Details for: DNAJC2

Gene ID: 27000

Symbol: DNAJC2

Ensembl ID: ENSG00000105821

Description: DnaJ heat shock protein family (Hsp40) member C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.8484
    Cell Significance Index: -38.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.1076
    Cell Significance Index: -32.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.5260
    Cell Significance Index: -45.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.6785
    Cell Significance Index: -35.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.7979
    Cell Significance Index: -42.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8217
    Cell Significance Index: -36.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.2186
    Cell Significance Index: -42.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2486
    Cell Significance Index: -38.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9831
    Cell Significance Index: -43.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1064
    Cell Significance Index: -27.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6768
    Cell Significance Index: -18.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8008
    Cell Significance Index: 24.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6643
    Cell Significance Index: 270.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2148
    Cell Significance Index: 33.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0762
    Cell Significance Index: 215.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9530
    Cell Significance Index: 189.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8131
    Cell Significance Index: 8.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8118
    Cell Significance Index: 38.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7989
    Cell Significance Index: 36.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7961
    Cell Significance Index: 102.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7961
    Cell Significance Index: 109.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7707
    Cell Significance Index: 20.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7553
    Cell Significance Index: 39.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7081
    Cell Significance Index: 45.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6859
    Cell Significance Index: 48.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6686
    Cell Significance Index: 120.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5966
    Cell Significance Index: 263.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5878
    Cell Significance Index: 72.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5864
    Cell Significance Index: 40.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5827
    Cell Significance Index: 8.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5725
    Cell Significance Index: 395.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5308
    Cell Significance Index: 11.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5096
    Cell Significance Index: 9.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4835
    Cell Significance Index: 10.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4615
    Cell Significance Index: 252.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4509
    Cell Significance Index: 53.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4368
    Cell Significance Index: 32.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3700
    Cell Significance Index: 28.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2803
    Cell Significance Index: 14.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2802
    Cell Significance Index: 27.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2766
    Cell Significance Index: 15.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2761
    Cell Significance Index: 16.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2732
    Cell Significance Index: 97.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2730
    Cell Significance Index: 246.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2681
    Cell Significance Index: 12.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2324
    Cell Significance Index: 5.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1789
    Cell Significance Index: 30.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1707
    Cell Significance Index: 32.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1315
    Cell Significance Index: 4.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1272
    Cell Significance Index: 4.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1242
    Cell Significance Index: 3.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1224
    Cell Significance Index: 15.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1059
    Cell Significance Index: 2.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0376
    Cell Significance Index: 57.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0220
    Cell Significance Index: 40.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0191
    Cell Significance Index: 35.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0183
    Cell Significance Index: 24.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0114
    Cell Significance Index: 0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0206
    Cell Significance Index: -15.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0230
    Cell Significance Index: -17.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0292
    Cell Significance Index: -13.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0305
    Cell Significance Index: -19.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0358
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0498
    Cell Significance Index: -5.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0556
    Cell Significance Index: -1.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0621
    Cell Significance Index: -9.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0755
    Cell Significance Index: -3.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0760
    Cell Significance Index: -4.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1046
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1085
    Cell Significance Index: -22.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1243
    Cell Significance Index: -35.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1558
    Cell Significance Index: -5.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1947
    Cell Significance Index: -13.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1975
    Cell Significance Index: -22.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2058
    Cell Significance Index: -5.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2121
    Cell Significance Index: -24.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2166
    Cell Significance Index: -24.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3095
    Cell Significance Index: -1.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3309
    Cell Significance Index: -5.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3464
    Cell Significance Index: -8.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3882
    Cell Significance Index: -11.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3938
    Cell Significance Index: -41.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4363
    Cell Significance Index: -22.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4415
    Cell Significance Index: -3.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4470
    Cell Significance Index: -35.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4662
    Cell Significance Index: -10.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5143
    Cell Significance Index: -12.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5299
    Cell Significance Index: -32.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5448
    Cell Significance Index: -10.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5885
    Cell Significance Index: -12.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6143
    Cell Significance Index: -31.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6219
    Cell Significance Index: -19.9200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6556
    Cell Significance Index: -4.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6938
    Cell Significance Index: -8.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7309
    Cell Significance Index: -10.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7316
    Cell Significance Index: -19.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7888
    Cell Significance Index: -23.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAJC2 is a small, 65-kDa protein that belongs to the Hsp40 family, which is known for its ability to interact with Hsp70 proteins to regulate protein folding and degradation. DNAJC2 is characterized by its high sequence similarity to other Hsp40 family members and its ability to bind to Hsp70 and other proteins, including histones and ubiquitin. **Pathways and Functions:** DNAJC2 is involved in various cellular pathways, including: 1. **De novo** cotranslational protein folding: DNAJC2 interacts with Hsp70 to facilitate the folding of newly synthesized proteins, ensuring proper protein structure and function. 2. **ATPase activator activity**: DNAJC2 activates the ATPase activity of Hsp70, which is essential for protein folding and degradation. 3. **Cellular responses to stimuli**: DNAJC2 regulates the response to various cellular stimuli, including heat shock, oxidative stress, and DNA damage. 4. **Chromatin binding and organization**: DNAJC2 interacts with histones and other chromatin proteins to regulate chromatin structure and gene expression. 5. **Regulation of DNA biosynthesis**: DNAJC2 regulates the expression of genes involved in DNA replication and repair. **Clinical Significance:** Dysregulation of DNAJC2 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of DNAJC2 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: DNAJC2 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it may play a role in regulating protein folding and aggregation. 3. **Inflammatory diseases**: DNAJC2 has been implicated in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, where it may regulate the response to inflammatory stimuli. 4. **Cardiovascular disease**: DNAJC2 has been linked to cardiovascular disease, where it may regulate the response to oxidative stress and inflammation. In conclusion, DNAJC2 plays a crucial role in maintaining cellular homeostasis by regulating various cellular processes, including protein folding, transcription, and response to stress. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 2660764196

Symbol: DNJC2_HUMAN

Name: DnaJ homolog subfamily C member 2

UniProtKB Accession Codes:

Q99543 A4VCI0 Q9BVX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8885239

Title: Identification of novel M phase phosphoproteins by expression cloning.

PubMed ID: 8885239

DOI: 10.1091/mbc.7.9.1455

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11034098

Title: A putative oncogenic role for MPP11 in head and neck squamous cell cancer.

PubMed ID: 11034098

PubMed ID: 12800198

Title: Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia.

PubMed ID: 12800198

DOI: 10.1002/ijc.11200

PubMed ID: 14696097

Title: mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies.

PubMed ID: 14696097

DOI: 10.1002/ijc.11623

PubMed ID: 16002468

Title: The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.

PubMed ID: 16002468

DOI: 10.1073/pnas.0504400102

PubMed ID: 15802566

Title: Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous.

PubMed ID: 15802566

DOI: 10.1126/science.1109247

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17242690

Title: C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.

PubMed ID: 17242690

DOI: 10.1038/sj.cr.7310121

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20231810

Title: Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes.

PubMed ID: 20231810

DOI: 10.1016/s1658-3876(10)50053-0

PubMed ID: 21179169

Title: Transcriptional activation of polycomb-repressed genes by ZRF1.

PubMed ID: 21179169

DOI: 10.1038/nature09574

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 621
  • Mass: 71996
  • Checksum: E4DAEE7A73D0F64C
  • Sequence:
    • MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS 
EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP 
DKRKAAGEPI KEGDNDYFTC ITKAYEMLSD PVKRRAFNSV DPTFDNSVPS KSEAKDNFFE 
VFTPVFERNS RWSNKKNVPK LGDMNSSFED VDIFYSFWYN FDSWREFSYL DEEEKEKAEC 
RDERRWIEKQ NRATRAQRKK EEMNRIRTLV DNAYSCDPRI KKFKEEEKAK KEAEKKAKAE 
AKRKEQEAKE KQRQAELEAA RLAKEKEEEE VRQQALLAKK EKDIQKKAIK KERQKLRNSC 
KTWNHFSDNE AERVKMMEEV EKLCDRLELA SLQCLNETLT SCTKEVGKAA LEKQIEEINE 
QIRKEKEEAE ARMRQASKNT EKSTGGGGNG SKNWSEDDLQ LLIKAVNLFP AGTNSRWEVI 
ANYMNIHSSS GVKRTAKDVI GKAKSLQKLD PHQKDDINKK AFDKFKKEHG VVPQADNATP 
SERFEGPYTD FTPWTTEEQK LLEQALKTYP VNTPERWEKI AEAVPGRTKK DCMKRYKELV 
EMVKAKKAAQ EQVLNASRAK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.