Details for: TIMM10B

Gene ID: 26515

Symbol: TIMM10B

Ensembl ID: ENSG00000132286

Description: translocase of inner mitochondrial membrane 10B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 126.7156
    Cell Significance Index: -19.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.1592
    Cell Significance Index: -18.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.9045
    Cell Significance Index: -20.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.4922
    Cell Significance Index: -21.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.9807
    Cell Significance Index: -18.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.7391
    Cell Significance Index: -21.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.1206
    Cell Significance Index: -19.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.4297
    Cell Significance Index: -21.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9988
    Cell Significance Index: -16.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5676
    Cell Significance Index: -21.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3688
    Cell Significance Index: -16.4900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 4.0375
    Cell Significance Index: 25.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6753
    Cell Significance Index: 272.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3301
    Cell Significance Index: 79.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2010
    Cell Significance Index: 130.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1922
    Cell Significance Index: 32.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9875
    Cell Significance Index: 51.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6293
    Cell Significance Index: 43.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6221
    Cell Significance Index: 17.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6046
    Cell Significance Index: 74.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4927
    Cell Significance Index: 36.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4679
    Cell Significance Index: 21.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4579
    Cell Significance Index: 28.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4357
    Cell Significance Index: 59.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4064
    Cell Significance Index: 11.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3913
    Cell Significance Index: 20.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3884
    Cell Significance Index: 18.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3741
    Cell Significance Index: 48.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3695
    Cell Significance Index: 201.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3582
    Cell Significance Index: 64.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3288
    Cell Significance Index: 65.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3033
    Cell Significance Index: 10.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2946
    Cell Significance Index: 13.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2535
    Cell Significance Index: 112.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2198
    Cell Significance Index: 14.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2188
    Cell Significance Index: 2.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1900
    Cell Significance Index: 13.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1779
    Cell Significance Index: 33.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1547
    Cell Significance Index: 15.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1329
    Cell Significance Index: 1.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1274
    Cell Significance Index: 16.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1245
    Cell Significance Index: 44.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1216
    Cell Significance Index: 20.7600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1048
    Cell Significance Index: 1.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1004
    Cell Significance Index: 2.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0698
    Cell Significance Index: 1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0370
    Cell Significance Index: 0.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0348
    Cell Significance Index: 0.8700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0247
    Cell Significance Index: 0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0161
    Cell Significance Index: 12.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0010
    Cell Significance Index: 0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0101
    Cell Significance Index: -0.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0119
    Cell Significance Index: -22.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -8.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0194
    Cell Significance Index: -0.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0252
    Cell Significance Index: -14.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0361
    Cell Significance Index: -4.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0375
    Cell Significance Index: -3.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0453
    Cell Significance Index: -3.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0490
    Cell Significance Index: -22.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0615
    Cell Significance Index: -12.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0924
    Cell Significance Index: -10.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1049
    Cell Significance Index: -2.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1077
    Cell Significance Index: -21.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1179
    Cell Significance Index: -13.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1247
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1389
    Cell Significance Index: -8.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1421
    Cell Significance Index: -16.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1510
    Cell Significance Index: -2.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1589
    Cell Significance Index: -23.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1812
    Cell Significance Index: -6.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1858
    Cell Significance Index: -4.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1917
    Cell Significance Index: -7.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1919
    Cell Significance Index: -8.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1939
    Cell Significance Index: -10.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2019
    Cell Significance Index: -5.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2027
    Cell Significance Index: -16.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2035
    Cell Significance Index: -3.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2091
    Cell Significance Index: -4.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2150
    Cell Significance Index: -22.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2513
    Cell Significance Index: -6.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2579
    Cell Significance Index: -2.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2685
    Cell Significance Index: -16.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2833
    Cell Significance Index: -3.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3044
    Cell Significance Index: -5.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3272
    Cell Significance Index: -5.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3336
    Cell Significance Index: -4.7400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3342
    Cell Significance Index: -3.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3766
    Cell Significance Index: -3.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3877
    Cell Significance Index: -11.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4384
    Cell Significance Index: -3.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4741
    Cell Significance Index: -16.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4827
    Cell Significance Index: -17.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4942
    Cell Significance Index: -4.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5096
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5263
    Cell Significance Index: -17.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5293
    Cell Significance Index: -10.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TIMM10B is a mitochondrial protein that belongs to the translocase of inner mitochondrial membrane (TIM) family. It is characterized by its ability to bind unfolded proteins and facilitate their import into the mitochondrial intermembrane space. TIMM10B is specifically localized to the inner mitochondrial membrane, where it interacts with other mitochondrial proteins to regulate protein import. The protein is highly expressed in various cell types, including immune cells, epithelial cells, and cells of the nervous system. **Pathways and Functions** TIMM10B is involved in several key pathways related to mitochondrial function and protein import. These include: 1. **Mitochondrial protein import**: TIMM10B plays a crucial role in the import of unfolded proteins into the mitochondrial intermembrane space. This process is essential for maintaining mitochondrial function and overall cellular homeostasis. 2. **Cell-matrix adhesion**: TIMM10B has been shown to interact with cell surface proteins, influencing cell-matrix adhesion and cell migration. 3. **Protein binding**: TIMM10B binds to unfolded proteins, facilitating their import into the mitochondrial intermembrane space. 4. **Protein localization**: TIMM10B regulates the localization of proteins within the cell, influencing cellular signaling and homeostasis. **Clinical Significance** Dysregulation of TIMM10B has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the TIMM10B gene have been associated with mitochondrial disorders, such as Leber hereditary optic neuropathy (LHON). 2. **Immune system dysfunction**: TIMM10B has been shown to play a role in immune cell function, and dysregulation of the protein may contribute to immune system dysfunction. 3. **Cancer**: TIMM10B has been implicated in cancer development, particularly in cells of the nervous system and immune cells. 4. **Neurodegenerative diseases**: TIMM10B has been shown to play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, TIMM10B is a crucial protein involved in mitochondrial function, protein import, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of TIMM10B in human health and disease.

Genular Protein ID: 3665047211

Symbol: T10B_HUMAN

Name: Mitochondrial import inner membrane translocase subunit Tim10 B

UniProtKB Accession Codes:

Q9Y5J6 Q96FF3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 EMBL 4 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10552927

Title: The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins.

PubMed ID: 10552927

DOI: 10.1006/geno.1999.5966

PubMed ID: 10611480

Title: The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PubMed ID: 10611480

DOI: 10.1016/s0014-5793(99)01665-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11489896

Title: Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.

PubMed ID: 11489896

DOI: 10.1074/jbc.m105313200

PubMed ID: 14726512

Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.

PubMed ID: 14726512

DOI: 10.1074/jbc.m312485200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28712724

Title: Acylglycerol kinase mutated in Sengers Syndrome is a subunit of the TIM22 protein translocase in mitochondria.

PubMed ID: 28712724

DOI: 10.1016/j.molcel.2017.06.013

Sequence Information:

  • Length: 103
  • Mass: 11586
  • Checksum: B76CCC81668B1F31
  • Sequence:
    • MERQQQQQQQ LRNLRDFLLV YNRMTELCFQ RCVPSLHHRA LDAEEEACLH SCAGKLIHSN 
HRLMAAYVQL MPALVQRRIA DYEAASAVPG VAAEQPGVSP SGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.