Details for: OR12D2

Gene ID: 26529

Symbol: OR12D2

Ensembl ID: ENSG00000280236

Description: olfactory receptor family 12 subfamily D member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.4731
    Cell Significance Index: 4.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1432
    Cell Significance Index: 2.3200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0611
    Cell Significance Index: 0.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0097
    Cell Significance Index: 0.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0096
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0055
    Cell Significance Index: 0.0500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0013
    Cell Significance Index: 0.2500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0036
    Cell Significance Index: -0.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0040
    Cell Significance Index: -0.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0055
    Cell Significance Index: -0.1400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0082
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0115
    Cell Significance Index: -0.1200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0131
    Cell Significance Index: -0.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0142
    Cell Significance Index: -0.1400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0147
    Cell Significance Index: -0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0151
    Cell Significance Index: -0.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0168
    Cell Significance Index: -0.1800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0172
    Cell Significance Index: -0.1700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0172
    Cell Significance Index: -0.1200
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0175
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0189
    Cell Significance Index: -0.1700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0209
    Cell Significance Index: -0.1900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0210
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0254
    Cell Significance Index: -0.2100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0255
    Cell Significance Index: -0.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0269
    Cell Significance Index: -0.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0292
    Cell Significance Index: -0.1900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0337
    Cell Significance Index: -0.2000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0355
    Cell Significance Index: -0.1900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0382
    Cell Significance Index: -0.4600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0395
    Cell Significance Index: -0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0439
    Cell Significance Index: -0.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0440
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0489
    Cell Significance Index: -0.5000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0591
    Cell Significance Index: -0.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0598
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0737
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1013
    Cell Significance Index: -1.5000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1105
    Cell Significance Index: -0.7700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1224
    Cell Significance Index: -1.6300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1545
    Cell Significance Index: -0.9900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1675
    Cell Significance Index: -1.4600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2207
    Cell Significance Index: -1.3800
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2508
    Cell Significance Index: -2.3600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2988
    Cell Significance Index: -3.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** OR12D2 is encoded by the ENSG00000280236 gene and is expressed in numerous cell types, including megakaryocytes, ependymal cells, ciliated epithelial cells, neurons, squamous epithelial cells, double negative thymocytes, neoplastic cells, sst GABAergic cortical interneurons, cerebral cortex neurons, and retinal rod cells. 2. **Function:** OR12D2 is an olfactory receptor that detects chemical stimuli involved in sensory perception of smell. It is a G protein-coupled receptor (GPCR) that activates G proteins upon binding to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 3. **Pathways and Signaling:** OR12D2 is involved in multiple signaling pathways, including detection of chemical stimulus involved in sensory perception of smell, expression and translocation of olfactory receptors, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, odorant binding, olfactory receptor activity, olfactory signaling pathway, plasma membrane, and sensory perception. **Pathways and Functions:** The OR12D2 gene is intricately involved in the following pathways: 1. **Detection of Chemical Stimulus:** OR12D2 detects odorant molecules, which bind to the receptor, triggering a conformational change that activates G proteins. This leads to the production of second messengers, such as cAMP, which ultimately modulate olfactory perception. 2. **Expression and Translocation of Olfactory Receptors:** OR12D2 is involved in the regulation of olfactory receptor expression and translocation, ensuring that the correct receptors are expressed in the right locations to detect specific odorant molecules. 3. **G Protein-Coupled Receptor Activity:** OR12D2 is a GPCR that activates G proteins upon binding to odorant molecules. This activation leads to the production of second messengers, which modulate olfactory perception. 4. **G Protein-Coupled Receptor Signaling Pathway:** OR12D2 is involved in the G protein-coupled receptor signaling pathway, which is a complex cascade of events that ultimately leads to the perception of smell. 5. **Odorant Binding:** OR12D2 binds to odorant molecules, which triggers a conformational change that activates G proteins. This binding is essential for the detection of chemical stimuli involved in sensory perception of smell. 6. **Olfactory Receptor Activity:** OR12D2 is an olfactory receptor that detects odorant molecules, which leads to the perception of smell. 7. **Olfactory Signaling Pathway:** OR12D2 is involved in the olfactory signaling pathway, which is a complex network of events that ultimately leads to the perception of smell. 8. **Plasma Membrane:** OR12D2 is embedded in the plasma membrane, where it can detect odorant molecules and trigger a signaling cascade. 9. **Sensory Perception:** OR12D2 is involved in the sensory perception of smell, which is essential for our ability to detect and distinguish between different odors. **Clinical Significance:** OR12D2 has significant implications for our understanding of olfactory perception and its disorders. Abnormalities in OR12D2 have been linked to various olfactory disorders, including: 1. **Olfactory Dysfunction:** OR12D2 plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Abnormalities in OR12D2 have been linked to olfactory dysfunction, which is characterized by a reduced ability to detect odors. 2. **Smell Loss:** OR12D2 is involved in the detection of odorant molecules, which is essential for our ability to smell. Abnormalities in OR12D2 have been linked to smell loss, which is a common symptom of various neurological disorders. 3. **Neurological Disorders:** OR12D2 is involved in the sensory perception of smell, which is essential for our ability to detect and distinguish between different odors. Abnormalities in OR12D2 have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, OR12D2 is a crucial gene involved in the detection of chemical stimuli involved in sensory perception of smell. Its abnormalities have been linked to various olfactory disorders, including olfactory dysfunction, smell loss, and neurological disorders. Further research is necessary to fully understand the role of OR12D2 in olfactory perception and its clinical significance.

Genular Protein ID: 1759343596

Symbol: O12D2_HUMAN

Name: Olfactory receptor 12D2

UniProtKB Accession Codes:

P58182 B0S862 Q5SUN9 Q6IET9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 307
  • Mass: 34813
  • Checksum: 982907668FCFDE8A
  • Sequence:
    • MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD PRLHSLMYFF 
LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH FFHSLGSTES MLFAVMAFDL 
SVAICKPLRY TVIMNPQLCT QMAITIWVIG FFHALLHSVM TSRLNFCGSN RIHHFLCDIK 
PLLKLACGNT ELNQWLLSTV TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC 
ASHFMVVILF YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL 
GRVIRRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.