Details for: UQCRQ

Gene ID: 27089

Symbol: UQCRQ

Ensembl ID: ENSG00000164405

Description: ubiquinol-cytochrome c reductase complex III subunit VII

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 578.8992
    Cell Significance Index: -90.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 378.2870
    Cell Significance Index: -95.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 296.1784
    Cell Significance Index: -122.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 248.8760
    Cell Significance Index: -117.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 229.8277
    Cell Significance Index: -118.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 176.2237
    Cell Significance Index: -118.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 92.4607
    Cell Significance Index: -114.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.2453
    Cell Significance Index: -99.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.8739
    Cell Significance Index: -121.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.5839
    Cell Significance Index: -81.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.7401
    Cell Significance Index: -32.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 10.0758
    Cell Significance Index: 92.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.0972
    Cell Significance Index: 1279.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.2644
    Cell Significance Index: 770.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.5108
    Cell Significance Index: 44.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2247
    Cell Significance Index: 243.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.7720
    Cell Significance Index: 125.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.6261
    Cell Significance Index: 28.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.6121
    Cell Significance Index: 269.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4003
    Cell Significance Index: 159.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2457
    Cell Significance Index: 1772.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1963
    Cell Significance Index: 167.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.1789
    Cell Significance Index: 165.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1658
    Cell Significance Index: 66.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.7576
    Cell Significance Index: 41.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7464
    Cell Significance Index: 194.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.6645
    Cell Significance Index: 1178.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6485
    Cell Significance Index: 363.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.6290
    Cell Significance Index: 60.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.5586
    Cell Significance Index: 68.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5172
    Cell Significance Index: 68.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5057
    Cell Significance Index: 323.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4511
    Cell Significance Index: 289.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3115
    Cell Significance Index: 26.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2327
    Cell Significance Index: 101.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2092
    Cell Significance Index: 283.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1681
    Cell Significance Index: 23.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2827
    Cell Significance Index: 15.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2243
    Cell Significance Index: 209.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1927
    Cell Significance Index: 1076.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1505
    Cell Significance Index: 33.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0659
    Cell Significance Index: 105.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0516
    Cell Significance Index: 66.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.0327
    Cell Significance Index: 781.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8731
    Cell Significance Index: 166.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8484
    Cell Significance Index: 15.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7842
    Cell Significance Index: 27.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7056
    Cell Significance Index: 18.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6403
    Cell Significance Index: 41.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4104
    Cell Significance Index: 81.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3357
    Cell Significance Index: 246.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3281
    Cell Significance Index: 9.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1802
    Cell Significance Index: 3.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1708
    Cell Significance Index: 27.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1572
    Cell Significance Index: 5.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0759
    Cell Significance Index: 15.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0155
    Cell Significance Index: -9.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0212
    Cell Significance Index: -39.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0270
    Cell Significance Index: -19.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0448
    Cell Significance Index: -4.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0540
    Cell Significance Index: -1.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0790
    Cell Significance Index: -145.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0888
    Cell Significance Index: -136.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1069
    Cell Significance Index: -145.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1163
    Cell Significance Index: -9.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1254
    Cell Significance Index: -70.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1370
    Cell Significance Index: -87.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1544
    Cell Significance Index: -55.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1817
    Cell Significance Index: -38.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2207
    Cell Significance Index: -100.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3022
    Cell Significance Index: -5.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3427
    Cell Significance Index: -98.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4418
    Cell Significance Index: -50.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5056
    Cell Significance Index: -6.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5508
    Cell Significance Index: -14.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6190
    Cell Significance Index: -13.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6376
    Cell Significance Index: -74.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6476
    Cell Significance Index: -73.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6837
    Cell Significance Index: -14.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7019
    Cell Significance Index: -20.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7113
    Cell Significance Index: -103.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1485
    Cell Significance Index: -28.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1639
    Cell Significance Index: -121.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2392
    Cell Significance Index: -76.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2491
    Cell Significance Index: -33.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2555
    Cell Significance Index: -17.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2578
    Cell Significance Index: -96.5300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.5564
    Cell Significance Index: -32.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5686
    Cell Significance Index: -88.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7174
    Cell Significance Index: -115.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.7285
    Cell Significance Index: -103.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7806
    Cell Significance Index: -109.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9029
    Cell Significance Index: -56.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.2319
    Cell Significance Index: -64.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.4191
    Cell Significance Index: -20.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5789
    Cell Significance Index: -94.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -2.6447
    Cell Significance Index: -44.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.9031
    Cell Significance Index: -128.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.0008
    Cell Significance Index: -77.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -3.0383
    Cell Significance Index: -44.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The UQCRQ gene is a mitochondrial gene, which means it is located in the mitochondrial genome and encodes a protein that is integral to the mitochondrial respiratory chain. The protein product of the UQCRQ gene, QCR8, is a subunit of the electron transport chain complex III, also known as the cytochrome b-c1 complex. This complex is responsible for the transfer of electrons from ubiquinol to cytochrome c, which is essential for the production of ATP through chemiosmosis. The UQCRQ gene is highly conserved across species, suggesting that it plays a critical role in the function of the mitochondrial respiratory chain. **Pathways and Functions** The UQCRQ gene is involved in several cellular pathways, including: 1. **Cellular respiration**: The UQCRQ gene plays a critical role in the production of ATP through the electron transport chain complex III. 2. **Mitochondrial electron transport**: The UQCRQ gene is involved in the transfer of electrons from ubiquinol to cytochrome c, which is essential for the production of ATP. 3. **Metabolism**: The UQCRQ gene is involved in the regulation of metabolic pathways, including glycolysis, the citric acid cycle, and fatty acid oxidation. 4. **Protein degradation**: The UQCRQ gene is involved in the regulation of protein degradation pathways, including the ubiquitin-proteasome pathway. **Clinical Significance** Mutations in the UQCRQ gene have been associated with various diseases, including: 1. **Mitochondrial disorders**: Mutations in the UQCRQ gene have been linked to mitochondrial disorders, including Kearns-Sayre syndrome and MERRF syndrome. 2. **Cancers**: Mutations in the UQCRQ gene have been associated with an increased risk of cancer, including breast and lung cancer. 3. **Neurodegenerative diseases**: Mutations in the UQCRQ gene have been linked to neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. 4. **Cardiovascular disease**: Mutations in the UQCRQ gene have been associated with an increased risk of cardiovascular disease, including heart failure and arrhythmias. In summary, the UQCRQ gene plays a critical role in the mitochondrial respiratory chain and is involved in several cellular pathways, including cellular respiration, metabolism, and protein degradation. Mutations in this gene have been associated with various diseases, including mitochondrial disorders, cancers, and neurodegenerative diseases. Further research is needed to fully understand the function of the UQCRQ gene and its role in human disease.

Genular Protein ID: 3499045634

Symbol: QCR8_HUMAN

Name: Cytochrome b-c1 complex subunit 8

UniProtKB Accession Codes:

O14949 Q5FVE2 Q9BV88 Q9T2V7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 8 EMBL 3 Ensembl 3 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8592474

Title: Ubiquinol-cytochrome-c reductase from human and bovine mitochondria.

PubMed ID: 8592474

DOI: 10.1016/0076-6879(95)60132-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 18439546

Title: Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.

PubMed ID: 18439546

DOI: 10.1016/j.ajhg.2008.03.020

Sequence Information:

  • Length: 82
  • Mass: 9906
  • Checksum: 5ED13ABDD2990DD2
  • Sequence:
    • MGREFGNLTR MRHVISYSLS PFEQRAYPHV FTKGIPNVLR RIRESFFRVV PQFVVFYLIY 
TWGTEEFERS KRKNPAAYEN DK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.