Filament Formation Pathway:** NARF is involved in the assembly of nuclear filaments, which are essential for maintaining the organization and structure of the nucleus. 3. **Nucleolar Organization Pathway:** NARF regulates nucleolar organization, which is critical for ribosome biogenesis and cellular homeostasis. 4. **Cellular Homeostasis:** NARF plays a role in maintaining cellular homeostasis by regulating the organization and function of the nucleus, which is essential for proper cellular function. **Clinical Significance:** 1. **Cancer Association:** Alterations in NARF expression have been linked to various types of cancer, suggesting its potential role as a tumor suppressor gene. 2. **Neurological Disorders:** NARF has been implicated in neurological disorders, such as Alzheimer's disease and frontotemporal dementia, highlighting its potential role in maintaining nuclear architecture and cellular homeostasis. 3. **Genetic Disorders:** NARF mutations have been associated with genetic disorders, such as Hutchinson-Gilford progeria syndrome, underscoring its importance in maintaining nuclear architecture and cellular homeostasis. 4. **Immunological Disorders:** NARF may also play a role in immunological disorders, such as autoimmune diseases, where alterations in nuclear architecture and cellular homeostasis contribute to disease pathology. In conclusion, the Nuclear Pre-lamin A Recognition Factor (NARF) gene plays a critical role in maintaining nuclear architecture and regulating cellular homeostasis. Its involvement in lamin binding, nuclear filament formation, and nucleolar organization underscores its importance in maintaining the structural and functional integrity of the nucleus. Further research is needed to fully elucidate the role of NARF in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3348727951

Symbol: NARF_HUMAN

Name: Nuclear prelamin A recognition factor

UniProtKB Accession Codes:

Q9UHQ1 A6NCJ3 B3KPX2 K4DI98 Q96AY9 Q9BWC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10514485

Title: Prenylated prelamin A interacts with Narf, a novel nuclear protein.

PubMed ID: 10514485

DOI: 10.1074/jbc.274.42.30008

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 456
  • Mass: 51156
  • Checksum: F615D812E7FC7D0F
  • Sequence:
    • MKCEHCTRKE CSKKTKTDDQ ENVSADAPSP AQENGEKGEF HKLADAKIFL SDCLACDSCM 
TAEEGVQLSQ QNAKDFFRVL NLNKKCDTSK HKVLVVSVCP QSLPYFAAKF NLSVTDASRR 
LCGFLKSLGV HYVFDTTIAA DFSILESQKE FVRRYRQHSE EERTLPMLTS ACPGWVRYAE 
RVLGRPITAH LCTAKSPQQV MGSLVKDYFA RQQNLSPEKI FHVIVAPCYD KKLEALQESL 
PPALHGSRGA DCVLTSGEIA QIMEQGDLSV RDAAVDTLFG DLKEDKVTRH DGASSDGHLA 
HIFRHAAKEL FNEDVEEVTY RALRNKDFQE VTLEKNGEVV LRFAAAYGFR NIQNMILKLK 
KGKFPFHFVE VLACAGGCLN GRGQAQTPDG HADKALLRQM EGIYADIPVR RPESSAHVQE 
LYQEWLEGIN SPKAREVLHT TYQSQERGTH SLDIKW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.