Details for: OR4D1

Gene ID: 26689

Symbol: OR4D1

Ensembl ID: ENSG00000141194

Description: olfactory receptor family 4 subfamily D member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6217
    Cell Significance Index: 3.3900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5819
    Cell Significance Index: 5.8400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2862
    Cell Significance Index: 3.2400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2661
    Cell Significance Index: 3.3600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1582
    Cell Significance Index: 1.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1530
    Cell Significance Index: 2.2000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1372
    Cell Significance Index: 1.4600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1214
    Cell Significance Index: 0.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0928
    Cell Significance Index: 1.3300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0358
    Cell Significance Index: 0.4400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0245
    Cell Significance Index: 0.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0172
    Cell Significance Index: 0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0115
    Cell Significance Index: 1.4800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0017
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0018
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0021
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0039
    Cell Significance Index: -0.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0052
    Cell Significance Index: -0.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0082
    Cell Significance Index: -0.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0083
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0090
    Cell Significance Index: -1.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0092
    Cell Significance Index: -1.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0094
    Cell Significance Index: -0.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0103
    Cell Significance Index: -0.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0104
    Cell Significance Index: -1.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0113
    Cell Significance Index: -1.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0118
    Cell Significance Index: -0.5100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0142
    Cell Significance Index: -0.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0145
    Cell Significance Index: -0.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0153
    Cell Significance Index: -0.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0171
    Cell Significance Index: -0.8100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0180
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0180
    Cell Significance Index: -0.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0182
    Cell Significance Index: -1.0200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0186
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0190
    Cell Significance Index: -1.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0192
    Cell Significance Index: -0.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0199
    Cell Significance Index: -1.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0215
    Cell Significance Index: -0.9500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0219
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0220
    Cell Significance Index: -0.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0227
    Cell Significance Index: -0.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0232
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0242
    Cell Significance Index: -0.1500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0249
    Cell Significance Index: -0.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0252
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0253
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0267
    Cell Significance Index: -1.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0269
    Cell Significance Index: -0.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0281
    Cell Significance Index: -0.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0282
    Cell Significance Index: -0.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0284
    Cell Significance Index: -0.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0302
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0303
    Cell Significance Index: -0.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0304
    Cell Significance Index: -0.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0318
    Cell Significance Index: -0.7700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0328
    Cell Significance Index: -0.4800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0328
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0328
    Cell Significance Index: -0.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0331
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0336
    Cell Significance Index: -1.0700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0345
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0345
    Cell Significance Index: -0.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0348
    Cell Significance Index: -0.9300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0353
    Cell Significance Index: -0.6000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0358
    Cell Significance Index: -0.1900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0361
    Cell Significance Index: -0.3200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0361
    Cell Significance Index: -0.4000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0364
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0366
    Cell Significance Index: -1.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0368
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0376
    Cell Significance Index: -0.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0389
    Cell Significance Index: -1.2300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0390
    Cell Significance Index: -0.4700
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0393
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0400
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0408
    Cell Significance Index: -1.0400
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.0411
    Cell Significance Index: -0.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0413
    Cell Significance Index: -1.0300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0418
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR4D1 is a member of the olfactory receptor family, specifically belonging to the 4th subfamily (OR4) and the D member (D1) group. This gene encodes a G protein-coupled receptor (GPCR) that plays a pivotal role in the detection of chemical stimuli involved in the sensory perception of smell. OR4D1 is expressed in various cell types, including glutamatergic neurons, goblet cells, granulocyte monocyte progenitor cells, and neoplastic cells, highlighting its widespread presence in the body. **Pathways and Functions:** OR4D1 is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR4D1 binds to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and translocation of olfactory receptors**: OR4D1 plays a crucial role in the expression and translocation of olfactory receptors to the plasma membrane, enabling their proper functioning. 3. **G protein-coupled receptor activity**: OR4D1 is a GPCR, which means it activates a G protein upon binding to its ligand, leading to various downstream signaling events. 4. **G protein-coupled receptor signaling pathway**: OR4D1 is involved in the G protein-coupled receptor signaling pathway, which is a complex network of signaling events that regulate various cellular processes. **Clinical Significance:** OR4D1 has several clinical implications, including: 1. **Olfactory disorders**: Alterations in OR4D1 expression or function have been linked to various olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced smell). 2. **Neurological disorders**: OR4D1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, which often involve olfactory dysfunction. 3. **Cancer**: OR4D1 is overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. In conclusion, the OR4D1 gene is a vital component of the human olfactory system, playing a crucial role in the detection of chemical stimuli and the perception of smell. Its dysregulation has been linked to various clinical disorders, highlighting the importance of further research into the functions and pathogenesis of OR4D1.

Genular Protein ID: 214464824

Symbol: OR4D1_HUMAN

Name: Olfactory receptor 4D1

UniProtKB Accession Codes:

Q15615 B2RN14 Q8NGB1 Q96R76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 9119360

Title: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

PubMed ID: 9119360

DOI: 10.1006/geno.1996.4490

Sequence Information:

  • Length: 310
  • Mass: 35240
  • Checksum: 058A7B0E8A6CF672
  • Sequence:
    • MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT FDCRLHTPMY 
FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ IFFFHLLGGG TVFFLSVMAY 
DRYIAISQPL RYVTIMNTQL CVGLVVAAWV GGFVHSIVQL ALILPLPFCG PNILDNFYCD 
VPQVLRLACT DTSLLEFLMI SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC 
TTHIIVVSMI FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR 
LGKCLVICRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.