Details for: LATS2

Gene ID: 26524

Symbol: LATS2

Ensembl ID: ENSG00000150457

Description: large tumor suppressor kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.1043
    Cell Significance Index: -26.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.2088
    Cell Significance Index: -24.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.6166
    Cell Significance Index: -26.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.6022
    Cell Significance Index: -21.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.3935
    Cell Significance Index: -21.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.8824
    Cell Significance Index: -26.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7243
    Cell Significance Index: -26.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0675
    Cell Significance Index: -19.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8195
    Cell Significance Index: -26.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3127
    Cell Significance Index: 88.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.6011
    Cell Significance Index: 66.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.0645
    Cell Significance Index: 34.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7611
    Cell Significance Index: 47.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5231
    Cell Significance Index: 116.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4710
    Cell Significance Index: 28.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2877
    Cell Significance Index: 18.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1358
    Cell Significance Index: 225.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0047
    Cell Significance Index: 21.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.9133
    Cell Significance Index: 11.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8421
    Cell Significance Index: 47.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7915
    Cell Significance Index: 22.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7527
    Cell Significance Index: 87.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7234
    Cell Significance Index: 17.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6971
    Cell Significance Index: 36.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5541
    Cell Significance Index: 28.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4883
    Cell Significance Index: 92.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3141
    Cell Significance Index: 4.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3136
    Cell Significance Index: 43.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2959
    Cell Significance Index: 4.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2270
    Cell Significance Index: 27.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2217
    Cell Significance Index: 200.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2120
    Cell Significance Index: 3.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1992
    Cell Significance Index: 9.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1679
    Cell Significance Index: 316.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1474
    Cell Significance Index: 80.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1208
    Cell Significance Index: 0.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1136
    Cell Significance Index: 154.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1087
    Cell Significance Index: 48.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0952
    Cell Significance Index: 2.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0917
    Cell Significance Index: 169.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0871
    Cell Significance Index: 5.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0763
    Cell Significance Index: 7.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0752
    Cell Significance Index: 115.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0736
    Cell Significance Index: 1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0664
    Cell Significance Index: 42.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0535
    Cell Significance Index: 8.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0428
    Cell Significance Index: 5.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0425
    Cell Significance Index: 19.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0274
    Cell Significance Index: 0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0214
    Cell Significance Index: 3.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0001
    Cell Significance Index: 0.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0114
    Cell Significance Index: -1.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0128
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0165
    Cell Significance Index: -0.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0255
    Cell Significance Index: -1.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0271
    Cell Significance Index: -20.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0305
    Cell Significance Index: -3.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0387
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0473
    Cell Significance Index: -9.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0540
    Cell Significance Index: -1.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0581
    Cell Significance Index: -11.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0589
    Cell Significance Index: -3.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0664
    Cell Significance Index: -23.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0767
    Cell Significance Index: -8.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0776
    Cell Significance Index: -22.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0779
    Cell Significance Index: -10.0600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0821
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0888
    Cell Significance Index: -9.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0937
    Cell Significance Index: -4.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1056
    Cell Significance Index: -7.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1142
    Cell Significance Index: -7.0000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1357
    Cell Significance Index: -2.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1484
    Cell Significance Index: -8.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1540
    Cell Significance Index: -11.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1668
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1728
    Cell Significance Index: -19.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1794
    Cell Significance Index: -4.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1801
    Cell Significance Index: -1.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2042
    Cell Significance Index: -24.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2045
    Cell Significance Index: -2.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2049
    Cell Significance Index: -3.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2076
    Cell Significance Index: -21.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2607
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2630
    Cell Significance Index: -20.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2659
    Cell Significance Index: -7.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2849
    Cell Significance Index: -5.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3420
    Cell Significance Index: -21.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3469
    Cell Significance Index: -9.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3594
    Cell Significance Index: -5.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3660
    Cell Significance Index: -12.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3882
    Cell Significance Index: -26.1000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3996
    Cell Significance Index: -6.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4254
    Cell Significance Index: -12.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4347
    Cell Significance Index: -9.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4401
    Cell Significance Index: -27.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LATS2 is a member of the large tumor suppressor kinase family, which is characterized by its ability to regulate cell growth and proliferation through the phosphorylation of downstream targets. The gene exhibits the following key characteristics: 1. **Serine/threonine kinase activity**: LATS2 possesses serine/threonine kinase activity, which enables it to phosphorylate and activate downstream targets. 2. **Hippo signaling pathway involvement**: LATS2 is a key component of the Hippo signaling pathway, which regulates cell growth, proliferation, and apoptosis. 3. **Negative regulation of cell proliferation**: LATS2 phosphorylates and activates downstream targets that inhibit cell proliferation, thereby preventing tumorigenesis. 4. **Induction of apoptosis**: LATS2 also promotes apoptosis in response to cellular stress or damage, ensuring the elimination of damaged or aberrant cells. **Pathways and Functions** The LATS2 gene is involved in various signaling pathways that regulate cell growth, proliferation, and apoptosis. The primary pathways associated with LATS2 include: 1. **Hippo signaling pathway**: LATS2 is a key component of the Hippo signaling pathway, which regulates cell growth, proliferation, and apoptosis. 2. **Canonical Wnt signaling pathway**: LATS2 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation and differentiation. 3. **Apoptotic signaling pathway**: LATS2 promotes apoptosis in response to cellular stress or damage, ensuring the elimination of damaged or aberrant cells. 4. **Cell cycle regulation**: LATS2 regulates the G1/S transition of the cell cycle, ensuring proper cell growth and proliferation. **Clinical Significance** The LATS2 gene has significant clinical implications, particularly in the context of cancer and tumor suppression. Mutations or alterations in the LATS2 gene have been associated with: 1. **Cancer development**: Loss of LATS2 function has been implicated in the development of various cancers, including colorectal, breast, and lung cancers. 2. **Tumor progression**: LATS2 inactivation can lead to increased cell proliferation and tumor progression. 3. **Genetic predisposition**: Germline mutations in the LATS2 gene have been identified in individuals with a predisposition to cancer. In conclusion, the LATS2 gene plays a critical role in regulating cell growth, proliferation, and apoptosis through its involvement in the Hippo signaling pathway. Its dysregulation has significant clinical implications, particularly in the context of cancer and tumor suppression. Further research is needed to fully understand the mechanisms by which LATS2 regulates cellular processes and to explore its potential as a therapeutic target in cancer treatment.

Genular Protein ID: 4009952920

Symbol: LATS2_HUMAN

Name: Serine/threonine-protein kinase LATS2

UniProtKB Accession Codes:

Q9NRM7 B1AM47 Q9P2X1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 ELM 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10871863

Title: Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor.

PubMed ID: 10871863

DOI: 10.1038/sj.onc.1203659

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 10673337

Title: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.

PubMed ID: 10673337

DOI: 10.1006/geno.1999.6065

PubMed ID: 12853976

Title: Lats2, a putative tumor suppressor, inhibits G1/S transition.

PubMed ID: 12853976

DOI: 10.1038/sj.onc.1206603

PubMed ID: 15147269

Title: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

PubMed ID: 15147269

DOI: 10.1111/j.1356-9597.2004.00732.x

PubMed ID: 15131260

Title: The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.

PubMed ID: 15131260

DOI: 10.1210/me.2004-0065

PubMed ID: 15688006

Title: The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.

PubMed ID: 15688006

DOI: 10.1038/sj.onc.1208445

PubMed ID: 16413547

Title: LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.

PubMed ID: 16413547

DOI: 10.1016/j.febslet.2005.12.096

PubMed ID: 18158288

Title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

PubMed ID: 18158288

DOI: 10.1074/jbc.m709037200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20303269

Title: Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

PubMed ID: 20303269

DOI: 10.1016/j.cub.2010.02.035

PubMed ID: 19739119

Title: Molecular characterization of human homologs of yeast MOB1.

PubMed ID: 19739119

DOI: 10.1002/ijc.24878

PubMed ID: 21952048

Title: Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.

PubMed ID: 21952048

DOI: 10.1038/emboj.2011.357

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24682284

Title: Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling.

PubMed ID: 24682284

DOI: 10.1093/molbev/msu115

PubMed ID: 26437443

Title: MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway.

PubMed ID: 26437443

DOI: 10.1038/ncomms9357

PubMed ID: 26598551

Title: Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.

PubMed ID: 26598551

DOI: 10.15252/embr.201540809

PubMed ID: 32845958

Title: A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.

PubMed ID: 32845958

DOI: 10.1084/jem.20191561

PubMed ID: 34404733

Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.

PubMed ID: 34404733

DOI: 10.26508/lsa.202000953

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1088
  • Mass: 120136
  • Checksum: 2866F6B75637AD36
  • Sequence:
    • MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSVQGLPAG PNSDTSLDAK VLGSKDATRQ 
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 
LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGK GLMPTPVTRR PSFEGTGDSF 
ASYHQLSGTP YEGPSFGADG PTALEEMPRP YVDYLFPGVG PHGPGHQHQH PPKGYGASVE 
AAGAHFPLQG AHYGRPHLLV PGEPLGYGVQ RSPSFQSKTP PETGGYASLP TKGQGGPPGA 
GLAFPPPAAG LYVPHPHHKQ AGPAAHQLHV LGSRSQVFAS DSPPQSLLTP SRNSLNVDLY 
ELGSTSVQQW PAATLARRDS LQKPGLEAPP RAHVAFRPDC PVPSRTNSFN SHQPRPGPPG 
KAEPSLPAPN TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVPAPA PAPAPAPAPA 
AEGLDAKEEH ALALGGAGAF PLDVEYGGPD RRCPPPPYPK HLLLRSKSEQ YDLDSLCAGM 
EQSLRAGPNE PEGGDKSRKS AKGDKGGKDK KQIQTSPVPV RKNSRDEEKR ESRIKSYSPY 
AFKFFMEQHV ENVIKTYQQK VNRRLQLEQE MAKAGLCEAE QEQMRKILYQ KESNYNRLKR 
AKMDKSMFVK IKTLGIGAFG EVCLACKVDT HALYAMKTLR KKDVLNRNQV AHVKAERDIL 
AEADNEWVVK LYYSFQDKDS LYFVMDYIPG GDMMSLLIRM EVFPEHLARF YIAELTLAIE 
SVHKMGFIHR DIKPDNILID LDGHIKLTDF GLCTGFRWTH NSKYYQKGSH VRQDSMEPSD 
LWDDVSNCRC GDRLKTLEQR ARKQHQRCLA HSLVGTPNYI APEVLLRKGY TQLCDWWSVG 
VILFEMLVGQ PPFLAPTPTE TQLKVINWEN TLHIPAQVKL SPEARDLITK LCCSADHRLG 
RNGADDLKAH PFFSAIDFSS DIRKQPAPYV PTISHPMDTS NFDPVDEESP WNDASEGSTK 
AWDTLTSPNN KHPEHAFYEF TFRRFFDDNG YPFRCPKPSG AEASQAESSD LESSDLVDQT 
EGCQPVYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.