Details for: TRUB2

Gene ID: 26995

Symbol: TRUB2

Ensembl ID: ENSG00000167112

Description: TruB pseudouridine synthase family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.9575
    Cell Significance Index: -17.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.2959
    Cell Significance Index: -15.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.9531
    Cell Significance Index: -20.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.1276
    Cell Significance Index: -22.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.1223
    Cell Significance Index: -17.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.1584
    Cell Significance Index: -22.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.8742
    Cell Significance Index: -18.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.4483
    Cell Significance Index: -20.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9918
    Cell Significance Index: -18.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2888
    Cell Significance Index: -20.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8907
    Cell Significance Index: 804.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7939
    Cell Significance Index: 41.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5286
    Cell Significance Index: 23.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4991
    Cell Significance Index: 6.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4939
    Cell Significance Index: 48.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4900
    Cell Significance Index: 88.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4820
    Cell Significance Index: 34.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4593
    Cell Significance Index: 31.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4306
    Cell Significance Index: 12.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4202
    Cell Significance Index: 68.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4003
    Cell Significance Index: 218.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3958
    Cell Significance Index: 3.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3905
    Cell Significance Index: 8.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3788
    Cell Significance Index: 75.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3784
    Cell Significance Index: 46.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3757
    Cell Significance Index: 51.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3683
    Cell Significance Index: 9.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3463
    Cell Significance Index: 69.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3420
    Cell Significance Index: 151.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3376
    Cell Significance Index: 3.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3249
    Cell Significance Index: 8.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3156
    Cell Significance Index: 10.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3148
    Cell Significance Index: 6.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3021
    Cell Significance Index: 19.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2856
    Cell Significance Index: 7.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2840
    Cell Significance Index: 13.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2278
    Cell Significance Index: 6.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2240
    Cell Significance Index: 154.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1964
    Cell Significance Index: 6.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1933
    Cell Significance Index: 14.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1856
    Cell Significance Index: 11.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1839
    Cell Significance Index: 23.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1831
    Cell Significance Index: 9.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1619
    Cell Significance Index: 19.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1562
    Cell Significance Index: 56.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1532
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1482
    Cell Significance Index: 28.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1411
    Cell Significance Index: 7.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1273
    Cell Significance Index: 1.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1070
    Cell Significance Index: 13.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0872
    Cell Significance Index: 2.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0566
    Cell Significance Index: 1.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0305
    Cell Significance Index: 0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0125
    Cell Significance Index: 9.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0005
    Cell Significance Index: -0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0081
    Cell Significance Index: -10.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0132
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0185
    Cell Significance Index: -3.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0193
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0253
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0276
    Cell Significance Index: -0.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0351
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0358
    Cell Significance Index: -16.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0442
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0448
    Cell Significance Index: -28.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0506
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0607
    Cell Significance Index: -17.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0654
    Cell Significance Index: -7.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0786
    Cell Significance Index: -11.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0813
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1012
    Cell Significance Index: -11.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1092
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1197
    Cell Significance Index: -25.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1319
    Cell Significance Index: -2.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1381
    Cell Significance Index: -3.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1413
    Cell Significance Index: -7.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1536
    Cell Significance Index: -10.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1588
    Cell Significance Index: -2.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1638
    Cell Significance Index: -12.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1946
    Cell Significance Index: -20.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2374
    Cell Significance Index: -3.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2536
    Cell Significance Index: -15.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2670
    Cell Significance Index: -11.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2821
    Cell Significance Index: -3.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3446
    Cell Significance Index: -13.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3918
    Cell Significance Index: -4.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3948
    Cell Significance Index: -11.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4527
    Cell Significance Index: -12.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4543
    Cell Significance Index: -9.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4590
    Cell Significance Index: -16.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4781
    Cell Significance Index: -12.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4856
    Cell Significance Index: -17.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4887
    Cell Significance Index: -16.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4937
    Cell Significance Index: -15.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudouridine Synthase Activity**: TRUB2 is a pseudouridine synthase, an enzyme that modifies RNA molecules by introducing a pseudouridine residue, which is essential for RNA stability and function. 2. **Mitochondrial Localization**: TRUB2 is primarily localized to the mitochondrial matrix, where it regulates mitochondrial translation and function. 3. **RNA Binding**: TRUB2 interacts with RNA molecules, including tRNAs and mRNAs, to regulate their processing and translation. 4. **Regulation of Cellular Processes**: TRUB2 is involved in various cellular processes, including positive regulation of mitochondrial translation, RNA pseudouridine synthesis, and ribonucleoprotein granule formation. **Pathways and Functions:** 1. **Mitochondrial Translation Regulation**: TRUB2 regulates mitochondrial translation by modifying tRNAs and mRNAs, ensuring the proper translation of mitochondrial proteins. 2. **RNA Pseudouridine Synthesis**: TRUB2 is involved in the synthesis of pseudouridine, a modification that is essential for RNA stability and function. 3. **Ribonucleoprotein Granule Formation**: TRUB2 is involved in the formation of ribonucleoprotein granules, which are involved in RNA processing and storage. 4. **Positive Regulation of Mitochondrial Translation**: TRUB2 regulates mitochondrial translation by modifying tRNAs and mRNAs, promoting the translation of mitochondrial proteins. **Clinical Significance:** 1. **Mitochondrial Diseases**: Alterations in TRUB2 expression have been linked to various mitochondrial diseases, including neurodegenerative disorders and metabolic disorders. 2. **Cancer**: TRUB2 has been implicated in cancer development and progression, with altered expression levels linked to poor prognosis. 3. **Neurological Disorders**: TRUB2 has been associated with various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune Cell Function**: TRUB2 is involved in immune cell function, and alterations in its expression have been linked to immune-related disorders. In conclusion, TRUB2 is a crucial gene involved in various cellular processes, including mitochondrial function, RNA processing, and translation regulation. Its widespread expression across different cell types highlights its importance in maintaining cellular homeostasis. Further studies are needed to elucidate the mechanisms by which TRUB2 regulates cellular processes and to explore its potential implications in various diseases.

Genular Protein ID: 3626158118

Symbol: TRUB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

O95900 B7Z7G5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 Rhea 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12736709

Title: The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1.

PubMed ID: 12736709

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27667664

Title: A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

PubMed ID: 27667664

DOI: 10.1016/j.cmet.2016.08.017

PubMed ID: 27974379

Title: A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability.

PubMed ID: 27974379

DOI: 10.15252/embr.201643391

PubMed ID: 28082677

Title: The pseudouridine synthase RPUSD4 is an essential component of mitochondrial RNA granules.

PubMed ID: 28082677

DOI: 10.1074/jbc.m116.771105

PubMed ID: 31477916

Title: mRNA structure determines modification by pseudouridine synthase 1.

PubMed ID: 31477916

DOI: 10.1038/s41589-019-0353-z

PubMed ID: 33023933

Title: Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA.

PubMed ID: 33023933

DOI: 10.1261/rna.076810.120

Sequence Information:

  • Length: 331
  • Mass: 36694
  • Checksum: 60DD5F9FEA998684
  • Sequence:
    • MGSAGLSRLH GLFAVYKPPG LKWKHLRDTV ELQLLKGLNA RKPPAPKQRV RFLLGPMEGS 
EEKELTLTAT SVPSFINHPL VCGPAFAHLK VGVGHRLDAQ ASGVLVLGVG HGCRLLTDMY 
NAHLTKDYTV RGLLGKATDD FREDGRLVEK TTYDHVTREK LDRILAVIQG SHQKALVMYS 
NLDLKTQEAY EMAVRGLIRP MNKSPMLITG IRCLYFAPPE FLLEVQCMHE TQKELRKLVH 
EIGLELKTTA VCTQVRRTRD GFFTLDSALL RTQWDLTNIQ DAIRAATPQV AAELEKSLSP 
GLDTKQLPSP GWSWDSQGPS STLGLERGAG Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.